Thomas W Honeyman PHD
Title Associate Professor
Institution University of Massachusetts Medical School
Department Microbiology & Physiological Systems
Address University of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Telephone 508-856-2407
Email
Narrative

Academic Background

B.A., Colgate University, 1967;
Ph.D., Harvard Medical School, 1974.

The Transduction of Hormonal Neurotransmitter Signals

Photo: Thomas W. Honeyman

The biochemical and physiological events involved in the transduction of hormonal neurotransmitter signals. Intracellular signalling pathways in the control of Ca2+, H+ and Na+ in smooth muscle. Application of computer-aided image analysis to the study of the pathogenesis of cancer.

Historical Figure

Historical Figure

Original kymograph used to record blood pressure. Described by Carl Ludwig, 1847.

Publications
1. Olson ML, Kargacin ME, Honeyman TW, Ward CA, Kargacin GJ. Effects of phytoestrogens on sarcoplasmic/endoplasmic reticulum calcium ATPase 2a and Ca2+ uptake into cardiac sarcoplasmic reticulum. J Pharmacol Exp Ther. 2006 Feb; 316(2):628-35.
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2. Cao LC, Honeyman TW, Cooney R, Kennington L, Scheid CR, Jonassen JA. Mitochondrial dysfunction is a primary event in renal cell oxalate toxicity. Kidney Int. 2004 Nov; 66(5):1890-900.
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3. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Intracellular events in the initiation of calcium oxalate stones. Nephron Exp Nephrol. 2004; 98(2):e61-4.
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4. Scheid CR, Cao LC, Honeyman T, Jonassen JA. How elevated oxalate can promote kidney stone disease: changes at the surface and in the cytosol of renal cells that promote crystal adherence and growth. Front Biosci. 2004 Jan 1; 9:797-808.
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5. Jonassen JA, Cao LC, Honeyman T, Scheid CR. Mechanisms mediating oxalate-induced alterations in renal cell functions. Crit Rev Eukaryot Gene Expr. 2003; 13(1):55-72.
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6. Cao LC, Jonassen J, Honeyman TW, Scheid C. Oxalate-induced redistribution of phosphatidylserine in renal epithelial cells: implications for kidney stone disease. Am J Nephrol. 2001 Jan-Feb; 21(1):69-77.
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7. Baran DT, Quail JM, Ray R, Honeyman T. Binding of 1alpha,25-dihydroxyvitamin D(3) to annexin II: effect of vitamin D metabolites and calcium. J Cell Biochem. 2000 Oct 20; 80(2):259-65.
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8. Kohjimoto Y, Honeyman TW, Jonassen J, Gravel K, Kennington L, Scheid CR. Phospholipase A2 mediates immediate early genes in cultured renal epithelial cells: possible role of lysophospholipid. Kidney Int. 2000 Aug; 58(2):638-46.
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9. Ignotz RA, Honeyman T. TGF-beta signaling in A549 lung carcinoma cells: lipid second messengers. J Cell Biochem. 2000 Jun 12; 78(4):588-94.
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10. Cao LC, Honeyman T, Jonassen J, Scheid C. Oxalate-induced ceramide accumulation in Madin-Darby canine kidney and LLC-PK1 cells. Kidney Int. 2000 Jun; 57(6):2403-11.
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11. Baran DT, Quail JM, Ray R, Leszyk J, Honeyman T. Annexin II is the membrane receptor that mediates the rapid actions of 1alpha,25-dihydroxyvitamin D(3). J Cell Biochem. 2000 Apr; 78(1):34-46.
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12. Miller C, Kennington L, Cooney R, Kohjimoto Y, Cao LC, Honeyman T, Pullman J, Jonassen J, Scheid C. Oxalate toxicity in renal epithelial cells: characteristics of apoptosis and necrosis. Toxicol Appl Pharmacol. 2000 Jan 15; 162(2):132-41.
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13. Scheid C, Honeyman T, Kohjimoto Y, Cao LC, Jonassen J. Oxalate-induced changes in renal epithelial cell function: role in stone disease. Mol Urol. 2000; 4(4):371-82.
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14. Jonassen JA, Cooney R, Kennington L, Gravel K, Honeyman T, Scheid CR. Oxalate-induced changes in the viability and growth of human renal epithelial cells. J Am Soc Nephrol. 1999 Nov; 10 Suppl 14:S446-51.
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15. Kohjimoto Y, Kennington L, Scheid CR, Honeyman TW. Role of phospholipase A2 in the cytotoxic effects of oxalate in cultured renal epithelial cells. Kidney Int. 1999 Oct; 56(4):1432-41.
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16. Woodiwiss AJ, Honeyman TW, Fenton RA, Dobson JG. Adenosine A2a-receptor activation enhances cardiomyocyte shortening via Ca2+-independent and -dependent mechanisms. Am J Physiol. 1999 May; 276(5 Pt 2):H1434-41.
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17. Norton GR, Woodiwiss AJ, McGinn RJ, Lorbar M, Chung ES, Honeyman TW, Fenton RA, Dobson JG, Meyer TE. Adenosine A1 receptor-mediated antiadrenergic effects are modulated by A2a receptor activation in rat heart. Am J Physiol. 1999 Feb; 276(2 Pt 2):H341-9.
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18. Duquette J, Honeyman T, Hoffman A, Ahmadi S, Baran D. Effect of bovine bone constituents on broadband ultrasound attenuation measurements. Bone. 1997 Sep; 21(3):289-94.
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19. Reddy D, Pollock AS, Clark SA, Sooy K, Vasavada RC, Stewart AF, Honeyman T, Christakos S. Transfection and overexpression of the calcium binding protein calbindin-D28k results in a stimulatory effect on insulin synthesis in a rat beta cell line (RIN 1046-38). Proc Natl Acad Sci U S A. 1997 Mar 4; 94(5):1961-6.
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20. Koul H, Kennington L, Honeyman T, Jonassen J, Menon M, Scheid C. Activation of c-myc gene mediates the mitogenic effects of oxalate in LLC-PK1 cells, a line of renal epithelial cells. Kidney Int. 1996 Nov; 50(5):1525-30.
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21. Park CS, Lee HS, Chang SH, Honeyman TW, Hong CD. Inhibitory effect of Ca2+ on renin secretion elicited by chemiosmotic stimuli through actomyosin mediation. Am J Physiol. 1996 Jul; 271(1 Pt 1):C248-54.
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22. Scheid C, Koul H, Hill WA, Luber-Narod J, Jonassen J, Honeyman T, Kennington L, Kohli R, Hodapp J, Ayvazian P, Menon M. Oxalate toxicity in LLC-PK1 cells, a line of renal epithelial cells. J Urol. 1996 Mar; 155(3):1112-6.
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23. Quinn DA, Dahlberg CG, Bonventre JP, Scheid CR, Honeyman T, Joseph PM, Thompson BT, Hales CA. The role of Na+/H+ exchange and growth factors in pulmonary artery smooth muscle cell proliferation. Am J Respir Cell Mol Biol. 1996 Feb; 14(2):139-45.
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24. Scheid C, Koul H, Hill WA, Luber-Narod J, Kennington L, Honeyman T, Jonassen J, Menon M. Oxalate toxicity in LLC-PK1 cells: role of free radicals. Kidney Int. 1996 Feb; 49(2):413-9.
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25. Pajor L, Honeyman TW. Combined light and fluorescent microscopical imaging of nucleolar organizer regions and cellular rRNA as detected by fluorescent in situ hybridization. Cytometry. 1995 Feb 1; 19(2):171-6.
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26. Scheid CR, Koul HK, Kennington L, Hill WA, Luber-Narod J, Jonassen J, Honeyman T, Menon M. Oxalate-induced damage to renal tubular cells. Scanning Microsc. 1995; 9(4):1097-105; discussion 1105-7.
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27. Koul H, Kennington L, Nair G, Honeyman T, Menon M, Scheid C. Oxalate-induced initiation of DNA synthesis in LLC-PK1 cells, a line of renal epithelial cells. Biochem Biophys Res Commun. 1994 Dec 30; 205(3):1632-7.
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28. Baran DT, Ray R, Sorensen AM, Honeyman T, Holick MF. Binding characteristics of a membrane receptor that recognizes 1 alpha,25-dihydroxyvitamin D3 and its epimer, 1 beta,25-dihydroxyvitamin D3. J Cell Biochem. 1994 Dec; 56(4):510-7.
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29. Ellstrom DR, Honeyman TW, Scheid CR. Role of blood pressure in regulating Na+/H+ exchange in vascular smooth muscle. Am J Hypertens. 1994 Apr; 7(4 Pt 1):340-5.
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30. Sonett J, Pagani FD, Baker LS, Honeyman T, Hsi C, Knox M, Cronin C, Landow L, Visner MS. Correction of intramyocardial hypercarbic acidosis with sodium bicarbonate. Circ Shock. 1994 Apr; 42(4):163-73.
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31. Ellstrom DR, Foster CD, Honeyman TW, Scheid CR. Regulation of Na+/H+ exchange in mesenteric arteries from spontaneously hypertensive rats. Am J Hypertens. 1993 Jan; 6(1):21-7.
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32. Carraway RE, Mitra SP, Honeyman TW. Effects of GTP analogs and metal ions on the binding of neurotensin to porcine brain membranes. Peptides. 1993 Jan-Feb; 14(1):37-45.
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33. Foster CD, Hill WA, Honeyman TW, Scheid CR. Characterization of Na(+)-H+ exchange in segments of rat mesenteric artery. Am J Physiol. 1992 Jun; 262(6 Pt 2):H1651-6.
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34. Foster CD, Honeyman TW, Scheid CR. Alterations in Na(+)-H+ exchange in mesenteric arteries from spontaneously hypertensive rats. Am J Physiol. 1992 Jun; 262(6 Pt 2):H1657-62.
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35. Park CS, Hong CD, Honeyman TW. Calcium-dependent inhibitory step in control of renin secretion. Am J Physiol. 1992 May; 262(5 Pt 2):F793-8.
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36. Quinn DA, Honeyman TW, Joseph PM, Thompson BT, Hales CA, Scheid CR. Contribution of Na+/H+ exchange to pH regulation in pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 1991 Dec; 5(6):586-91.
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37. Park CS, Honeyman TW, Ha SK, Choi HK, Chung CL, Hong CD. Mechanisms of ionophore-induced stimulation of renin secretion with special reference to a chemiosmotic hypothesis. J Pharmacol Exp Ther. 1991 Oct; 259(1):211-8.
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38. Doh PS, Lee CJ, Hwang PM, Cho KW, Honeyman TW, Park CS. Role of membrane sulfhydryl groups in stimulation of renin secretion by sulfhydryl reagents. Kidney Int. 1991 May; 39(5):867-73.
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39. Cooney RA, Honeyman TW, Scheid CR. Contribution of Na(+)-dependent and ATP-dependent Ca2+ transport to smooth muscle calcium homeostasis. Ann N Y Acad Sci. 1991; 639:558-60.
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40. Goodman HM, Gorin E, Schwartz Y, Tai LR, Chipkin SR, Honeyman TW, Frick GP, Yamaguchi H. Cellular effects of growth hormone on adipocytes. Chin J Physiol. 1991; 34(1):27-44.
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41. Gorin E, Tai LR, Honeyman TW, Goodman HM. Evidence for a role of protein kinase C in the stimulation of lipolysis by growth hormone and isoproterenol. Endocrinology. 1990 Jun; 126(6):2973-82.
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42. Baran DT, Sorensen AM, Honeyman TW, Ray R, Holick MF. 1 alpha,25-dihydroxyvitamin D3-induced increments in hepatocyte cytosolic calcium and lysophosphatidylinositol: inhibition by pertussis toxin and 1 beta,25-dihydroxyvitamin D3. J Bone Miner Res. 1990 May; 5(5):517-24.
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43. Lucchesi PA, Scheid CR, Romano FD, Kargacin ME, Mullikin-Kilpatrick D, Yamaguchi H, Honeyman TW. Ligand binding and G protein coupling of muscarinic receptors in airway smooth muscle. Am J Physiol. 1990 Apr; 258(4 Pt 1):C730-8.
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44. Baran DT, Sorensen AM, Honeyman TW, Ray R, Holick MF. Rapid actions of 1 alpha,25-dihydroxyvitamin D3 on Ca2+ and phospholipids in isolated rat liver nuclei. FEBS Lett. 1989 Dec 18; 259(1):205-8.
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45. Lee DY, Cho KW, Lee JS, Honeyman TW, Park CS. Stimulation of renin secretion by non-diuretic sulfhydryl reagents. Kidney Int. 1989 Mar; 35(3):812-6.
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46. Lucchesi PA, Romano FD, Scheid CR, Yamaguchi H, Honeyman TW. Interaction of agonists and selective antagonists with gastric smooth muscle muscarinic receptors. Naunyn Schmiedebergs Arch Pharmacol. 1989 Jan-Feb; 339(1-2):145-51.
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47. Baran DT, Sorensen AM, Honeyman TW. Rapid action of 1,25-dihydroxyvitamin D3 on hepatocyte phospholipids. J Bone Miner Res. 1988 Dec; 3(6):593-600.
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48. Kargacin ME, Scheid CR, Honeyman TW. Continuous monitoring of Ca2+ uptake in membrane vesicles with fura-2. Am J Physiol. 1988 Nov; 255(5 Pt 1):C694-8.
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49. Lucchesi PA, Cooney RA, Mangsen-Baker C, Honeyman TW, Scheid CR. Assessment of transport capacity of plasmalemmal Ca2+ pump in smooth muscle. Am J Physiol. 1988 Aug; 255(2 Pt 1):C226-36.
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50. Gorin E, Honeyman TW, Tai LR, Goodman HM. Adenosine 3',5'-monophosphate-dependent loss of growth hormone binding in rat adipocytes. Endocrinology. 1988 Jul; 123(1):328-34.
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51. Yamaguchi H, Honeyman TW, Fay FS. Beta-adrenergic actions on membrane electrical properties of dissociated smooth muscle cells. Am J Physiol. 1988 Mar; 254(3 Pt 1):C423-31.
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52. Kargacin ME, Bassell G, Ryan PJ, Honeyman TW. Separation and analysis of fluorescent derivatives of myo-inositol and myo-inositol 2-phosphate by high-performance liquid chromatography. J Chromatogr. 1987 May 1; 393(3):454-8.
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53. Park CS, Honeyman TW, Chung ES, Lee JS, Sigmon DH, Fray JC. Involvement of calmodulin in mediating inhibitory action of intracellular Ca2+ on renin secretion. Am J Physiol. 1986 Dec; 251(6 Pt 2):F1055-62.
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54. Park CS, Sigmon DH, Han DS, Honeyman TW, Fray JC. Control of renin secretion by Ca2+ and cyclic AMP through two parallel mechanisms. Am J Physiol. 1986 Sep; 251(3 Pt 2):R531-6.
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55. Schimmel RJ, Dzierzanowski D, Elliott ME, Honeyman TW. Stimulation of phosphoinositide metabolism in hamster brown adipocytes exposed to alpha 1-adrenergic agents and its inhibition with phorbol esters. Biochem J. 1986 Jun 15; 236(3):757-64.
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56. Campbell MD, Deth RC, Payne RA, Honeyman TW. Phosphoinositide hydrolysis is correlated with agonist-induced calcium flux and contraction in the rabbit aorta. Eur J Pharmacol. 1985 Oct 8; 116(1-2):129-36.
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57. Ryan PJ, Honeyman TW. Determination of fatty acids by high-performance liquid chromatography of Dns-ethanolamine derivatives. J Chromatogr. 1984 Nov 16; 312:461-6.
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58. Simon CD, Honeyman TW, Fray JC. Renin-angiotensin system in hypophysectomized rats. I. Control of blood pressure. Am J Physiol. 1984 Jan; 246(1 Pt 1):E84-8.
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59. Honeyman TW, Strohsnitter W, Scheid CR, Schimmel RJ. Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. Relationship to the metabolic effects of insulin and insulin-like agents. Biochem J. 1983 May 15; 212(2):489-98.
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60. Schimmel RJ, Honeyman TW, McMahon KK. Phosphatidic acid and phosphatidylinositol labelling in adipose tissue. The role of endogenously formed adenosine. Biochem J. 1983 May 15; 212(2):499-506.
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61. Honeyman TW, Goodman HM, Fray JC. The effects of growth hormone on blood pressure and renin secretion in hypophysectomized rats. Endocrinology. 1983 May; 112(5):1613-7.
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62. Nemecek GM, Honeyman TW. The role of cyclic nucleotide phosphodiesterase in the inhibition of cyclic AMP accumulation by carbachol and phosphatidate. J Cyclic Nucleotide Res. 1982; 8(6):395-408.
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63. Honeyman TW, Goodman HM. Effects of growth hormone on glycogen metabolism in adipose tissue of hypophysectomized rats. Am J Physiol. 1980 Apr; 238(4):E389-94.
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64. Salmon DM, Honeyman TW. Proposed mechanism of cholinergic action in smooth muscle. Nature. 1980 Mar 27; 284(5754):344-5.
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65. Clark RB, Salmon DM, Honeyman TW. Phosphatidic acid inhibition of PGE1-stimulated cAMP accumulation in WI-38 fibroblasts: similarities with carbachol inhibition. J Cyclic Nucleotide Res. 1980; 6(1):37-49.
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66. Schimmel RJ, Honeyman TW, McMahon KK, Serio R, Clark RB. Inhibition of cyclic AMP accumulation in hamster adipocytes with phosphatidic acid: differences and similarities with alpha adrenergic effects. J Cyclic Nucleotide Res. 1980; 6(6):437-49.
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67. Salmon DM, Honeyman TW. Increased phosphatidate accumulation during single contractions of isolated smooth-muscle cells [proceedings]. Biochem Soc Trans. 1979 Oct; 7(5):986-8.
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68. Honeyman TW, Levy LK, Goodman HM. Independent regulation of phosphorylase and lipolysis in adipose tissue. Am J Physiol. 1979 Jul; 237(1):E11-7.
  View in: PubMed
 
69. Scheid CR, Honeyman TW, Fay FS. Mechanism of beta-adrenergic relaxation of smooth muscle. Nature. 1979 Jan 4; 277(5691):32-6.
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70. Brown DF, Honeyman TW, Dobson JG. Properties of epinephrine-induced activation of cardiac adenosine 3',5'-monophosphate-dependent protein kinase. Biochim Biophys Acta. 1978 Dec 18; 544(3):462-73.
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71. Honeyman T, Merriam P, Fay FS. The effects of isoproterenol on adenosine cyclic 3', 5'- monophosphate and contractility in isolated smooth muscle cells. Mol Pharmacol. 1978 Jan; 14(1):86-98.
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72. Gorin E, Honeyman TW, Goodman HM. Independent modulation of hepatic protein kinase activities. Biochim Biophys Acta. 1976 Dec 21; 451(2):491-8.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Oxalates
Calcium
Calcitriol
Annexin A2
Epithelial Cells
See all (389) keywords
Co-Authors  
Dobson, James
Goodman, H
Jonassen, Julie
Leszyk, John
Strohsnitter, William
See all (5) people
Physical Neighbors  
Rittenhouse, Ann
Schrader, Carol
He, Feng
Papavinasasundaram, Kadambavan
Ikebe, Mitsuo

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