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    Vijay K Vanguri MD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentPathology
    AddressUniversity of Massachusetts Medical School
    One Innovation Drive, Biotech Three
    Worcester MA 01605
    Phone774-443-2204
        Biography 
        awards and honors
        Harvard Medical School2006Excellent in Tutoring Award (Human Pathology)
        Brigham and Women's Hospital / Partners HealthCare2007Partners in Excellence Award (Student Success Jobs Program)
        University of Massachusetts Medical School2010Second Year Oath Ceremony Speaker
        UMass Memorial Medical Center2010Champion of Excellence Team Award (Renal Pathology)
        University of Massachusetts Medical School2011Outstanding Medical Educator (preclinical)
        University of Massachusetts Medical School2012Outstanding Medical Educator (preclinical)
        University of Massachusetts Medical School2012Outstanding Clinical Educator
        University of Massachusetts Medical School2013Outstanding Medical Educator (preclinical)
        University of Massachusetts Medical School2014Outstanding Medical Educator (preclinical)
        Overview 
        Narrative
        Dr. Vijay Vanguri

        I am an anatomic pathologist with subspecialty expertise in renal pathology and a research background in cellular immunology. I am a dedicated teacher of medical students, residents, and fellows, with a focus on pre-clinical medical student education. In addition to serving as the Director of Renal Pathology, I also serve as the Director of Autopsy Pathology and lead the perinatal/placental pathology service.



        Education and Clinical Training

        7/2005-6/2006 Clinical Fellow in Renal Pathology, Brigham and Women's Hospital and Partners HealthCare, Boston, MA

        7/2004-6/2007 Resident in Anatomic Pathology, Brigham and Women's Hospital and Partners HealthCare, Boston, MA

        2004 Doctor of Medicine, The George Washington University School of Medicine and Health Sciences, Washington, DC

        7/2002-6/2003 Post-Sophomore Fellow in Anatomic Pathology, University of Massachusetts Medical School and UMass Memorial Medical Center, Worcester, MA

        1999 Bachelor of Science in Electrical Engineering, magna cum laude, The George Washington University School of Engineering and Applied Science, Washington, DC

        Research Training

        1/2009-4/2011 Instructor of Pathology, Laboratory of Eric Huseby, University of Massachusetts Medical School, Worcester, MA

        7/2007-12/2008 Research Fellow in Immunology and Pathology, Laboratory of Arlene Sharpe, Harvard Medical School and Brigham and Women's Hospital, Boston, MA

        5/1996-1/1999 Research Intern in Vascular Biology, Laboratory of Gene Liau, Jerome H. Holland Laboratories for the Biomedical Sciences, American Red Cross, Rockville, MD



        Clinical Activities:

        As Director of Renal Pathology, I am responsible for the diagnosis and work-up of kidney biopsies obtained from patients with evidence of medical renal disease using light microscopy, immunofluorescence microscopy, and electron microscopy. I work closely with adult and pediatric nephrologists, rheumatologists, transplant surgeons, and other clinicians to guide management decisions for our patients by playing a critical role in the histopathologic diagnosis of renal parenchymal disease in native and transplant kidneys. Preliminary diagnoses are typically rendered within 6 to 24 hours after biopsy for optimal patient care, including night, weekend, and holiday coverage. I am also an active participant in the weekly Interhospital Renal Rounds held in conjunction with the nephrology faculty of the University and Memorial campuses of the UMass Memorial Medical Center, as well as our cross-town colleagues at St. Vincent’s Hospital / Worcester Medical Center. Clickherefor more information on diagnostic consultation services for medical renal biopsies.

        Teaching Activities:

        I have a strong interest in medical student teaching. I am a co-director of the Organ System Diseases course covering pathophysiology, pathology, and pharmacology and spanning the first and second years of medical school. I serve as the co-director for the Renal Block in the Organ System Diseases course, as well as a lecturer in the Cardiovascular, Musculoskeletal / Dermatology, and Reproductive Blocks of the same course. I am also an immunology small group leader in Host Defense and Blood in the first year. I also routinely teach renal pathophysiology and histopathology to pathology trainees and nephrology fellows through classroom seminars and multiheaded microscope sessions, and started the Flexible Clinical Experience in Pathology for rotating third year students.

        Research Activities:

        My basic science research interests are in varied areas of T cell immunobiology. I study the effects of affinity of the T cell receptor for MHC-peptide on the primary and memory responses of the CD4 T cell repertoire in a murine model of viral infection, as well as the role of modulators of T cell function on affinity-based responses and their applicability to vaccine design. In addition, I am involved in several collaborative projects with investigators at UMass, Harvard Medical School, and Brigham and Women’s Hospital, primarily as a diagnostic pathologist, predominantly in murine models of disease. My clinical and translational research interests lie in renal diseases, transplant immunology, autoimmunity, host response to infection, and vascular biology and involve human subjects research and relevant experimental animal models.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Sasaki K, Bean A, Shah S, Schutten E, Huseby PG, Peters B, Shen ZT, Vanguri V, Liggitt D, Huseby ES. Relapsing-Remitting Central Nervous System Autoimmunity Mediated by GFAP-Specific CD8 T Cells. J Immunol. 2014 Apr 1; 192(7):3029-42.
          View in: PubMed
        2. Jandhyala DM, Vanguri V, Boll EJ, Lai Y, McCormick BA, Leong JM. Shiga toxin-producing Escherichia coli O104:H4: an emerging pathogen with enhanced virulence. Infect Dis Clin North Am. 2013 Sep; 27(3):631-49.
          View in: PubMed
        3. Riella LV, Yang J, Chock S, Safa K, Magee CN, Vanguri V, Elyaman W, Lahoud Y, Yagita H, Abdi R, Najafian N, Medina-Pestana JO, Chandraker A. Jagged2-signaling promotes IL-6-dependent transplant rejection. Eur J Immunol. 2013 Jun; 43(6):1449-58.
          View in: PubMed
        4. Verma A, Vanguri VK, Golla V, Rhyee S, Trainor M, Abramov K. Acute kidney injury due to intravenous bleach injection. J Med Toxicol. 2013 Mar; 9(1):71-4.
          View in: PubMed
        5. Vanguri V, Govern CC, Smith R, Huseby ES. Viral antigen density and confinement time regulate the reactivity pattern of CD4 T-cell responses to vaccinia virus infection. Proc Natl Acad Sci U S A. 2013 Jan 2; 110(1):288-93.
          View in: PubMed
        6. Mallick EM, McBee ME, Vanguri VK, Melton-Celsa AR, Schlieper K, Karalius BJ, O'Brien AD, Butterton JR, Leong JM, Schauer DB. A novel murine infection model for Shiga toxin-producing Escherichia coli. J Clin Invest. 2012 Nov 1; 122(11):4012-24.
          View in: PubMed
        7. Mallick EM, Brady MJ, Luperchio SA, Vanguri VK, Magoun L, Liu H, Sheppard BJ, Mukherjee J, Donohue-Rolfe A, Tzipori S, Leong JM, Schauer DB. Allele- and tir-independent functions of intimin in diverse animal infection models. Front Microbiol. 2012; 3:11.
          View in: PubMed
        8. Yang J, Riella LV, Chock S, Liu T, Zhao X, Yuan X, Paterson AM, Watanabe T, Vanguri V, Yagita H, Azuma M, Blazar BR, Freeman GJ, Rodig SJ, Sharpe AH, Chandraker A, Sayegh MH. The novel costimulatory programmed death ligand 1/B7.1 pathway is functional in inhibiting alloimmune responses in vivo. J Immunol. 2011 Aug 1; 187(3):1113-9.
          View in: PubMed
        9. Paterson AM, Brown KE, Keir ME, Vanguri VK, Riella LV, Chandraker A, Sayegh MH, Blazar BR, Freeman GJ, Sharpe AH. The programmed death-1 ligand 1:B7-1 pathway restrains diabetogenic effector T cells in vivo. J Immunol. 2011 Aug 1; 187(3):1097-105.
          View in: PubMed
        10. Keszei M, Latchman YE, Vanguri VK, Brown DR, Detre C, Morra M, Arancibia-Carcamo CV, Arancibia CV, Paul E, Calpe S, Castro W, Wang N, Terhorst C, Sharpe AH. Auto-antibody production and glomerulonephritis in congenic Slamf1-/- and Slamf2-/- [B6.129] but not in Slamf1-/- and Slamf2-/- [BALB/c.129] mice. Int Immunol. 2011 Feb; 23(2):149-58.
          View in: PubMed
        11. Mueller SN, Vanguri VK, Ha SJ, West EE, Keir ME, Glickman JN, Sharpe AH, Ahmed R. PD-L1 has distinct functions in hematopoietic and nonhematopoietic cells in regulating T cell responses during chronic infection in mice. J Clin Invest. 2010 Jul; 120(7):2508-15.
          View in: PubMed
        12. Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, Sharpe AH. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med. 2009 Dec 21; 206(13):3015-29.
          View in: PubMed
        13. Paterson AM, Vanguri VK, Sharpe AH. SnapShot: B7/CD28 costimulation. Cell. 2009 May 29; 137(5):974-4.e1.
          View in: PubMed
        14. O'Regan EM, Vanguri V, Allen CM, Eversole LR, Wright JM, Woo SB. Solitary fibrous tumor of the oral cavity: clinicopathologic and immunohistochemical study of 21 cases. Head Neck Pathol. 2009 Jun; 3(2):106-15.
          View in: PubMed
        15. Yang J, Popoola J, Khandwala S, Vadivel N, Vanguri V, Yuan X, Dada S, Guleria I, Tian C, Ansari MJ, Shin T, Yagita H, Azuma M, Sayegh MH, Chandraker A. Critical role of donor tissue expression of programmed death ligand-1 in regulating cardiac allograft rejection and vasculopathy. Circulation. 2008 Feb 5; 117(5):660-9.
          View in: PubMed
        16. Vanguri VK, Nosé V. Transthyretin amyloid goiter in a renal allograft recipient. Endocr Pathol. 2008; 19(1):66-73.
          View in: PubMed
        17. Humphreys BD, Vanguri VK, Henderson J, Antin JH. Minimal-change nephrotic syndrome in a hematopoietic stem-cell transplant recipient. Nat Clin Pract Nephrol. 2006 Sep; 2(9):535-9; quiz 540.
          View in: PubMed
        18. Vanguri VK, Woda BA, Jiang Z. Sensitivity of P504S/alpha-methylacyl-CoA racemase (AMACR) immunohistochemistry for the detection of prostate carcinoma on stored needle biopsies. Appl Immunohistochem Mol Morphol. 2006 Sep; 14(3):365-8.
          View in: PubMed
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