Zvi Bar-Shavit PHD
Title Associate Professor
Institution University of Massachusetts Medical School
Department Cell and Developmental Biology
Address University of Massachusetts Medical School
55 Lake Avenue North, S3-322
Worcester MA 01655
Telephone 508-856-5943
Publications
1. Aker M, Rouvinski A, Hashavia S, Ta-Shma A, Shaag A, Zenvirt S, Israel S, Weintraub M, Taraboulos A, Bar-Shavit Z, Elpeleg O. An SNX10 mutation causes malignant osteopetrosis of infancy. J Med Genet. 2012 Apr; 49(4):221-6.
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2. Bar-Shavit Z. Taking a toll on the bones: regulation of bone metabolism by innate immune regulators. Autoimmunity. 2008 Apr; 41(3):195-203.
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3. Bar-Shavit Z. The osteoclast: a multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell. J Cell Biochem. 2007 Dec 1; 102(5):1130-9.
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4. Amcheslavsky A, Bar-Shavit Z. Toll-like receptor 9 ligand blocks osteoclast differentiation through induction of phosphatase. J Bone Miner Res. 2007 Aug; 22(8):1301-10.
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5. Aharon R, Bar-Shavit Z. Involvement of aquaporin 9 in osteoclast differentiation. J Biol Chem. 2006 Jul 14; 281(28):19305-9.
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6. Amcheslavsky A, Bar-Shavit Z. Interleukin (IL)-12 mediates the anti-osteoclastogenic activity of CpG-oligodeoxynucleotides. J Cell Physiol. 2006 Apr; 207(1):244-50.
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7. Saltman LH, Javed A, Ribadeneyra J, Hussain S, Young DW, Osdoby P, Amcheslavsky A, van Wijnen AJ, Stein JL, Stein GS, Lian JB, Bar-Shavit Z. Organization of transcriptional regulatory machinery in osteoclast nuclei: compartmentalization of Runx1. J Cell Physiol. 2005 Sep; 204(3):871-80.
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8. Amcheslavsky A, Hemmi H, Akira S, Bar-Shavit Z. Differential contribution of osteoclast- and osteoblast-lineage cells to CpG-oligodeoxynucleotide (CpG-ODN) modulation of osteoclastogenesis. J Bone Miner Res. 2005 Sep; 20(9):1692-9.
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9. Zou W, Amcheslavsky A, Takeshita S, Drissi H, Bar-Shavit Z. TNF-alpha expression is transcriptionally regulated by RANK ligand. J Cell Physiol. 2005 Feb; 202(2):371-8.
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10. Amcheslavsky A, Zou W, Bar-Shavit Z. Toll-like receptor 9 regulates tumor necrosis factor-alpha expression by different mechanisms. Implications for osteoclastogenesis. J Biol Chem. 2004 Dec 24; 279(52):54039-45.
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11. Hakim I, Bar-Shavit Z. Modulation of TNF-alpha expression in bone marrow macrophages: involvement of vitamin D response element. J Cell Biochem. 2003 Apr 1; 88(5):986-98.
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12. Zou W, Amcheslavsky A, Bar-Shavit Z. CpG oligodeoxynucleotides modulate the osteoclastogenic activity of osteoblasts via Toll-like receptor 9. J Biol Chem. 2003 May 9; 278(19):16732-40.
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13. Zou W, Bar-Shavit Z. Dual modulation of osteoclast differentiation by lipopolysaccharide. J Bone Miner Res. 2002 Jul; 17(7):1211-8.
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14. Zou W, Schwartz H, Endres S, Hartmann G, Bar-Shavit Z. CpG oligonucleotides: novel regulators of osteoclast differentiation. FASEB J. 2002 Mar; 16(3):274-82.
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15. Zou W, Hakim I, Tschoep K, Endres S, Bar-Shavit Z. Tumor necrosis factor-alpha mediates RANK ligand stimulation of osteoclast differentiation by an autocrine mechanism. J Cell Biochem. 2001 Jun 26-Jul 25; 83(1):70-83.
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16. Rosen H, Krichevsky A, Bar-Shavit Z. The enkephalinergic osteoblast. J Bone Miner Res. 1998 Oct; 13(10):1515-20.
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17. Rosen H, Krichevsky A, Polakiewicz RD, Benzakine S, Bar-Shavit Z. Developmental regulation of proenkephalin gene expression in osteoblasts. Mol Endocrinol. 1995 Nov; 9(11):1621-31.
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18. Abu-Amer Y, Bar-Shavit Z. Regulation of TNF-alpha release from bone marrow-derived macrophages by vitamin D. J Cell Biochem. 1994 Aug; 55(4):435-44.
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19. Abu-Amer Y, Bar-Shavit Z. Modulation of vitamin D increased H2O2 production and MAC-2 expression in the bone marrow-derived macrophages by estrogen. Calcif Tissue Int. 1994 Jul; 55(1):29-32.
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20. Rosen H, Bar-Shavit Z. Dual role of osteoblastic proenkephalin derived peptides in skeletal tissues. J Cell Biochem. 1994 Jul; 55(3):334-9.
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21. Abu-Amer Y, Bar-Shavit Z. Impaired bone marrow-derived macrophage differentiation in vitamin D deficiency. Cell Immunol. 1993 Oct 15; 151(2):356-68.
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22. Rosen H, Polakiewicz RD, Benzakine S, Bar-Shavit Z. Proenkephalin A in bone-derived cells. Proc Natl Acad Sci U S A. 1991 May 1; 88(9):3705-9.
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23. Levi-Schaffer F, Bar-Shavit Z. Osteoblast-like cell line maintains in vitro rat peritoneal mast cell viability and functional activity. Immunology. 1990 Jan; 69(1):145-9.
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24. Gavison R, Bar-Shavit Z. Impaired macrophage activation in vitamin D3 deficiency: differential in vitro effects of 1,25-dihydroxyvitamin D3 on mouse peritoneal macrophage functions. J Immunol. 1989 Dec 1; 143(11):3686-90.
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25. Schlesinger M, Bar-Shavit Z, Hadar R, Rabinowitz R. Modulation of the expression of CD4 on HL-60 cells by exposure to 1,25-dihydroxyvitamin D3. Immunol Lett. 1989 Oct; 22(4):307-11.
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26. Hruska KA, Bar-Shavit Z, Malone JD, Teitelbaum S. Ca2+ priming during vitamin D-induced monocytic differentiation of a human leukemia cell line. J Biol Chem. 1988 Nov 5; 263(31):16039-44.
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27. Stenson WF, Teitelbaum SL, Bar-Shavit Z. Arachidonic acid metabolism by a vitamin D3-differentiated human leukemic cell line. J Bone Miner Res. 1988 Oct; 3(5):561-71.
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28. Clohisy DR, Bar-Shavit Z, Chappel JC, Teitelbaum SL. 1,25-Dihydroxyvitamin D3 modulates bone marrow macrophage precursor proliferation and differentiation. Up-regulation of the mannose receptor. J Biol Chem. 1987 Nov 25; 262(33):15922-9.
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29. Rodan SB, Imai Y, Thiede MA, Wesolowski G, Thompson D, Bar-Shavit Z, Shull S, Mann K, Rodan GA. Characterization of a human osteosarcoma cell line (Saos-2) with osteoblastic properties. Cancer Res. 1987 Sep 15; 47(18):4961-6.
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30. Bar-Shavit Z, Horst RL, Chappel JC, Ross FP, Gray RW, Teitelbaum SL. 25-Hydroxyvitamin D3 metabolism in a human leukemia cell line. Calcif Tissue Int. 1986 Nov; 39(5):328-33.
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31. Bar-Shavit Z, Kahn AJ, Stone KR, Trial J, Hilliard T, Reitsma PH, Teitelbaum SL. Reversibility of vitamin D-induced human leukemia cell-line maturation. Endocrinology. 1986 Feb; 118(2):679-86.
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32. Bar-Shavit Z, Goldman R. Substance P and neurotensin. Methods Enzymol. 1986; 132:326-34.
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33. Bar-Shavit Z, Teitelbaum SL, Stricklin GP, Eisen AZ, Kahn AJ, Welgus HG. Differentiation of a human leukemia cell line and expression of collagenase inhibitor. Proc Natl Acad Sci U S A. 1985 Aug; 82(16):5380-4.
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34. Welgus HG, Campbell EJ, Bar-Shavit Z, Senior RM, Teitelbaum SL. Human alveolar macrophages produce a fibroblast-like collagenase and collagenase inhibitor. J Clin Invest. 1985 Jul; 76(1):219-24.
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35. Bar-Shavit Z, Kahn AJ, Pegg LE, Stone KR, Teitelbaum SL. Glucocorticoids modulate macrophage surface oligosaccharides and their bone binding activity. J Clin Invest. 1984 May; 73(5):1277-83.
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36. Key L, Carnes D, Cole S, Holtrop M, Bar-Shavit Z, Shapiro F, Arceci R, Steinberg J, Gundberg C, Kahn A, et al. Treatment of congenital osteopetrosis with high-dose calcitriol. N Engl J Med. 1984 Feb 16; 310(7):409-15.
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37. Teitelbaum SL, Bar-Shavit Z, Fallon MD, Imbimbo C, Malone JD, Kahn AJ. Glucocorticoids and bone resorption. Adv Exp Med Biol. 1984; 171:121-9.
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38. Reitsma PH, Rothberg PG, Astrin SM, Trial J, Bar-Shavit Z, Hall A, Teitelbaum SL, Kahn AJ. Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite. Nature. 1983 Dec 1-7; 306(5942):492-4.
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39. Bar-Shavit Z, Teitelbaum SL, Reitsma P, Hall A, Pegg LE, Trial J, Kahn AJ. Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A. 1983 Oct; 80(19):5907-11.
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40. Goldman R, Bar-Shavit Z, Romeo D. Neurotensin modulates human neutrophil locomotion and phagocytic capability. FEBS Lett. 1983 Aug 8; 159(1-2):63-7.
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41. Bar-Shavit Z, Teitelbaum SL, Kahn AJ. Saccharides mediate the attachment of rat macrophages to bone in vitro. J Clin Invest. 1983 Aug; 72(2):516-25.
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42. Bar-Shavit Z, Kahn AJ, Teitelbaum SL. Defective binding of macrophages to bone in rodent osteomalacia and vitamin D deficiency. In vitro evidence for a cellular defect and altered saccharides in the bone matrix. J Clin Invest. 1983 Aug; 72(2):526-34.
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43. Goldman R, Bar-Shavit Z. On the mechanism of the augmentation of the phagocytic capability of phagocytic cells by Tuftsin, substance P, neurotensin, and kentsin and the interrelationship between their receptors. Ann N Y Acad Sci. 1983; 419:143-55.
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44. Bar-Shavit Z, Goldman R. Tuftsin and substance P as modulators of phagocyte functions. Adv Exp Med Biol. 1982; 141:549-58.
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45. Goldman R, Bar-Shavit Z, Shezen E, Terry S, Blumberg S. Enhancement of phagocytosis by neurotensin, a newly found biological activity of the neuropeptide. Adv Exp Med Biol. 1982; 155:133-41.
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46. Bar-Shavit Z, Noff D, Edelstein S, Meyer M, Shibolet S, Goldman R. 1,25-dihydroxyvitamin D3 and the regulation of macrophage function. Calcif Tissue Int. 1981; 33(6):673-6.
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47. Bar-Shavit Z, Goldman R, Ofek I, Sharon N, Mirelman D. Mannose-binding activity of Escherichia coli: a determinant of attachment and ingestion of the bacteria by macrophages. Infect Immun. 1980 Aug; 29(2):417-24.
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48. Bar-Shavit Z, Goldman R, Stabinsky Y, Gottlieb P, Fridkin M, Teichberg VI, Blumberg S. Enhancement of phagocytosis - a newly found activity of substance P residing in its N-terminal tetrapeptide sequence. Biochem Biophys Res Commun. 1980 Jun 30; 94(4):1445-51.
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49. Bar-Shavit Z, Bursuker I, Goldman R. Functional tuftsin binding sites on macrophage-like tumor line P388D1 and on bone marrow cells differentiated in vitro into mononuclear phagocytes. Mol Cell Biochem. 1980 May 7; 30(3):151-5.
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50. Stabinsky Y, Bar-Shavit Z, Fridkin M, Goldman R. On the mechanism of action of the phagocytosis-stimulating peptide tuftsin. Mol Cell Biochem. 1980 Apr 18; 30(2):71-7.
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51. Goldman R, Bar-Shavit Z. Dual effect of normal and stimulated macrophages and their conditioned media on target cell proliferation. J Natl Cancer Inst. 1979 Oct; 63(4):1009-16.
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52. Bar-Shavit Z, Stabinsky Y, Fridkin M, Goldman R. Tuftsin-macrophage interaction: specific binding and augmentation of phagocytosis. J Cell Physiol. 1979 Jul; 100(1):55-62.
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53. Bar-Shavit Z, Raz A, Goldman R. Complement and Fc receptor-mediated phagocytosis of normal and stimulated mouse peritoneal macrophages. Eur J Immunol. 1979 May; 9(5):385-91.
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54. Goldman R, Bar-Shavit Z, Raz A. Functional similarity and diversity in peritoneal macrophage populations induced in vivo by various stimuli. Adv Exp Med Biol. 1979; 121(A):323-32.
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55. Bar-Shavit Z, Ofek I, Goldman R, Mirelman D, Sharon N. Mannose residues on phagocytes as receptors for the attachment of Escherichia coli and Salmonella typhi. Biochem Biophys Res Commun. 1977 Sep 9; 78(1):455-60.
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56. Bar-Shavit Z, Goldman R. Concanavalin A-mediated attachment and ingestion of yeast cells by macrophages. Exp Cell Res. 1976 May; 99(2):221-36.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Osteoclasts
Macrophages
Oligodeoxyribonucleotides
Osteoblasts
Cell Differentiation
See all (272) keywords
Co-Authors  
Drissi, Hicham
Javed, Amjad
Lian, Jane
Stein, Gary
Stein, Janet
See all (5) people
Physical Neighbors  
Urano, Fumihiko
Daigneault, Joseph
Manno, Mariann
Milman, Morris
Zwerdling, Robert

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