Jeffrey Bailey graduated from Saint Olaf College (Northfield Minnesota) in
1989 with a B.A. in Biology Suma Cum Laude. He then pursued
volunteer work as a science and math teacher in Liberia and Botswana with
the United States Peace Corps. He returned to the United States
and entered the Medical Scientist Training Program at Case Western Reserve University.
He received his PhD in Genetics characterizing and studying segmental duplications
within the human genome in the laboratory of Dr. Evan Eichler. His
postdoctoral research has focused on the detection and analysis of copy number
variation—particularly in relationship to segmental duplications.
After receiving his MD in 2005, he completed a residency in Clinical Pathology
at Case Medical Center in Cleveland and the Cleveland City-wide Transfusion
Medicine Fellowship. In August of 2009, Dr. Bailey joined the faculty
as a tenure-track assistant professor in the Program in Bioinformatics and Integrative
Biology. He continues to pursue clinical medicine in the Division of Transfusion
Medicine. He is Board certified in Clinical Pathology.
Our overall research focus involves understanding the role of segmental duplication
and copy number variation in human disease susceptibility and pathogenesis.
Segmental duplications, blocks of transposed genomic DNA within or between chromosomes,
have long been recognized as an important substrate for the evolution of novel
genes. As a result of the human genome project, they are now generally recognized
as a significant source of copy number variation (variation between normal individuals)
that can impact human disease. We are optimizing both experimental and computational
approaches for the assessment of copy number variation within the context of
several specific diseases. Utilizing technologies such as array comparative
genomic hybridization and massively-parallel sequencing we hope to gain novel
insight into etiologic and pathogenic mechanisms.
One focus of the lab is directed towards dissecting the role of copy number
variation in the pathogenesis of malaria. Malaria has been one of the strongest
selective forces affecting the human population and still accounts for an estimated
two to three million deaths per year. Another focus of the lab is examining
the role of copy number variation in amyotrophic lateral sclerosis (ALS) or
Lou Gehrig disease. We are collaborating with Dr. Robert Brown here at UMass
to identify copy number variants affecting susceptibility and/or disease progression.