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    Sonia Ortiz-Miranda PhD

    TitleResearch Assistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMicrobiology and Physiological Systems
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-8927
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentNeuroscience

        Overview 
        Narrative

        Academic Background

        1983, B.S., University of Puerto Rico, Rio Piedras
        1986, M.S., University of Puerto Rico, Pio Piedras
        1997, Ph.D., University of California, Davis

        Opioid effects on ion channels and neuropeptide release

        Sonia PicMy work focuses on opioid regulation of ion channel conductances in peptidergic nerve terminals. Magnocellular neurons (MCN) in the hypothalamus control neuroendocrine processes such as parturition, lactation, and sodium and water retention, by releasing the neuropeptides Oxytocin and Vasopressin into the blood circulation at their nerve endings in the Neurohypophysis. Endogenous and exogenous opioids modulate neuropeptide release in MCN by targeting voltage-gated channels at the cell’s soma as well as at their nerve endings. We study how the activation of the μ and κ opioid receptors can selectively inhibit the release of these neuropeptides.My laboratory is also interested in studying the cellular mechanisms used by exogenous drugs such as nicotine and alcohol to modulate synaptic efficacy at these presynaptic nerve endings.



        Bibliographic 
        selected publications
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        1. Pietrzykowski AZ, Ortiz-Miranda S, Knott TK, Custer E, Puig S, Lemos JR, Treistman SN. Molecular Tolerance of Voltage-Gated Calcium Channels is Evident After Short Exposures to Alcohol in Vasopressin-Releasing Nerve Terminals. Alcohol Clin Exp Res. 2013 Feb 19.
          View in: PubMed
        2. Knott TK, Hussy N, Cuadra AE, Lee RH, Ortiz-Miranda S, Custer EE, Lemos JR. Adenosine Trisphosphate Appears to Act via Different Receptors in Terminals Versus Somata of the Hypothalamic Neurohypophysial System. J Neuroendocrinol. 2012 Apr; 24(4):681-9.
          View in: PubMed
        3. Custer EE, Knott TK, Cuadra AE, Ortiz-Miranda S, Lemos JR. P2X Purinergic Receptor Knockout Mice Reveal Endogenous ATP Modulation of Both Vasopressin and Oxytocin Release from the Intact Neurohypophysis. J Neuroendocrinol. 2012 Apr; 24(4):674-80.
          View in: PubMed
        4. Lemos JR, Ortiz-Miranda SI, Cuadra AE, Velázquez-Marrero C, Custer EE, Dad T, Dayanithi G. Modulation/physiology of calcium channel sub-types in neurosecretory terminals. Cell Calcium. 2012 Mar; 51(3-4):284-92.
          View in: PubMed
        5. Ortiz-Miranda SI, Dayanithi G, Velázquez-Marrero C, Custer EE, Treistman SN, Lemos JR. Differential modulation of N-type calcium channels by micro-opioid receptors in oxytocinergic versus vasopressinergic neurohypophysial terminals. J Cell Physiol. 2010 Oct; 225(1):276-88.
          View in: PubMed
        6. Custer EE, Ortiz-Miranda S, Knott TK, Rawson R, Elvey C, Lee RH, Lemos JR. Identification of the neuropeptide content of individual rat neurohypophysial terminals. J Neurosci Methods. 2007 Jul 30; 163(2):226-34.
          View in: PubMed
        7. Ortiz-Miranda S, Dayanithi G, Custer E, Treistman SN, Lemos JR. Micro-opioid receptor preferentially inhibits oxytocin release from neurohypophysial terminals by blocking R-type Ca2+ channels. J Neuroendocrinol. 2005 Sep; 17(9):583-90.
          View in: PubMed
        8. Ortiz-Miranda SI, Dayanithi G, Coccia V, Custer EE, Alphandery S, Mazuc E, Treistman S, Lemos JR. mu-Opioid receptor modulates peptide release from rat neurohypophysial terminals by inhibiting Ca(2+) influx. J Neuroendocrinol. 2003 Sep; 15(9):888-94.
          View in: PubMed
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