Masanori Terajima MD, PHD
Title Associate Professor
Institution University of Massachusetts Medical School
Department Medicine
Division Infectious Diseases And Immunology
Address University of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Telephone 508-856-2886
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Immunology & Virology

Institution UMMS - Programs, Centers and Institutes
Department Center for Infectious Disease and Vaccine Research
Narrative

Academic Background

Education:

  • B.S., Tohoku University School of Medicine, Sendai, Japan, 1988
  • M.D., Tohoku University School of Medicine, Sendai, Japan, 1988
  • Ph.D., Tohoku University School of Medicine, Sendai, Japan, 1994

Research and Professional Experience:

  • Resident, Suifu Hospital, Mito, Japan, 1988-1990
  • Graduate Student, Department of Cell Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan, 1990-1994
  • Medical Stuff, Department of Geriatric Medicine, Tohoku University School of Medicine, Sendai, Japan, 1994-1997
  • Post-Doctoral Research Associate, Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, 1997-2000
  • Assistant Professor, Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, 8/2000-5/2009
  • Associate Professor, Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, 5/2009-present

Host Immune Responses Against Viruses

Our research interest is host (especially human) immune responses against viruses.

We are studying (1) immune responses to influenza viruses (2) antiviral genes against vaccinia virus, (3) Immunopathogenesis of hantavirus infections.

(1) Immune responses to influenza viruses

We are studying humoral and cellular immune responses to influenza virus infection and vaccination with emphasis on subtype cross-reactive T cell responses in humans.

(2) antiviral genes against vaccinia virus

We are studying host range genes in vaccinia to understand the mechanisms of species specificity and to identify new antiviral mechanisms.

(3) Immunopathogenesis of hantavirus infections

Hantavirus infection causes two clinically different diseases, hantavirus pulmonary syndrome (HPS) and hemorrhagic fever renal syndrome (HFRS) depending on the hantavirus species infecting the patients. We are studying immunopathological mechanisms of these diseases focusing on the virus-specific T cells-endothelial cells interaction.

Publications
1. Kondo Y, Uno K, Machida K, Terajima M. PPARs and Liver Disease. PPAR Res. 2013; 2013:896412.
  View in: PubMed
 
2. Terajima M, Urban SL, Leporati AM. The N-terminus of vaccinia virus host range protein C7L is essential for function. Virus Genes. 2013 Feb; 46(1):20-7.
  View in: PubMed
 
3. Terajima M, Ennis FA. Nuclear Export Signal and Immunodominant CD8+ T Cell Epitope in Influenza A Virus Matrix Protein 1. J Virol. 2012 Sep; 86(18):10258.
  View in: PubMed
 
4. Dawn Co M, Cruz J, Takeda A, Ennis F, Terajima M. Comparison of complement dependent lytic, hemagglutination inhibition and microneutralization antibody responses in influenza vaccinated individuals. Hum Vaccin Immunother. 2012 Sep 1; 8(9):1218-22.
  View in: PubMed
 
5. Terajima M, Babon JA, Ennis FA. Epidemiology of the Influenza A Virus H5N1 Subtype and Memory of Immunity to the H2N2 Subtype. MBio. 2012; 3(4).
  View in: PubMed
 
6. Babon JA, Cruz J, Ennis FA, Yin L, Terajima M. A Human CD4+ T Cell Epitope in the Influenza Hemagglutinin Is Cross-Reactive to Influenza A Virus Subtypes and to Influenza B Virus. J Virol. 2012 Sep; 86(17):9233-43.
  View in: PubMed
 
7. Terajima M, Cruz J, Co MD, Lee JH, Kaur K, Wilson PC, Ennis FA. Complement-dependent lysis of influenza a virus-infected cells by broadly cross-reactive human monoclonal antibodies. J Virol. 2011 Dec; 85(24):13463-7.
  View in: PubMed
 
8. Terajima M, Ennis FA. T cells and pathogenesis of hantavirus cardiopulmonary syndrome and hemorrhagic Fever with renal syndrome. Viruses. 2011 Jul; 3(7):1059-73.
  View in: PubMed
 
9. Smith HL, Monath TP, Pazoles P, Rothman AL, Casey DM, Terajima M, Ennis FA, Guirakhoo F, Green S. Development of Antigen-Specific Memory CD8+ T Cells Following Live-Attenuated Chimeric West Nile Virus Vaccination. J Infect Dis. 2011 Feb; 203(4):513-22.
  View in: PubMed
 
10. Jameson JM, Cruz J, Costanzo A, Terajima M, Ennis FA. A role for the mevalonate pathway in the induction of subtype cross-reactive immunity to influenza A virus by human gammadelta T lymphocytes. Cell Immunol. 2010; 264(1):71-7.
  View in: PubMed
 
11. Moutaftsi M, Tscharke DC, Vaughan K, Koelle DM, Stern L, Calvo-Calle M, Ennis F, Terajima M, Sutter G, Crotty S, Drexler I, Franchini G, Yewdell JW, Head SR, Blum J, Peters B, Sette A. Uncovering the interplay between CD8, CD4 and antibody responses to complex pathogens. Future Microbiol. 2010 Feb; 5(2):221-39.
  View in: PubMed
 
12. Babon JA, Cruz J, Orphin L, Pazoles P, Co MD, Ennis FA, Terajima M. Genome-wide screening of human T-cell epitopes in influenza A virus reveals a broad spectrum of CD4(+) T-cell responses to internal proteins, hemagglutinins, and neuraminidases. Hum Immunol. 2009 Sep; 70(9):711-21.
  View in: PubMed
 
13. Co MD, Orphin L, Cruz J, Pazoles P, Green KM, Potts J, Leporati AM, Babon JA, Evans JE, Ennis FA, Terajima M. In vitro evidence that commercial influenza vaccines are not similar in their ability to activate human T cell responses. Vaccine. 2009 Jan 7; 27(2):319-27.
  View in: PubMed
 
14. Terajima M, Orphin L, Leporati AM, Pazoles P, Cruz J, Rothman AL, Ennis FA. Vaccinia virus-specific CD8(+) T-cell responses target a group of epitopes without a strong immunodominance hierarchy in humans. Hum Immunol. 2008 Dec; 69(12):815-25.
  View in: PubMed
 
15. Mathew A, O'Bryan J, Marshall W, Kotwal GJ, Terajima M, Green S, Rothman AL, Ennis FA. Robust intrapulmonary CD8 T cell responses and protection with an attenuated N1L deleted vaccinia virus. PLoS One. 2008; 3(10):e3323.
  View in: PubMed
 
16. Terajima M, Cruz J, Leporati AM, Orphin L, Babon JA, Co MD, Pazoles P, Jameson J, Ennis FA. Influenza A virus matrix protein 1-specific human CD8+ T-cell response induced in trivalent inactivated vaccine recipients. J Virol. 2008 Sep; 82(18):9283-7.
  View in: PubMed
 
17. Co MD, Orphin L, Cruz J, Pazoles P, Rothman AL, Ennis FA, Terajima M. Discordance between antibody and T cell responses in recipients of trivalent inactivated influenza vaccine. Vaccine. 2008 Apr 7; 26(16):1990-8.
  View in: PubMed
 
18. Terajima M, Hayasaka D, Maeda K, Ennis FA. Immunopathogenesis of hantavirus pulmonary syndrome and hemorrhagic fever with renal syndrome: Do CD8+ T cells trigger capillary leakage in viral hemorrhagic fevers? Immunol Lett. 2007 Nov 15; 113(2):117-20.
  View in: PubMed
 
19. Mitra-Kaushik S, Cruz J, Stern LJ, Ennis FA, Terajima M. Human cytotoxic CD4+ T cells recognize HLA-DR1-restricted epitopes on vaccinia virus proteins A24R and D1R conserved among poxviruses. J Immunol. 2007 Jul 15; 179(2):1303-12.
  View in: PubMed
 
20. Hayasaka D, Ennis FA, Terajima M. Pathogeneses of respiratory infections with virulent and attenuated vaccinia viruses. Virol J. 2007; 4:22.
  View in: PubMed
 
21. Hayasaka D, Maeda K, Ennis FA, Terajima M. Increased permeability of human endothelial cell line EA.hy926 induced by hantavirus-specific cytotoxic T lymphocytes. Virus Res. 2007 Feb; 123(2):120-7.
  View in: PubMed
 
22. Terajima M, Cruz J, Leporati AM, Demkowicz WE, Kennedy JS, Ennis FA. Identification of vaccinia CD8+ T-cell epitopes conserved among vaccinia and variola viruses restricted by common MHC class I molecules, HLA-A2 or HLA-B7. Hum Immunol. 2006 Jul; 67(7):512-20.
  View in: PubMed
 
23. Terajima M, Ennis FA. Using HLA-transgenic mice to identify immunodominant human CD8+ T cell epitopes--does (genome) size matter? Immunol Lett. 2006 May 15; 105(1):97-8.
  View in: PubMed
 
24. Bradley RR, Terajima M. Vaccinia virus K1L protein mediates host-range function in RK-13 cells via ankyrin repeat and may interact with a cellular GTPase-activating protein. Virus Res. 2005 Dec; 114(1-2):104-12.
  View in: PubMed
 
25. Mathew A, Terajima M, West K, Green S, Rothman AL, Ennis FA, Kennedy JS. Identification of murine poxvirus-specific CD8+ CTL epitopes with distinct functional profiles. J Immunol. 2005 Feb 15; 174(4):2212-9.
  View in: PubMed
 
26. Maeda K, West K, Hayasaka D, Ennis FA, Terajima M. Recombinant adenovirus vector vaccine induces stronger cytotoxic T-cell responses than recombinant vaccinia virus vector, plasmid DNA, or a combination of these. Viral Immunol. 2005; 18(4):657-67.
  View in: PubMed
 
27. Terajima M, Leporati AM. Role of Indoleamine 2,3-Dioxygenase in Antiviral Activity of Interferon-gamma Against Vaccinia Virus. Viral Immunol. 2005; 18(4):722-9.
  View in: PubMed
 
28. Maeda K, West K, Toyosaki-Maeda T, Rothman AL, Ennis FA, Terajima M. Identification and analysis for cross-reactivity among hantaviruses of H-2b-restricted cytotoxic T-lymphocyte epitopes in Sin Nombre virus nucleocapsid protein. J Gen Virol. 2004 Jul; 85(Pt 7):1909-19.
  View in: PubMed
 
29. Kilpatrick ED, Terajima M, Koster FT, Catalina MD, Cruz J, Ennis FA. Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome. J Immunol. 2004 Mar 1; 172(5):3297-304.
  View in: PubMed
 
30. Terajima M, Vapalahti O, Van Epps HL, Vaheri A, Ennis FA. Immune responses to Puumala virus infection and the pathogenesis of nephropathia epidemica. Microbes Infect. 2004 Feb; 6(2):238-45.
  View in: PubMed
 
31. Terajima M, Ennis FA. Quantitation of antibody-bound and unbound Sin Nombre virus in the plasma of patient with hantavirus pulmonary syndrome. J Virol Methods. 2003 Jun 30; 110(2):159-62.
  View in: PubMed
 
32. Terajima M, Cruz J, Raines G, Kilpatrick ED, Kennedy JS, Rothman AL, Ennis FA. Quantitation of CD8+ T cell responses to newly identified HLA-A*0201-restricted T cell epitopes conserved among vaccinia and variola (smallpox) viruses. J Exp Med. 2003 Apr 7; 197(7):927-32.
  View in: PubMed
 
33. Van Epps HL, Terajima M, Mustonen J, Arstila TP, Corey EA, Vaheri A, Ennis FA. Long-lived memory T lymphocyte responses after hantavirus infection. J Exp Med. 2002 Sep 2; 196(5):579-88.
  View in: PubMed
 
34. Terajima M, Van Epps HL, Li D, Leporati AM, Juhlin SE, Mustonen J, Vaheri A, Ennis FA. Generation of recombinant vaccinia viruses expressing Puumala virus proteins and use in isolating cytotoxic T cells specific for Puumala virus. Virus Res. 2002 Mar 20; 84(1-2):67-77.
  View in: PubMed
 
35. Co MD, Terajima M, Cruz J, Ennis FA, Rothman AL. Human cytotoxic T lymphocyte responses to live attenuated 17D yellow fever vaccine: identification of HLA-B35-restricted CTL epitopes on nonstructural proteins NS1, NS2b, NS3, and the structural protein E. Virology. 2002 Feb 1; 293(1):151-63.
  View in: PubMed
 
36. Terajima M, Hendershot JD, Kariwa H, Koster FT, Hjelle B, Goade D, DeFronzo MC, Ennis FA. High levels of viremia in patients with the Hantavirus pulmonary syndrome. J Infect Dis. 1999 Dec; 180(6):2030-4.
  View in: PubMed
 
37. Yamaya M, Sekizawa K, Suzuki T, Yamada N, Furukawa M, Ishizuka S, Nakayama K, Terajima M, Numazaki Y, Sasaki H. Infection of human respiratory submucosal glands with rhinovirus: effects on cytokine and ICAM-1 production. Am J Physiol. 1999 Aug; 277(2 Pt 1):L362-71.
  View in: PubMed
 
38. Terajima M, Jameson J, Norman JE, Cruz J, Ennis FA. High-yield reassortant influenza vaccine production virus has a mutation at an HLA-A 2.1-restricted CD8+ CTL epitope on the NS1 protein. Virology. 1999 Jun 20; 259(1):135-40.
  View in: PubMed
 
39. Jameson J, Cruz J, Terajima M, Ennis FA. Human CD8+ and CD4+ T lymphocyte memory to influenza A viruses of swine and avian species. J Immunol. 1999 Jun 15; 162(12):7578-83.
  View in: PubMed
 
40. Ohrui T, Yamaya M, Sekizawa K, Yamada N, Suzuki T, Terajima M, Okinaga S, Sasaki H. Effects of rhinovirus infection on hydrogen peroxide- induced alterations of barrier function in the cultured human tracheal epithelium. Am J Respir Crit Care Med. 1998 Jul; 158(1):241-8.
  View in: PubMed
 
41. Yamaya M, Sekizawa K, Terajima M, Okinaga S, Ohrui T, Sasaki H. Dipeptidase inhibitor and epithelial removal potentiate leukotriene D4-induced human tracheal smooth muscle contraction. Respir Physiol. 1998 Jan; 111(1):101-9.
  View in: PubMed
 
42. Arai H, Terajima M, Miura M, Higuchi S, Muramatsu T, Matsushita S, Machida N, Nakagawa T, Lee VM, Trojanowski JQ, Sasaki H. Effect of genetic risk factors and disease progression on the cerebrospinal fluid tau levels in Alzheimer's disease. J Am Geriatr Soc. 1997 Oct; 45(10):1228-31.
  View in: PubMed
 
43. Terajima M, Yamaya M, Sekizawa K, Okinaga S, Suzuki T, Yamada N, Nakayama K, Ohrui T, Oshima T, Numazaki Y, Sasaki H. Rhinovirus infection of primary cultures of human tracheal epithelium: role of ICAM-1 and IL-1beta. Am J Physiol. 1997 Oct; 273(4 Pt 1):L749-59.
  View in: PubMed
 
44. Sassa S, Kondo M, Taketani S, Nomura N, Furuyama K, Akagi R, Nagai T, Terajima M, Galbraith RA, Fujita H. Molecular defects of the coproporphyrinogen oxidase gene in hereditary coproporphyria. Cell Mol Biol (Noisy-le-grand). 1997 Feb; 43(1):59-66.
  View in: PubMed
 
45. Ohrui T, Yamaya M, Sekizawa K, Terajima M, Yamada N, Suzuki T, Okinaga S, Hoshi H, Suzuki H, Sasaki H. [Rhinovirus infection and expression of adhesion molecules in human tracheal epithelium]. Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Dec; 34 Suppl:121-5.
  View in: PubMed
 
46. Funayama T, Sekizawa K, Yamaya M, Yamauchi K, Ohno I, Ohrui T, Terajima M, Okinaga S, Sasaki H. Role of Leukotriene-degrading enzymes in pulmonary response to antigen infusion in sensitized guinea pigs in vivo. Am J Respir Cell Mol Biol. 1996 Aug; 15(2):260-7.
  View in: PubMed
 
47. Nemoto Y, Terajima M, Shoji W, Obinata M. Regulatory function of delta/YY-1 on the locus control region-like sequence of mouse glycophorin gene in erythroleukemia cells. J Biol Chem. 1996 Jun 7; 271(23):13542-8.
  View in: PubMed
 
48. Arai H, Terajima M, Nakagawa T, Higuchi S, Mochizuki H, Sasaki H. Pupil dilatation assay by tropicamide is modulated by apolipoprotein E epsilon 4 allele dosage in Alzheimer's disease. Neuroreport. 1996 Mar 22; 7(4):918-20.
  View in: PubMed
 
49. Arai H, Terajima M, Miura M, Higuchi S, Muramatsu T, Machida N, Seiki H, Takase S, Clark CM, Lee VM, et al. Tau in cerebrospinal fluid: a potential diagnostic marker in Alzheimer's disease. Ann Neurol. 1995 Oct; 38(4):649-52.
  View in: PubMed
 
50. Fujita H, Kondo M, Taketani S, Nomura N, Furuyama K, Akagi R, Nagai T, Terajima M, Galbraith RA, Sassa S. Characterization and expression of cDNA encoding coproporphyrinogen oxidase from a patient with hereditary coproporphyria. Hum Mol Genet. 1994 Oct; 3(10):1807-10.
  View in: PubMed
 
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Keyword
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Co-Authors  
Co, Marydawn
Ennis, Francis
Green, Sharone
Mathew, Anuja
Smith, Heidi
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Physical Neighbors  
Madoff, Lawrence
Co, Marydawn
Glew, Richard
Ellison, Richard
Hatch, Steven

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