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    Daniel Libraty MD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-4905
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMasters in Clinical Investigation

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for Infectious Disease and Vaccine Research

        Overview 
        Narrative

        Studies of human cellular immune responses contributing to pathogenesis and/or protective immunity in emerging viral diseases:

        In particular, the bridge between innate and adaptive immunity and immune responses during infancy are studied. Infectious diseases include Dengue hemorrhagic fever, HIV vaccines, and hantavirus infections (Hemorrhagic fever renal syndrome and hantavirus cardiopulmonary syndrome).

        Rotation Projects
        position open- please inquire


        Post Docs
        position open- please inquire


        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Srikiatkhachorn A, Wichit S, Gibbons RV, Green S, Libraty DH, Endy TP, Ennis FA, Kalayanarooj S, Rothman AL. Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status. PLoS One. 2012; 7(12):e51335.
          View in: PubMed
        2. Madera RF, Libraty DH. The role of MyD88 signaling in heterosubtypic influenza A virus infections. Virus Res. 2013 Jan; 171(1):216-21.
          View in: PubMed
        3. Patkar C, Giaya K, Libraty DH. Dengue Virus Type 2 Modulates Endothelial Barrier Function through CD73. Am J Trop Med Hyg. 2013 Jan; 88(1):89-94.
          View in: PubMed
        4. Yoon IK, Getis A, Aldstadt J, Rothman AL, Tannitisupawong D, Koenraadt CJ, Fansiri T, Jones JW, Morrison AC, Jarman RG, Nisalak A, Mammen MP, Thammapalo S, Srikiatkhachorn A, Green S, Libraty DH, Gibbons RV, Endy T, Pimgate C, Scott TW. Fine Scale Spatiotemporal Clustering of Dengue Virus Transmission in Children and Aedes aegypti in Rural Thai Villages. PLoS Negl Trop Dis. 2012 Jul; 6(7):e1730.
          View in: PubMed
        5. Wang JP, Zhang L, Madera RF, Woda M, Libraty DH. Plasmacytoid dendritic cell interferon-alpha production to R-848 stimulation is decreased in male infants. BMC Immunol. 2012 Jul 6; 13(1):35.
          View in: PubMed
        6. Yoon IK, Rothman AL, Tannitisupawong D, Srikiatkhachorn A, Jarman RG, Aldstadt J, Nisalak A, Mammen MP, Thammapalo S, Green S, Libraty DH, Gibbons RV, Getis A, Endy T, Jones JW, Koenraadt CJ, Morrison AC, Fansiri T, Pimgate C, Scott TW. Under-Recognized Mildly Symptomatic Viremic Dengue Virus Infections in Rural Thai Schools and Villages. J Infect Dis. 2012 May 21.
          View in: PubMed
        7. Libraty DH, Mäkelä S, Vlk J, Hurme M, Vaheri A, Ennis FA, Mustonen J. The Degree of Leukocytosis and Urine GATA-3 mRNA Levels Are Risk Factors for Severe Acute Kidney Injury in Puumala Virus Nephropathia Epidemica. PLoS One. 2012; 7(4):e35402.
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        8. Libraty DH, Patkar C, Torres B. Staphylococcus aureus reactivation osteomyelitis after 75 years. N Engl J Med. 2012 Feb 2; 366(5):481-2.
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        9. Madera RF, Wang JP, Libraty DH. The combination of early and rapid type I IFN, IL-1a, and IL-1ß production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses. PLoS One. 2011; 6(12):e29412.
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        10. Laine O, Joutsi-Korhonen L, Mäkelä S, Mikkelsson J, Pessi T, Tuomisto S, Huhtala H, Libraty D, Vaheri A, Karhunen P, Mustonen J. Polymorphisms of PAI-1 and platelet GP Ia may associate with impairment of renal function and thrombocytopenia in Puumala hantavirus infection. Thromb Res. 2012 May; 129(5):611-5.
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        11. Anderson KB, Gibbons RV, Thomas SJ, Rothman AL, Nisalak A, Berkelman RL, Libraty DH, Endy TP. Preexisting Japanese encephalitis virus neutralizing antibodies and increased symptomatic dengue illness in a school-based cohort in Thailand. PLoS Negl Trop Dis. 2011 Oct; 5(10):e1311.
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        12. Mathew A, West K, Kalayanarooj S, Gibbons RV, Srikiatkhachorn A, Green S, Libraty D, Jaiswal S, Rothman AL. B-cell responses during primary and secondary dengue virus infections in humans. J Infect Dis. 2011 Nov; 204(10):1514-22.
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        13. Outinen TK, Mäkelä SM, Ala-Houhala IO, Huhtala HS, Hurme M, Libraty DH, Oja SS, Pörsti IH, Syrjänen JT, Vaheri A, Mustonen JT. High activity of indoleamine 2,3-dioxygenase is associated with renal insufficiency in Puumala hantavirus induced nephropathia epidemica. J Med Virol. 2011 Apr; 83(4):731-7.
          View in: PubMed
        14. Endy TP, Anderson KB, Nisalak A, Yoon IK, Green S, Rothman AL, Thomas SJ, Jarman RG, Libraty DH, Gibbons RV. Determinants of inapparent and symptomatic dengue infection in a prospective study of primary school children in kamphaeng phet, Thailand. PLoS Negl Trop Dis. 2011; 5(3):e975.
          View in: PubMed
        15. Hatch S, Endy TP, Thomas S, Mathew A, Potts J, Pazoles P, Libraty DH, Gibbons R, Rothman AL. Intracellular Cytokine Production by Dengue Virus-specific T cells Correlates with Subclinical Secondary Infection. J Infect Dis. 2011 May; 203(9):1282-91.
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        16. Potts JA, Thomas SJ, Srikiatkhachorn A, Supradish PO, Li W, Nisalak A, Nimmannitya S, Endy TP, Libraty DH, Gibbons RV, Green S, Rothman AL, Kalayanarooj S. Classification of dengue illness based on readily available laboratory data. Am J Trop Med Hyg. 2010 Oct; 83(4):781-8.
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        17. Potts JA, Gibbons RV, Rothman AL, Srikiatkhachorn A, Thomas SJ, Supradish PO, Lemon SC, Libraty DH, Green S, Kalayanarooj S. Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators. PLoS Negl Trop Dis. 2010; 4(8):e769.
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        18. Srikiatkhachorn A, Gibbons RV, Green S, Libraty DH, Thomas SJ, Endy TP, Vaughn DW, Nisalak A, Ennis FA, Rothman AL, Nimmannitaya S, Kalayanarooj S. Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005. Clin Infect Dis. 2010 Apr 15; 50(8):1135-43.
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        19. Capeding RZ, Brion JD, Caponpon MM, Gibbons RV, Jarman RG, Yoon IK, Libraty DH. The incidence, characteristics, and presentation of dengue virus infections during infancy. Am J Trop Med Hyg. 2010 Feb; 82(2):330-6.
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        20. Thomas SJ, Nisalak A, Anderson KB, Libraty DH, Kalayanarooj S, Vaughn DW, Putnak R, Gibbons RV, Jarman R, Endy TP. Dengue plaque reduction neutralization test (PRNT) in primary and secondary dengue virus infections: How alterations in assay conditions impact performance. Am J Trop Med Hyg. 2009 Nov; 81(5):825-33.
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        21. Libraty DH, Acosta LP, Tallo V, Segubre-Mercado E, Bautista A, Potts JA, Jarman RG, Yoon IK, Gibbons RV, Brion JD, Capeding RZ. A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model. PLoS Med. 2009 Oct; 6(10):e1000171.
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        22. Liu P, Woda M, Ennis FA, Libraty DH. Dengue virus infection differentially regulates endothelial barrier function over time through type I interferon effects. J Infect Dis. 2009 Jul 15; 200(2):191-201.
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        23. Vejbaesya S, Luangtrakool P, Luangtrakool K, Kalayanarooj S, Vaughn DW, Endy TP, Mammen MP, Green S, Libraty DH, Ennis FA, Rothman AL, Stephens HA. TNF and LTA gene, allele, and extended HLA haplotype associations with severe dengue virus infection in ethnic Thais. J Infect Dis. 2009 May 15; 199(10):1442-8.
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        24. Mammen MP, Pimgate C, Koenraadt CJ, Rothman AL, Aldstadt J, Nisalak A, Jarman RG, Jones JW, Srikiatkhachorn A, Ypil-Butac CA, Getis A, Thammapalo S, Morrison AC, Libraty DH, Green S, Scott TW. Spatial and temporal clustering of dengue virus transmission in Thai villages. PLoS Med. 2008 Nov 4; 5(11):e205.
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        25. Pavlin JA, Hickey AC, Ulbrandt N, Chan YP, Endy TP, Boukhvalova MS, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Ennis FA, Jarman R, Gibbons RV, Broder CC. Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein. J Infect Dis. 2008 Sep 15; 198(6):836-42.
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        26. Zota V, Angelis SM, Fraire AE, McNamee C, Kielbasa S, Libraty DH. Lessons from Mycobacterium avium complex-associated pneumonitis: a case report. J Med Case Reports. 2008; 2:152.
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        27. Jarman RG, Holmes EC, Rodpradit P, Klungthong C, Gibbons RV, Nisalak A, Rothman AL, Libraty DH, Ennis FA, Mammen MP, Endy TP. Microevolution of Dengue viruses circulating among primary school children in Kamphaeng Phet, Thailand. J Virol. 2008 Jun; 82(11):5494-500.
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        28. Libraty DH, Myint KS, Murray CK, Gibbons RV, Mammen MP, Endy TP, Li W, Vaughn DW, Nisalak A, Kalayanarooj S, Hospenthal DR, Green S, Rothman AL, Ennis FA. A comparative study of leptospirosis and dengue in Thai children. PLoS Negl Trop Dis. 2007; 1(3):e111.
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        29. Libraty DH, O'Neil KM, Baker LM, Acosta LP, Olveda RM. Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection. Virology. 2007 Nov 25; 368(2):317-21.
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        30. Anderson KB, Chunsuttiwat S, Nisalak A, Mammen MP, Libraty DH, Rothman AL, Green S, Vaughn DW, Ennis FA, Endy TP. Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study. Lancet. 2007 Apr 28; 369(9571):1452-9.
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        31. Srikiatkhachorn A, Krautrachue A, Ratanaprakarn W, Wongtapradit L, Nithipanya N, Kalayanarooj S, Nisalak A, Thomas SJ, Gibbons RV, Mammen MP, Libraty DH, Ennis FA, Rothman AL, Green S. Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study. Pediatr Infect Dis J. 2007 Apr; 26(4):283-90; discussion 291-2.
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        32. Laoprasopwattana K, Libraty DH, Endy TP, Nisalak A, Chunsuttiwat S, Ennis FA, Rothman AL, Green S. Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication. J Infect Dis. 2007 Apr 15; 195(8):1108-16.
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        33. Srikiatkhachorn A, Ajariyakhajorn C, Endy TP, Kalayanarooj S, Libraty DH, Green S, Ennis FA, Rothman AL. Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever. J Virol. 2007 Feb; 81(4):1592-600.
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        34. Wang JP, Liu P, Latz E, Golenbock DT, Finberg RW, Libraty DH. Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition. J Immunol. 2006 Nov 15; 177(10):7114-21.
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        35. Myint KS, Endy TP, Mongkolsirichaikul D, Manomuth C, Kalayanarooj S, Vaughn DW, Nisalak A, Green S, Rothman AL, Ennis FA, Libraty DH. Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis. J Infect Dis. 2006 Sep 1; 194(5):600-7.
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        36. Ajariyakhajorn C, Mammen MP, Endy TP, Gettayacamin M, Nisalak A, Nimmannitya S, Libraty DH. Randomized, placebo-controlled trial of nonpegylated and pegylated forms of recombinant human alpha interferon 2a for suppression of dengue virus viremia in rhesus monkeys. Antimicrob Agents Chemother. 2005 Nov; 49(11):4508-14.
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        37. Rothman AL, Green S, Libraty DH, Ennis FA. Dengue: translating scientific progress into workable solutions. Expert Rev Anti Infect Ther. 2005 Oct; 3(5):689-92.
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        38. Charnsilpa W, Takhampunya R, Endy TP, Mammen MP, Libraty DH, Ubol S. Nitric oxide radical suppresses replication of wild-type dengue 2 viruses in vitro. J Med Virol. 2005 Sep; 77(1):89-95.
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        39. Laoprasopwattana K, Libraty DH, Endy TP, Nisalak A, Chunsuttiwat S, Vaughn DW, Reed G, Ennis FA, Rothman AL, Green S. Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection. J Infect Dis. 2005 Aug 1; 192(3):510-9.
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        40. Endy TP, Nisalak A, Chunsuttitwat S, Vaughn DW, Green S, Ennis FA, Rothman AL, Libraty DH. Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand. J Infect Dis. 2004 Mar 15; 189(6):990-1000.
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        41. Pichyangkul S, Endy TP, Kalayanarooj S, Nisalak A, Yongvanitchit K, Green S, Rothman AL, Ennis FA, Libraty DH. A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity. J Immunol. 2003 Nov 15; 171(10):5571-8.
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        42. Stephens HA, Klaythong R, Sirikong M, Vaughn DW, Green S, Kalayanarooj S, Endy TP, Libraty DH, Nisalak A, Innis BL, Rothman AL, Ennis FA, Chandanayingyong D. HLA-A and -B allele associations with secondary dengue virus infections correlate with disease severity and the infecting viral serotype in ethnic Thais. Tissue Antigens. 2002 Oct; 60(4):309-18.
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        43. Libraty DH, Young PR, Pickering D, Endy TP, Kalayanarooj S, Green S, Vaughn DW, Nisalak A, Ennis FA, Rothman AL. High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever. J Infect Dis. 2002 Oct 15; 186(8):1165-8.
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        44. Endy TP, Nisalak A, Chunsuttiwat S, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA. Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol. 2002 Jul 1; 156(1):52-9.
          View in: PubMed
        45. Endy TP, Chunsuttiwat S, Nisalak A, Libraty DH, Green S, Rothman AL, Vaughn DW, Ennis FA. Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand. Am J Epidemiol. 2002 Jul 1; 156(1):40-51.
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        46. Mangada MM, Endy TP, Nisalak A, Chunsuttiwat S, Vaughn DW, Libraty DH, Green S, Ennis FA, Rothman AL. Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren. J Infect Dis. 2002 Jun 15; 185(12):1697-703.
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        47. Libraty DH, Endy TP, Kalayanarooj S, Chansiriwongs W, Nisalak A, Green S, Ennis FA, Rothman AL. Assessment of body fluid compartment volumes by multifrequency bioelectrical impedance spectroscopy in children with dengue. Trans R Soc Trop Med Hyg. 2002 May-Jun; 96(3):295-9.
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        48. Libraty DH, Endy TP, Houng HS, Green S, Kalayanarooj S, Suntayakorn S, Chansiriwongs W, Vaughn DW, Nisalak A, Ennis FA, Rothman AL. Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections. J Infect Dis. 2002 May 1; 185(9):1213-21.
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        49. Libraty DH, Nisalak A, Endy TP, Suntayakorn S, Vaughn DW, Innis BL. Clinical and immunological risk factors for severe disease in Japanese encephalitis. Trans R Soc Trop Med Hyg. 2002 Mar-Apr; 96(2):173-8.
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        50. Libraty DH, Pichyangkul S, Ajariyakhajorn C, Endy TP, Ennis FA. Human dendritic cells are activated by dengue virus infection: enhancement by gamma interferon and implications for disease pathogenesis. J Virol. 2001 Apr; 75(8):3501-8.
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        51. Brightbill HD, Libraty DH, Krutzik SR, Yang RB, Belisle JT, Bleharski JR, Maitland M, Norgard MV, Plevy SE, Smale ST, Brennan PJ, Bloom BR, Godowski PJ, Modlin RL. Host defense mechanisms triggered by microbial lipoproteins through toll-like receptors. Science. 1999 Jul 30; 285(5428):732-6.
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        52. Libraty DH, Airan LE, Uyemura K, Jullien D, Spellberg B, Rea TH, Modlin RL. Interferon-gamma differentially regulates interleukin-12 and interleukin-10 production in leprosy. J Clin Invest. 1997 Jan 15; 99(2):336-41.
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