Sign in to edit your profile (add interests, mentoring, photo, etc.)
    Keywords
    Last Name
    Institution

    William J Schwartz MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentNeurology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-334-2527
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentTranslational Science

        Overview 
        Narrative

        Biography

        William J. Schwartz received his M.D. (1974) and neurology residency training (1978-1981) at the University of California, San Francisco, completed a research fellowship at the National Institute of Mental Health (1975-1978), and was on the faculties of Harvard Medical School and the Massachusetts General Hospital (1981-1986) before moving to the University of Massachusetts. Visiting Professorships have included the Boerhaave Professor at Leiden University Medical Centre (2005) and the Baerends Visiting Chair at Rijksuniversiteit Groningen (2008), both in the Netherlands; and the Hood Fellow at the University of Auckland (2012), in New Zealand.

        Dr. William Schwartz, M.D.

        On the Neurobiology of Circadian Timekeeping

        Daily rhythms of physiology and behavior are governed by an endogenous timekeeping mechanism (a circadian "clock"), with the alternation of environmental light and darkness synchronizing (entraining) these rhythms to the natural day-night cycle. Our knowledge of circadian timekeeping of animals at the molecular and cellular levels is remarkable, and laboratories here in the Department of Neurobiology are playing major roles in these advances (Emery, Reppert, Weaver). This laboratory is focused at the tissue, organismal, and even supra-organismal levels of analysis, and how all levels of biological organization contribute to the emergent properties and increased complexity of the circadian system as a whole.

        Much of our work has focused on the suprachiasmatic nucleus (SCN) of the hypothalamus, the "master" circadian pacemaker of mammals, a tissue composed of multiple autonomous single-cell circadian oscillators (Figs 1 - 3). Our interests have included functional localization and energy metabolism, light-induced and endogenous gene expression, and the underyling dual oscillatory structure of the circadian pacemaker. We have been using molecular tools to show that some well-known circadian behaviors (e.g., "splitting," "forced desynchronization," and perhaps photoperiodism) emerge at the tissue level, in the dynamic interactions between SCN neurons rather than in the expression of "clock genes" within neurons.

        For the most part, experiments on circadian rhythmicity (including our own) have been carried out using singly-housed animals in plastic cages with temperature, humidity, and access to food rigidly controlled. Of course, many species ordinarily would not live out their lives in such seclusion. They form real ecological communities, and some live in colonies with highly developed social structures and a clear division of labor, requiring modifications to daily rhythms. For other animals living in the wild, social factors might act to synchronize their behaviors to achieve common goals or, alternatively, actively avoid each other to lessen competition for limited resources. We have been asking if the circadian system is involved in the inter-individual temporal adaptations of cohabiting animals and what mechanisms might be responsible (e.g., whether social interactions alter the rhythmicity of animals with genetically-defective clocks, and the identification of the neurobiological substrates (molecules, cells, and pathways) that underlie circadian adaptation to complex habitats).

        Figure 1. Coronal Nissl-stained section through the rat forebrain, including the bilaterally paired SCN (arrow).

        Figure 1. Coronal Nissl-stained section through the rat forebrain, including the bilaterally paired SCN (arrow).

        . Immunohistochemical arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) protein expression in a coronal section of the rat SCN, processed for double-label immunofluorescence and viewed using excitation wavelengths of 488 nm (green, for AVP) and 568 nm (red, for VIP).

        Figure 2. Immunohistochemical arginine vasopressin (AVP) and vasoactive intestinal polypeptide (VIP) protein expression in a coronal section of the rat SCN, processed for double-label immunofluorescence and viewed using excitation wavelengths of 488 nm (green, for AVP) and 568 nm (red, for VIP).

        Figure 3. The SCN exhibits endogenous day-night rhythms in energy metabolism, gene expression, and electrophysiological activity.

        Figure 3. The SCN exhibits endogenous day-night rhythms in energy metabolism, gene expression, and electrophysiological activity.



        Rotation Projects

        Rotations

        Rotation projects are available for students using a range of experimental approaches, including small animal stereotaxic neurosurgical procedures, longitudinal behavioral analyses, histochemical and autoradiographic imaging of neural patterns of protein and gene expression, and confocal microscopy. Contact the lab regarding specific interests and projects.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Paul MJ, Indic P, Schwartz WJ. Social forces can impact the circadian clocks of cohabiting hamsters. Proc Biol Sci. 2014; 281(1779):20132535.
          View in: PubMed
        2. Bloch G, Herzog ED, Levine JD, Schwartz WJ. Socially synchronized circadian oscillators. Proc Biol Sci. 2013 Aug 22; 280(1765):20130035.
          View in: PubMed
        3. Kronfeld-Schor N, Bloch G, Schwartz WJ. Animal clocks: when science meets nature. Proc Biol Sci. 2013 Aug 22; 280(1765):20131354.
          View in: PubMed
        4. Leise TL, Indic P, Paul MJ, Schwartz WJ. Wavelet meets actogram. J Biol Rhythms. 2013 Feb; 28(1):62-8.
          View in: PubMed
        5. Michel S, Marek R, Vanderleest HT, Vansteensel MJ, Schwartz WJ, Colwell CS, Meijer JH. Mechanism of bilateral communication in the suprachiasmatic nucleus. Eur J Neurosci. 2013 Mar; 37(6):964-71.
          View in: PubMed
        6. Gu C, Liu Z, Schwartz WJ, Indic P. Photic desynchronization of two subgroups of circadian oscillators in a network model of the suprachiasmatic nucleus with dispersed coupling strengths. PLoS One. 2012; 7(5):e36900.
          View in: PubMed
        7. Castillo-Ruiz A, Paul MJ, Schwartz WJ. In search of a temporal niche: social interactions. Prog Brain Res. 2012; 199:267-80.
          View in: PubMed
        8. Schwartz WJ, Tavakoli-Nezhad M, Lambert CM, Weaver DR, de la Iglesia HO. Distinct patterns of Period gene expression in the suprachiasmatic nucleus underlie circadian clock photoentrainment by advances or delays. Proc Natl Acad Sci U S A. 2011 Oct 11; 108(41):17219-24.
          View in: PubMed
        9. Paul MJ, Indic P, Schwartz WJ. A role for the habenula in the regulation of locomotor activity cycles. Eur J Neurosci. 2011 Aug; 34(3):478-88.
          View in: PubMed
        10. Paydarfar D, Schwartz WJ. A piece of my mind. Dear provider. JAMA. 2011 May 25; 305(20):2046-7.
          View in: PubMed
        11. Paul MJ, Schwartz WJ. Circadian rhythms: how does a reindeer tell time? Curr Biol. 2010 Mar 23; 20(6):R280-2.
          View in: PubMed
        12. Haddady S, Low HP, Billings-Gagliardi S, Riskind PN, Schwartz WJ. Pregnancy modulates precursor cell proliferation in a murine model of focal demyelination. Neuroscience. 2010 May 19; 167(3):656-64.
          View in: PubMed
        13. Schwartz WJ. Circadian rhythms: a tale of two nuclei. Curr Biol. 2009 Jun 9; 19(11):R460-2.
          View in: PubMed
        14. Paul MJ, Galang J, Schwartz WJ, Prendergast BJ. Intermediate-duration day lengths unmask reproductive responses to nonphotic environmental cues. Am J Physiol Regul Integr Comp Physiol. 2009 May; 296(5):R1613-9.
          View in: PubMed
        15. Low HP, Gréco B, Tanahashi Y, Gallant J, Jones SN, Billings-Gagliardi S, Recht LD, Schwartz WJ. Embryonic stem cell rescue of tremor and ataxia in myelin-deficient shiverer mice. J Neurol Sci. 2009 Jan 15; 276(1-2):133-7.
          View in: PubMed
        16. Mitome M, Low HP, Lora Rodriguez KM, Kitamoto M, Kitamura T, Schwartz WJ. Neuronal differentiation of EGF-propagated neurosphere cells after engraftment to the nucleus of the solitary tract. Neurosci Lett. 2008 Oct 31; 444(3):250-3.
          View in: PubMed
        17. Indic P, Schwartz WJ, Paydarfar D. Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms. J R Soc Interface. 2008 Aug 6; 5(25):873-83.
          View in: PubMed
        18. Paul MJ, Zucker I, Schwartz WJ. Tracking the seasons: the internal calendars of vertebrates. Philos Trans R Soc Lond B Biol Sci. 2008 Jan 27; 363(1490):341-61.
          View in: PubMed
        19. Indic P, Schwartz WJ, Herzog ED, Foley NC, Antle MC. Modeling the behavior of coupled cellular circadian oscillators in the suprachiasmatic nucleus. J Biol Rhythms. 2007 Jun; 22(3):211-9.
          View in: PubMed
        20. Tavakoli-Nezhad M, Tao-Cheng JH, Weaver DR, Schwartz WJ. PER1-like immunoreactivity in oxytocin cells of the hamster hypothalamo-neurohypophyseal system. J Biol Rhythms. 2007 Feb; 22(1):81-4.
          View in: PubMed
        21. Paul MJ, Schwartz WJ. On the chronobiology of cohabitation. Cold Spring Harb Symp Quant Biol. 2007; 72:615-21.
          View in: PubMed
        22. Tavakoli-Nezhad M, Schwartz WJ. Hamsters running on time: is the lateral habenula a part of the clock? Chronobiol Int. 2006; 23(1-2):217-24.
          View in: PubMed
        23. de la Iglesia HO, Schwartz WJ. Minireview: timely ovulation: circadian regulation of the female hypothalamo-pituitary-gonadal axis. Endocrinology. 2006 Mar; 147(3):1148-53.
          View in: PubMed
        24. Tavakoli-Nezhad M, Schwartz WJ. c-Fos expression in the brains of behaviorally "split" hamsters in constant light: calling attention to a dorsolateral region of the suprachiasmatic nucleus and the medial division of the lateral habenula. J Biol Rhythms. 2005 Oct; 20(5):419-29.
          View in: PubMed
        25. Schwartz WJ, Aronin N, Sassone-Corsi P. Photoinducible and rhythmic ICER-CREM immunoreactivity in the rat suprachiasmatic nucleus. Neurosci Lett. 2005 Sep 2; 385(1):87-91.
          View in: PubMed
        26. Nair G, Tanahashi Y, Low HP, Billings-Gagliardi S, Schwartz WJ, Duong TQ. Myelination and long diffusion times alter diffusion-tensor-imaging contrast in myelin-deficient shiverer mice. Neuroimage. 2005 Oct 15; 28(1):165-74.
          View in: PubMed
        27. Silver R, Schwartz WJ. The suprachiasmatic nucleus is a functionally heterogeneous timekeeping organ. Methods Enzymol. 2005; 393:451-65.
          View in: PubMed
        28. Schwartz WJ. Sunrise and sunset in fly brains. Nature. 2004 Oct 14; 431(7010):751-2.
          View in: PubMed
        29. Schwartz WJ, Meijer JH. Real-time imaging reveals spatiotemporal dynamics of cellular circadian clocks. Trends Neurosci. 2004 Sep; 27(9):513-6.
          View in: PubMed
        30. de la Iglesia HO, Meyer J, Schwartz WJ. Using Per gene expression to search for photoperiodic oscillators in the hamster suprachiasmatic nucleus. Brain Res Mol Brain Res. 2004 Aug 23; 127(1-2):121-7.
          View in: PubMed
        31. de la Iglesia HO, Cambras T, Schwartz WJ, Díez-Noguera A. Forced desynchronization of dual circadian oscillators within the rat suprachiasmatic nucleus. Curr Biol. 2004 May 4; 14(9):796-800.
          View in: PubMed
        32. de la Iglesia HO, Meyer J, Schwartz WJ. Lateralization of circadian pacemaker output: Activation of left- and right-sided luteinizing hormone-releasing hormone neurons involves a neural rather than a humoral pathway. J Neurosci. 2003 Aug 13; 23(19):7412-4.
          View in: PubMed
        33. Van Gelder RN, Herzog ED, Schwartz WJ, Taghert PH. Circadian rhythms: in the loop at last. Science. 2003 Jun 6; 300(5625):1534-5.
          View in: PubMed
        34. Meijer JH, Schwartz WJ. In search of the pathways for light-induced pacemaker resetting in the suprachiasmatic nucleus. J Biol Rhythms. 2003 Jun; 18(3):235-49.
          View in: PubMed
        35. Edelstein K, de la Iglesia HO, Schwartz WJ, Mrosovsky N. Behavioral arousal blocks light-induced phase advances in locomotor rhythmicity but not light-induced Per1 and Fos expression in the hamster suprachiasmatic nucleus. Neuroscience. 2003; 118(1):253-61.
          View in: PubMed
        36. Schwartz WJ. Suprachiasmatic nucleus. Curr Biol. 2002 Oct 1; 12(19):R644.
          View in: PubMed
        37. De la Iglesia HO, Schwartz WJ. A subpopulation of efferent neurons in the mouse suprachiasmatic nucleus is also light responsive. Neuroreport. 2002 May 7; 13(6):857-60.
          View in: PubMed
        38. Zlomanczuk P, Mrugala M, de la Iglesia HO, Ourednik V, Quesenberry PJ, Snyder EY, Schwartz WJ. Transplanted clonal neural stem-like cells respond to remote photic stimulation following incorporation within the suprachiasmatic nucleus. Exp Neurol. 2002 Apr; 174(2):162-8.
          View in: PubMed
        39. Herzog ED, Schwartz WJ. A neural clockwork for encoding circadian time. J Appl Physiol (1985). 2002 Jan; 92(1):401-8.
          View in: PubMed
        40. Mitome M, Low HP, van den Pol A, Nunnari JJ, Wolf MK, Billings-Gagliardi S, Schwartz WJ. Towards the reconstruction of central nervous system white matter using neural precursor cells. Brain. 2001 Nov; 124(Pt 11):2147-61.
          View in: PubMed
        41. Schwartz WJ, de la Iglesia HO, Zlomanczuk P, Illnerová H. Encoding le quattro stagioni within the mammalian brain: photoperiodic orchestration through the suprachiasmatic nucleus. J Biol Rhythms. 2001 Aug; 16(4):302-11.
          View in: PubMed
        42. Daan S, Albrecht U, van der Horst GT, Illnerová H, Roenneberg T, Wehr TA, Schwartz WJ. Assembling a clock for all seasons: are there M and E oscillators in the genes? J Biol Rhythms. 2001 Apr; 16(2):105-16.
          View in: PubMed
        43. Paydarfar D, Schwartz WJ. An algorithm for discovery. Science. 2001 Apr 6; 292(5514):13.
          View in: PubMed
        44. Low HP, Savarese TM, Schwartz WJ. Neural precursor cells form rudimentary tissue-like structures in a rotating-wall vessel bioreactor. In Vitro Cell Dev Biol Anim. 2001 Mar; 37(3):141-7.
          View in: PubMed
        45. de la Iglesia HO, Meyer J, Carpino A, Schwartz WJ. Antiphase oscillation of the left and right suprachiasmatic nuclei. Science. 2000 Oct 27; 290(5492):799-801.
          View in: PubMed
        46. Mrugala M, Zlomanczuk P, Jagota A, Schwartz WJ. Rhythmic multiunit neural activity in slices of hamster suprachiasmatic nucleus reflect prior photoperiod. Am J Physiol Regul Integr Comp Physiol. 2000 Apr; 278(4):R987-94.
          View in: PubMed
        47. Jagota A, de la Iglesia HO, Schwartz WJ. Morning and evening circadian oscillations in the suprachiasmatic nucleus in vitro. Nat Neurosci. 2000 Apr; 3(4):372-6.
          View in: PubMed
        48. Schwartz WJ, Carpino A, de la Iglesia HO, Baler R, Klein DC, Nakabeppu Y, Aronin N. Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus. Neuroscience. 2000; 98(3):535-47.
          View in: PubMed
        49. Bennett MR, Schwartz WJ. Altered circadian rhythmicity is an early sign of murine dietary thiamine deficiency. J Neurol Sci. 1999 Feb 1; 163(1):6-10.
          View in: PubMed
        50. Delville Y, De Vries GJ, Schwartz WJ, Ferris CF. Flank-marking behavior and the neural distribution of vasopressin innervation in golden hamsters with suprachiasmatic lesions. Behav Neurosci. 1998 Dec; 112(6):1486-501.
          View in: PubMed
        51. Castel M, Belenky M, Cohen S, Wagner S, Schwartz WJ. Light-induced c-Fos expression in the mouse suprachiasmatic nucleus: immunoelectron microscopy reveals co-localization in multiple cell types. Eur J Neurosci. 1997 Sep; 9(9):1950-60.
          View in: PubMed
        52. Schwartz WJ. Molecular time machines. The first gene involved in mammalian circadian timekeeping has been identified. Nat Med. 1997 Jul; 3(7):718-9.
          View in: PubMed
        53. Schwartz WJ. Understanding circadian clocks: from c-fos to fly balls. Ann Neurol. 1997 Mar; 41(3):289-97.
          View in: PubMed
        54. Bennett MR, Aronin N, Schwartz WJ. In vitro stimulation of c-Fos protein expression in the suprachiasmatic nucleus of hypothalamic slices. Brain Res Mol Brain Res. 1996 Nov; 42(1):140-4.
          View in: PubMed
        55. Miller JD, Morin LP, Schwartz WJ, Moore RY. New insights into the mammalian circadian clock. Sleep. 1996 Oct; 19(8):641-67.
          View in: PubMed
        56. Trávnícková Z, Sumová A, Peters R, Schwartz WJ, Illnerová H. Photoperiod-dependent correlation between light-induced SCN c-fos expression and resetting of circadian phase. Am J Physiol. 1996 Oct; 271(4 Pt 2):R825-31.
          View in: PubMed
        57. Peters RV, Aronin N, Schwartz WJ. c-Fos expression in the rat intergeniculate leaflet: photic regulation, co-localization with Fos-B, and cellular identification. Brain Res. 1996 Jul 29; 728(2):231-41.
          View in: PubMed
        58. Schwartz WJ, Peters RV, Aronin N, Bennett MR. Unexpected c-fos gene expression in the suprachiasmatic nucleus of mice entrained to a skeleton photoperiod. J Biol Rhythms. 1996 Mar; 11(1):35-44.
          View in: PubMed
        59. Recht LD, Lew RA, Schwartz WJ. Baseball teams beaten by jet lag. Nature. 1995 Oct 19; 377(6550):583.
          View in: PubMed
        60. Sumová A, Trávnícková Z, Peters R, Schwartz WJ, Illnerová H. The rat suprachiasmatic nucleus is a clock for all seasons. Proc Natl Acad Sci U S A. 1995 Aug 15; 92(17):7754-8.
          View in: PubMed
        61. Shiromani PJ, Schwartz WJ. Towards a molecular biology of the circadian clock and sleep of mammals. Adv Neuroimmunol. 1995; 5(2):217-30.
          View in: PubMed
        62. Peters RV, Aronin N, Schwartz WJ. Circadian regulation of Fos B is different from c-Fos in the rat suprachiasmatic nucleus. Brain Res Mol Brain Res. 1994 Dec; 27(2):243-8.
          View in: PubMed
        63. Bennett MR, Schwartz WJ. Are glia among the cells that express immunoreactive c-Fos in the suprachiasmatic nucleus? Neuroreport. 1994 Sep 8; 5(14):1737-40.
          View in: PubMed
        64. Schwartz WJ, Takeuchi J, Shannon W, Davis EM, Aronin N. Temporal regulation of light-induced Fos and Fos-like protein expression in the ventrolateral subdivision of the rat suprachiasmatic nucleus. Neuroscience. 1994 Feb; 58(3):573-83.
          View in: PubMed
        65. Takeuchi J, Shannon W, Aronin N, Schwartz WJ. Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock. Neuron. 1993 Nov; 11(5):825-36.
          View in: PubMed
        66. Schwartz WJ. Circadian clockwork. Science. 1993 Aug 6; 261(5122):772-3.
          View in: PubMed
        67. Takeuchi J, Schwartz WJ. Was Aesop a chronobiologist? Lancet. 1993 Jun 19; 341(8860):1606.
          View in: PubMed
        68. Schwartz WJ. A clinician's primer on the circadian clock: its localization, function, and resetting. Adv Intern Med. 1993; 38:81-106.
          View in: PubMed
        69. Keilson GR, Schwartz WJ, Recht LD. The preponderance of posterior circulatory events is independent of the route of cardiac catheterization. Stroke. 1992 Sep; 23(9):1358-9.
          View in: PubMed
        70. Siwicki KK, Schwartz WJ, Hall JC. An antibody to the Drosophila period protein labels antigens in the suprachiasmatic nucleus of the rat. J Neurogenet. 1992 Feb; 8(1):33-42.
          View in: PubMed
        71. Lippa CF, Koh ET, Schwartz WJ. Architecture of the suprachiasmatic nuclei in BALB/c and C57BL/6 inbred mouse strains. Brain Res Bull. 1992 Feb; 28(2):347-9.
          View in: PubMed
        72. Schwartz WJ, Zimmerman P. Lesions of the suprachiasmatic nucleus disrupt circadian locomotor rhythms in the mouse. Physiol Behav. 1991 Jun; 49(6):1283-7.
          View in: PubMed
        73. Schwartz WJ. Further evaluation of the tetrodotoxin-resistant circadian pacemaker in the suprachiasmatic nuclei. J Biol Rhythms. 1991; 6(2):149-58.
          View in: PubMed
        74. Schwartz WJ. Different in vivo metabolic activities of suprachiasmatic nuclei of Turkish and golden hamsters. Am J Physiol. 1990 Nov; 259(5 Pt 2):R1083-5.
          View in: PubMed
        75. Schwartz WJ, Zimmerman P. Circadian timekeeping in BALB/c and C57BL/6 inbred mouse strains. J Neurosci. 1990 Nov; 10(11):3685-94.
          View in: PubMed
        76. Aronin N, Sagar SM, Sharp FR, Schwartz WJ. Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. Proc Natl Acad Sci U S A. 1990 Aug; 87(15):5959-62.
          View in: PubMed
        77. Felice KJ, Keilson GR, Schwartz WJ. 'Rubral' gait ataxia. Neurology. 1990 Jun; 40(6):1004-5.
          View in: PubMed
        78. Scammell TE, Schwartz WJ, Smith CB. No evidence for a circadian rhythm of protein synthesis in the rat suprachiasmatic nuclei. Brain Res. 1989 Aug 7; 494(1):155-8.
          View in: PubMed
        79. Robinson BG, Frim DM, Schwartz WJ, Majzoub JA. Vasopressin mRNA in the suprachiasmatic nuclei: daily regulation of polyadenylate tail length. Science. 1988 Jul 15; 241(4863):342-4.
          View in: PubMed
        80. Schwartz WJ, Lydic R, Moore-Ede MC. In vivo metabolic activity of the suprachiasmatic nuclei: non-uniform intranuclear distribution of 14C-labeled deoxyglucose uptake. Brain Res. 1987 Oct 27; 424(2):249-57.
          View in: PubMed
        81. Schwartz WJ, Gross RA, Morton MT. The suprachiasmatic nuclei contain a tetrodotoxin-resistant circadian pacemaker. Proc Natl Acad Sci U S A. 1987 Mar; 84(6):1694-8.
          View in: PubMed
        82. Reppert SM, Henshaw D, Schwartz WJ, Weaver DR. The circadian-gated timing of birth in rats: disruption by maternal SCN lesions or by removal of the fetal brain. Brain Res. 1987 Feb 17; 403(2):398-402.
          View in: PubMed
        83. Schwartz WJ. In vivo metabolic activity of hamster suprachiasmatic nuclei: use of anesthesia. Am J Physiol. 1987 Feb; 252(2 Pt 2):R419-22.
          View in: PubMed
        84. Reppert SM, Schwartz WJ. Maternal endocrine extirpations do not abolish maternal coordination of the fetal circadian clock. Endocrinology. 1986 Oct; 119(4):1763-7.
          View in: PubMed
        85. Reppert SM, Schwartz WJ. Maternal suprachiasmatic nuclei are necessary for maternal coordination of the developing circadian system. J Neurosci. 1986 Sep; 6(9):2724-9.
          View in: PubMed
        86. Schwartz WJ, Busis NA, Hedley-Whyte ET. A discrete lesion of ventral hypothalamus and optic chiasm that disturbed the daily temperature rhythm. J Neurol. 1986 Feb; 233(1):1-4.
          View in: PubMed
        87. Schwartz WJ, Morton MT, Williams RS, Tamarkin L, Baker TL, Dement WC. Circadian timekeeping in narcoleptic dogs. Sleep. 1986; 9(1 Pt 2):120-5.
          View in: PubMed
        88. Schwartz WJ, Reppert SM. Neural regulation of the circadian vasopressin rhythm in cerebrospinal fluid: a pre-eminent role for the suprachiasmatic nuclei. J Neurosci. 1985 Oct; 5(10):2771-8.
          View in: PubMed
        89. Schwartz WJ, Crosby G. Local cerebral glucose utilization in the homozygous Brattleboro rat. Neurosci Lett. 1985 Jul 31; 58(2):171-6.
          View in: PubMed
        90. Schwartz WJ, Stakes JW, Hobson JA. Transient cataplexy after removal of a craniopharyngioma. Neurology. 1984 Oct; 34(10):1372-5.
          View in: PubMed
        91. Reppert SM, Schwartz WJ. The suprachiasmatic nuclei of the fetal rat: characterization of a functional circadian clock using 14C-labeled deoxyglucose. J Neurosci. 1984 Jul; 4(7):1677-82.
          View in: PubMed
        92. Aronin N, Difiglia M, Graveland GA, Schwartz WJ, Wu JY. Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum. Brain Res. 1984 May 23; 300(2):376-80.
          View in: PubMed
        93. Reppert SM, Schwartz WJ. Functional activity of the suprachiasmatic nuclei in the fetal primate. Neurosci Lett. 1984 May 4; 46(2):145-9.
          View in: PubMed
        94. Schwartz WJ, Reppert SM, Eagan SM, Moore-Ede MC. In vivo metabolic activity of the suprachiasmatic nuclei: a comparative study. Brain Res. 1983 Sep 5; 274(1):184-7.
          View in: PubMed
        95. Reppert SM, Schwartz WJ. Maternal coordination of the fetal biological clock in utero. Science. 1983 May 27; 220(4600):969-71.
          View in: PubMed
        96. Schwartz WJ, Coleman RJ, Reppert SM. A daily vasopressin rhythm in rat cerebrospinal fluid. Brain Res. 1983 Mar 14; 263(1):105-12.
          View in: PubMed
        97. Reppert SM, Schwartz WJ, Artman HG, Fisher DA. Comparison of the temporal profiles of vasopressin and oxytocin in the cerebrospinal fluid of the cat, monkey and rat. Brain Res. 1983 Feb 21; 261(2):341-5.
          View in: PubMed
        98. Schwartz WJ, Hutchison HT, Berg BO. Computerized tomography in subacute necrotizing encephalomyelopathy (Leigh disease). Ann Neurol. 1981 Sep; 10(3):268-71.
          View in: PubMed
        99. Schwartz WJ, Gainer H. Localization of the 'biological clock' in the brain. JAMA. 1981 Aug 7; 246(6):681.
          View in: PubMed
        100. Schwartz WJ, Davidsen LC, Smith CB. In vivo metabolic activity of a putative circadian oscillator, the rat suprachiasmatic nucleus. J Comp Neurol. 1980 Jan 1; 189(1):157-67.
          View in: PubMed
        101. Mata M, Fink DJ, Gainer H, Smith CB, Davidsen L, Savaki H, Schwartz WJ, Sokoloff L. Activity-dependent energy metabolism in rat posterior pituitary primarily reflects sodium pump activity. J Neurochem. 1980 Jan; 34(1):213-5.
          View in: PubMed
        102. Schwartz WJ, Smith CB, Davidsen L, Savaki H, Sokoloff L, Mata M, Fink DJ, Gainer H. Metabolic mapping of functional activity in the hypothalamo-neurohypophysial system of the rat. Science. 1979 Aug 17; 205(4407):723-5.
          View in: PubMed
        103. Schwartz WJ. A role for the dopaminergic nigrostriatal bundle in the pathogenesis of altered brain glucose consumption after lateral hypothalamic lesions. Evidence using the 14C-labeled deoxyglucose technique. Brain Res. 1978 Dec 8; 158(1):129-47.
          View in: PubMed
        104. Rapoport SI, Ohno K, Schwartz WJ. Activity-related regional uptake of [14C]deoxyglucose by rat quadriceps femoris muscle. Exp Neurol. 1978 May 15; 60(1):168-74.
          View in: PubMed
        105. Schwartz WJ. 6-Hydroxydopamine lesions of rat locus coeruleus alter brain glucose consumption, as measured by the 2-deoxy-D-[(14)C]glucose tracer technique. Neurosci Lett. 1978 Feb; 7(2-3):141-50.
          View in: PubMed
        106. Schwartz WJ, Sharp FR. Autoradiographic maps of regional brain glucose consumption in resting, awake rats using (14C) 2-deoxyglucose. J Comp Neurol. 1978 Jan 15; 177(2):335-59.
          View in: PubMed
        107. Sharp FR, Schwartz WJ. Proposed effects of brain noradrenaline on neuronal activity and cerebral blood flow during REM sleep. Experientia. 1977 Dec 15; 33(12):1618-20.
          View in: PubMed
        108. Schwartz WJ, Gainer H. Suprachiasmatic nucleus: use of 14C-labeled deoxyglucose uptake as a functional marker. Science. 1977 Sep 9; 197(4308):1089-91.
          View in: PubMed
        109. Schwartz WJ, Sharp FR, Gunn RH, Evarts EV. Lesions of ascending dopaminergic pathways decrease forebrain glucose uptake. Nature. 1976 May 13; 261(5556):155-7.
          View in: PubMed
        110. Schwartz WJ, Gunn RH, Sharp FR, Evarts EV. Unilateral electrolytic lesions of the substantia nigra cause contralateral circling in rats. Brain Res. 1976 Mar 26; 105(2):358-61.
          View in: PubMed
        For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
        William's Networks
        Click the "See All" links for more information and interactive visualizations!
        Concepts
        _
        Co-Authors
        _
        Similar People
        _
        Same Department
        Physical Neighbors
        _

        This is an official Page/Publication of the University of Massachusetts Worcester Campus
        Office of the Vice Provost for Research, 55 Lake Ave North, Worcester, Massachusetts 01655
        Questions or Comments? Email: publicaffairs@umassmed.edu Phone: 508-856-1572