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1.
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Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A. Identification of Early Replicating Fragile Sites that Contribute to Genome Instability. Cell. 2013 Jan 31; 152(3):620-32.
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2.
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Chang H, Yanachkov IB, Dix EJ, Li YF, Barnard MR, Wright GE, Michelson AD, Frelinger AL. Modified diadenosine tetraphosphates with dual specificity for P2Y(1) and P2Y(12) are potent antagonists of ADP-induced platelet activation. J Thromb Haemost. 2012 Dec; 10(12):2573-80.
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3.
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Barnes MH, Butler MM, Wright GE, Brown NC. Antimicrobials Targeted to the Replication-Specific DNA Polymerases of Gram-Positive Bacteria: Target Potential of dnaE. Infect Disord Drug Targets. 2012 Oct 1; 12(5):327-31.
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4.
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Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012 Aug 12; 490(7418):116-20.
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5.
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Yang Y, Shaffer AL, Emre NC, Ceribelli M, Zhang M, Wright G, Xiao W, Powell J, Platig J, Kohlhammer H, Young RM, Zhao H, Yang Y, Xu W, Buggy JJ, Balasubramanian S, Mathews LA, Shinn P, Guha R, Ferrer M, Thomas C, Waldmann TA, Staudt LM. Exploiting Synthetic Lethality for the Therapy of ABC Diffuse Large B Cell Lymphoma. Cancer Cell. 2012 Jun 12; 21(6):723-37.
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6.
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Melchior DL, Sharom FJ, Evers R, Wright GE, Chu JW, Wright SE, Chu X, Yabut J. Determining P-glycoprotein-drug interactions: Evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers. J Pharmacol Toxicol Methods. 2012 Mar; 65(2):64-74.
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7.
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Xu WC, Wright GE, Brown NC, Long ZY, Zhi CX, Dvoskin S, Gambino JJ, Barnes MH, Butler MM. 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. Bioorg Med Chem Lett. 2011 Jul 15; 21(14):4197-202.
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8.
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Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM. Oncogenically active MYD88 mutations in human lymphoma. Nature. 2011 Feb 3; 470(7332):115-9.
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9.
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Yanachkov IB, Dix EJ, Yanachkova MI, Wright GE. P(1),P(2)-Diimidazolyl derivatives of pyrophosphate and bis-phosphonates - synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs. Org Biomol Chem. 2011 Feb 7; 9(3):730-8.
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10.
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Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, Kohlhammer H, Lamy L, Zhao H, Yang Y, Xu W, Shaffer AL, Wright G, Xiao W, Powell J, Jiang JK, Thomas CJ, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Johnson NA, Rimsza LM, Campo E, Jaffe ES, Wilson WH, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pierce SK, Staudt LM. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010 Jan 7; 463(7277):88-92.
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11.
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Chang H, Yanachkov IB, Michelson AD, Li Y, Barnard MR, Wright GE, Frelinger AL. Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors. Thromb Res. 2010 Feb; 125(2):159-65.
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12.
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Lam LT, Davis RE, Ngo VN, Lenz G, Wright G, Xu W, Zhao H, Yu X, Dang L, Staudt LM. Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20798-803.
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13.
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Tabatadze D, Zamecnik P, Yanachkov I, Wright G, Pierson K, Zhang S, Bogdanov A, Metelev V. A novel thymidine phosphoramidite synthon for incorporation of internucleoside phosphate linkers during automated oligodeoxynucleotide synthesis. Nucleosides Nucleotides Nucleic Acids. 2008 Feb; 27(2):157-72.
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14.
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Focher F, Lossani A, Verri A, Spadari S, Maioli A, Gambino JJ, Wright GE, Eberle R, Black DH, Medveczky P, Medveczky M, Shugar D. Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. Antimicrob Agents Chemother. 2007 Jun; 51(6):2028-34.
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15.
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Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL. Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother. 2007 Jan; 51(1):119-27.
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16.
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Zhi C, Long ZY, Manikowski A, Comstock J, Xu WC, Brown NC, Tarantino PM, Holm KA, Dix EJ, Wright GE, Barnes MH, Butler MM, Foster KA, LaMarr WA, Bachand B, Bethell R, Cadilhac C, Charron S, Lamothe S, Motorina I, Storer R. Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. J Med Chem. 2006 Feb 23; 49(4):1455-65.
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17.
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Zhi C, Long ZY, Manikowski A, Brown NC, Tarantino PM, Holm K, Dix EJ, Wright GE, Foster KA, Butler MM, LaMarr WA, Skow DJ, Motorina I, Lamothe S, Storer R. Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. J Med Chem. 2005 Nov 3; 48(22):7063-74.
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18.
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Manikowski A, Verri A, Lossani A, Gebhardt BM, Gambino J, Focher F, Spadari S, Wright GE. Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo. J Med Chem. 2005 Jun 2; 48(11):3919-29.
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19.
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Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM. Active site directed inhibitors of replication-specific bacterial DNA polymerases. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):729-32.
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20.
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Vlahou A, Giannopoulos A, Gregory BW, Manousakas T, Kondylis FI, Wilson LL, Schellhammer PF, Wright GL, Semmes OJ. Protein profiling in urine for the diagnosis of bladder cancer. Clin Chem. 2004 Aug; 50(8):1438-41.
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21.
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Ciavarra RP, Holterman DA, Brown RR, Mangiotti P, Yousefieh N, Wright GL, Schellhammer PF, Glass WF, Somers KD. Prostate tumor microenvironment alters immune cells and prevents long-term survival in an orthotopic mouse model following flt3-ligand/CD40-ligand immunotherapy. J Immunother. 2004 Jan-Feb; 27(1):13-26.
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22.
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Zhi C, Long ZY, Gambino J, Xu WC, Brown NC, Barnes M, Butler M, LaMarr W, Wright GE. Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth. J Med Chem. 2003 Jun 19; 46(13):2731-9.
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23.
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Cazares LH, Adam BL, Ward MD, Nasim S, Schellhammer PF, Semmes OJ, Wright GL. Normal, benign, preneoplastic, and malignant prostate cells have distinct protein expression profiles resolved by surface enhanced laser desorption/ionization mass spectrometry. Clin Cancer Res. 2002 Aug; 8(8):2541-52.
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24.
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Adam BL, Qu Y, Davis JW, Ward MD, Clements MA, Cazares LH, Semmes OJ, Schellhammer PF, Yasui Y, Feng Z, Wright GL. Serum protein fingerprinting coupled with a pattern-matching algorithm distinguishes prostate cancer from benign prostate hyperplasia and healthy men. Cancer Res. 2002 Jul 1; 62(13):3609-14.
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25.
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Daly JS, Giehl TJ, Brown NC, Zhi C, Wright GE, Ellison RT. In vitro antimicrobial activities of novel anilinouracils which selectively inhibit DNA polymerase III of gram-positive bacteria. Antimicrob Agents Chemother. 2000 Aug; 44(8):2217-21.
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26.
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Stattel JM, Wright GE. Sensitivity of bacteriophage RB69 DNA polymerase to N2-(p-n-butylphenyl)-2'-deoxyguanosine nucleotides. Nucleosides Nucleotides. 1999 Oct; 18(10):2193-9.
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27.
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Tarantino PM, Zhi C, Wright GE, Brown NC. Inhibitors of DNA polymerase III as novel antimicrobial agents against gram-positive eubacteria. Antimicrob Agents Chemother. 1999 Aug; 43(8):1982-7.
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28.
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Sun H, Zhi C, Wright GE, Ubiali D, Pregnolato M, Verri A, Focher F, Spadari S. Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase. J Med Chem. 1999 Jul 1; 42(13):2344-50.
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29.
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Tarantino PM, Zhi C, Gambino JJ, Wright GE, Brown NC. 6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3. J Med Chem. 1999 Jun 3; 42(11):2035-40.
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30.
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Stattel JM, Yanachkov I, Wright GE. Synthesis and biochemical study of N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-(alpha,beta-imido)triphosphate (BuPdGMPNHPP): a non-substrate inhibitor of B family DNA polymerases. Nucleosides Nucleotides. 1998 Aug; 17(8):1505-13.
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31.
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Young JK, Hicks RP, Wright GE, Morrison TG. The role of leucine residues in the structure and function of a leucine zipper peptide inhibitor of paramyxovirus (NDV) fusion. Virology. 1998 Mar 30; 243(1):21-31.
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32.
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Young JK, Hicks RP, Wright GE, Morrison TG. Analysis of a peptide inhibitor of paramyxovirus (NDV) fusion using biological assays, NMR, and molecular modeling. Virology. 1997 Nov 24; 238(2):291-304.
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33.
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Young JK, Marí F, Xu M, Humphreys RE, Clemente NM, Stattel JM, Nelson DJ, Gambino J, Wright GE. Structural studies by 1H NMR of a prototypic alpha-helical peptide (LYQELQKLTQTLK) and homologs in trifluoroethanol/water and on sodium dodecyl sulfate micelles. J Pept Res. 1997 Aug; 50(2):122-31.
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34.
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Yanachkov I, Pan JY, Wessling-Resnick M, Wright GE. Synthesis and effect of nonhydrolyzable xanthosine triphosphate derivatives on prenylation of Rab5D136N. Mol Pharmacol. 1997 Jan; 51(1):47-51.
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35.
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Veronikis IE, Alex S, Fang SL, Wright G, Wu SY, Chanoine JP, Emerson CH, Braverman LE. Serum iodothyronine concentrations in intestinally decontaminated rats treated with a 5'-deiodinase type I inhibitor 6-anilino-2-thiouracil. Eur J Endocrinol. 1996 Apr; 134(4):519-23.
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36.
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Wright GE. Nucleotide probes of DNA polymerases. Acta Biochim Pol. 1996; 43(1):115-24.
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37.
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Burstein SH, Young JK, Wright GE. Relationships between eicosanoids and cannabinoids. Are eicosanoids cannabimimetic agents?. Biochem Pharmacol. 1995 Nov 27; 50(11):1735-42.
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38.
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Xu H, Maga G, Focher F, Smith ER, Spadari S, Gambino J, Wright GE. Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases. J Med Chem. 1995 Jan 6; 38(1):49-57.
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39.
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Brown NC, Wright GE. Mechanisms of inhibition of DNA polymerases by 2'-deoxyribonucleoside 5'-triphosphate analogs. Methods Enzymol. 1995; 262:202-17.
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40.
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Stattel JM, Wright GE. Butylphenyl-dGTP as a structural probe of B family DNA polymerases. Postepy Biochem. 1995; 41(5 Suppl):332-7.
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41.
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Wright GE, Hübscher U, Khan NN, Focher F, Verri A. Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon. FEBS Lett. 1994 Mar 14; 341(1):128-30.
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42.
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Khan NN, Reha-Krantz LJ, Wright GE. Analysis of inhibitors of bacteriophage T4 DNA polymerase. Nucleic Acids Res. 1994 Jan 25; 22(2):232-7.
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43.
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Misra HK, Khan NN, Agrawal S, Wright GE. Chemical and enzymatic incorporation of N2-(p-n-butylphenyl)-2'-deoxyguanosine into an oligodeoxyribonucleotide. Nucleic Acids Res. 1992 Sep 11; 20(17):4547-51.
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44.
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Gambino J, Focher F, Hildebrand C, Maga G, Noonan T, Spadari S, Wright G. Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases. J Med Chem. 1992 Aug 7; 35(16):2979-83.
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45.
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Khan NN, Wright GE, Brown NC. The molecular mechanism of inhibition of alpha-type DNA polymerases by N2-(butylphenyl)dGTP and 2-(butylanilino)dATP: variation in susceptibility to polymerization. Nucleic Acids Res. 1991 Apr 11; 19(7):1627-32.
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46.
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Noonan T, Brown N, Dudycz L, Wright G. Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins. J Med Chem. 1991 Apr; 34(4):1302-7.
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47.
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Butler MM, Dudycz LW, Khan NN, Wright GE, Brown NC. Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanine. Nucleic Acids Res. 1990 Dec 25; 18(24):7381-7.
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48.
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Arabshahi L, Khan NN, Butler M, Noonan T, Brown NC, Wright GE. (Difluoromethylene)phosphates of guanine nucleosides as probes of DNA polymerases and G proteins. Biochemistry. 1990 Jul 24; 29(29):6820-6.
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49.
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Hildebrand C, Sandoli D, Focher F, Gambino J, Ciarrocchi G, Spadari S, Wright G. Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases. J Med Chem. 1990 Jan; 33(1):203-6.
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50.
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Talanian RV, Wright GE. The roles of DNA polymerases alpha and delta in DNA replication. Pharmacol Ther. 1990; 47(1):105-15.
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51.
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Wright GE, Brown NC. Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases. Pharmacol Ther. 1990; 47(3):447-97.
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52.
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Talanian RV, Brown NC, McKenna CE, Ye TG, Levy JN, Wright GE. Carbonyldiphosphonate, a selective inhibitor of mammalian DNA polymerase delta. Biochemistry. 1989 Oct 17; 28(21):8270-4.
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53.
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Arabshahi L, Brown N, Khan N, Wright G. Inhibition of DNA polymerase alpha by aphidicolin derivatives. Nucleic Acids Res. 1988 Jun 10; 16(11):5107-13.
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54.
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Wright G, Dudycz L. Sugar ring conformations of guanine nucleosides by proton nuclear magnetic resonance. Acta Biochim Pol. 1987; 34(2):123-34.
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