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    Last Name

    Vijay K Vanguri MD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    AddressUniversity of Massachusetts Medical School
    One Innovation Drive, Biotech Three
    Worcester MA 01605
        awards and honors
        Harvard Medical School2006Excellent in Tutoring Award (Human Pathology)
        University of Massachusetts Medical School2010Second Year Oath Ceremony Speaker
        UMass Memorial Medical Center2010Champion of Excellence Team Award (Renal Pathology)
        University of Massachusetts Medical School2011Outstanding Medical Educator (preclinical)
        University of Massachusetts Medical School2012Outstanding Medical Educator (preclinical)
        University of Massachusetts Medical School2012Outstanding Clinical Educator
        University of Massachusetts Medical School2013Outstanding Medical Educator (preclinical)
        University of Massachusetts Medical School2014Outstanding Medical Educator (preclinical)
        University of Massachusetts Medical School2015Outstanding Medical Educator (preclinical)
        University of Massachusetts Medical School2015Outstanding Clinical Educator
        University of Massachusetts Medical School2015Educational Achievement (Star) Award

        Dr. Vijay Vanguri


        I am an anatomic surgical pathologist with subspecialty expertise in renal pathology and a research background in cellular immunology. I am a dedicated teacher of medical students, residents, and fellows, with a focus on undergraduate medical student education, and serve the faculty and students of the School of Medicine as chair of the Educational Policy Committee. In addition to serving as the Director of Renal Pathology, I also contribute to the general surgical pathology and perinatal/obstetrical pathology services.


        selected publications
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        1. Mallick EM, Garber JJ, Vanguri VK, Balasubramanian S, Blood T, Clark S, Vingadassalom D, Louissaint C, McCormick B, Snapper SB, Leong JM. The ability of an attaching and effacing pathogen to trigger localized actin assembly contributes to virulence by promoting mucosal attachment. Cell Microbiol. 2014 Sep; 16(9):1405-24.
          View in: PubMed
        2. Sasaki K, Bean A, Shah S, Schutten E, Huseby PG, Peters B, Shen ZT, Vanguri V, Liggitt D, Huseby ES. Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells. J Immunol. 2014 Apr 1; 192(7):3029-42.
          View in: PubMed
        3. Jandhyala DM, Vanguri V, Boll EJ, Lai Y, McCormick BA, Leong JM. Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence. Infect Dis Clin North Am. 2013 Sep; 27(3):631-49.
          View in: PubMed
        4. Riella LV, Yang J, Chock S, Safa K, Magee CN, Vanguri V, Elyaman W, Lahoud Y, Yagita H, Abdi R, Najafian N, Medina-Pestana JO, Chandraker A. Jagged2-signaling promotes IL-6-dependent transplant rejection. Eur J Immunol. 2013 Jun; 43(6):1449-58.
          View in: PubMed
        5. Verma A, Vanguri VK, Golla V, Rhyee S, Trainor M, Abramov K. Acute kidney injury due to intravenous bleach injection. J Med Toxicol. 2013 Mar; 9(1):71-4.
          View in: PubMed
        6. Vanguri V, Govern CC, Smith R, Huseby ES. Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection. Proc Natl Acad Sci U S A. 2013 Jan 2; 110(1):288-93.
          View in: PubMed
        7. Mallick EM, McBee ME, Vanguri VK, Melton-Celsa AR, Schlieper K, Karalius BJ, O'Brien AD, Butterton JR, Leong JM, Schauer DB. A novel murine infection model for Shiga toxin-producing Escherichia coli. J Clin Invest. 2012 Nov 1; 122(11):4012-24.
          View in: PubMed
        8. Mallick EM, Brady MJ, Luperchio SA, Vanguri VK, Magoun L, Liu H, Sheppard BJ, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM, Schauer DB. Allele- and tir-independent functions of intimin in diverse animal infection models. Front Microbiol. 2012; 3:11.
          View in: PubMed
        9. Yang J, Riella LV, Chock S, Liu T, Zhao X, Yuan X, Paterson AM, Watanabe T, Vanguri V, Yagita H, Azuma M, Blazar BR, Freeman GJ, Rodig SJ, Sharpe AH, Chandraker A, Sayegh MH. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol. 2011 Aug 1; 187(3):1113-9.
          View in: PubMed
        10. Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol. 2011 Aug 1; 187(3):1097-105.
          View in: PubMed
        11. Riella LV, Watanabe T, Sage PT, Yang J, Yeung M, Azzi J, Vanguri V, Chandraker A, Sharpe AH, Sayegh MH, Najafian N. Essential role of PDL1 expression on nonhematopoietic donor cells in acquired tolerance to vascularized cardiac allografts. Am J Transplant. 2011 Apr; 11(4):832-40.
          View in: PubMed
        12. Keszei M, Latchman YE, Vanguri VK, Brown DR, Detre C, Morra M, Arancibia-Carcamo CV, Arancibia CV, Paul E, Calpe S, Castro W, Wang N, Terhorst C, Sharpe AH. Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice. Int Immunol. 2011 Feb; 23(2):149-58.
          View in: PubMed
        13. Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, Glickman JN, Sharpe AH, Ahmed R. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest. 2010 Jul; 120(7):2508-15.
          View in: PubMed
        14. Yamaura K, Boenisch O, Watanabe T, Ueno T, Vanguri V, Yang J, Tanaka K, Guleria I, Borst J, Zhai Y, Kupiec-Weglinski JW, Najafian N. Differential requirement of CD27 costimulatory signaling for naïve versus alloantigen-primed effector/memory CD8+ T cells. Am J Transplant. 2010 May; 10(5):1210-20.
          View in: PubMed
        15. Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009 Dec 21; 206(13):3015-29.
          View in: PubMed
        16. Yang J, Riella LV, Boenisch O, Popoola J, Robles S, Watanabe T, Vanguri V, Yuan X, Guleria I, Turka LA, Sayegh MH, Chandraker A. Paradoxical functions of B7: CD28 costimulation in a MHC class II-mismatched cardiac transplant model. Am J Transplant. 2009 Dec; 9(12):2837-44.
          View in: PubMed
        17. Paterson AM, Vanguri VK, Sharpe AH. SnapShot: B7/CD28 costimulation. Cell. 2009 May 29; 137(5):974-4.e1.
          View in: PubMed
        18. O'Regan EM, Vanguri V, Allen CM, Eversole LR, Wright JM, Woo SB. Solitary fibrous tumor of the oral cavity: clinicopathologic and immunohistochemical study of 21 cases. Head Neck Pathol. 2009 Jun; 3(2):106-15.
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        19. Yang J, Popoola J, Khandwala S, Vadivel N, Vanguri V, Yuan X, Dada S, Guleria I, Tian C, Ansari MJ, Shin T, Yagita H, Azuma M, Sayegh MH, Chandraker A. Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy. Circulation. 2008 Feb 5; 117(5):660-9.
          View in: PubMed
        20. Vanguri VK, Nosé V. Transthyretin amyloid goiter in a renal allograft recipient. Endocr Pathol. 2008; 19(1):66-73.
          View in: PubMed
        21. Humphreys BD, Vanguri VK, Henderson J, Antin JH. Minimal-change nephrotic syndrome in a hematopoietic stem-cell transplant recipient. Nat Clin Pract Nephrol. 2006 Sep; 2(9):535-9; quiz 540.
          View in: PubMed
        22. Vanguri VK, Woda BA, Jiang Z. Sensitivity of P504S/alpha-methylacyl-CoA racemase (AMACR) immunohistochemistry for the detection of prostate carcinoma on stored needle biopsies. Appl Immunohistochem Mol Morphol. 2006 Sep; 14(3):365-8.
          View in: PubMed
        23. Vanguri VK, Wang S, Godyna S, Ranganathan S, Liau G. Thrombospondin-1 binds to polyhistidine with high affinity and specificity. Biochem J. 2000 Apr 15; 347(Pt 2):469-73.
          View in: PubMed
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