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    David Ayers MD

    TitleChair and Professor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentOrthopedics and Physical Rehabilitation
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-334-7928
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentClinical Population Health Research

        Overview 
        Narrative
        TitlesArthur M. Pappas, Chair, Orthopedics and Physical Rehabilitation, UMass Memorial Medical Center
        Professor of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School
        Clinical InterestsArthritis of the hip and knee, avascular necrosis of the hip, hip and knee replacement
        Practice LocationUMass Memorial Medical Center - Memorial Campus
        119 Belmont Street
        Worcester, MA 01605
        Appointments: 508-334-1955 Fax: 508-334-9762
        Primary HospitalUMass Memorial Medical Center
        Board CertifiedOrthopedic Surgery
        Medical SchoolUniversity of Rochester School of Medicine 1982
        ResidencyStrong Memorial Hospital University of Rochester
        FellowshipNuffield Orthopedic Center, University of Oxford (Joint Replacement)
        Research Interests
      • Radiostereometric (RSA) Imaging of Hip Prostheses and Spine Fusion
      • Total Knee Replacement (TKR) (in collaboration with Prof. P. Franklin)
      • Link to David Ayers research page



        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Liu P, Domingue E, Ayers DC, Song J. Modification of Ti6Al4V Substrates with Well-defined Zwitterionic Polysulfobetaine Brushes for Improved Surface Mineralization. ACS Appl Mater Interfaces. 2014 May 28; 6(10):7141-52.
          View in: PubMed
        2. Ayers D, Franklin P. Improve care through outcomes reporting. Mod Healthc. 2013 Dec 2; 43(48):34.
          View in: PubMed
        3. Ayers DC, Franklin PD, Ring DC. The Role of Emotional Health in Functional Outcomes After Orthopaedic Surgery: Extending the Biopsychosocial Model to Orthopaedics: AOA Critical Issues. J Bone Joint Surg Am. 2013 Nov 6; 95(21):e1651-7.
          View in: PubMed
        4. Ayers DC, Zheng H, Franklin PD. Integrating patient-reported outcomes into orthopaedic clinical practice: proof of concept from FORCE-TJR. Clin Orthop Relat Res. 2013 Nov; 471(11):3419-25.
          View in: PubMed
        5. Franklin PD, Harrold L, Ayers DC. Incorporating patient-reported outcomes in total joint arthroplasty registries: challenges and opportunities. Clin Orthop Relat Res. 2013 Nov; 471(11):3482-8.
          View in: PubMed
        6. Ayers DC, Li W, Oatis C, Rosal MC, Franklin PD. Patient-reported outcomes after total knee replacement vary on the basis of preoperative coexisting disease in the lumbar spine and other nonoperatively treated joints: the need for a musculoskeletal comorbidity index. J Bone Joint Surg Am. 2013 Oct 16; 95(20):1833-7.
          View in: PubMed
        7. Ayers DC, Bozic KJ. The importance of outcome measurement in orthopaedics. Clin Orthop Relat Res. 2013 Nov; 471(11):3409-11.
          View in: PubMed
        8. Li X, Xu J, Filion TM, Ayers DC, Song J. pHEMA-nHA encapsulation and delivery of vancomycin and rhBMP-2 enhances its role as a bone graft substitute. Clin Orthop Relat Res. 2013 Aug; 471(8):2540-7.
          View in: PubMed
        9. Franklin PD, Allison JJ, Ayers DC. Beyond joint implant registries: a patient-centered research consortium for comparative effectiveness in total joint replacement. JAMA. 2012 Sep 26; 308(12):1217-8.
          View in: PubMed
        10. Rosal MC, Ayers D, Li W, Oatis C, Borg A, Zheng H, Franklin P. A randomized clinical trial of a peri-operative behavioral intervention to improve physical activity adherence and functional outcomes following total knee replacement. BMC Musculoskelet Disord. 2011; 12:226.
          View in: PubMed
        11. Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95.
          View in: PubMed
        12. St Pierre CA, Chan M, Iwakura Y, Ayers DC, Kurt-Jones EA, Finberg RW. Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles. J Orthop Res. 2010 Nov; 28(11):1418-24.
          View in: PubMed
        13. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11.
          View in: PubMed
        14. Jones MD, Liu JC, Barthel TK, Hussain S, Lovria E, Cheng D, Schoonmaker JA, Mulay S, Ayers DC, Bouxsein ML, Stein GS, Mukherjee S, Lian JB. A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes. Clin Cancer Res. 2010 Oct 15; 16(20):4978-89.
          View in: PubMed
        15. Franklin PD, Karbassi JA, Li W, Yang W, Ayers DC. Reduction in narcotic use after primary total knee arthroplasty and association with patient pain relief and satisfaction. J Arthroplasty. 2010 Sep; 25(6 Suppl):12-6.
          View in: PubMed
        16. Wixted JJ, Fanning PJ, Gaur T, O'Connell SL, Silva J, Mason-Savas A, Ayers DC, Stein GS, Lian JB. Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor. J Cell Physiol. 2009 Oct; 221(1):31-9.
          View in: PubMed
        17. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11.
          View in: PubMed
        18. Ayers DC, Hays PL, Drew JM, Eskander MS, Osuch D, Bragdon CR. Two-year radiostereometric analysis evaluation of femoral head penetration in a challenging population of young total hip arthroplasty patients. J Arthroplasty. 2009 Sep; 24(6 Suppl):9-14.
          View in: PubMed
        19. Gaur T, Wixted JJ, Hussain S, O'Connell SL, Morgan EF, Ayers DC, Komm BS, Bodine PV, Stein GS, Lian JB. Secreted frizzled related protein 1 is a target to improve fracture healing. J Cell Physiol. 2009 Jul; 220(1):174-81.
          View in: PubMed
        20. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107.
          View in: PubMed
        21. Franklin PD, Li W, Ayers DC. The Chitranjan Ranawat Award: functional outcome after total knee replacement varies with patient attributes. Clin Orthop Relat Res. 2008 Nov; 466(11):2597-604.
          View in: PubMed
        22. Jäger M, Fischer J, Dohrn W, Li X, Ayers DC, Czibere A, Prall WC, Lensing-Höhn S, Krauspe R. Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro. J Orthop Res. 2008 Nov; 26(11):1440-8.
          View in: PubMed
        23. Jäger M, Urselmann F, Witte F, Zanger K, Li X, Ayers DC, Krauspe R. Osteoblast differentiation onto different biometals with an endoprosthetic surface topography in vitro. J Biomed Mater Res A. 2008 Jul; 86(1):61-75.
          View in: PubMed
        24. Franklin PD, McLaughlin J, Boisvert CB, Li W, Ayers DC. Pilot study of methods to document quantity and variation of independent patient exercise and activity after total knee arthroplasty. J Arthroplasty. 2006 Sep; 21(6 Suppl 2):157-63.
          View in: PubMed
        25. Gaur T, Rich L, Lengner CJ, Hussain S, Trevant B, Ayers D, Stein JL, Bodine PV, Komm BS, Stein GS, Lian JB. Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation. J Cell Physiol. 2006 Jul; 208(1):87-96.
          View in: PubMed
        26. Ayers DC, Franklin PD, Ploutz-Snyder R, Boisvert CB. Total knee replacement outcome and coexisting physical and emotional illness. Clin Orthop Relat Res. 2005 Nov; 440:157-61.
          View in: PubMed
        27. Werner FW, Ayers DC, Maletsky LP, Rullkoetter PJ. The effect of valgus/varus malalignment on load distribution in total knee replacements. J Biomech. 2005 Feb; 38(2):349-55.
          View in: PubMed
        28. Ayers DC, Franklin PD, Trief PM, Ploutz-Snyder R, Freund D. Psychological attributes of preoperative total joint replacement patients: implications for optimal physical outcome. J Arthroplasty. 2004 Oct; 19(7 Suppl 2):125-30.
          View in: PubMed
        29. Mann KA, Gupta S, Race A, Miller MA, Cleary RJ, Ayers DC. Cement microcracks in thin-mantle regions after in vitro fatigue loading. J Arthroplasty. 2004 Aug; 19(5):605-12.
          View in: PubMed
        30. Mann KA, Damron LA, Race A, Ayers DC. Early cementing does not increase debond energy of grit blasted interfaces. J Orthop Res. 2004 Jul; 22(4):822-7.
          View in: PubMed
        31. Ayers D, Mann K. The importance of proximal cement filling of the calcar region: a biomechanical justification. J Arthroplasty. 2003 Oct; 18(7 Suppl 1):103-9.
          View in: PubMed
        32. Mann KA, Mocarski R, Damron LA, Allen MJ, Ayers DC. Mixed-mode failure response of the cement-bone interface. J Orthop Res. 2001 Nov; 19(6):1153-61.
          View in: PubMed
        33. Ayers DC. Maximizing ultra high molecular weight polyethylene performance in total knee replacement. Instr Course Lect. 2001; 50:421-9.
          View in: PubMed
        34. Mann KA, Allen MJ, Ayers DC. Pre-yield and post-yield shear behavior of the cement-bone interface. J Orthop Res. 1998 May; 16(3):370-8.
          View in: PubMed
        35. Francis CW, Pellegrini VD, Totterman S, Boyd AD, Marder VJ, Liebert KM, Stulberg BN, Ayers DC, Rosenberg A, Kessler C, Johanson NA. Prevention of deep-vein thrombosis after total hip arthroplasty. Comparison of warfarin and dalteparin. J Bone Joint Surg Am. 1997 Sep; 79(9):1365-72.
          View in: PubMed
        36. Mann KA, Bartel DL, Ayers DC. Influence of stem geometry on mechanics of cemented femoral hip components with a proximal bond. J Orthop Res. 1997 Sep; 15(5):700-6.
          View in: PubMed
        37. Ayers DC. Supracondylar fracture of the distal femur proximal to a total knee replacement. Instr Course Lect. 1997; 46:197-203.
          View in: PubMed
        38. Ayers DC. Polyethylene wear and osteolysis following total knee replacement. Instr Course Lect. 1997; 46:205-13.
          View in: PubMed
        39. Mann KA, Ayers DC, Damron TA. Effects of stem length on mechanics of the femoral hip component after cemented revision. J Orthop Res. 1997 Jan; 15(1):62-8.
          View in: PubMed
        40. Riebel GD, Werner FW, Ayers DC, Bromka J, Murray DG. Early failure of the femoral component in unicompartmental knee arthroplasty. J Arthroplasty. 1995 Oct; 10(5):615-21.
          View in: PubMed
        41. Ayers DC, Murray DG, Duerr DM. Blood salvage after total hip arthroplasty. J Bone Joint Surg Am. 1995 Sep; 77(9):1347-51.
          View in: PubMed
        42. Ayers DC, Athanasou NA, Woods CG, Duthie RB. Dialysis arthropathy of the hip. Clin Orthop Relat Res. 1993 May; (290):216-24.
          View in: PubMed
        43. Ayers DC, Pellegrini VD, Evarts CM. Prevention of heterotopic ossification in high-risk patients by radiation therapy. Clin Orthop Relat Res. 1991 Feb; (263):87-93.
          View in: PubMed
        44. Evarts CM, Ayers DC, Puzas JE. Prevention of heterotopic bone formation in high-risk patients by postoperative irradiation. Hip. 1987; 70-83.
          View in: PubMed
        45. Ayers DC, Evarts CM, Parkinson JR. The prevention of heterotopic ossification in high-risk patients by low-dose radiation therapy after total hip arthroplasty. J Bone Joint Surg Am. 1986 Dec; 68(9):1423-30.
          View in: PubMed
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