Daniel R Caffrey PHD
Title Assistant Professor
Institution University of Massachusetts Medical School
Department Medicine
Division Infectious Diseases And Immunology
Address University of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Biochemistry & Molecular Pharmacology

Institution UMMS - Graduate School of Biomedical Sciences
Department Bioinformatics & Computational Biology
Publications
1. Ermler ME, Yerukhim E, Schriewer J, Schattgen S, Traylor Z, Wespiser AR, Caffrey DR, Chen ZJ, King CH, Gale M, Colonna M, Fitzgerald KA, Buller RM, Hise AG. RNA Helicase Signaling Is Critical for Type I Interferon Production and Protection against Rift Valley Fever Virus during Mucosal Challenge. J Virol. 2013 May; 87(9):4846-60.
  View in: PubMed
 
2. Aiello D, Caffrey DR. Evolution of specific protein-protein interaction sites following gene duplication. J Mol Biol. 2012 Oct 19; 423(2):257-72.
  View in: PubMed
 
3. Caffrey DR, Fitzgerald KA. Immunology. Select inflammasome assembly. Science. 2012 Apr 27; 336(6080):420-1.
  View in: PubMed
 
4. Caffrey DR, Zhao J, Song Z, Schaffer ME, Haney SA, Subramanian RR, Seymour AB, Hughes JD. siRNA Off-Target Effects Can Be Reduced at Concentrations That Match Their Individual Potency. PLoS One. 2011; 6(7):e21503.
  View in: PubMed
 
5. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature. 2009 Mar 26; 458(7237):514-8.
  View in: PubMed
 
6. Caffrey DR, Lunney EA, Moshinsky DJ. Prediction of specificity-determining residues for small-molecule kinase inhibitors. BMC Bioinformatics. 2008; 9:491.
  View in: PubMed
 
7. Caffrey DR, Dana PH, Mathur V, Ocano M, Hong EJ, Wang YE, Somaroo S, Caffrey BE, Potluri S, Huang ES. PFAAT version 2.0: a tool for editing, annotating, and analyzing multiple sequence alignments. BMC Bioinformatics. 2007; 8:381.
  View in: PubMed
 
8. Cheng AC, Coleman RG, Smyth KT, Cao Q, Soulard P, Caffrey DR, Salzberg AC, Huang ES. Structure-based maximal affinity model predicts small-molecule druggability. Nat Biotechnol. 2007 Jan; 25(1):71-5.
  View in: PubMed
 
9. Lauw FN, Caffrey DR, Golenbock DT. Of mice and man: TLR11 (finally) finds profilin. Trends Immunol. 2005 Oct; 26(10):509-11.
  View in: PubMed
 
10. Caffrey DR, Somaroo S, Hughes JD, Mintseris J, Huang ES. Are protein-protein interfaces more conserved in sequence than the rest of the protein surface? Protein Sci. 2004 Jan; 13(1):190-202.
  View in: PubMed
 
11. Fitzgerald KA, Rowe DC, Barnes BJ, Caffrey DR, Visintin A, Latz E, Monks B, Pitha PM, Golenbock DT. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003 Oct 6; 198(7):1043-55.
  View in: PubMed
 
12. Hokamp K, Shields DC, Wolfe KH, Caffrey DR. Wrapping up BLAST and other applications for use on Unix clusters. Bioinformatics. 2003 Feb 12; 19(3):441-2.
  View in: PubMed
 
13. Cotter PJ, Caffrey DR, Shields DC. Improved database searches for orthologous sequences by conditioning on outgroup sequences. Bioinformatics. 2002 Jan; 18(1):83-91.
  View in: PubMed
 
14. Caffrey DR, O'Neill LA, Shields DC. A method to predict residues conferring functional differences between related proteins: application to MAP kinase pathways. Protein Sci. 2000 Apr; 9(4):655-70.
  View in: PubMed
 
15. Caffrey DR, O'Neill LA, Shields DC. The evolution of the MAP kinase pathways: coduplication of interacting proteins leads to new signaling cascades. J Mol Evol. 1999 Nov; 49(5):567-82.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Sequence Analysis, Protein
Proteins
Protein Kinase Inhibitors
Software
Proteomics
See all (100) keywords
Co-Authors  
Fitzgerald, Katherine
Golenbock, Douglas
Latz, Eicke
Monks, Brian
See all (4) people
Physical Neighbors  
Chen, Jason
Lewis, Lisa
Agarwal, Sarika
Levitz, Stuart
Marshall, William

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