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    Last Name

    Gang Han PhD

    TitleAssociate Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentBiochemistry and Molecular Pharmacology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB 806
    Worcester MA 01605
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - School of Medicine
      DepartmentRNA Therapeutics Institute

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

        awards and honors
        The Hudson Hoagland Society 2011 - 2012Worcester Foundation Mel Cutler Award
        University of Massachusetts2013 - 20142013 Commercial Ventures and Intellectual Property Award (UMass)
        NIH2013 - 2017Exceptional Unconventional Research Enabling Knowledge Acceleration (EUREKA) Award
        HFSP2014the Human Frontier Science Program Award
        University of Massachusetts2014UMASS Clinical and Translational Science Award (UMCCTS) Pilot Award
        Alex’s Lemonade Stand Foundation for Childhood Cancer2014 - 2016Alex’s Lemonade Stand Foundation Innovation Award
        Royal Society of Chemistry2014Materials Horizons Symposia Award
        University of Massachusetts2016OTCV Technology development Fund

        Nanomaterials for Neuroscience, Biomolecule Imaging and Therapy


        B.S. Nanjing University,Ph.D. University of Massachusetts-Amherst ,Postdoctoral Fellow. The Molecule Foundry, Lawrence Berkeley Lab. Phone: 508-856-3297

        My research is at the intersection between nanotechnology, neuroscience, bioimaging and therapy. We focus on developing both small and bright tools for biology, that is, designing synthetic/semi-synthetic nanomaterials or small molecules with unique programmable physical properties for basic science and biomedical applications.  These tools will be developed using a synergetic multidisciplinary approach, including synthetic chemistry, materials science, biochemistry, and cell biology.  In particular, we are most interested in developing optically active nanomaterials/molecules for probing signal transduction pathways, single-molecule imaging, sptiotemperol activation of neurons as well as diagnosis and drug delivery.

        Contact: email: Phone : 508-856-3297

        People in Lab:

        Postdoctoral fellows:Yuanwei Zhang, Zhanjun Li, Jie Shen,  Graduate student: Xiang Wu,LWA/MQP student : Amol Punjabi, Hyungseok Alex Lee, George Han, Andrew Seto,  Rohit Maudgal


        Postdoctoral fellows Yekui Zou (  2010- 2012, MIT)

        Graduate students: Liang Zhao (2012 , Lecturer, Dalian University of Technology)

        LWA students :Samuel J. Kesseli (2010-2013,  now MD student at Dartmouth Geisel School of Medicine)

        Lucas J. Brutvan, (2011, Process Engineer at 3M),
        Anne-Marie Vu (2013, Tufts University)
        Steven Buchholz (2011, Product Analyst at Boston Scientific)

        El-rifai, Mahmoud (2013-1014 Massachusetts Eye and Ear, Harvard Medical School), Amira Tokatli-Apollon(2013-2014  Design Assurance Engineer, HOLOGIC)

         Erin May Laroche; Rachael M. Matty; Babeu, Amy Monique; Cardoso, Marlisa Anne(2013 WPI)

        Ayers, Brian Christopher (2013, MD/MBA Student - University of Rochester)

        Luis Figueroa(2014, UMASS-Amherst)

        Past rotation students: Xizhe Gao (2011, now Ph.D student at University of Maryland Baltimore School of Pharmacy), Artem Kutikov, (2011, Ph.D student at UMMS ), Lejie Zhang( 2013, Ph. D student at UMMS)


        Rotation Projects

        Rotation projects

        (1) Specific cell membrane component labeling using bioconjugated nanoparticles

        (2) To develop tools for targeted and traceable siRNA delivery

        (3) To synthesize functional nanomaterials for detecting biomarkers in biological fluids

        Post Docs

        Positions for  postdoctoral fellows are available in the laboratory of Dr. Gang Han at the Department of Biochemistry and Molecular Pharmacology of The University of Massachusetts- Medical School.

        Research will focus on developing   novel small molecule/ nanoparticle approaches for translational biomedical sciences and molecular imaging.

        Qualifications: Candidates have a Ph.D degree in (1)Organic Chemistry/polymer synthesis , (2) Molecular cell biology , (3) Biophysics or (4) Biochemistry. A solid training and substantial organic synthesis, animal experiments,  spectroscopy and  microscopy are desired.  Candidates need to have strong work ethic, creativity, and enthusiasm with proven ability to work independently and collaboratively.

        To apply: Applicants should submit their CV including a full publication list and sources of three reference letters by email to

        selected publications
        List All   |   Timeline
        1. Stable colloids of nanocrystals in inorganic salts. Nature (In press), 2016. 2016.
        2. Huang L, Li Z, Zhao Y, Zhang Y, Wu S, Zhao J, Han G. Ultralow-Power Near Infrared Lamp Light Operable Targeted Organic Nanoparticle Photodynamic Therapy. J Am Chem Soc. 2016 Oct 27.
          View in: PubMed
        3. Zhanjun Li, Yuanwei Zhang, Ling Huang, Yuchen Yang, Yang Zhao, Ghida El-Banna, Gang Han. Nanoscale “fluorescent stone”: Luminescent Calcium Fluoride Nanoparticles as Theranostic Platforms. Theranostics. 2016; 6(13):2380-2393.
        4. Peng Tan, Lian He, Gang Han*, Yubin Zhou*. Optogenetic Immunomodulation: Shedding Light on Antitumor Immunity. Trends in Biotechnology. 2016.
        5. Regino Mercado-Lubo, Yuanwei Zhang, Liang Zhao, Kyle Rossi, Xiang Wu, Yekui Zou, Antonio Castillo, Jack Leonard, Rita Bortell, Dale Greiner, Leonard D. Shultz, Gang Han*, and Beth McCormick*. Salmonella Nanoparticle Mimic Overcomes Multidrug Resistance in Tumors. Nature Communications. 2016; 7(12).
        6. Zhang Y, Huang L, Li Z, Ma G, Zhou Y, Han G. Illuminating Cell Signaling with Near-Infrared Light-Responsive Nanomaterials. ACS Nano. 2016 Apr 26; 10(4):3881-5.
          View in: PubMed
        7. Ling Huang, Ran Duan, Zhanjun Li, Yuanwei Zhang, Jianzhang Zhao and Gang Han. BODIPY-Based Nanomicelles as Near-Infrared Fluorescent “Turn-On” Sensors for Biogenic Thiols (Selected as Front cover article) DOI: 10.1002/cnma.201600019. ChemNanoMat. 2016.
        8. Wu X, Zhang Y, Takle K, Bilsel O, Li Z, Lee H, Zhang Z, Li D, Fan W, Duan C, Chan EM, Lois C, Xiang Y, Han G. Dye-Sensitized Core/Active Shell Upconversion Nanoparticles for Optogenetics and Bioimaging Applications. ACS Nano. 2016 Jan 26; 10(1):1060-6.
          View in: PubMed
        9. Lian He, Yuanwei Zhang, Guolin Ma, Peng Tan, Zhanjun Li, Shengbing Zhang, Xiang Wu, Ji Jing, Shaohai Fang, Lijuan Zhou, Youjun Wang, Yun Huang, Patrick Hogan, Gang Han*, Yubin Zhou* (*Corresponding Authors). Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation. eLife 2015;4:e10024. 2015.
        10. Zhanjun Li,Yuanwei Zhang, Hieu La,Richard Zhu,Ghida El-Banna ,Yuzou Wei ,Gang Han . Upconverting NIR Photons for Bioimaging. Nanomaterials. 2015; 4(5):2148-2168.
        11. Wu X, Lee H, Bilsel O, Zhang Y, Li Z, Chen T, Liu Y, Duan C, Shen J, Punjabi A, Han G. Tailoring dye-sensitized upconversion nanoparticle excitation bands towards excitation wavelength selective imaging. Nanoscale. 2015 Nov 28; 7(44):18424-8.
          View in: PubMed
        12. Chen G, Damasco J, Qiu H, Shao W, Ohulchanskyy TY, Valiev RR, Wu X, Han G, Wang Y, Yang C, Ågren H, Prasad PN. Energy-Cascaded Upconversion in an Organic Dye-Sensitized Core/Shell Fluoride Nanocrystal. Nano Lett. 2015 Nov 11; 15(11):7400-7.
          View in: PubMed
        13. Zhanjun Li, Yuanwei Zhang, Xiang Wu, Ling Huang, Dongsheng Li, Wei Fan,Gang Han. Direct Aqueous-Phase Synthesis of Sub-10 nm “Luminous Pearls” with Enhanced in Vivo Renewable Near-Infrared Persistent Luminescence (Selected as ACS Editors' Choice Article and JACS Spotlight Article). Journal of the American Chemical Society Apr 29; 137(16):5304-7. 2015.
        14. Zhanjun Li, Yuanwei Zhang, Xiang Wu, Xiaoqiong Wu, Rohit Maudgal, Hongwu Zhang and Gang Han. In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO2/ZnGa2O4:Cr3+ Persistent Luminescence Nanocomposites (Cover feature). Advanced Science. 2015; 2(3):1500001.
        15. Li Z, Zhang Y, Wu X, Wu X, Maudgal R, Zhang H, Han G. In Vivo Repeatedly Charging Near-Infrared-Emitting Mesoporous SiO2/ZnGa2O4:Cr(3+) Persistent Luminescence Nanocomposites. Adv Sci (Weinh). 2015 Mar; 2(3).
          View in: PubMed
        16. Bogdanov AA, Gupta S, Koshkina N, Corr SJ, Zhang S, Curley SA, Han G. Gold nanoparticles stabilized with MPEG-grafted poly(l-lysine): in vitro and in vivo evaluation of a potential theranostic agent. Bioconjug Chem. 2015 Jan 21; 26(1):39-50.
          View in: PubMed
        17. Wu X, Chen G, Shen J, Li Z, Zhang Y, Han G. Upconversion nanoparticles: a versatile solution to multiscale biological imaging. Bioconjug Chem. 2015 Feb 18; 26(2):166-75.
          View in: PubMed
        18. Punjabi A, Wu X, Tokatli-Apollon A, El-Rifai M, Lee H, Zhang Y, Wang C, Liu Z, Chan EM, Duan C, Han G. Amplifying the red-emission of upconverting nanoparticles for biocompatible clinically used prodrug-induced photodynamic therapy. ACS Nano. 2014 Oct 28; 8(10):10621-30.
          View in: PubMed
        19. Jie Shen, Guanying Chen, Anne-Marie Vu, Wei Fan, Osman S Bilsel, Chun-Chih Chang and Gang Han. Engineering the Upconversion Nanoparticle Excitation Wavelength: Cascade Sensitization of Tri-doped Upconversion Colloidal Nanoparticles at 800nm. Advanced Optical Materials. 2013; 9(1):644-650.
        20. Shen J, Chen G, Ohulchanskyy TY, Kesseli SJ, Buchholz S, Li Z, Prasad PN, Han G. Tunable near infrared to ultraviolet upconversion luminescence enhancement in (a-NaYF4 :Yb,Tm)/CaF2 core/shell nanoparticles for in situ real-time recorded biocompatible photoactivation. Small. 2013 Oct 11; 9(19):3213-7.
          View in: PubMed
        21. Han G, Chen G. Theranostic upconversion nanoparticles (II). Theranostics. 2013; 3(5):354-5.
          View in: PubMed
        22. Chen G, Han G. Theranostic upconversion nanoparticles (I). Theranostics. 2013; 3(4):289-91.
          View in: PubMed
        23. Liang Zhao, Artem Kutikov, Jie Shen, Chunying Duan, Jie Song and Gang Han . Stem Cell Labeling using Polyethylenimine Conjugated (a-NaYbF4:Tm3+)/CaF2 Upconversion Nanoparticles. Theranostics (featured on cover). 2013; 4(3):249-257.
        24. Guanying Chen, Hailong Qiu, Rongwei Fan, Shuwei Hao, Shuo Tan, Chunhui Yang, and Gang Han. Lanthanide-Doped Ultrasmall Yttrium Fluoride Nanoparticles with Enhanced Multicolor Upconversion Photoluminescence. J. Mater. Chem.,( featured on front cover). 2012; 38(22):20190 - 20196 .
        25. Chen G, Shen J, Ohulchanskyy TY, Patel NJ, Kutikov A, Li Z, Song J, Pandey RK, Agren H, Prasad PN, Han G. (a-NaYbF4:Tm(3+))/CaF2 core/shell nanoparticles with efficient near-infrared to near-infrared upconversion for high-contrast deep tissue bioimaging. ACS Nano. 2012 Sep 25; 6(9):8280-7.
          View in: PubMed
        26. Chan EM, Han G, Goldberg JD, Gargas DJ, Ostrowski AD, Schuck PJ, Cohen BE, Milliron DJ. Combinatorial discovery of lanthanide-doped nanocrystals with spectrally pure upconverted emission. Nano Lett. 2012 Jul 11; 12(7):3839-45.
          View in: PubMed
        27. Shen J, Zhao L, Han G. Lanthanide-doped upconverting luminescent nanoparticle platforms for optical imaging-guided drug delivery and therapy. Adv Drug Deliv Rev. 2013 May; 65(5):744-55.
          View in: PubMed
        28. Ostrowski AD, Chan EM, Gargas DJ, Katz EM, Han G, Schuck PJ, Milliron DJ, Cohen BE. Controlled synthesis and single-particle imaging of bright, sub-10 nm lanthanide-doped upconverting nanocrystals. ACS Nano. 2012 Mar 27; 6(3):2686-92.
          View in: PubMed
        29. Zhang X, Jing X, Liu T, Han G, Li H, Duan C. Dual-functional gadolinium-based copper(II) probe for selective magnetic resonance imaging and fluorescence sensing. Inorg Chem. 2012 Feb 20; 51(4):2325-31.
          View in: PubMed
        30. Qiu, H., Chen, Sun,L., Hao, S., Han, G * and Yang, C.* .(* co- corresponding authors). Ethylenediaminetetraacetic acid (EDTA)-Controlled Synthesis of Multicolor Lanthanide Doped BaYF5 Upconversion Nanocrystals. J Mater Chem. 2011; (21):17202-17208.
        31. Liang X, Chen T, Jung YS, Miyamoto Y, Han G, Cabrini S, Ma B, Olynick DL. Nanoimprint-induced molecular stacking and pattern stabilization in a solution-processed subphthalocyanine film. ACS Nano. 2010 May 25; 4(5):2627-34.
          View in: PubMed
        32. Chan EM, Xu C, Mao AW, Han G, Owen JS, Cohen BE, Milliron DJ. Reproducible, high-throughput synthesis of colloidal nanocrystals for optimization in multidimensional parameter space. Nano Lett. 2010 May 12; 10(5):1874-85.
          View in: PubMed
        33. Kim B, Han G, Toley BJ, Kim CK, Rotello VM, Forbes NS. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat Nanotechnol. 2010 Jun; 5(6):465-72.
          View in: PubMed
        34. Jordan BJ, Hong R, Han G, Rana S, Rotello VM. Modulation of enzyme-substrate selectivity using tetraethylene glycol functionalized gold nanoparticles. Nanotechnology. 2009 Oct 28; 20(43):434004.
          View in: PubMed
        35. Wu S*, Han G*, Milliron DJ, Aloni S, Altoe V, Talapin DV, Cohen BE, Schuck PJ. (co-first authors) . Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals. Proc Natl Acad Sci U S A. 2009; 106(27):10917-21.
        36. Han G, Mokari T, Ajo-Franklin C, Cohen BE. Caged quantum dots. J Am Chem Soc. 2008 Nov 26; 130(47):15811-3.
          View in: PubMed
        37. Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano. 2008 Nov 25; 2(11):2213-8.
          View in: PubMed
        38. Chompoosor A, Han G, Rotello VM. Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols. Bioconjug Chem. 2008 Jul; 19(7):1342-5.
          View in: PubMed
        39. Ghosh P, Han G, De M, Kim CK, Rotello VM. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev. 2008 Aug 17; 60(11):1307-15.
          View in: PubMed
        40. Ghosh PS, Han G, Erdogan B, Rosado O, Rotello VM. Binding of nanoparticle receptors to peptide alpha-helices using amino acid-functionalized nanoparticles. J Pept Sci. 2008 Feb; 14(2):134-8.
          View in: PubMed
        41. Leroueil PR, Berry SA, Duthie K, Han G, Rotello VM, McNerny DQ, Baker JR, Orr BG, Holl MM. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. Nano Lett. 2008 Feb; 8(2):420-4.
          View in: PubMed
        42. Ghosh PS, Han G, Erdogan B, Rosado O, Krovi SA, Rotello VM. Nanoparticles featuring amino acid-functionalized side chains as DNA receptors. Chem Biol Drug Des. 2007 Jul; 70(1):13-8.
          View in: PubMed
        43. Han G, Ghosh P, Rotello VM. Functionalized gold nanoparticles for drug delivery. Nanomedicine (Lond). 2007 Feb; 2(1):113-23.
          View in: PubMed
        44. Srivastava, S.; Samanta, B.; Arumugam, P.; Han, G. Rotello, V. M. . Journal of Material chemistry. Influence of DNA on Spacing and Magnetic Properties of Iron Platinum (Fe-Pt) Nanoparticles. 2007; 17(1):52-55.
        45. Nakade H, Jordan BJ, Xu H, Han G, Srivastava S, Arvizo RR, Cooke G, Rotello VM. Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. J Am Chem Soc. 2006 Nov 22; 128(46):14924-9.
          View in: PubMed
        46. Vanderpuije BN, Han G, Rotello VM, Vachet RW. Mixed monolayer-protected gold nanoclusters as selective peptide extraction agents for MALDI-MS analysis. Anal Chem. 2006 Aug 1; 78(15):5491-6.
          View in: PubMed
        47. Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 2006 May 5; 45(19):3165-9.
          View in: PubMed
        48. Goodman CM, Chari NS, Han G, Hong R, Ghosh P, Rotello VM. DNA-binding by functionalized gold nanoparticles: mechanism and structural requirements. Chem Biol Drug Des. 2006 Apr; 67(4):297-304.
          View in: PubMed
        49. Hong R, Han G, Fernández JM, Kim BJ, Forbes NS, Rotello VM. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 2006 Feb 1; 128(4):1078-9.
          View in: PubMed
        50. Han G, Martin CT, Rotello VM. Stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents. Chem Biol Drug Des. 2006 Jan; 67(1):78-82.
          View in: PubMed
        51. Han G, Chari NS, Verma A, Hong R, Martin CT, Rotello VM. Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione. Bioconjug Chem. 2005 Nov-Dec; 16(6):1356-9.
          View in: PubMed
        52. You CC, De M, Han G, Rotello VM. Tunable inhibition and denaturation of alpha-chymotrypsin with amino acid-functionalized gold nanoparticles. J Am Chem Soc. 2005 Sep 21; 127(37):12873-81.
          View in: PubMed
        53. Chen, G ; Ou, SJ; Bai, ZP ; Han, G; Duan, CY . Synthesis, crystal structure and electrochemistry of biferrocene palladium complex. CHINESE JOURNAL OF INORGANIC CHEMISTRY. 2003; 19(5):501-505.
        54. Dong G, Gang H, Chun-ying D, Ke-liang P, Qing-jin M. Novel ferrocene-containing helical triangular macrocycle achieved via an exchange reaction. Chem Commun (Camb). 2002 May 21; (10):1096-7.
          View in: PubMed
        55. Gang, H ; Dong, G ; Duan, CY ; Hong, M ; Meng, QJ . Self-assembly of a novel mixed-valence tetranuclear molecular square [(Fe3FeL2)-Fe-II-L-III(HL)(2)](3+) and [M(HL)](4)(4+) squares (M = Ni, Zn and Cd) {H2L = bis(2-acetylpyridine) thiocarbazone}. NEW JOURNAL OF CHEMISTRY. 2002; 26(10):1371-1377.
        56. Fang, CJ ; Duan, CY ; He, C; Han, G ; Meng, QJ . A supramolecular analog of cyclohexane sustained by aromatic C-H center dot center dot center dot pi interactions between ferrocene moieties: molecular packing of ferrocene-containing thiosemicarbazato metal complexes. NEW JOURNAL OF CHEMISTRY. 2000; 24(9):697-701.
        57. Fang, CJ ; Han, G ; Liu, YJ ; Duan, CY; Meng, QJ . Acetylferrocene thiosemicarbazone. 1999; 55 :2058-2060.
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