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    Alexei A Bogdanov PhD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentRadiology
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-856-5571
      Other Positions
      InstitutionUMMS - School of Medicine
      DepartmentCell and Developmental Biology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentBiochemistry and Molecular Pharmacology

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentCell Biology

      InstitutionUMMS - Programs, Centers and Institutes
      DepartmentChemical Biology

        Biography 
        awards and honors
        AUR1993Association of University Radiologists Memorial Award Paper
        CRS, Nice France1994Outstanding Pharmaceutical Paper Award, Controlled Release Society
        RSNA, Chicago IL1997Fuji Photo Film/ RSNA Research and Education Fund Seed Grant
        CIMIT-MGH, Boston MA1997Center for Innovative Minimally Invasive Therapy. Pilot Study Award
        ISMRM, Berkeley CA1998ISMRM Rabi Award
        AMI, Orlando Florida2004Academy of Molecular Imaging Top Scientific Abstract Award
        Emory University2007Distinguished Visiting Professor and Lecturer
        Karolinska Institutet, Stockholm Sweden2007Nobel Conference Speaker
        DKFZ, Heidelberg Germany2009DFG Visiting Professor
        Moscow State University, Moscow Russia2009Doctor of Sciences in Biophysics
        Overview 
        Narrative
        http://www.bogdanovlab.orgMolecular imaging probes and relevance of our researchMicroscopy of tissue samples has traditionally been one of the mainstays of experimental biology. However, advances in our understanding of the biochemical basis of disease has made it desirable and even necessary to be able to image these changes as they happen in vivo, using techniques which are noninvasive. The goal of such techniques are several fold:1) to obtain, analyze, and monitor disease related changes in molecular physiology over time and with high spatial resolution, i.e., up to the level of individual cells,2) to simultaneously acquire highly accurate anatomical images (tissue mapping) while mapping the functional status of tissues and organs, and3) to allow fundamental research findings to be translated into clinically diagnostic imaging strategies.Towards this end, ‘molecular imaging’ utilizes signals from endogenous or exogenous (chemically engeneered) substrates to probe chemical reactions in living cells. Such ‘reporters’ or ‘sensors’ have been successfully used to track real time changes in molecular physiology using modern diagnostic imaging methods such as magnetic resonance imaging (MRI), positron emission tomography (PET), gamma scintigraphy, optical fluorescence and near-infrared imaging, to relate these changes to the initiation and progression of diseases such as atherosclerosis and cancer. In order to gain wide-spread use in a clinical setting, molecular probes must be biocompatible, easily administered, specific and effective at low dosages.Our research addresses the issue of increasing selectivity and sensitivity of imaging probes. We also apply this research in realistic models of diseases.

        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Metelev V, Zhang S, Tabatadze D, Kumar AT, Bogdanov A. The three-dimensional context of a double helix determines the fluorescence of the internucleoside-tethered pair of fluorophores. Mol Biosyst. 2013 Aug 27; 9(10):2447-53.
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        2. Bogdanov AA, Mazzanti ML. Fluorescent macromolecular sensors of enzymatic activity for in vivo imaging. Prog Mol Biol Transl Sci. 2013; 113:349-87.
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        3. Reichstetter S, Castillo GM, Rubinstein I, Nishimoto-Ashfield A, Lai M, Jones CC, Banjeree A, Lyubimov A, Bloedow DC, Bogdanov A, Bolotin EM. Protected graft copolymer excipient leads to a higher acute maximum tolerated dose and extends residence time of vasoactive intestinal Peptide significantly better than sterically stabilized micelles. Pharm Res. 2013 Mar; 30(3):670-82.
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        4. Shazeeb MS, Xie Y, Gupta S, Bogdanov AA. A novel paramagnetic substrate for detecting myeloperoxidase activity in vivo. Mol Imaging. 2012 Sep-Oct; 11(5):433-43.
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        5. Kang HW, Gupta S, Bogdanov A. Orthotopic expression of noggin protein in cancer cells inhibits human lung carcinoma growth in vivo. Mol Imaging Biol. 2012 Aug; 14(4):480-8.
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        6. Bogdanov AA, Metelev V, Zhang S, Kumar AT. Sensing of transcription factor binding via cyanine dye pair fluorescence lifetime changes. Mol Biosyst. 2012 Aug 3; 8(8):2166-73.
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        7. Bogdanov AA, Mazzanti M, Castillo G, Bolotin E. Protected Graft Copolymer (PGC) in Imaging and Therapy: A Platform for the Delivery of Covalently and Non-Covalently Bound Drugs. Theranostics. 2012; 2(6):553-76.
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        8. Goergen CJ, Chen HH, Bogdanov A, Sosnovik DE, Kumar AT. In vivo fluorescence lifetime detection of an activatable probe in infarcted myocardium. J Biomed Opt. 2012 May; 17(5):056001.
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        9. Reichstetter S, Castillo GM, Lai M, Nishimoto-Ashfield A, Banerjee A, Bogdanov A, Lyubimov AV, Bolotin EM. Protected Graft Copolymer (PGC) Basal Formulation of Insulin as Potentially Safer Alternative to Lantus® (Insulin-Glargine): A Streptozotocin-Induced, Diabetic Sprague Dawley Rats Study. Pharm Res. 2012 Apr; 29(4):1033-9.
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        10. Medarova Z, Greiner DL, Ifediba M, Dai G, Bolotin E, Castillo G, Bogdanov A, Kumar M, Moore A. Imaging the pancreatic vasculature in diabetes models. Diabetes Metab Res Rev. 2011 Nov; 27(8):767-72.
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        11. Metelev V, Zhang S, Tabatadze D, Bogdanov A. Hairpin-Like Fluorescent Probe for Imaging of NF-?B Transcription Factor Activity. Bioconjug Chem. 2011 Apr 20; 22(4):759-65.
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        12. Bogdanov A, Mazzanti ML. Molecular magnetic resonance contrast agents for the detection of cancer: past and present. Semin Oncol. 2011 Feb; 38(1):42-54.
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        13. Shazeeb MS, Sotak CH, Deleo M, Bogdanov A. Targeted Signal-Amplifying Enzymes Enhance MRI of EGFR Expression in an Orthotopic Model of Human Glioma. Cancer Res. 2011 Mar 15; 71(6):2230-9.
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        14. Kang HW, Walvick R, Bogdanov A. In vitro and In vivo imaging of antivasculogenesis induced by Noggin protein expression in human venous endothelial cells. FASEB J. 2009 Dec; 23(12):4126-34.
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        15. Ronald JA, Chen JW, Chen Y, Hamilton AM, Rodriguez E, Reynolds F, Hegele RA, Rogers KA, Querol M, Bogdanov A, Weissleder R, Rutt BK. Enzyme-sensitive magnetic resonance imaging targeting myeloperoxidase identifies active inflammation in experimental rabbit atherosclerotic plaques. Circulation. 2009 Aug 18; 120(7):592-9.
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        16. Zhang S, Bogdanov A. Plate capture assay of fluorescent oligonucleotide duplex reporter-transcription factor complexes. Bioconjug Chem. 2009 Aug 19; 20(8):1444-8.
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        17. DeLeo MJ, Gounis MJ, Hong B, Ford JC, Wakhloo AK, Bogdanov AA. Carotid artery brain aneurysm model: in vivo molecular enzyme-specific MR imaging of active inflammation in a pilot study. Radiology. 2009 Sep; 252(3):696-703.
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        18. Kim YR, Tejima E, Huang S, Atochin DN, Dai G, Lo EH, Huang PL, Bogdanov A, Rosen BR. In vivo quantification of transvascular water exchange during the acute phase of permanent stroke. Magn Reson Med. 2008 Oct; 60(4):813-21.
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        19. Bogdanov AA. Merging molecular imaging and RNA interference: early experience in live animals. J Cell Biochem. 2008 Jul 1; 104(4):1113-23.
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        20. Zhang S, Metelev V, Tabatadze D, Zamecnik PC, Bogdanov A. Fluorescence resonance energy transfer in near-infrared fluorescent oligonucleotide probes for detecting protein-DNA interactions. Proc Natl Acad Sci U S A. 2008 Mar 18; 105(11):4156-61.
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        21. Tabatadze D, Zamecnik P, Yanachkov I, Wright G, Pierson K, Zhang S, Bogdanov A, Metelev V. A novel thymidine phosphoramidite synthon for incorporation of internucleoside phosphate linkers during automated oligodeoxynucleotide synthesis. Nucleosides Nucleotides Nucleic Acids. 2008 Feb; 27(2):157-72.
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        22. Querol M, Bogdanov A. Environment-sensitive and enzyme-sensitive MR contrast agents. Handb Exp Pharmacol. 2008; (185 Pt 2):37-57.
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        23. Zhang S, Metelev V, Tabatadze D, Zamecnik P, Bogdanov A. Near-infrared fluorescent oligodeoxyribonucleotide reporters for sensing NF-kappaB DNA interactions in vitro. Oligonucleotides. 2008; 18(3):235-43.
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        24. Querol M, Bennett DG, Sotak C, Kang HW, Bogdanov A. A paramagnetic contrast agent for detecting tyrosinase activity. Chembiochem. 2007 Sep 24; 8(14):1637-41.
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        25. Medarova Z, Castillo G, Dai G, Bolotin E, Bogdanov A, Moore A. Noninvasive magnetic resonance imaging of microvascular changes in type 1 diabetes. Diabetes. 2007 Nov; 56(11):2677-82.
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        26. Bogdanov A, Kang HW, Querol M, Pretorius PH, Yudina A. Synthesis and testing of a binary catalytic system for imaging of signal amplification in vivo. Bioconjug Chem. 2007 Jul-Aug; 18(4):1123-30.
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        27. Bogdanov AA, Querol M, Chen JW. [Visualization of the enzymatic activity in living systems using activated NMR contrast agents]. Biofizika. 2007 May-Jun; 52(3):389-400.
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        28. Bogdanov AA, Lin CP, Kang HW. Optical imaging of the adoptive transfer of human endothelial cells in mice using anti-human CD31 monoclonal antibody. Pharm Res. 2007 Jun; 24(6):1186-92.
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        29. Laguillier C, Hbibi AT, Baran-Marszak F, Metelev V, Cao A, Cymbalista F, Bogdanov A, Fagard R. Cell death in NF-kappaB-dependent tumour cell lines as a result of NF-kappaB trapping by linker-modified hairpin decoy oligonucleotide. FEBS Lett. 2007 Mar 20; 581(6):1143-50.
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        30. Querol M, Bogdanov A. Amplification strategies in MR imaging: activation and accumulation of sensing contrast agents (SCAs). J Magn Reson Imaging. 2006 Nov; 24(5):971-82.
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        31. Raman V, Artemov D, Pathak AP, Winnard PT, McNutt S, Yudina A, Bogdanov A, Bhujwalla ZM. Characterizing vascular parameters in hypoxic regions: a combined magnetic resonance and optical imaging study of a human prostate cancer model. Cancer Res. 2006 Oct 15; 66(20):9929-36.
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        32. Chen JW, Querol Sans M, Bogdanov A, Weissleder R. Imaging of myeloperoxidase in mice by using novel amplifiable paramagnetic substrates. Radiology. 2006 Aug; 240(2):473-81.
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        33. Kang HW, Torres D, Wald L, Weissleder R, Bogdanov AA. Targeted imaging of human endothelial-specific marker in a model of adoptive cell transfer. Lab Invest. 2006 Jun; 86(6):599-609.
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        34. Querol M, Chen JW, Bogdanov AA. A paramagnetic contrast agent with myeloperoxidase-sensing properties. Org Biomol Chem. 2006 May 21; 4(10):1887-95.
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        35. Banerjee P, Weissleder R, Bogdanov A. Linear polyethyleneimine grafted to a hyperbranched poly(ethylene glycol)-like core: a copolymer for gene delivery. Bioconjug Chem. 2006 Jan-Feb; 17(1):125-31.
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        36. Runnels JM, Zamiri P, Spencer JA, Veilleux I, Wei X, Bogdanov A, Lin CP. Imaging molecular expression on vascular endothelial cells by in vivo immunofluorescence microscopy. Mol Imaging. 2006 Jan-Mar; 5(1):31-40.
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        37. Querol Sans M, Chen JW, Weissleder R, Bogdanov AA. Myeloperoxidase activity imaging using (67)Ga labeled substrate. Mol Imaging Biol. 2005 Nov-Dec; 7(6):403-10.
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        38. Kim YR, Yudina A, Figueiredo J, Reichardt W, Hu-Lowe D, Petrovsky A, Kang HW, Torres D, Mahmood U, Weissleder R, Bogdanov AA. Detection of early antiangiogenic effects in human colon adenocarcinoma xenografts: in vivo changes of tumor blood volume in response to experimental VEGFR tyrosine kinase inhibitor. Cancer Res. 2005 Oct 15; 65(20):9253-60.
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        39. Reichardt W, Hu-Lowe D, Torres D, Weissleder R, Bogdanov A. Imaging of VEGF receptor kinase inhibitor-induced antiangiogenic effects in drug-resistant human adenocarcinoma model. Neoplasia. 2005 Sep; 7(9):847-53.
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        40. Querol M, Chen JW, Weissleder R, Bogdanov A. DTPA-bisamide-based MR sensor agents for peroxidase imaging. Org Lett. 2005 Apr 28; 7(9):1719-22.
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        41. Bogdanov AA, Chen JW, Kang HW, Weissleder R. Magnetic resonance signal amplification probes. Ernst Schering Res Found Workshop. 2005; (49):147-57.
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        42. Wunder A, Schellenberger E, Mahmood U, Bogdanov A, Müller-Ladner U, Weissleder R, Josephson L. Methotrexate-induced accumulation of fluorescent annexin V in collagen-induced arthritis. Mol Imaging. 2005 Jan-Mar; 4(1):1-6.
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        43. Metelev V, Weissleder R, Bogdanov A. Synthesis and properties of fluorescent NF-kappa B-recognizing hairpin oligodeoxyribonucleotide decoys. Bioconjug Chem. 2004 Nov-Dec; 15(6):1481-7.
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        44. Chen JW, Pham W, Weissleder R, Bogdanov A. Human myeloperoxidase: a potential target for molecular MR imaging in atherosclerosis. Magn Reson Med. 2004 Nov; 52(5):1021-8.
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        45. Banerjee P, Reichardt W, Weissleder R, Bogdanov A. Novel hyperbranched dendron for gene transfer in vitro and in vivo. Bioconjug Chem. 2004 Sep-Oct; 15(5):960-8.
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        46. Kim YR, Savellano MD, Savellano DH, Weissleder R, Bogdanov A. Measurement of tumor interstitial volume fraction: method and implication for drug delivery. Magn Reson Med. 2004 Sep; 52(3):485-94.
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        47. Ntziachristos V, Schellenberger EA, Ripoll J, Yessayan D, Graves E, Bogdanov A, Josephson L, Weissleder R. Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate. Proc Natl Acad Sci U S A. 2004 Aug 17; 101(33):12294-9.
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        48. Bogdanov A. In vivo imaging in the development of gene therapy vectors. Curr Opin Mol Ther. 2003 Dec; 5(6):594-602.
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        49. Simonova M, Shtanko O, Sergeyev N, Weissleder R, Bogdanov A. Engineering of technetium-99m-binding artificial receptors for imaging gene expression. J Gene Med. 2003 Dec; 5(12):1056-66.
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        50. Schellenberger EA, Bogdanov A, Petrovsky A, Ntziachristos V, Weissleder R, Josephson L. Optical imaging of apoptosis as a biomarker of tumor response to chemotherapy. Neoplasia. 2003 May-Jun; 5(3):187-92.
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        51. Petrovsky A, Schellenberger E, Josephson L, Weissleder R, Bogdanov A. Near-infrared fluorescent imaging of tumor apoptosis. Cancer Res. 2003 Apr 15; 63(8):1936-42.
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        52. Kim YR, Savellano MD, Weissleder R, Bogdanov A. Steady-state and dynamic contrast MR imaging of human prostate cancer xenograft tumors: a comparative study. Technol Cancer Res Treat. 2002 Dec; 1(6):489-95.
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        53. Schellingerhout D, Bogdanov AA. Viral imaging in gene therapy noninvasive demonstration of gene delivery and expression. Neuroimaging Clin N Am. 2002 Nov; 12(4):571-81, vi-vii.
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        54. Bogdanov AA, Lin CP, Simonova M, Matuszewski L, Weissleder R. Cellular activation of the self-quenched fluorescent reporter probe in tumor microenvironment. Neoplasia. 2002 May-Jun; 4(3):228-36.
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        55. Schellenberger EA, Bogdanov A, Högemann D, Tait J, Weissleder R, Josephson L. Annexin V-CLIO: a nanoparticle for detecting apoptosis by MRI. Mol Imaging. 2002 Apr-Jun; 1(2):102-7.
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        56. Kang HW, Weissleder R, Bogdanov A. Targeting of MPEG-protected polyamino acid carrier to human E-selectin in vitro. Amino Acids. 2002; 23(1-3):301-8.
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        57. Kang HW, Josephson L, Petrovsky A, Weissleder R, Bogdanov A. Magnetic resonance imaging of inducible E-selectin expression in human endothelial cell culture. Bioconjug Chem. 2002 Jan-Feb; 13(1):122-7.
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        58. Bogdanov A, Matuszewski L, Bremer C, Petrovsky A, Weissleder R. Oligomerization of paramagnetic substrates result in signal amplification and can be used for MR imaging of molecular targets. Mol Imaging. 2002 Jan-Mar; 1(1):16-23.
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        59. Bogdanov A, Tung CH, Bredow S, Weissleder R. DNA binding chelates for nonviral gene delivery imaging. Gene Ther. 2001 Apr; 8(7):515-22.
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        60. Weissleder R, Bogdanov A, Tung CH, Weinmann HJ. Size optimization of synthetic graft copolymers for in vivo angiogenesis imaging. Bioconjug Chem. 2001 Mar-Apr; 12(2):213-9.
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        61. Bremer C, Bogdanov AA, Weissleder R. [Imaging of angiogenesis]. Radiologe. 2001 Feb; 41(2):138-45.
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        62. Simonova M, Wall A, Weissleder R, Bogdanov A. Tyrosinase mutants are capable of prodrug activation in transfected nonmelanotic cells. Cancer Res. 2000 Dec 1; 60(23):6656-62.
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        63. Bogdanov AA, Simonova M, Weissleder R. Engineering membrane proteins for nuclear medicine: applications for gene therapy and cell tracking. Q J Nucl Med. 2000 Sep; 44(3):224-35.
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        64. Wunderbaldinger P, Bogdanov A, Weissleder R. New approaches for imaging in gene therapy. Eur J Radiol. 2000 Jun; 34(3):156-65.
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        65. Moore A, Marecos E, Bogdanov A, Weissleder R. Tumoral distribution of long-circulating dextran-coated iron oxide nanoparticles in a rodent model. Radiology. 2000 Feb; 214(2):568-74.
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        66. Lewin M, Bredow S, Sergeyev N, Marecos E, Bogdanov A, Weissleder R. In vivo assessment of vascular endothelial growth factor-induced angiogenesis. Int J Cancer. 1999 Dec 10; 83(6):798-802.
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        67. Mahmood U, Tung CH, Bogdanov A, Weissleder R. Near-infrared optical imaging of protease activity for tumor detection. Radiology. 1999 Dec; 213(3):866-70.
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        68. Bogdanov A, Marecos E, Cheng HC, Chandrasekaran L, Krutzsch HC, Roberts DD, Weissleder R. Treatment of experimental brain tumors with trombospondin-1 derived peptides: an in vivo imaging study. Neoplasia. 1999 Nov; 1(5):438-45.
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        69. Zaharchuk G, Mandeville JB, Bogdanov AA, Weissleder R, Rosen BR, Marota JJ. Cerebrovascular dynamics of autoregulation and hypoperfusion. An MRI study of CBF and changes in total and microvascular cerebral blood volume during hemorrhagic hypotension. Stroke. 1999 Oct; 30(10):2197-204; discussion 2204-5.
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        70. Simonova M, Weissleder R, Sergeyev N, Vilissova N, Bogdanov A. Targeting of green fluorescent protein expression to the cell surface. Biochem Biophys Res Commun. 1999 Sep 7; 262(3):638-42.
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        71. Weissleder R, Tung CH, Mahmood U, Bogdanov A. In vivo imaging of tumors with protease-activated near-infrared fluorescent probes. Nat Biotechnol. 1999 Apr; 17(4):375-8.
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        72. Hofmann B, Bogdanov A, Marecos E, Ebert W, Semmler W, Weissleder R. Mechanism of gadophrin-2 accumulation in tumor necrosis. J Magn Reson Imaging. 1999 Feb; 9(2):336-41.
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        73. Zaharchuk G, Bogdanov AA, Marota JJ, Shimizu-Sasamata M, Weisskoff RM, Kwong KK, Jenkins BG, Weissleder R, Rosen BR. Continuous assessment of perfusion by tagging including volume and water extraction (CAPTIVE): a steady-state contrast agent technique for measuring blood flow, relative blood volume fraction, and the water extraction fraction. Magn Reson Med. 1998 Nov; 40(5):666-78.
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        74. Moore A, Marecos E, Simonova M, Weissleder R, Bogdanov A. Novel gliosarcoma cell line expressing green fluorescent protein: A model for quantitative assessment of angiogenesis. Microvasc Res. 1998 Nov; 56(3):145-53.
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        75. Weissleder R, Cheng HC, Marecos E, Kwong K, Bogdanov A. Non-invasive in vivo mapping of tumour vascular and interstitial volume fractions. Eur J Cancer. 1998 Aug; 34(9):1448-54.
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        76. Schellingerhout D, Bogdanov A, Marecos E, Spear M, Breakefield X, Weissleder R. Mapping the in vivo distribution of herpes simplex virions. Hum Gene Ther. 1998 Jul 20; 9(11):1543-9.
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        77. de Marco G, Bogdanov A, Marecos E, Moore A, Simonova M, Weissleder R. MR imaging of gene delivery to the central nervous system with an artificial vector. Radiology. 1998 Jul; 208(1):65-71.
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        78. Callahan RJ, Bogdanov A, Fischman AJ, Brady TJ, Weissleder R. Preclinical evaluation and phase I clinical trial of a 99mTc-labeled synthetic polymer used in blood pool imaging. AJR Am J Roentgenol. 1998 Jul; 171(1):137-43.
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        79. Bogdanov A, Simonova M, Weissleder R. Design of metal-binding green fluorescent protein variants. Biochim Biophys Acta. 1998 Apr 1; 1397(1):56-64.
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        80. Marecos E, Weissleder R, Bogdanov A. Antibody-mediated versus nontargeted delivery in a human small cell lung carcinoma model. Bioconjug Chem. 1998 Mar-Apr; 9(2):184-91.
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        81. Bogdanov A, Weissleder R. The development of in vivo imaging systems to study gene expression. Trends Biotechnol. 1998 Jan; 16(1):5-10.
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        82. Cheng HC, Khan MA, Bogdanov A, Kwong K, Weissleder R. Relative blood volume measurements by magnetic resonance imaging facilitate detection of testicular torsion. Invest Radiol. 1997 Dec; 32(12):763-9.
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        83. Moore A, Weissleder R, Bogdanov A. Uptake of dextran-coated monocrystalline iron oxides in tumor cells and macrophages. J Magn Reson Imaging. 1997 Nov-Dec; 7(6):1140-5.
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        84. Bogdanov A, Petherick P, Marecos E, Weissleder R. In vivo localization of diglycylcysteine-bearing synthetic peptides by nuclear imaging of oxotechnetate transchelation. Nucl Med Biol. 1997 Nov; 24(8):739-42.
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        85. Weissleder R, Simonova M, Bogdanova A, Bredow S, Enochs WS, Bogdanov A. MR imaging and scintigraphy of gene expression through melanin induction. Radiology. 1997 Aug; 204(2):425-9.
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        86. Weissleder R, Cheng HC, Bogdanova A, Bogdanov A. Magnetically labeled cells can be detected by MR imaging. J Magn Reson Imaging. 1997 Jan-Feb; 7(1):258-63.
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        87. Bogdanov A, Wright SC, Marecos EM, Bogdanova A, Martin C, Petherick P, Weissleder R. A long-circulating co-polymer in "passive targeting" to solid tumors. J Drug Target. 1997; 4(5):321-30.
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        88. Donahue KM, Weisskoff RM, Chesler DA, Kwong KK, Bogdanov AA, Mandeville JB, Rosen BR. Improving MR quantification of regional blood volume with intravascular T1 contrast agents: accuracy, precision, and water exchange. Magn Reson Med. 1996 Dec; 36(6):858-67.
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        89. Shen TT, Bogdanov A, Bogdanova A, Poss K, Brady TJ, Weissleder R. Magnetically labeled secretin retains receptor affinity to pancreas acinar cells. Bioconjug Chem. 1996 May-Jun; 7(3):311-6.
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        90. Remsen LG, McCormick CI, Roman-Goldstein S, Nilaver G, Weissleder R, Bogdanov A, Hellström I, Kroll RA, Neuwelt EA. MR of carcinoma-specific monoclonal antibody conjugated to monocrystalline iron oxide nanoparticles: the potential for noninvasive diagnosis. AJNR Am J Neuroradiol. 1996 Mar; 17(3):411-8.
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        91. Bogdanov AA, Martin C, Bogdanova AV, Brady TJ, Weissleder R. An adduct of cis-diamminedichloroplatinum(II) and poly(ethylene glycol)poly(L-lysine)-succinate: synthesis and cytotoxic properties. Bioconjug Chem. 1996 Jan-Feb; 7(1):144-9.
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        92. Gupta H, Wilkinson RA, Bogdanov AA, Callahan RJ, Weissleder R. Inflammation: imaging with methoxy poly(ethylene glycol)-poly-L-lysine-DTPA, a long-circulating graft copolymer. Radiology. 1995 Dec; 197(3):665-9.
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        93. Gupta H, Weissleder R, Bogdanov AA, Brady TJ. Experimental gastrointestinal hemorrhage: detection with contrast-enhanced MR imaging and scintigraphy. Radiology. 1995 Jul; 196(1):239-44.
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        94. Weissleder R, Poss K, Wilkinson R, Zhou C, Bogdanov A. Quantitation of slow drug release from an implantable and degradable gentamicin conjugate by in vivo magnetic resonance imaging. Antimicrob Agents Chemother. 1995 Apr; 39(4):839-45.
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        95. van Everdingen KJ, Enochs WS, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R. Determinants of in vivo MR imaging of slow axonal transport. Radiology. 1994 Nov; 193(2):485-91.
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        96. Bogdanov AA, Callahan RJ, Wilkinson RA, Martin C, Cameron JA, Fischman AJ, Brady TJ, Weissleder R. Synthetic copolymer kit for radionuclide blood-pool imaging. J Nucl Med. 1994 Nov; 35(11):1880-6.
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        97. Torchilin VP, Omelyanenko VG, Papisov MI, Bogdanov AA, Trubetskoy VS, Herron JN, Gentry CA. Poly(ethylene glycol) on the liposome surface: on the mechanism of polymer-coated liposome longevity. Biochim Biophys Acta. 1994 Oct 12; 1195(1):11-20.
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        98. Bogdanov AA, Martin C, Weissleder R, Brady TJ. Trapping of dextran-coated colloids in liposomes by transient binding to aminophospholipid: preparation of ferrosomes. Biochim Biophys Acta. 1994 Jul 13; 1193(1):212-8.
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        99. Frank H, Weissleder R, Bogdanov AA, Brady TJ. Detection of pulmonary emboli by using MR angiography with MPEG-PL-GdDTPA: an experimental study in rabbits. AJR Am J Roentgenol. 1994 May; 162(5):1041-6.
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        100. Weissleder R, Heautot JF, Schaffer BK, Nossiff N, Papisov MI, Bogdanov A, Brady TJ. MR lymphography: study of a high-efficiency lymphotrophic agent. Radiology. 1994 Apr; 191(1):225-30.
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        101. Weissleder R, Bogdanov A, Frank H, Nossiff N, Bogdanova A, Schaffer BK, Brady T, Wittenberg J. AUR Memorial Award 1993. A drug system (PDH) for interventional radiology. Synthesis, properties, and efficacy. Invest Radiol. 1993 Dec; 28(12):1083-9.
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        102. Enochs WS, Schaffer B, Bhide PG, Nossiff N, Papisov M, Bogdanov A, Brady TJ, Weissleder R. MR imaging of slow axonal transport in vivo. Exp Neurol. 1993 Oct; 123(2):235-42.
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        103. Bogdanov AA, Weissleder R, Frank HW, Bogdanova AV, Nossif N, Schaffer BK, Tsai E, Papisov MI, Brady TJ. A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies. Radiology. 1993 Jun; 187(3):701-6.
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        104. Shen T, Weissleder R, Papisov M, Bogdanov A, Brady TJ. Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med. 1993 May; 29(5):599-604.
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        105. Schaffer BK, Linker C, Papisov M, Tsai E, Nossiff N, Shibata T, Bogdanov A, Brady TJ, Weissleder R. MION-ASF: biokinetics of an MR receptor agent. Magn Reson Imaging. 1993; 11(3):411-7.
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        106. Weissleder R, Wang YM, Papisov M, Bogdanov A, Schaffer B, Brady TJ, Wittenberg J. Polymeric contrast agents for MR imaging of adrenal glands. J Magn Reson Imaging. 1993 Jan-Feb; 3(1):93-7.
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        107. Weissleder R, Bogdanov A, Papisov M. Drug targeting in magnetic resonance imaging. Magn Reson Q. 1992 Mar; 8(1):55-63.
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