Babs R Soller PHD
Title Professor Emeritus
Institution University of Massachusetts Medical School
Department Anesthesiology
Address University of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Telephone 508-856-5904
Other Positions
Institution UMMS - School of Medicine
Department Surgery
Division Cardiothoracic Surgery

Institution UMMS - Graduate School of Biomedical Sciences
Department Biochemistry & Molecular Pharmacology
Narrative

Academic Background

Ph.D. (Physical Chemistry), Princeton

Photo: Babs Soller, Ph.D.

We are exploring the application of optical spectroscopy for the noninvasive measurement of blood and tissue chemistry, ultimately to be able to perform chemical analysis and diagnosis without removing a sample from the patient.   We are currently investigating the use of near infrared spectroscopy in combination with in-vivo chemometric techniques to determine tissue pH, tissue oxygen tension and blood hematocrit.   We are also interested in the application of this technology in the triage and treatment of trauma patients.

Publications
1. Soller BR, Zou F, Ryan KL, Rickards CA, Ward K, Convertino VA. Lightweight noninvasive trauma monitor for early indication of central hypovolemia and tissue acidosis: A review. J Trauma Acute Care Surg. 2012 Aug; 73(2 Suppl 1):S106-11.
  View in: PubMed
 
2. Lee SM, Clarke MS, O'Connor DP, Stroud L, Ellerby GE, Soller BR. Near infrared spectroscopy-derived interstitial hydrogen ion concentration and tissue oxygen saturation during ambulation. Eur J Appl Physiol. 2011 Aug; 111(8):1705-14.
  View in: PubMed
 
3. Ward KR, Tiba MH, Ryan KL, Filho IP, Rickards CA, Witten T, Soller BR, Ludwig DA, Convertino VA. Oxygen transport characterization of a human model of progressive hemorrhage. Resuscitation. 2010 Aug; 81(8):987-93.
  View in: PubMed
 
4. Soller BR, Ryan KL, Rickards CA, Cooke WH, Yang Y, Soyemi OO, Crookes BA, Heard SO, Convertino VA. Oxygen saturation determined from deep muscle, not thenar tissue, is an early indicator of central hypovolemia in humans. Crit Care Med. 2008 Jan; 36(1):176-82.
  View in: PubMed
 
5. Soller BR, Yang Y, Lee SM, Wilson C, Hagan RD. Noninvasive determination of exercise-induced hydrodgen ion threshold through direct optical measurement. J Appl Physiol. 2008 Mar; 104(3):837-44.
  View in: PubMed
 
6. Soller BR, Yang Y, Soyemi OO, Ryan KL, Rickards CA, Walz JM, Heard SO, Convertino VA. Noninvasively determined muscle oxygen saturation is an early indicator of central hypovolemia in humans. J Appl Physiol. 2008 Feb; 104(2):475-81.
  View in: PubMed
 
7. Yang Y, Soyemi O, Scott PJ, Landry MR, Lee SM, Stroud L, Soller BR. Quantitative measurement of muscle oxygen saturation without influence from skin and fat using continuous-wave near infrared spectroscopy. Opt Express. 2007 Oct 17; 15(21):13715-30.
  View in: PubMed
 
8. Soller BR, Hagan RD, Shear M, Walz JM, Landry M, Anunciacion D, Orquiola A, Heard SO. Comparison of intramuscular and venous blood pH, PCO(2) and PO(2) during rhythmic handgrip exercise. Physiol Meas. 2007 Jun; 28(6):639-49.
  View in: PubMed
 
9. Yang Y, Soyemi OO, Landry MR, Soller BR. Noninvasive in vivo measurement of venous blood pH during exercise using near-infrared reflectance spectroscopy. Appl Spectrosc. 2007 Feb; 61(2):223-9.
  View in: PubMed
 
10. Yang Y, Shoer L, Soyemi OO, Landry MR, Soller BR. Removal of analyte-irrelevant variations in near-infrared tissue spectra. Appl Spectrosc. 2006 Sep; 60(9):1070-7.
  View in: PubMed
 
11. Yang Y, Landry MR, Soyemi OO, Shear MA, Anunciacion DS, Soller BR. Simultaneous correction of the influence of skin color and fat on tissue spectroscopy by use of a two-distance fiber-optic probe and orthogonalization technique. Opt Lett. 2005 Sep 1; 30(17):2269-71.
  View in: PubMed
 
12. Yang Y, Soyemi OO, Landry MR, Soller BR. Influence of a fat layer on the near infrared spectra of human muscle: quantitative analysis based on two-layered Monte Carlo simulations and phantom experiments. Opt Express. 2005 Mar 7; 13(5):1570-9.
  View in: PubMed
 
13. Soyemi OO, Landry MR, Yang Y, Idwasi PO, Soller BR. Skin color correction for tissue spectroscopy: demonstration of a novel approach with tissue-mimicking phantoms. Appl Spectrosc. 2005 Feb; 59(2):237-44.
  View in: PubMed
 
14. Khan T, Soller B, Naghavi M, Casscells W. Tissue pH determination for the detection of metabolically active, inflamed vulnerable plaques using near-infrared spectroscopy: an in-vitro feasibility study. Cardiology. 2005; 103(1):10-6.
  View in: PubMed
 
15. Soller BR, Hsi C, Favreau J, Cingo N, Lancey RA, Okike ON, Vander Salm TJ. Multiparameter fiber optic sensor for the assessment of intramyocardial perfusion. J Card Surg. 2004 Mar-Apr; 19(2):167-74.
  View in: PubMed
 
16. Soller BR, Khan T, Favreau J, Hsi C, Puyana JC, Heard SO. Investigation of muscle pH as an indicator of liver pH and injury from hemorrhagic shock. J Surg Res. 2003 Oct; 114(2):195-201.
  View in: PubMed
 
17. Soller BR, Idwasi PO, Balaguer J, Levin S, Simsir SA, Vander Salm TJ, Collette H, Heard SO. Noninvasive, near infrared spectroscopic-measured muscle pH and PO2 indicate tissue perfusion for cardiac surgical patients undergoing cardiopulmonary bypass. Crit Care Med. 2003 Sep; 31(9):2324-31.
  View in: PubMed
 
18. Soller BR, Favreau J, Idwasi PO. Investigation of electrolyte measurement in diluted whole blood using spectroscopic and chemometric methods. Appl Spectrosc. 2003 Feb; 57(2):146-51.
  View in: PubMed
 
19. Hsi C, Cuenoud H, Soller BR, Kim H, Favreau J, Vander Salm TJ, Moran JM. Experimental coronary artery occlusion: relevance to off-pump cardiac surgery. Asian Cardiovasc Thorac Ann. 2002 Dec; 10(4):293-7.
  View in: PubMed
 
20. Soller BR, Cabrera M, Smith SM, Sutton JP. Smart medical systems with application to nutrition and fitness in space. Nutrition. 2002 Oct; 18(10):930-6.
  View in: PubMed
 
21. Soller BR, Heard SO, Cingo NA, Hsi C, Favreau J, Khan T, Ross RR, Puyana JC. Application of fiberoptic sensors for the study of hepatic dysoxia in swine hemorrhagic shock. Crit Care Med. 2001 Jul; 29(7):1438-44.
  View in: PubMed
 
22. Soller BR, Cingo N, Puyana JC, Khan T, Hsi C, Kim H, Favreau J, Heard SO. Simultaneous measurement of hepatic tissue pH, venous oxygen saturation and hemoglobin by near infrared spectroscopy. Shock. 2001 Feb; 15(2):106-11.
  View in: PubMed
 
23. Puyana JC, Soller BR, Parikh B, Heard SO. Directly measured tissue pH is an earlier indicator of splanchnic acidosis than tonometric parameters during hemorrhagic shock in swine. Crit Care Med. 2000 Jul; 28(7):2557-62.
  View in: PubMed
 
24. Lancey RA, Soller BR, Vander Salm TJ. Off-pump versus on-pump coronary artery bypass surgery: a case-matched comparison of clinical outcomes and costs. Heart Surg Forum. 2000; 3(4):277-81.
  View in: PubMed
 
25. Puyana JC, Soller BR, Zhang S, Heard SO. Continuous measurement of gut pH with near-infrared spectroscopy during hemorrhagic shock. J Trauma. 1999 Jan; 46(1):9-15.
  View in: PubMed
 
26. Conlan AA, Hsi C, Soller BR, BelleIsle JM, Vander Salm TJ. Thoracoscopic lobectomy with endoarterial vascular control: an experimental study in swine. Ann Thorac Surg. 1998 Feb; 65(2):336-9.
  View in: PubMed
 
27. Shortt KG, Stahl RF, Soller BR, Parikh B. Diminished myocardial function precedes tissue acidosis during coronary hypoperfusion. Cardiology. 1997 Jan-Feb; 88(1):14-8.
  View in: PubMed
 
28. Shortt KG, Stahl RF, Soller BR, Belle Isle JM, Auerbach AH, Hsi CC. Hypothermic cardioplegic arrest is associated with increased myocardial adenosine. Cardiology. 1996 Nov-Dec; 87(6):516-23.
  View in: PubMed
 
29. Soller BR, Micheels RH, Coen J, Parikh B, Chu L, Hsi C. Feasibility of non-invasive measurement of tissue pH using near-infrared reflectance spectroscopy. J Clin Monit. 1996 Sep; 12(5):387-95.
  View in: PubMed
 
30. Rao PV, Stahl RF, Soller BR, Shortt KG, Hsi C, Cotter KJ, BelleIsle JM, Moran JM. Retrograde abdominal visceral perfusion: is it beneficial? Ann Thorac Surg. 1995 Dec; 60(6):1704-8.
  View in: PubMed
 
31. Stahl RF, Soller BR, Hsi C, BelleIsle J, Vander Salm TJ. Decreasing myocardial pH reflects ischemia during continuous warm retrograde cardioplegic arrest. Ann Thorac Surg. 1994 Dec; 58(6):1645-50.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Muscle, Skeletal
Oxygen
Spectroscopy, Near-Infrared
Hydrogen-Ion Concentration
Algorithms
See all (181) keywords
Co-Authors  
Heard, Stephen
Orquiola, Alan
Walz, Jens
See all (3) people
Physical Neighbors  
Aponte-Feliciano, Antonio
Zanconato, Rebecca
Breed, Richard
Spanakis, Spiro
Matheos, Theofilos

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