Ellen M Gravallese MD
Title Professor
Institution University of Massachusetts Medical School
Department Medicine
Division Rheumatology
Address University of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Telephone 508-856-8730
Email
Other Positions
Institution UMMS - School of Medicine
Department Cell and Developmental Biology

Institution UMMS - Graduate School of Biomedical Sciences
Department Cell Biology
Publications
1. Schett G, Gravallese E. Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol. 2012 Nov; 8(11):656-64.
  View in: PubMed
 
2. Matzelle MM, Gallant MA, Condon KW, Walsh NC, Manning CA, Stein GS, Lian JB, Burr DB, Gravallese EM. Resolution of inflammation induces osteoblast function and regulates the Wnt signaling pathway. Arthritis Rheum. 2012 May; 64(5):1540-50.
  View in: PubMed
 
3. Gravallese EM, Walsh NC. Rheumatoid arthritis: Repair of erosion in RA--shifting the balance to formation. Nat Rev Rheumatol. 2011 Nov; 7(11):626-8.
  View in: PubMed
 
4. Salomon-Escoto KI, Gravallese EM, Kay J. Assessment of control of rheumatoid arthritis disease activity. Best Pract Res Clin Rheumatol. 2011 Aug; 25(4):497-507.
  View in: PubMed
 
5. Karmakar S, Kay J, Gravallese EM. Bone damage in rheumatoid arthritis: mechanistic insights and approaches to prevention. Rheum Dis Clin North Am. 2010 May; 36(2):385-404.
  View in: PubMed
 
6. Walsh NC, Gravallese EM. Bone remodeling in rheumatic disease: a question of balance. Immunol Rev. 2010 Jan; 233(1):301-12.
  View in: PubMed
 
7. Desai SP, Gravallese EM, Shadick NA, Glass R, Cui J, Frits M, Chibnik LB, Maher N, Weinblatt ME, Solomon DH. Hand bone mineral density is associated with both total hip and lumbar spine bone mineral density in post-menopausal women with RA. Rheumatology (Oxford). 2010 Mar; 49(3):513-9.
  View in: PubMed
 
8. Walsh NC, Reinwald S, Manning CA, Condon KW, Iwata K, Burr DB, Gravallese EM. Osteoblast function is compromised at sites of focal bone erosion in inflammatory arthritis. J Bone Miner Res. 2009 Sep; 24(9):1572-85.
  View in: PubMed
 
9. Colbert RA, Deodhar AA, Fox D, Gravallese EM, Khan MA, McGonagle D, Reveille JD, Schett G, Weisman M, Clegg DO. Entheses and bones in spondyloarthritis: 2008 Annual Research and Education Meeting of the Spondyloarthritis Research and Therapy Network (SPARTAN). J Rheumatol. 2009 Jul; 36(7):1527-31.
  View in: PubMed
 
10. Solomon DH, Finkelstein JS, Shadick N, LeBoff MS, Winalski CS, Stedman M, Glass R, Brookhart MA, Weinblatt ME, Gravallese EM. The relationship between focal erosions and generalized osteoporosis in postmenopausal women with rheumatoid arthritis. Arthritis Rheum. 2009 Jun; 60(6):1624-31.
  View in: PubMed
 
11. Shen Z, Crotti TN, McHugh KP, Matsuzaki K, Gravallese EM, Bierbaum BE, Goldring SR. The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis. Arthritis Res Ther. 2006; 8(3):R70.
  View in: PubMed
 
12. Pettit AR, Walsh NC, Manning C, Goldring SR, Gravallese EM. RANKL protein is expressed at the pannus-bone interface at sites of articular bone erosion in rheumatoid arthritis. Rheumatology (Oxford). 2006 Sep; 45(9):1068-76.
  View in: PubMed
 
13. Walsh NC, Crotti TN, Goldring SR, Gravallese EM. Rheumatic diseases: the effects of inflammation on bone. Immunol Rev. 2005 Dec; 208:228-51.
  View in: PubMed
 
14. Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB. A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation. J Biol Chem. 2005 Nov 18; 280(46):38544-55.
  View in: PubMed
 
15. Grall FT, Prall WC, Wei W, Gu X, Cho JY, Choy BK, Zerbini LF, Inan MS, Goldring SR, Gravallese EM, Goldring MB, Oettgen P, Libermann TA. The Ets transcription factor ESE-1 mediates induction of the COX-2 gene by LPS in monocytes. FEBS J. 2005 Apr; 272(7):1676-87.
  View in: PubMed
 
16. Jacobs JP, Pettit AR, Shinohara ML, Jansson M, Cantor H, Gravallese EM, Mathis D, Benoist C. Lack of requirement of osteopontin for inflammation, bone erosion, and cartilage damage in the K/BxN model of autoantibody-mediated arthritis. Arthritis Rheum. 2004 Aug; 50(8):2685-94.
  View in: PubMed
 
17. Walsh NC, Gravallese EM. Bone loss in inflammatory arthritis: mechanisms and treatment strategies. Curr Opin Rheumatol. 2004 Jul; 16(4):419-27.
  View in: PubMed
 
18. Goldring SR, Gravallese EM. Bisphosphonates: environmental protection for the joint? Arthritis Rheum. 2004 Jul; 50(7):2044-7.
  View in: PubMed
 
19. Brown C, Gaspar J, Pettit A, Lee R, Gu X, Wang H, Manning C, Voland C, Goldring SR, Goldring MB, Libermann TA, Gravallese EM, Oettgen P. ESE-1 is a novel transcriptional mediator of angiopoietin-1 expression in the setting of inflammation. J Biol Chem. 2004 Mar 26; 279(13):12794-803.
  View in: PubMed
 
20. Gravallese EM. Osteopontin: a bridge between bone and the immune system. J Clin Invest. 2003 Jul; 112(2):147-9.
  View in: PubMed
 
21. Grall F, Gu X, Tan L, Cho JY, Inan MS, Pettit AR, Thamrongsak U, Choy BK, Manning C, Akbarali Y, Zerbini L, Rudders S, Goldring SR, Gravallese EM, Oettgen P, Goldring MB, Libermann TA. Responses to the proinflammatory cytokines interleukin-1 and tumor necrosis factor alpha in cells derived from rheumatoid synovium and other joint tissues involve nuclear factor kappaB-mediated induction of the Ets transcription factor ESE-1. Arthritis Rheum. 2003 May; 48(5):1249-60.
  View in: PubMed
 
22. Pisetsky DS, Hunder GG, Gravallese EM. New policy on disclosure of interest for American College of Rheumatology Journals. Arthritis Rheum. 2003 Apr 15; 49(2):149-50.
  View in: PubMed
 
23. Pisetsky DS, Hunder GG, Gravallese EM. New policy on disclosure of interest for American College of Rheumatology journals. Arthritis Rheum. 2003 Apr; 48(4):873-5.
  View in: PubMed
 
24. Gravallese EM, Pettit AR, Lee R, Madore R, Manning C, Tsay A, Gaspar J, Goldring MB, Goldring SR, Oettgen P. Angiopoietin-1 is expressed in the synovium of patients with rheumatoid arthritis and is induced by tumour necrosis factor alpha. Ann Rheum Dis. 2003 Feb; 62(2):100-7.
  View in: PubMed
 
25. Gravallese EM. Bone destruction in arthritis. Ann Rheum Dis. 2002 Nov; 61 Suppl 2:ii84-6.
  View in: PubMed
 
26. Lubberts E, Oppers-Walgreen B, Pettit AR, Van Den Bersselaar L, Joosten LA, Goldring SR, Gravallese EM, Van Den Berg WB. Increase in expression of receptor activator of nuclear factor kappaB at sites of bone erosion correlates with progression of inflammation in evolving collagen-induced arthritis. Arthritis Rheum. 2002 Nov; 46(11):3055-64.
  View in: PubMed
 
27. Ji H, Pettit A, Ohmura K, Ortiz-Lopez A, Duchatelle V, Degott C, Gravallese E, Mathis D, Benoist C. Critical roles for interleukin 1 and tumor necrosis factor alpha in antibody-induced arthritis. J Exp Med. 2002 Jul 1; 196(1):77-85.
  View in: PubMed
 
28. Goldring SR, Gravallese EM. Pathogenesis of bone lesions in rheumatoid arthritis. Curr Rheumatol Rep. 2002 Jun; 4(3):226-31.
  View in: PubMed
 
29. Husni ME, Maier AL, Mease PJ, Overman SS, Fraser P, Gravallese EM, Weinblatt ME. Etanercept in the treatment of adult patients with Still's disease. Arthritis Rheum. 2002 May; 46(5):1171-6.
  View in: PubMed
 
30. Hou WS, Li W, Keyszer G, Weber E, Levy R, Klein MJ, Gravallese EM, Goldring SR, Brömme D. Comparison of cathepsins K and S expression within the rheumatoid and osteoarthritic synovium. Arthritis Rheum. 2002 Mar; 46(3):663-74.
  View in: PubMed
 
31. Raffel GD, Gravallese EM, Schwab P, Joseph JT, Cannistra SA. Diagnostic dilemmas in oncology: case 2. Dermatomyositis and ovarian cancer. J Clin Oncol. 2001 Dec 1; 19(23):4341-3.
  View in: PubMed
 
32. Pettit AR, Ji H, von Stechow D, MĂĽller R, Goldring SR, Choi Y, Benoist C, Gravallese EM. TRANCE/RANKL knockout mice are protected from bone erosion in a serum transfer model of arthritis. Am J Pathol. 2001 Nov; 159(5):1689-99.
  View in: PubMed
 
33. Reimold AM, Iwakoshi NN, Manis J, Vallabhajosyula P, Szomolanyi-Tsuda E, Gravallese EM, Friend D, Grusby MJ, Alt F, Glimcher LH. Plasma cell differentiation requires the transcription factor XBP-1. Nature. 2001 Jul 19; 412(6844):300-7.
  View in: PubMed
 
34. Gravallese EM, Galson DL, Goldring SR, Auron PE. The role of TNF-receptor family members and other TRAF-dependent receptors in bone resorption. Arthritis Res. 2001; 3(1):6-12.
  View in: PubMed
 
35. Gravallese EM, Goldring SR. Cellular mechanisms and the role of cytokines in bone erosions in rheumatoid arthritis. Arthritis Rheum. 2000 Oct; 43(10):2143-51.
  View in: PubMed
 
36. Wexler EJ, Gravallese EM, Czerniak PM, Devenny JJ, Longtine J, Wong MK, Slee AM, Kerr JS. Tumor biology: use of tiled images in conjunction with measurements of cellular proliferation and death in response to drug treatments. Clin Cancer Res. 2000 Aug; 6(8):3361-70.
  View in: PubMed
 
37. Goldring SR, Gravallese EM. Pathogenesis of bone erosions in rheumatoid arthritis. Curr Opin Rheumatol. 2000 May; 12(3):195-9.
  View in: PubMed
 
38. Mandl LA, Folkerth RD, Pick MA, Weinblatt ME, Gravallese EM. Amyloid myopathy masquerading as polymyositis. J Rheumatol. 2000 Apr; 27(4):949-52.
  View in: PubMed
 
39. Gravallese EM, Manning C, Tsay A, Naito A, Pan C, Amento E, Goldring SR. Synovial tissue in rheumatoid arthritis is a source of osteoclast differentiation factor. Arthritis Rheum. 2000 Feb; 43(2):250-8.
  View in: PubMed
 
40. Ranger AM, Gerstenfeld LC, Wang J, Kon T, Bae H, Gravallese EM, Glimcher MJ, Glimcher LH. The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis. J Exp Med. 2000 Jan 3; 191(1):9-22.
  View in: PubMed
 
41. Goldring SR, Gravallese EM. Mechanisms of bone loss in inflammatory arthritis: diagnosis and therapeutic implications. Arthritis Res. 2000; 2(1):33-7.
  View in: PubMed
 
42. Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR. Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998 Apr; 152(4):943-51.
  View in: PubMed
 
43. Ranger AM, Grusby MJ, Hodge MR, Gravallese EM, de la Brousse FC, Hoey T, Mickanin C, Baldwin HS, Glimcher LH. The transcription factor NF-ATc is essential for cardiac valve formation. Nature. 1998 Mar 12; 392(6672):186-90.
  View in: PubMed
 
44. Kelleher Doyle M, Telford SR, Criscione L, Lin SR, Spielman A, Gravallese EM. Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain. J Infect Dis. 1998 Jan; 177(1):242-6.
  View in: PubMed
 
45. Ranger AM, Hodge MR, Gravallese EM, Oukka M, Davidson L, Alt FW, de la Brousse FC, Hoey T, Grusby M, Glimcher LH. Delayed lymphoid repopulation with defects in IL-4-driven responses produced by inactivation of NF-ATc. Immunity. 1998 Jan; 8(1):125-34.
  View in: PubMed
 
46. Darling JM, Goldring SR, Harada Y, Handel ML, Glowacki J, Gravallese EM. Multinucleated cells in pigmented villonodular synovitis and giant cell tumor of tendon sheath express features of osteoclasts. Am J Pathol. 1997 Apr; 150(4):1383-93.
  View in: PubMed
 
47. Ruderman EM, Crawford JM, Maier A, Liu JJ, Gravallese EM, Weinblatt ME. Histologic liver abnormalities in an autopsy series of patients with rheumatoid arthritis. Br J Rheumatol. 1997 Feb; 36(2):210-3.
  View in: PubMed
 
48. Gravallese EM, Handel ML, Coblyn J, Anderson RJ, Sperling RI, Karlson EW, Maier A, Ruderman EM, Formelli F, Weinblatt ME. N-[4-hydroxyphenyl] retinamide in rheumatoid arthritis: a pilot study. Arthritis Rheum. 1996 Jun; 39(6):1021-6.
  View in: PubMed
 
49. Handel ML, McMorrow LB, Gravallese EM. Nuclear factor-kappa B in rheumatoid synovium. Localization of p50 and p65. Arthritis Rheum. 1995 Dec; 38(12):1762-70.
  View in: PubMed
 
50. Gravallese EM, Weissman BN, Brodsky G, Maguire J. Loosening of a revision total hip replacement in a 60-year-old woman with longstanding rheumatoid arthritis. Arthritis Rheum. 1995 Sep; 38(9):1315-24.
  View in: PubMed
 
51. Gravallese EM, Waksmonski C, Winters GL, Simms RW. Fever, arthralgias, skin lesions, and ischemic digits in a 59-year-old man. Arthritis Rheum. 1995 Aug; 38(8):1161-8.
  View in: PubMed
 
52. Ruderman EM, Kerr JS, Telford SR, Spielman A, Glimcher LH, Gravallese EM. Early murine Lyme carditis has a macrophage predominance and is independent of major histocompatibility complex class II-CD4+ T cell interactions. J Infect Dis. 1995 Feb; 171(2):362-70.
  View in: PubMed
 
53. Ruderman EM, Weinblatt ME, Thurmond LM, Pinkus GS, Gravallese EM. Synovial tissue response to treatment with Campath-1H. Arthritis Rheum. 1995 Feb; 38(2):254-8.
  View in: PubMed
 
54. Darling JM, Glimcher LH, Shortkroff S, Albano B, Gravallese EM. Expression of metalloproteinases in pigmented villonodular synovitis. Hum Pathol. 1994 Aug; 25(8):825-30.
  View in: PubMed
 
55. Gravallese EM, Winalski CS, Longtine J, Helfgott SM. Polyarthritis in a 78-year-old woman. Arthritis Rheum. 1994 Jul; 37(7):1087-95.
  View in: PubMed
 
56. Gravallese EM, Weissman BN, Corson JM, Greene JM. Synovitis of the knee in a 42-year-old man. Arthritis Rheum. 1993 Jun; 36(6):860-70.
  View in: PubMed
 
57. Clauss IM, Gravallese EM, Darling JM, Shapiro F, Glimcher MJ, Glimcher LH. In situ hybridization studies suggest a role for the basic region-leucine zipper protein hXBP-1 in exocrine gland and skeletal development during mouse embryogenesis. Dev Dyn. 1993 Jun; 197(2):146-56.
  View in: PubMed
 
58. Gravallese EM, Baker N, Lester S, Kay J, Owen WF. Musculoskeletal manifestations in beta 2-microglobulin amyloidosis. Case discussion. Arthritis Rheum. 1992 May; 35(5):592-602.
  View in: PubMed
 
59. Gravallese EM, Darling JM, Glimcher LH, Boothby M. Role of lipopolysaccharide and IL-4 in control of transcription of the class II A alpha gene. J Immunol. 1991 Oct 1; 147(7):2377-83.
  View in: PubMed
 
60. Gravallese EM, Darling JM, Ladd AL, Katz JN, Glimcher LH. In situ hybridization studies of stromelysin and collagenase messenger RNA expression in rheumatoid synovium. Arthritis Rheum. 1991 Sep; 34(9):1076-84.
  View in: PubMed
 
61. Boothby M, Liou HC, Finn PW, Gravallese E, Glimcher LH. Control of transcription at the murine A alpha locus. Immunol Res. 1990; 9(2):77-92.
  View in: PubMed
 
62. Gravallese EM, Boothby MR, Smas CM, Glimcher LH. A lipopolysaccharide-induced DNA-binding protein for a class II gene in B cells is distinct from NF-kappa B. Mol Cell Biol. 1989 Aug; 9(8):3184-92.
  View in: PubMed
 
63. Gravallese EM, Corson JM, Coblyn JS, Pinkus GS, Weinblatt ME. Rheumatoid aortitis: a rarely recognized but clinically significant entity. Medicine (Baltimore). 1989 Mar; 68(2):95-106.
  View in: PubMed
 
64. Boothby M, Gravallese E, Liou HC, Glimcher LH. A DNA binding protein regulated by IL-4 and by differentiation in B cells. Science. 1988 Dec 16; 242(4885):1559-62.
  View in: PubMed
 
65. Shmerling RH, Stern SH, Gravallese EM, Kantrowitz FG. Tophaceous deposition in the finger pads without gouty arthritis. Arch Intern Med. 1988 Aug; 148(8):1830-2.
  View in: PubMed
 
66. Gravallese EM, Kantrowitz FG. Arthritic manifestations of inflammatory bowel disease. Am J Gastroenterol. 1988 Jul; 83(7):703-9.
  View in: PubMed
 
67. Merot Y, Gravallese E, Guillén FJ, Murphy GF. Lymphocyte subsets and Langerhans' cells in toxic epidermal necrolysis. Report of a case. Arch Dermatol. 1986 Apr; 122(4):455-8.
  View in: PubMed
 
68. Miller JA, Gravallese E, Bunn HF. Nonenzymatic glycosylation of erythrocyte membrane proteins. Relevance to diabetes. J Clin Invest. 1980 Apr; 65(4):896-901.
  View in: PubMed
 
For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Arthritis, Rheumatoid
Bone Resorption
Synovial Membrane
Bone and Bones
Osteoclasts
See all (382) keywords
Co-Authors  
Kay, Jonathan
Lian, Jane
Raffel, Glen
Stein, Gary
Tsuda, Eva
See all (6) people
Physical Neighbors  
Rothstein, Ann
Wang, Donghai
Houghton, Jeanmarie
Bress, Norman
Zurier, Robert

UMMS Home

Intranet

This is an official Page/Publication of the University of Massachusetts Worcester Campus
Office of the Vice Provost for Research, 55 Lake Ave North, Worcester, Massachusetts 01655
Questions or Comments? Email: publicaffairs@umassmed.edu Phone: 508-856-1572