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    Gang Han PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentBiochemistry and Molecular Pharmacology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentRNA Therapeutics Institute

        Biography 
        awards and honors
        2011 - 2012Worcester Foundation Mel Cutler Award
        University of Massachusetts2013 - 20142013 Commercial Ventures & Intellectual Property Award (UMass)
        NIH2013 - 2017Exceptional Unconventional Research Enabling Knowledge Acceleration (EUREKA) Award
        HFSP2014the Human Frontier Science Program Award
        University of Massachusetts2014UMASS Clinical and Translational Science Award (UMCCTS) Pilot Award
        Overview 
        Narrative

        Nanomaterials for Biomolecule Imaging and Therapy

        B.S. Nanjing University,Ph.D. University of Massachusetts-Amherst ,Postdoctoral Fellow. The Molecule Foundry, Lawrence Berkeley Lab. Phone: 508-856-3297

        http://scholar.google.com/citations?user=zmGmLBoAAAAJ

        My research focuses on developing both small and bright tools for biomedical applications, that is, designing synthetic/semi-synthetic nanomaterials with unique programmable physical properties for basic science and biomedical applications.  These nanomaterials will be developed using a synergetic multidisciplinary approach, including synthetic chemistry, materials science, biochemistry, and cell biology.  In particular, we are most interested in developing optically active nanomaterials for probing signal transduction pathways, single-molecule imaging, synthesizing functional nanoscale scaffolds for targeted and traceable delivery of small molecules to cells and organelles, as well as for accurately detecting biomarkers in early stage disease.

        Contact: email: gang.han@umassmed.edu Phone : 508-856-3297

        People in Lab:

        Postdoctoral fellows: Jie Shen,  Graduate student: Xiang Wu, Liang Zhao,LWA/MQP student : , Amol Punjabi, Hyungseok Alex Lee, El-rifai, Mahmoud , Erin May Laroche, Rachael M. Matty, Amira Tokatli-Apollon

        Alumni:

        Postdoctoral fellows Yekui Zou (  2010- 2012, MIT)

        LWA students :Samuel J. Kesseli (2010-2013,  now MD student at Dartmouth Geisel School of Medicine)

        Lucas J. Brutvan, (2011, Process Engineer at 3M),
        Anne-Marie Vu (2013, Tufts University)
        Steven Buchholz (2011, Product Analyst at Boston Scientific)

        Past rotation students: Xizhe Gao (2011, now Ph.D student at University of Maryland Baltimore School of Pharmacy), Artem Kutikov, (2011, Ph.D student at UMMS ), Lejie Zhang( 2013, Ph. D student at UMMS)




        Rotation Projects

        Rotation projects

        (1) Specific cell membrane component labeling using bioconjugated nanoparticles

        (2) To develop tools for targeted and traceable siRNA delivery

        (3) To synthesize functional nanomaterials for detecting biomarkers in biological fluids



        Post Docs

        Positions for  postdoctoral fellows are available in the laboratory of Dr. Gang Han at the Department of Biochemistry and Molecular Pharmacology of The University of Massachusetts- Medical School.

        Research will focus on developing   novel small molecule/ nanoparticle approaches for translational biomedical sciences and molecular imaging.

        Qualifications: Candidates have a Ph.D degree in (1)Organic Chemistry/polymer synthesis , (2) Molecular cell biology , (3) Biophysics or (4) Biochemistry. A solid training and substantial organic synthesis, animal experiments,  spectroscopy and  microscopy are desired.  Candidates need to have strong work ethic, creativity, and enthusiasm with proven ability to work independently and collaboratively.

        To apply: Applicants should submit their CV including a full publication list and sources of three reference letters by email to gang.han@umassmed.edu



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Jie Shen, Guanying Chen, Anne-Marie Vu, Wei Fan, Osman S Bilsel, Chun-Chih Chang and Gang Han. Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri-doped Upconversion Colloidal Nanoparticles at 800nm. Advanced Optical Materials , In press. 2013.
        2. Shen J, Chen G, Ohulchanskyy TY, Kesseli SJ, Buchholz S, Li Z, Prasad PN, Han G. Tunable Near Infrared to Ultraviolet Upconversion Luminescence Enhancement in (a-NaYF4 :Yb,Tm)/CaF2 Core/Shell Nanoparticles for In situ Real-time Recorded Biocompatible Photoactivation. Small. 2013 May 22.
          View in: PubMed
        3. Han G, Chen G. Theranostic Upconversion Nanoparticles (II). Theranostics. 2013; 3(5):354-5.
          View in: PubMed
        4. Chen G, Han G. Theranostic upconversion nanoparticles (I). Theranostics. 2013; 3(4):289-91.
          View in: PubMed
        5. Liang Zhao, Artem Kutikov, Jie Shen, Chunying Duan, Jie Song and Gang Han . Stem Cell Labeling using Polyethylenimine Conjugated (a-NaYbF4:Tm3+)/CaF2 Upconversion Nanoparticles. Theranostics (featured on cover). 2013; 4(3):249-257.
        6. Guanying Chen, Hailong Qiu, Rongwei Fan, Shuwei Hao, Shuo Tan, Chunhui Yang, and Gang Han. Lanthanide-Doped Ultrasmall Yttrium Fluoride Nanoparticles with Enhanced Multicolor Upconversion Photoluminescence. J. Mater. Chem.,( featured on front cover). 2012; 38(22):20190 - 20196 .
        7. Chen G, Shen J, Ohulchanskyy TY, Patel NJ, Kutikov A, Li Z, Song J, Pandey RK, Agren H, Prasad PN, Han G. (a-NaYbF(4):Tm(3+))/CaF(2) Core/Shell Nanoparticles with Efficient Near-Infrared to Near-Infrared Upconversion for High-Contrast Deep Tissue Bioimaging. ACS Nano. 2012 Sep 4.
          View in: PubMed
        8. Chan EM, Han G, Goldberg JD, Gargas DJ, Ostrowski AD, Schuck PJ, Cohen BE, Milliron DJ. Combinatorial discovery of lanthanide-doped nanocrystals with spectrally pure upconverted emission. Nano Lett. 2012 Jul 11; 12(7):3839-45.
          View in: PubMed
        9. Shen J, Zhao L, Han G. Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy. Adv Drug Deliv Rev. 2012 May 22.
          View in: PubMed
        10. Ostrowski AD, Chan EM, Gargas DJ, Katz EM, Han G, Schuck PJ, Milliron DJ, Cohen BE. Controlled Synthesis and Single-Particle Imaging of Bright, Sub-10 nm Lanthanide-Doped Upconverting Nanocrystals. ACS Nano. 2012 Feb 22.
          View in: PubMed
        11. Zhang X, Jing X, Liu T, Han G, Li H, Duan C. Dual-Functional Gadolinium-Based Copper(II) Probe for Selective Magnetic Resonance Imaging and Fluorescence Sensing. Inorg Chem. 2012 Feb 20; 51(4):2325-31.
          View in: PubMed
        12. Qiu, H., Chen, Sun,L., Hao, S., Han, G * and Yang, C.* .(* co- corresponding authors). Ethylenediaminetetraacetic acid (EDTA)-Controlled Synthesis of Multicolor Lanthanide Doped BaYF5 Upconversion Nanocrystals. J Mater Chem. 2011; (21):17202-17208.
        13. Liang X, Chen T, Jung YS, Miyamoto Y, Han G, Cabrini S, Ma B, Olynick DL. Nanoimprint-induced molecular stacking and pattern stabilization in a solution-processed subphthalocyanine film. ACS Nano. 2010 May 25; 4(5):2627-34.
          View in: PubMed
        14. Chan EM, Xu C, Mao AW, Han G, Owen JS, Cohen BE, Milliron DJ. Reproducible, high-throughput synthesis of colloidal nanocrystals for optimization in multidimensional parameter space. Nano Lett. 2010 May 12; 10(5):1874-85.
          View in: PubMed
        15. Kim B, Han G, Toley BJ, Kim CK, Rotello VM, Forbes NS. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat Nanotechnol. 2010 Jun; 5(6):465-72.
          View in: PubMed
        16. Jordan BJ, Hong R, Han G, Rana S, Rotello VM. Modulation of enzyme-substrate selectivity using tetraethylene glycol functionalized gold nanoparticles. Nanotechnology. 2009 Oct 28; 20(43):434004.
          View in: PubMed
        17. Wu S*, Han G*, Milliron DJ, Aloni S, Altoe V, Talapin DV, Cohen BE, Schuck PJ. (co-first authors) . Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals. Proc Natl Acad Sci U S A. 2009; 106(27):10917-21.
        18. Han G, Mokari T, Ajo-Franklin C, Cohen BE. Caged quantum dots. J Am Chem Soc. 2008 Nov 26; 130(47):15811-3.
          View in: PubMed
        19. Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano. 2008 Nov 25; 2(11):2213-8.
          View in: PubMed
        20. Chompoosor A, Han G, Rotello VM. Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols. Bioconjug Chem. 2008 Jul; 19(7):1342-5.
          View in: PubMed
        21. Ghosh P, Han G, De M, Kim CK, Rotello VM. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev. 2008 Aug 17; 60(11):1307-15.
          View in: PubMed
        22. Ghosh PS, Han G, Erdogan B, Rosado O, Rotello VM. Binding of nanoparticle receptors to peptide alpha-helices using amino acid-functionalized nanoparticles. J Pept Sci. 2008 Feb; 14(2):134-8.
          View in: PubMed
        23. Leroueil PR, Berry SA, Duthie K, Han G, Rotello VM, McNerny DQ, Baker JR, Orr BG, Holl MM. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. Nano Lett. 2008 Feb; 8(2):420-4.
          View in: PubMed
        24. Ghosh PS, Han G, Erdogan B, Rosado O, Krovi SA, Rotello VM. Nanoparticles featuring amino acid-functionalized side chains as DNA receptors. Chem Biol Drug Des. 2007 Jul; 70(1):13-8.
          View in: PubMed
        25. Han G, Ghosh P, Rotello VM. Functionalized gold nanoparticles for drug delivery. Nanomedicine (Lond). 2007 Feb; 2(1):113-23.
          View in: PubMed
        26. Srivastava, S.; Samanta, B.; Arumugam, P.; Han, G. Rotello, V. M. . Journal of Material chemistry. Influence of DNA on Spacing and Magnetic Properties of Iron Platinum (Fe-Pt) Nanoparticles. 2007; 17(1):52-55.
        27. Han G, Ghosh P, Rotello VM. Multi-functional gold nanoparticles for drug delivery. Adv Exp Med Biol. 2007; 620:48-56.
          View in: PubMed
        28. Nakade H, Jordan BJ, Xu H, Han G, Srivastava S, Arvizo RR, Cooke G, Rotello VM. Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. J Am Chem Soc. 2006 Nov 22; 128(46):14924-9.
          View in: PubMed
        29. Vanderpuije BN, Han G, Rotello VM, Vachet RW. Mixed monolayer-protected gold nanoclusters as selective peptide extraction agents for MALDI-MS analysis. Anal Chem. 2006 Aug 1; 78(15):5491-6.
          View in: PubMed
        30. Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 2006 May 5; 45(19):3165-9.
          View in: PubMed
        31. Goodman CM, Chari NS, Han G, Hong R, Ghosh P, Rotello VM. DNA-binding by functionalized gold nanoparticles: mechanism and structural requirements. Chem Biol Drug Des. 2006 Apr; 67(4):297-304.
          View in: PubMed
        32. Hong R, Han G, Fernández JM, Kim BJ, Forbes NS, Rotello VM. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 2006 Feb 1; 128(4):1078-9.
          View in: PubMed
        33. Han G, Martin CT, Rotello VM. Stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents. Chem Biol Drug Des. 2006 Jan; 67(1):78-82.
          View in: PubMed
        34. Han G, Chari NS, Verma A, Hong R, Martin CT, Rotello VM. Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione. Bioconjug Chem. 2005 Nov-Dec; 16(6):1356-9.
          View in: PubMed
        35. You CC, De M, Han G, Rotello VM. Tunable inhibition and denaturation of alpha-chymotrypsin with amino acid-functionalized gold nanoparticles. J Am Chem Soc. 2005 Sep 21; 127(37):12873-81.
          View in: PubMed
        36. Chen, G ; Ou, SJ; Bai, ZP ; Han, G; Duan, CY . Synthesis, crystal structure and electrochemistry of biferrocene palladium complex. CHINESE JOURNAL OF INORGANIC CHEMISTRY. 2003; 19(5):501-505.
        37. Dong G, Gang H, Chun-ying D, Ke-liang P, Qing-jin M. Novel ferrocene-containing helical triangular macrocycle achieved via an exchange reaction. Chem Commun (Camb). 2002 May 21; (10):1096-7.
          View in: PubMed
        38. Gang, H ; Dong, G ; Duan, CY ; Hong, M ; Meng, QJ . Self-assembly of a novel mixed-valence tetranuclear molecular square [(Fe3FeL2)-Fe-II-L-III(HL)(2)](3+) and [M(HL)](4)(4+) squares (M = Ni, Zn and Cd) {H2L = bis(2-acetylpyridine) thiocarbazone}. NEW JOURNAL OF CHEMISTRY. 2002; 26(10):1371-1377.
        39. Fang, CJ ; Duan, CY ; He, C; Han, G ; Meng, QJ . A supramolecular analog of cyclohexane sustained by aromatic C-H center dot center dot center dot pi interactions between ferrocene moieties: molecular packing of ferrocene-containing thiosemicarbazato metal complexes. NEW JOURNAL OF CHEMISTRY. 2000; 24(9):697-701.
        40. Fang, CJ ; Han, G ; Liu, YJ ; Duan, CY; Meng, QJ . Acetylferrocene thiosemicarbazone. 1999; 55 :2058-2060.
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