Marko Z Radic PhD
Title Associate Professor
Institution University of Massachusetts Medical School
Department Medicine
Address University of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
Telephone
Publications
1. Neeli I, Radic M. Opposition between PKC isoforms regulates histone deimination and neutrophil extracellular chromatin release. Front Immunol. 2013; 4:38.
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2. Radic M, Kaplan MJ. Jumbled NETs promote vasculitis. Arthritis Rheum. 2012 Nov; 64(11):3498-501.
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3. Kaplan MJ, Radic M. Neutrophil extracellular traps: double-edged swords of innate immunity. J Immunol. 2012 Sep 15; 189(6):2689-95.
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4. Dwivedi N, Radic M. Neutrophil activation and B-cell stimulation in the pathogenesis of Felty's syndrome. Pol Arch Med Wewn. 2012 Jul 19; 122(7-8):374-9.
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5. Neeli I, Radic M. Knotting the NETs: Analyzing histone modifications in neutrophil extracellular traps. Arthritis Res Ther. 2012; 14(2):115.
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6. Radic M. Armed and accurate: engineering cytotoxic T cells for eradication of leukemia. BMC Biotechnol. 2012; 12:6.
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7. Iannaccone A, Neeli I, Krishnamurthy P, Lenchik NI, Wan H, Gerling IC, Desiderio DM, Radic MZ. Autoimmune biomarkers in age-related macular degeneration: a possible role player in disease development and progression. Adv Exp Med Biol. 2012; 723:11-6.
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8. Dwivedi N, Upadhyay J, Neeli I, Khan S, Pattanaik D, Myers L, Kirou KA, Hellmich B, Knuckley B, Thompson PR, Crow MK, Mikuls TR, Csernok E, Radic M. Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps. Arthritis Rheum. 2012 Apr; 64(4):982-92.
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9. Khan SN, Cox JV, Nishimoto SK, Chen C, Fritzler MJ, Hendershot LM, Weigert M, Radic M. Intra-Golgi formation of IgM-glycosaminoglycan complexes promotes Ig deposition. J Immunol. 2011 Sep 15; 187(6):3198-207.
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10. Radic M, Herrmann M, van der Vlag J, Rekvig OP. Regulatory and pathogenetic mechanisms of autoantibodies in SLE. Autoimmunity. 2011 Aug; 44(5):349-56.
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11. Neeli I, Dwivedi N, Khan S, Radic M. Regulation of extracellular chromatin release from neutrophils. J Innate Immun. 2009; 1(3):194-201.
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12. Radic M. Tracking and trapping somatic mutations in Ig genes. J Immunol. 2008 May 1; 180(9):5763-4.
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13. Kiefer K, Nakajima PB, Oshinsky J, Seeholzer SH, Radic M, Bosma GC, Bosma MJ. Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM. J Immunol. 2008 May 1; 180(9):6094-106.
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14. Khan SN, Witsch EJ, Goodman NG, Panigrahi AK, Chen C, Jiang Y, Cline AM, Erikson J, Weigert M, Prak ET, Radic M. Editing and escape from editing in anti-DNA B cells. Proc Natl Acad Sci U S A. 2008 Mar 11; 105(10):3861-6.
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15. Neeli I, Khan SN, Radic M. Histone deimination as a response to inflammatory stimuli in neutrophils. J Immunol. 2008 Feb 1; 180(3):1895-902.
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16. Neeli I, Richardson MM, Khan SN, Nicolo D, Monestier M, Radic MZ. Divergent members of a single autoreactive B cell clone retain specificity for apoptotic blebs. Mol Immunol. 2007 Mar; 44(8):1914-21.
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17. Bosma GC, Oshinsky J, Kiefer K, Nakajima PB, Charan D, Congelton C, Radic M, Bosma MJ. Development of functional B cells in a line of SCID mice with transgenes coding for anti-double-stranded DNA antibody. J Immunol. 2006 Jan 15; 176(2):889-98.
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18. Radic MZ, Shah K, Zhang W, Lu Q, Lemke G, Hilliard GM. Heterogeneous nuclear ribonucleoprotein P2 is an autoantibody target in mice deficient for Mer, Axl, and Tyro3 receptor tyrosine kinases. J Immunol. 2006 Jan 1; 176(1):68-74.
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19. Cline AM, Radic MZ. Apoptosis, subcellular particles, and autoimmunity. Clin Immunol. 2004 Aug; 112(2):175-82.
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20. Radic M, Marion T, Monestier M. Nucleosomes are exposed at the cell surface in apoptosis. J Immunol. 2004 Jun 1; 172(11):6692-700.
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21. Brady GF, Congdon KL, Clark AG, Sackey FN, Rudolph EH, Radic MZ, Foster MH. Kappa editing rescues autoreactive B cells destined for deletion in mice transgenic for a dual specific anti-laminin Ig. J Immunol. 2004 May 1; 172(9):5313-21.
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22. Radic MZ, Weigert M. Intricacies of anti-DNA autoantibodies. J Immunol. 2004 Mar 15; 172(6):3367; author reply 3367-8.
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23. Cline AM, Radic MZ. Murine lupus autoantibodies identify distinct subsets of apoptotic bodies. Autoimmunity. 2004 Mar; 37(2):85-93.
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24. Li H, Jiang Y, Cao H, Radic M, Prak EL, Weigert M. Regulation of anti-phosphatidylserine antibodies. Immunity. 2003 Feb; 18(2):185-92.
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25. Bosma GC, Kim J, Urich T, Fath DM, Cotticelli MG, Ruetsch NR, Radic MZ, Bosma MJ. DNA-dependent protein kinase activity is not required for immunoglobulin class switching. J Exp Med. 2002 Dec 2; 196(11):1483-95.
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26. Cocca BA, Cline AM, Radic MZ. Blebs and apoptotic bodies are B cell autoantigens. J Immunol. 2002 Jul 1; 169(1):159-66.
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27. Li H, Jiang Y, Prak EL, Radic M, Weigert M. Editors and editing of anti-DNA receptors. Immunity. 2001 Dec; 15(6):947-57.
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28. Cocca BA, Seal SN, D'Agnillo P, Mueller YM, Katsikis PD, Rauch J, Weigert M, Radic MZ. Structural basis for autoantibody recognition of phosphatidylserine-beta 2 glycoprotein I and apoptotic cells. Proc Natl Acad Sci U S A. 2001 Nov 20; 98(24):13826-31.
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29. Seal SN, Monestier M, Radic MZ. Diverse roles for the third complementarity determining region of the heavy chain (H3) in the binding of immunoglobulin Fv fragments to DNA, nucleosomes and cardiolipin. Eur J Immunol. 2000 Dec; 30(12):3432-40.
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30. Seal SN, Hoet RM, Raats JM, Radic MZ. Analysis of autoimmune bone marrow by antibody-phage display: somatic mutations and third complementarity-determining region arginines in anti-DNA gamma and kappa V genes. Arthritis Rheum. 2000 Sep; 43(9):2132-8.
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31. Chen ZC, Radic MZ, Galili U. Genes coding evolutionary novel anti-carbohydrate antibodies: studies on anti-Gal production in alpha 1,3galactosyltransferase knock out mice. Mol Immunol. 2000 Jun; 37(8):455-66.
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32. Cocca BA, Seal SN, Radic MZ. Tandem affinity tags for the purification of bivalent anti-DNA single-chain Fv expressed in Escherichia coli. Protein Expr Purif. 1999 Nov; 17(2):290-8.
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33. Radic MZ, Cocca BA, Seal SN. Initiation of systemic autoimmunity and sequence specific anti-DNA autoantibodies. Crit Rev Immunol. 1999; 19(2):117-26.
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34. Galili U, LaTemple DC, Radic MZ. A sensitive assay for measuring alpha-Gal epitope expression on cells by a monoclonal anti-Gal antibody. Transplantation. 1998 Apr 27; 65(8):1129-32.
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35. Wang L, Radic MZ, Siegel D, Chang T, Bracy J, Galili U. Cloning of anti-Gal Fabs from combinatorial phage display libraries: structural analysis and comparison of Fab expression in pComb3H and pComb8 phage. Mol Immunol. 1997 Jun; 34(8-9):609-18.
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36. Radic MZ, Seal SN. Selection of recurrent V genes and somatic mutations in autoantibodies to DNA. Methods. 1997 Jan; 11(1):20-6.
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37. Radic MZ, Zouali M. Receptor editing, immune diversification, and self-tolerance. Immunity. 1996 Dec; 5(6):505-11.
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38. Monestier M, Kandiah DA, Kouts S, Novick KE, Ong GL, Radic MZ, Krilis SA. Monoclonal antibodies from NZW x BXSB F1 mice to beta2 glycoprotein I and cardiolipin. Species specificity and charge-dependent binding. J Immunol. 1996 Apr 1; 156(7):2631-41.
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39. Radic MZ, Weigert M. Origins of anti-DNA antibodies and their implications for B-cell tolerance. Ann N Y Acad Sci. 1995 Sep 29; 764:384-96.
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40. Radic MZ, Ibrahim SM, Rauch J, Camper SA, Weigert M. Constitutive secretion of transgene-encoded IgG2b autoantibodies leads to symptoms of autoimmune disease. J Immunol. 1995 Sep 15; 155(6):3213-22.
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41. Ibrahim SM, Weigert M, Basu C, Erikson J, Radic MZ. Light chain contribution to specificity in anti-DNA antibodies. J Immunol. 1995 Sep 15; 155(6):3223-33.
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42. Wang L, Radic MZ, Galili U. Human anti-Gal heavy chain genes. Preferential use of VH3 and the presence of somatic mutations. J Immunol. 1995 Aug 1; 155(3):1276-85.
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43. Chen C, Nagy Z, Radic MZ, Hardy RR, Huszar D, Camper SA, Weigert M. The site and stage of anti-DNA B-cell deletion. Nature. 1995 Jan 19; 373(6511):252-5.
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44. Chen C, Radic MZ, Erikson J, Camper SA, Litwin S, Hardy RR, Weigert M. Deletion and editing of B cells that express antibodies to DNA. J Immunol. 1994 Feb 15; 152(4):1970-82.
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45. Radic MZ, Weigert M. Genetic and structural evidence for antigen selection of anti-DNA antibodies. Annu Rev Immunol. 1994; 12:487-520.
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46. Galili U, Anaraki F, Thall A, Hill-Black C, Radic M. One percent of human circulating B lymphocytes are capable of producing the natural anti-Gal antibody. Blood. 1993 Oct 15; 82(8):2485-93.
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47. Radic MZ, Mackle J, Erikson J, Mol C, Anderson WF, Weigert M. Residues that mediate DNA binding of autoimmune antibodies. J Immunol. 1993 Jun 1; 150(11):4966-77.
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48. Radic MZ, Erikson J, Litwin S, Weigert M. B lymphocytes may escape tolerance by revising their antigen receptors. J Exp Med. 1993 Apr 1; 177(4):1165-73.
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49. Yui K, Bhandoola A, Radic MZ, Komori S, Katsumata M, Greene MI. Inhibition of abnormal T cell development and autoimmunity in gld mice by transgenic T cell receptor beta chain. Eur J Immunol. 1992 Jul; 22(7):1693-700.
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50. Erikson J, Radic MZ, Camper SA, Hardy RR, Carmack C, Weigert M. Expression of anti-DNA immunoglobulin transgenes in non-autoimmune mice. Nature. 1991 Jan 24; 349(6307):331-4.
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51. Radic MZ, Mascelli MA, Erikson J, Shan H, Weigert M. Ig H and L chain contributions to autoimmune specificities. J Immunol. 1991 Jan 1; 146(1):176-82.
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52. Shlomchik M, Mascelli M, Shan H, Radic MZ, Pisetsky D, Marshak-Rothstein A, Weigert M. Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. J Exp Med. 1990 Jan 1; 171(1):265-92.
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53. Radic MZ, Mascelli MA, Erikson J, Shan H, Shlomchik M, Weigert M. Structural patterns in anti-DNA antibodies from MRL/lpr mice. Cold Spring Harb Symp Quant Biol. 1989; 54 Pt 2:933-46.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Antibodies, Antinuclear
DNA
B-Lymphocytes
Immunoglobulin Variable Region
Apoptosis
See all (220) keywords
Co-Authors  
Galili, Uri
See all (1) people
Physical Neighbors  
Rosmarin, Alan
Basil, Anjali
Hartman, Christian
Kabat-Zinn, Jon
Konz, Richard

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