Zhong Jiang MD
Title Professor
Institution University of Massachusetts Medical School
Department Pathology
Division Anatomic Pathology
Address University of Massachusetts Medical School
One Innovation Drive, Biotech Three
Worcester MA 01605
Telephone 508-856-6212
Email
Narrative

Academic Background:

MD, 1982, Beijing College of Chinese Medicine, Beijing, 100029 P.R. China

Research Fellow in Pathology, University of Massachusetts Medical Center, Worcester, MA

Resident in Anatomic Pathology – University of Massachusetts Medical Center, Worcester, MA

Surgical and GU Pathology Fellow, MD Anderson Cancer Center, Houston, TX

Research Interests:Dr. Jiang's picture

I am a surgical pathologist with a specialty in genitourinary pathology (GU) and oncological pathology.   My major field of research interest is the development of biomarkers for the diagnosis and prognosis of malignant tumors.  I first found P504S/a-methylacyl-CoA racemase (AMACR) to be a good diagnostic marker for prostatic adenocarcinoma in 2001 and then he published a series papers discussing the various diagnostic utilities of P504S/AMACR in prostate cancer. Now, P504S/AMACR is being widely used in clinical practice for the diagnosis of prostatic carcinoma.  Furthermore, I recently discovered IMP3, an oncofetal protein, as a new prognostic biomarker for renal cell carcinoma and urothelial carcinoma.  In addition, IMP3 may have potential diagnostic and prognostic values for other malignant tumors, such as gastrointestinal and gynecological cancers.

Publications
1. Cornejo K, Shi M, Jiang Z. Oncofetal protein IMP3: a useful diagnostic biomarker for leiomyosarcoma. Hum Pathol. 2012 Oct; 43(10):1567-72.
  View in: PubMed
 
2. Lu D, Yang X, Jiang NY, Woda BA, Liu Q, Dresser K, Mercurio AM, Rock KL, Jiang Z. IMP3, a New Biomarker to Predict Progression of Cervical Intraepithelial Neoplasia Into Invasive Cancer. Am J Surg Pathol. 2011 Nov; 35(11):1638-45.
  View in: PubMed
 
3. Hao S, Smith TW, Chu PG, Liu Q, Ok CY, Woda BA, Lu D, Lin P, Wang SA, Dresser K, Rock KL, Jiang Z. The Oncofetal Protein IMP3: A Novel Molecular Marker to Predict Aggressive Meningioma. Arch Pathol Lab Med. 2011 Aug; 135(8):1032-6.
  View in: PubMed
 
4. Shi M, Fraire AE, Chu P, Cornejo K, Woda BA, Dresser K, Rock KL, Jiang Z. Oncofetal Protein IMP3, a New Diagnostic Biomarker to Distinguish Malignant Mesothelioma From Reactive Mesothelial Proliferation. Am J Surg Pathol. 2011 Jun; 35(6):878-82.
  View in: PubMed
 
5. Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, Languino LR, Altieri DC. Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol. 2010 Jan; 176(1):393-401.
  View in: PubMed
 
6. Altieri DC, Languino LR, Lian JB, Stein JL, Leav I, van Wijnen AJ, Jiang Z, Stein GS. Prostate cancer regulatory networks. J Cell Biochem. 2009 Aug 1; 107(5):845-52.
  View in: PubMed
 
7. Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR. Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1. Cancer Res. 2009 Jul 1; 69(13):5374-82.
  View in: PubMed
 
8. Lu D, Vohra P, Chu PG, Woda B, Rock KL, Jiang Z. An oncofetal protein IMP3: a new molecular marker for the detection of esophageal adenocarcinoma and high-grade dysplasia. Am J Surg Pathol. 2009 Apr; 33(4):521-5.
  View in: PubMed
 
9. Jiang Z, Chu PG, Woda BA, Liu Q, Balaji KC, Rock KL, Wu CL. Combination of quantitative IMP3 and tumor stage: a new system to predict metastasis for patients with localized renal cell carcinomas. Clin Cancer Res. 2008 Sep 1; 14(17):5579-84.
  View in: PubMed
 
10. Jiang Z, Lohse CM, Chu PG, Wu CL, Woda BA, Rock KL, Kwon ED. Oncofetal protein IMP3: a novel molecular marker that predicts metastasis of papillary and chromophobe renal cell carcinomas. Cancer. 2008 Jun 15; 112(12):2676-82.
  View in: PubMed
 
11. Sitnikova L, Mendese G, Liu Q, Woda BA, Lu D, Dresser K, Mohanty S, Rock KL, Jiang Z. IMP3 predicts aggressive superficial urothelial carcinoma of the bladder. Clin Cancer Res. 2008 Mar 15; 14(6):1701-6.
  View in: PubMed
 
12. Brodsky JR, Kim DY, Jiang Z. Cervical lipoblastoma: case report, review of literature, and genetic analysis. Head Neck. 2007 Nov; 29(11):1055-60.
  View in: PubMed
 
13. Jiang Z. Prognostic biomarkers in renal cell carcinoma. Expert Rev Mol Diagn. 2007 May; 7(3):293-307.
  View in: PubMed
 
14. Li C, Rock KL, Woda BA, Jiang Z, Fraire AE, Dresser K. IMP3 is a novel biomarker for adenocarcinoma in situ of the uterine cervix: an immunohistochemical study in comparison with p16(INK4a) expression. Mod Pathol. 2007 Feb; 20(2):242-7.
  View in: PubMed
 
15. Jiang Z, Chu PG, Woda BA, Rock KL, Liu Q, Hsieh CC, Li C, Chen W, Duan HO, McDougal S, Wu CL. Analysis of RNA-binding protein IMP3 to predict metastasis and prognosis of renal-cell carcinoma: a retrospective study. Lancet Oncol. 2006 Jul; 7(7):556-64.
  View in: PubMed
 
16. Leung YK, Lau KM, Mobley J, Jiang Z, Ho SM. Overexpression of cytochrome P450 1A1 and its novel spliced variant in ovarian cancer cells: alternative subcellular enzyme compartmentation may contribute to carcinogenesis. Cancer Res. 2005 May 1; 65(9):3726-34.
  View in: PubMed
 
17. Jiang Z, Li C, Fischer A, Dresser K, Woda BA. Using an AMACR (P504S)/34betaE12/p63 cocktail for the detection of small focal prostate carcinoma in needle biopsy specimens. Am J Clin Pathol. 2005 Feb; 123(2):231-6.
  View in: PubMed
 
18. Jiang Z, Woda BA. Diagnostic utility of alpha-methylacyl CoA racemase (P504S) on prostate needle biopsy. Adv Anat Pathol. 2004 Nov; 11(6):316-21.
  View in: PubMed
 
19. Jiang Z, Ma K, Wu CL, Yang XJ. [Alpha-methylacyl-CoA racemase: a useful marker for diagnosis of prostatic carcinoma]. Zhonghua Bing Li Xue Za Zhi. 2004 Oct; 33(5):401-3.
  View in: PubMed
 
20. Jiang Z, Woda BA, Wu CL, Yang XJ. Discovery and clinical application of a novel prostate cancer marker: alpha-methylacyl CoA racemase (P504S). Am J Clin Pathol. 2004 Aug; 122(2):275-89.
  View in: PubMed
 
21. Fischer AH, Bardarov S, Jiang Z. Molecular aspects of diagnostic nucleolar and nuclear envelope changes in prostate cancer. J Cell Biochem. 2004 Jan 1; 91(1):170-84.
  View in: PubMed
 
22. Jiang Z, Iczkowski KA, Woda BA, Tretiakova M, Yang XJ. P504S immunostaining boosts diagnostic resolution of "suspicious" foci in prostatic needle biopsy specimens. Am J Clin Pathol. 2004 Jan; 121(1):99-107.
  View in: PubMed
 
23. Pais V, Leav I, Lau KM, Jiang Z, Ho SM. Estrogen receptor-beta expression in human testicular germ cell tumors. Clin Cancer Res. 2003 Oct 1; 9(12):4475-82.
  View in: PubMed
 
24. Mobley JA, Leav I, Zielie P, Wotkowitz C, Evans J, Lam YW, L'Esperance BS, Jiang Z, Ho SM. Branched fatty acids in dairy and beef products markedly enhance alpha-methylacyl-CoA racemase expression in prostate cancer cells in vitro. Cancer Epidemiol Biomarkers Prev. 2003 Aug; 12(8):775-83.
  View in: PubMed
 
25. Jiang Z, Fanger GR, Woda BA, Banner BF, Algate P, Dresser K, Xu J, Chu PG. Expression of alpha-methylacyl-CoA racemase (P504s) in various malignant neoplasms and normal tissues: astudy of 761 cases. Hum Pathol. 2003 Aug; 34(8):792-6.
  View in: PubMed
 
26. Leav I, McNeal JE, Ho SM, Jiang Z. Alpha-methylacyl-CoA racemase (P504S) expression in evolving carcinomas within benign prostatic hyperplasia and in cancers of the transition zone. Hum Pathol. 2003 Mar; 34(3):228-33.
  View in: PubMed
 
27. Jiang Z, Fanger GR, Banner BF, Woda BA, Algate P, Dresser K, Xu J, Reed SG, Rock KL, Chu PG. A dietary enzyme: alpha-methylacyl-CoA racemase/P504S is overexpressed in colon carcinoma. Cancer Detect Prev. 2003; 27(6):422-6.
  View in: PubMed
 
28. Jiang Z, Wu CL, Woda BA, Dresser K, Xu J, Fanger GR, Yang XJ. P504S/alpha-methylacyl-CoA racemase: a useful marker for diagnosis of small foci of prostatic carcinoma on needle biopsy. Am J Surg Pathol. 2002 Sep; 26(9):1169-74.
  View in: PubMed
 
29. Pais VM, Jiang Z, Fung LC. Foreign body reaction to bovine pericardium: a previously unreported complication of pediatric chordee repair. J Urol. 2002 Aug; 168(2):702-3; discussion 703.
  View in: PubMed
 
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Keyword
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Co-Authors  
Fischer, Andrew
Fraire, Armando
Goel, Hira
Rock, Kenneth
Woda, Bruce
See all (11) people
Physical Neighbors  
Akalin, Ali
Fischer, Andrew
Deng, April
Kandil, Dina
Walter, Otto

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