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    Hira Lal Goel PhD

    TitleAssistant Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentCancer Biology
    AddressUniversity of Massachusetts Medical School
    364 Plantation Street, LRB
    Worcester MA 01605
    Phone508-856-1936
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentRadiation Oncology

        Bibliographic 
        selected publications
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        1. Goel HL, Gritsko T, Pursell B, Chang C, Shultz LD, Greiner DL, Norum JH, Toftgard R, Shaw LM, Mercurio AM. Regulated Splicing of the a6 Integrin Cytoplasmic Domain Determines the Fate of Breast Cancer Stem Cells. Cell Rep. 2014 May 8; 7(3):747-61.
          View in: PubMed
        2. Goel HL, Mercurio AM. VEGF targets the tumour cell. Nat Rev Cancer. 2013 Nov 22; 13(12):871-82.
          View in: PubMed
        3. Goel HL, Sayeed A, Breen M, Zarif MJ, Garlick DS, Leav I, Davis RJ, Fitzgerald TJ, Morrione A, Hsieh CC, Liu Q, Dicker AP, Altieri DC, Languino LR. ß1 integrins mediate resistance to ionizing radiation in vivo by inhibiting c-Jun amino terminal kinase 1. J Cell Physiol. 2013 Jul; 228(7):1601-9.
          View in: PubMed
        4. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Vander Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6ß1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Apr; 5(4):488-508.
          View in: PubMed
        5. Goel HL, Mercurio AM. Enhancing integrin function by VEGF/neuropilin signaling: implications for tumor biology. Cell Adh Migr. 2012 Nov-Dec; 6(6):554-60.
          View in: PubMed
        6. Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/neuropilin-2 regulation of Bmi-1 and consequent repression of IGF-IR define a novel mechanism of aggressive prostate cancer. Cancer Discov. 2012 Oct; 2(10):906-21.
          View in: PubMed
        7. Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM. Neuropilin-2 regulates a6ß1 integrin in the formation of focal adhesions and signaling. J Cell Sci. 2012 Jan 15; 125(Pt 2):497-506.
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        8. Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM. Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. Development. 2011 Jul; 138(14):2969-76.
          View in: PubMed
        9. Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR. Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1. J Cell Physiol. 2010 Jul; 224(1):210-7.
          View in: PubMed
        10. Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Jiang Z, Languino LR. CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells. Am J Transl Res. 2010; 2(2):135-44.
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        11. Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, Languino LR, Altieri DC. Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol. 2010 Jan; 176(1):393-401.
          View in: PubMed
        12. Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR. Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1. Cancer Res. 2009 Jul 1; 69(13):5374-82.
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        13. Goel HL, Alam N, Johnson IN, Languino LR. Integrin signaling aberrations in prostate cancer. Am J Transl Res. 2009; 1(3):211-20.
          View in: PubMed
        14. Wang T, Alavian MR, Goel HL, Languino LR, Fitzgerald TJ. Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation. Prostate. 2008 Dec 1; 68(16):1734-42.
          View in: PubMed
        15. Goel HL, Li J, Kogan S, Languino LR. Integrins in prostate cancer progression. Endocr Relat Cancer. 2008 Sep; 15(3):657-64.
          View in: PubMed
        16. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 2008 Jun; 8(6):967-74.
          View in: PubMed
        17. Alam N, Goel HL, Zarif MJ, Butterfield JE, Perkins HM, Sansoucy BG, Sawyer TK, Languino LR. The integrin-growth factor receptor duet. J Cell Physiol. 2007 Dec; 213(3):649-53.
          View in: PubMed
        18. Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR. Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment. Cancer Res. 2006 Jan 1; 66(1):331-42.
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        19. Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM, Elgavish A, Languino LR. beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts. Cancer Res. 2005 Aug 1; 65(15):6692-700.
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        20. Simon EL, Goel HL, Teider N, Wang T, Languino LR, Fitzgerald TJ. High dose fractionated ionizing radiation inhibits prostate cancer cell adhesion and beta(1) integrin expression. Prostate. 2005 Jun 15; 64(1):83-91.
          View in: PubMed
        21. Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, Languino LR. Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. J Cell Biol. 2004 Aug 2; 166(3):407-18.
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        22. Goel HL, Languino LR. Integrin signaling in cancer. Cancer Treat Res. 2004; 119:15-31.
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        23. Goel HL, Dey CS. Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases. J Cell Physiol. 2002 Nov; 193(2):187-98.
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        24. Goel HL, Dey CS. PKC-regulated myogenesis is associated with increased tyrosine phosphorylation of FAK, Cas, and paxillin, formation of Cas-CRK complex, and JNK activation. Differentiation. 2002 Aug; 70(6):257-71.
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        25. Goel HL, Dey CS. Role of protein kinase C during insulin mediated skeletal muscle cell spreading. J Muscle Res Cell Motil. 2002; 23(4):269-77.
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        26. Goel HL, Dey CS. Insulin-mediated tyrosine phosphorylation of myosin heavy chain and concomitant enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. Cell Biol Int. 2002; 26(6):557-61.
          View in: PubMed
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