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    Anuja Mathew PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-8414
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentImmunology and Virology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentCenter for Infectious Disease and Vaccine Research

        Overview 
        Narrative

        Academic Background

        Education:

        • B.Sc. Women’s Christian College, Madras, India. 1989
        • M.Sc. Christian Medical College, Vellore, India. 1992
        • Ph.D. University of Massachusetts Medical School, Worcester, MA. 1999

        Post-Doctoral Training:

        • Massachusetts General Hospital, 1999-2002

        Research Interests

      • Human immune responses to dengue virus infections
      • Adaptive immune responses to dengue virus infections in humanized mice
      • Human and Murine immune responses to influenza infections
      • Dengue viruses

        Dengue viruses are mosquito-borne viruses that infect individuals in tropical and subtropical countries. They comprise four closely related but distinct viruses termed serotypes 1 through 4. Studies on humans infected with dengue provide strong evidence for an immunologic basis for the pathogenesis of severe disease DHF. We are involved with understanding T cell and memory B cell responses during acute dengue infection and in convalescence. We use samples obtained during the acute phase of dengue illness and up to 3 years post infection in a clinical cohort in Bangkok, Thailand to assess CD8 T cell responses to dengue.

        Experimental manipulation of in vivo immune responses to dengue would be a desirable approach to explore models of DHF pathogenesis and to test the potential for candidate vaccines to prevent disease. Unfortunately there are no currently acceptable animal models to study dengue pathogenesis. We are evaluating “humanized” mice as a small animal model for the study of dengue virus infection, immunity, and disease. We assess human T and B cell immunity in NSG and BLT-NSG mice after infection with laboratory and clinical strains of dengue virus.

        Influenza virus

        Despite significant advances, it is unclear how age-related changes in one or both compartments of the immune system contribute to the increased susceptibility of older individuals to infectious diseases such as influenza viral infections. We are interested in delineating the underlying mechanisms that affect the size and quality of immune responses to influenza. We would like to understand how aging impacts innate and adaptive immunity using murine models.



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. O'Bryan JM, Woda M, Co M, Mathew A, Rothman AL. Telomere length dynamics in human memory T cells specific for viruses causing acute or latent infections. Immun Ageing. 2013; 10(1):37.
          View in: PubMed
        2. Townsley E, Woda M, Thomas SJ, Kalayanarooj S, Gibbons RV, Nisalak A, Srikiatkhachorn A, Green S, Stephens HA, Rothman AL, Mathew A. Distinct Activation Phenotype of a Highly Conserved Novel HLA-B57-Restricted Epitope during Dengue Virus Infection. Immunology. 2013 Aug 14.
          View in: PubMed
        3. Ramirez A, Rathinam V, Fitzgerald KA, Golenbock DT, Mathew A. Defective pro-IL-1ß responses in macrophages from aged mice. Immun Ageing. 2012; 9(1):27.
          View in: PubMed
        4. Friberg H, Jaiswal S, West K, O'Ketch M, Rothman AL, Mathew A. Analysis of human monoclonal antibodies generated by dengue virus-specific memory B cells. Viral Immunol. 2012 Oct; 25(5):348-59.
          View in: PubMed
        5. Jaiswal S, Pazoles P, Woda M, Shultz LD, Greiner DL, Brehm MA, Mathew A. Enhanced humoral and hla-a2-restricted dengue virus-specific t cell responses in humanized blt nsg mice. Immunology. 2012 Mar 2.
          View in: PubMed
        6. Mathew A, West K, Kalayanarooj S, Gibbons RV, Srikiatkhachorn A, Green S, Libraty D, Jaiswal S, Rothman AL. B-cell responses during primary and secondary dengue virus infections in humans. J Infect Dis. 2011 Nov; 204(10):1514-22.
          View in: PubMed
        7. Friberg H, Bashyam H, Toyosaki-Maeda T, Potts James A., Greenough T, Kalayanarooj S, Gibbons Robert V, Nisalak A, Srikiatkhachorn A, Green S, Stephens H.A.F., Rothman A. L., Mathew A. Nature: Sci Rep DOI:10.1038/srep00051. Cross-Reactivity and Expansion of Dengue-Specific T cells During Acute Primary and Secondary Infections in Humans. 2011; (1):51.
        8. O'Bryan JM, Potts JA, Bonkovsky HL, Mathew A, Rothman AL. Extended interferon-alpha therapy accelerates telomere length loss in human peripheral blood T lymphocytes. PLoS One. 2011; 6(8):e20922.
          View in: PubMed
        9. Hatch S, Endy TP, Thomas S, Mathew A, Potts J, Pazoles P, Libraty DH, Gibbons R, Rothman AL. Intracellular Cytokine Production by Dengue Virus-specific T cells Correlates with Subclinical Secondary Infection. J Infect Dis. 2011 May; 203(9):1282-91.
          View in: PubMed
        10. Green S, Ennis FA, Mathew A. Long term recall of memory CD8 T cells in mice to first and third generation smallpox vaccines. Vaccine. 2011 Feb 11; 29(8):1666-76.
          View in: PubMed
        11. Beaumier CM, Jaiswal S, West KY, Friberg H, Mathew A, Rothman AL. Differential in vivo clearance and response to secondary heterologous infections by H2(b)-restricted dengue virus-specific CD8+ T cells. Viral Immunol. 2010 Oct; 23(5):477-85.
          View in: PubMed
        12. Friberg H, Burns L, Woda M, Kalayanarooj S, Endy TP, Stephens HA, Green S, Rothman AL, Mathew A. Memory CD8(+) T cells from naturally acquired primary dengue virus infection are highly cross-reactive. Immunol Cell Biol. 2011 Jan; 89(1):122-9.
          View in: PubMed
        13. Jaiswal S, Pearson T, Friberg H, Shultz LD, Greiner DL, Rothman AL, Mathew A. Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice. PLoS One. 2009; 4(10):e7251.
          View in: PubMed
        14. Mathew A, O'Bryan J, Marshall W, Kotwal GJ, Terajima M, Green S, Rothman AL, Ennis FA. Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus. PLoS One. 2008; 3(10):e3323.
          View in: PubMed
        15. Mathew A, Rothman AL. Understanding the contribution of cellular immunity to dengue disease pathogenesis. Immunol Rev. 2008 Oct; 225:300-13.
          View in: PubMed
        16. Beaumier CM, Mathew A, Bashyam HS, Rothman AL. Cross-reactive memory CD8(+) T cells alter the immune response to heterologous secondary dengue virus infections in mice in a sequence-specific manner. J Infect Dis. 2008 Feb 15; 197(4):608-17.
          View in: PubMed
        17. Hatch S, Mathew A, Rothman A. Dengue vaccine: opportunities and challenges. IDrugs. 2008 Jan; 11(1):42-5.
          View in: PubMed
        18. Yuan Q, Campanella GS, Colvin RA, Hamilos DL, Jones KJ, Mathew A, Means TK, Luster AD. Membrane-bound eotaxin-3 mediates eosinophil transepithelial migration in IL-4-stimulated epithelial cells. Eur J Immunol. 2006 Oct; 36(10):2700-14.
          View in: PubMed
        19. Mathew A, Terajima M, West K, Green S, Rothman AL, Ennis FA, Kennedy JS. Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles. J Immunol. 2005 Feb 15; 174(4):2212-9.
          View in: PubMed
        20. Mathew A, Medoff BD, Carafone AD, Luster AD. Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling. J Immunol. 2002 Jul 15; 169(2):651-5.
          View in: PubMed
        21. Medoff BD, Sauty A, Tager AM, Maclean JA, Smith RN, Mathew A, Dufour JH, Luster AD. IFN-gamma-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J Immunol. 2002 May 15; 168(10):5278-86.
          View in: PubMed
        22. Mathew A, MacLean JA, DeHaan E, Tager AM, Green FH, Luster AD. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J Exp Med. 2001 May 7; 193(9):1087-96.
          View in: PubMed
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