Guangping Gao PHD
Title Professor
Institution University of Massachusetts Medical School
Department Microbiology & Physiological Systems
Address University of Massachusetts Medical School
 381 Plantation Street
 Worcester MA 01605
Telephone 508-856-3563
Email
Other Positions
Institution UMMS - School of Medicine
Department Gene Therapy Center

Institution UMMS - Graduate School of Biomedical Sciences
Department Immunology & Virology

Institution UMMS - Graduate School of Biomedical Sciences
Department Interdisciplinary Graduate Program

Institution UMMS - Graduate School of Biomedical Sciences
Department MD/PhD Program

Institution UMMS - Graduate School of Biomedical Sciences
Department Molecular Genetics & Microbiology

Institution UMMS - Programs, Centers and Institutes
Department Gene Therapy Center

Institution UMMS - Programs, Centers and Institutes
Department RNA Therapeutics Institute
Narrative

Academic Background

B.A. West China Univ. of Med. Sciences, Chengdu, China
M.S. Florida International University, Miami, FL
Ph.D. Florida International University, Miami, FL
Postdoctoral training at the University of Pennsylvania - School of Medicine

Overview:

Research in the Gao Lab primarily involves the discovery, development and use of adeno-associated virus vectors for gene therapy of genetic diseases and the study of miRNA functions in mammals. The lab works on isolation, characterization and vectorology of novel AAV vectors from primate tissues, molecular mechanisms of AAV evolution and diversity, and molecular interactions between endogenous AAV, AAV vector, host genomes and innate RNAi defense pathways. We also develop novel strategies for rAAV gene therapy of an inherited neurodegenerative disease, Canavan Disease, using novel AAVs that can cross the blood-brain-barrier for efficient CNS gene delivery and endogenous miRNA-mediated posttranscriptional de-targeting. Another area of research interest in the lab is to explore AAV vectors for delivery of denovo synthesized biological miRNA antagonists or over expression of microRNAs to elucidate micro RNA functions in adult mammals.
Publications
1. Zhong L, Malani N, Li M, Brady T, Xie J, Bell P, Li S, Jones H, Wilson JM, Flotte TR, Bushman FD, Gao G. Recombinant adeno-associated virus integration sites in murine liver after ornithine transcarbamylase gene correction. Hum Gene Ther. 2013 May; 24(5):520-5.
  View in: PubMed
 
2. Ahmed SS, Gao G. Gene Therapy for Canavan's Disease Takes a Step Forward. Mol Ther. 2013 Mar; 21(3):505-6.
  View in: PubMed
 
3. Gruntman AM, Bish LT, Mueller C, Sweeney HL, Flotte TR, Gao G. Gene transfer in skeletal and cardiac muscle using recombinant adeno-associated virus. Curr Protoc Microbiol. 2013 Feb; Chapter 14:Unit14D.3.
  View in: PubMed
 
4. Venkatesh A, Ma S, Langellotto F, Gao G, Punzo C. Retinal Gene Delivery by rAAV and DNA Electroporation. Curr Protoc Microbiol. 2013 Feb; Chapter 14:Unit14D.4.
  View in: PubMed
 
5. Mueller C, Zhong L, Ratner D, Esteves-Sena M, Gao G. Production and discovery of novel recombinant adeno-associated viral vectors. Curr Protoc Microbiol. 2012 Aug; Chapter 14:Unit14D.1.
  View in: PubMed
 
6. Gruntman AM, Mueller C, Flotte TR, Gao G. Gene transfer in the lung using recombinant adeno-associated virus. Curr Protoc Microbiol. 2012 Aug; Chapter 14:Unit14D.2.
  View in: PubMed
 
7. Xie J, Ameres SL, Friedline R, Hung JH, Zhang Y, Xie Q, Zhong L, Su Q, He R, Li M, Li H, Mu X, Zhang H, Broderick JA, Kim JK, Weng Z, Flotte TR, Zamore PD, Gao G. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods. 2012; 9(4):403-9.
  View in: PubMed
 
8. Gao G, Bish LT, Sleeper MM, Mu X, Sun L, Lou Y, Duan J, Hu C, Wang L, Sweeney HL. Transendocardial Delivery of AAV6 Results in Highly Efficient and Global Cardiac Gene Transfer in Rhesus Macaques. Hum Gene Ther. 2011 Aug; 22(8):979-84.
  View in: PubMed
 
9. Zhang H, Yang B, Mu X, Ahmed SS, Su Q, He R, Wang H, Mueller C, Sena-Esteves M, Brown R, Xu Z, Gao G. Several rAAV Vectors Efficiently Cross the Blood-brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System. Mol Ther. 2011 Aug; 19(8):1440-8.
  View in: PubMed
 
10. Gao G, Zhong L, Danos O. Exploiting natural diversity of AAV for the design of vectors with novel properties. Methods Mol Biol. 2011; 807:93-118.
  View in: PubMed
 
11. Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q, He R, Mu X, Seher Ahmed S, Park S, Kato H, Li C, Mueller C, Mello CC, Weng Z, Flotte TR, Zamore PD, Gao G. MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression. Mol Ther. 2011 Mar; 19(3):526-35.
  View in: PubMed
 
12. Jakovcevski M, Guo Y, Su Q, Gao G, Akbarian S. rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5417.
  View in: PubMed
 
13. Zhang H, Xie J, Xie Q, Wilson JM, Gao G. Adenovirus-adeno-associated virus hybrid for large-scale recombinant adeno-associated virus production. Hum Gene Ther. 2009 Sep; 20(9):922-9.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Dependovirus
Recombination, Genetic
Gene Therapy
Genetic Vectors
Gyrus Cinguli
See all (15) keywords
Co-Authors  
Flotte, Terence
Mueller, Christian
Weng, Zhiping
Xie, Jun
Zhong, Li
See all (12) people
Physical Neighbors  
Punzo, Claudio
Velez, Gisela
Pechhold, Klaus
Beaulieu, Lea
Tang, Qiushi

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