Elisabet Mandon PHD
Title Research Associate Professor
Institution University of Massachusetts Medical School
Department Biochemistry & Molecular Pharmacology
Address University of Massachusetts Medical School
364 Plantation Street, LRB-970
Worcester MA 01605
Telephone 508-856-6051
Email
Narrative
Lab web-page: www.umassmed.edu/mandonlab
Publications
1. Mandon EC, Trueman SF, Gilmore R. Protein Translocation across the Rough Endoplasmic Reticulum. Cold Spring Harb Perspect Biol. 2013; 5(2).
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2. Trueman SF, Mandon EC, Gilmore R. A gating motif in the translocation channel sets the hydrophobicity threshold for signal sequence function. J Cell Biol. 2012 Dec 10; 199(6):907-18.
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3. Gilmore R, Mandon EC. Understanding integration of a-helical membrane proteins: the next steps. Trends Biochem Sci. 2012 Aug; 37(8):303-8.
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4. Trueman SF, Mandon EC, Gilmore R. Translocation channel gating kinetics balances protein translocation efficiency with signal sequence recognition fidelity. Mol Biol Cell. 2011 Sep; 22(17):2983-93.
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5. Becker T, Bhushan S, Jarasch A, Armache JP, Funes S, Jossinet F, Gumbart J, Mielke T, Berninghausen O, Schulten K, Westhof E, Gilmore R, Mandon EC, Beckmann R. Structure of monomeric yeast and mammalian Sec61 complexes interacting with the translating ribosome. Science. 2009 Dec 4; 326(5958):1369-73.
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6. Mandon EC, Trueman SF, Gilmore R. Translocation of proteins through the Sec61 and SecYEG channels. Curr Opin Cell Biol. 2009 Aug; 21(4):501-7.
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7. Jiang Y, Cheng Z, Mandon EC, Gilmore R. An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation. J Cell Biol. 2008 Mar 24; 180(6):1149-61.
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8. Mandon EC, Gilmore R. The tail end of membrane insertion. Cell. 2007 Mar 23; 128(6):1031-2.
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9. Cheng Z, Jiang Y, Mandon EC, Gilmore R. Identification of cytoplasmic residues of Sec61p involved in ribosome binding and cotranslational translocation. J Cell Biol. 2005 Jan 3; 168(1):67-77.
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10. Mandon EC, Gilmore R. GTPase twins in the SRP family. Nat Struct Mol Biol. 2004 Feb; 11(2):115-6.
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11. Mandon EC, Jiang Y, Gilmore R. Dual recognition of the ribosome and the signal recognition particle by the SRP receptor during protein targeting to the endoplasmic reticulum. J Cell Biol. 2003 Aug 18; 162(4):575-85.
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12. Kelleher DJ, Karaoglu D, Mandon EC, Gilmore R. Oligosaccharyltransferase isoforms that contain different catalytic STT3 subunits have distinct enzymatic properties. Mol Cell. 2003 Jul; 12(1):101-11.
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13. Song W, Raden D, Mandon EC, Gilmore R. Role of Sec61alpha in the regulated transfer of the ribosome-nascent chain complex from the signal recognition particle to the translocation channel. Cell. 2000 Feb 4; 100(3):333-43.
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14. Puglielli L, Mandon EC, Hirschberg CB. Identification, purification, and characterization of the rat liver golgi membrane ATP transporter. J Biol Chem. 1999 Apr 30; 274(18):12665-9.
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15. Puglielli L, Mandon EC, Rancour DM, Menon AK, Hirschberg CB. Identification and purification of the rat liver Golgi membrane UDP-N-acetylgalactosamine transporter. J Biol Chem. 1999 Feb 12; 274(7):4474-9.
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16. Abeijon C, Mandon EC, Hirschberg CB. Transporters of nucleotide sugars, nucleotide sulfate and ATP in the Golgi apparatus. Trends Biochem Sci. 1997 Jun; 22(6):203-7.
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17. Abeijon C, Mandon EC, Robbins PW, Hirschberg CB. A mutant yeast deficient in Golgi transport of uridine diphosphate N-acetylglucosamine. J Biol Chem. 1996 Apr 12; 271(15):8851-4.
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18. de Gómez Dumm NT, Mandon EC. Indomethacin, esculetin and nordihydroguaiaretic acid modify arachidonate biosynthesis in rat adrenocortical cells. Acta Physiol Pharmacol Ther Latinoam. 1995; 45(3):155-64.
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19. Mandon EC, Milla ME, Kempner E, Hirschberg CB. Purification of the Golgi adenosine 3'-phosphate 5'-phosphosulfate transporter, a homodimer within the membrane. Proc Natl Acad Sci U S A. 1994 Oct 25; 91(22):10707-11.
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20. Mandon E, Kempner ES, Ishihara M, Hirschberg CB. A monomeric protein in the Golgi membrane catalyzes both N-deacetylation and N-sulfation of heparan sulfate. J Biol Chem. 1994 Apr 22; 269(16):11729-33.
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21. Hurtado de Catalfo GE, de Gómez Dumm IN, Mandon EC. Long-chain acyl-CoA synthetase of rat testis microsomes. Substrate specificity and hormonal regulation. Biochem Mol Biol Int. 1993 Nov; 31(4):643-9.
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22. Abeijon C, Yanagisawa K, Mandon EC, Häusler A, Moremen K, Hirschberg CB, Robbins PW. Guanosine diphosphatase is required for protein and sphingolipid glycosylation in the Golgi lumen of Saccharomyces cerevisiae. J Cell Biol. 1993 Jul; 122(2):307-23.
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23. Hurtado de Catalfo GE, Mandon EC, de Gómez Dumm IN. Arachidonic acid biosynthesis in non-stimulated and adrenocorticotropin-stimulated Sertoli and Leydig cells. Lipids. 1992 Aug; 27(8):593-8.
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24. Mandon EC, Ehses I, Rother J, van Echten G, Sandhoff K. Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver. J Biol Chem. 1992 Jun 5; 267(16):11144-8.
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25. Mandon EC, van Echten G, Birk R, Schmidt RR, Sandhoff K. Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases. Eur J Biochem. 1991 Jun 15; 198(3):667-74.
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26. Igal RA, Mandon EC, de Gómez Dumm IN. Abnormal metabolism of polyunsaturated fatty acids in adrenal glands of diabetic rats. Mol Cell Endocrinol. 1991 May; 77(1-3):217-27.
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27. Mandon EC, de Gómez Dumm IN. Biosynthesis of polyunsaturated fatty acids of (n-6) and (n-3) series in isolated adrenocortical cells of rats. Effect of ACTH. Mol Cell Endocrinol. 1989 Aug; 65(1-2):175-85.
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28. Mandon EC, de Gómez Dumm IN, Brenner RR. Long-chain fatty acyl-CoA synthetase of rat adrenal microsomes. Effect of ACTH and epinephrine. Mol Cell Endocrinol. 1988 Mar; 56(1-2):123-31.
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29. Mandon EC, de Gómez Dumm IN, Brenner RR. Effect of high carbohydrate and high protein diets on microsomal fatty acid composition, "fluidity" and delta 6 desaturation activity in kidney and lung. Acta Physiol Pharmacol Latinoam. 1988; 38(1):49-58.
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30. Mandon EC, de Gómez Dumm IN, de Alaníz MJ, Marra CA, Brenner RR. ACTH depresses delta 6 and delta 5 desaturation activity in rat adrenal gland and liver. J Lipid Res. 1987 Dec; 28(12):1377-83.
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31. Mandon EC, de Gómez Dumm IN, Gómez Dumm CL, Brenner RR. Epinephrine effect on arachidonic acid biosynthesis in isolated adrenocortical cells. Mol Cell Endocrinol. 1987 May; 51(1-2):127-33.
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32. Mandon EC, de Gómez Dumm IN, Brenner RR. Effect of dietary columbinic acid on the fatty acid composition and physical membrane properties of different tissues of EFA-deficient rats. Arch Latinoam Nutr. 1986 Sep; 36(3):401-14.
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33. Mandon EC, de Gomez Dumm IN, Brenner RR. Effect of epinephrine on the oxidative desaturation of fatty acids in the rat adrenal gland. Lipids. 1986 Jun; 21(6):401-4.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Membrane Proteins
Endoplasmic Reticulum
Signal Recognition Particle
Microsomes
Liver
See all (177) keywords
Co-Authors  
Gilmore, James Reid
See all (1) people
Physical Neighbors  
Ross, Alonzo
Weaver, David
Cao, Hong
Mordes, John
Moore, Melissa

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