Graham F Barnard MD, PHD
Title Associate Professor
Institution University of Massachusetts Medical School
Department Medicine
Division Gastroenterology
Address University of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Telephone 508-856-3068
Email
Other Positions
Institution UMMS - School of Medicine
Department Biochemistry & Molecular Pharmacology

Institution UMMS - Graduate School of Biomedical Sciences
Department Biochemistry & Molecular Pharmacology

Institution UMMS - Programs, Centers and Institutes
Department Cancer Center
Publications
1. Yokobori T, Iinuma H, Shimamura T, Imoto S, Sugimachi K, Ishii H, Iwatsuki M, Ota D, Ohkuma M, Iwaya T, Nishida N, Kogo R, Sudo T, Tanaka F, Shibata K, Toh H, Sato T, Barnard GF, Fukagawa T, Yamamoto S, Nakanishi H, Sasaki S, Miyano S, Watanabe T, Kuwano H, Mimori K, Pantel K, Mori M. Plastin3 is a novel marker for circulating tumor cells undergoing the epithelial-mesenchymal transition and is associated with colorectal cancer prognosis. Cancer Res. 2013 Apr 1; 73(7):2059-69.
  View in: PubMed
 
2. Ishimaru S, Mimori K, Yamamoto K, Inoue H, Imoto S, Kawano S, Yamaguchi R, Sato T, Toh H, Iinuma H, Maeda T, Ishii H, Suzuki S, Tokudome S, Watanabe M, Tanaka J, Kudo SE, Sugihara K, Hase K, Mochizuki H, Kusunoki M, Yamada K, Shimada Y, Moriya Y, Barnard GF, Miyano S, Mori M. Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24. Ann Surg Oncol. 2012 Sep; 19(9):2853-8.
  View in: PubMed
 
3. Haraguchi N, Ishii H, Mimori K, Tanaka F, Ohkuma M, Kim HM, Akita H, Takiuchi D, Hatano H, Nagano H, Barnard GF, Doki Y, Mori M. CD13 is a therapeutic target in human liver cancer stem cells. J Clin Invest. 2010 Sep 1; 120(9):3326-39.
  View in: PubMed
 
4. Mimori K, Ishii H, Inoue H, Barnard GF, Mori M. Identification of the expression profile of apoptotic esophageal cancer cells by adenoviral-fragile histidine triad treatment. J Gastroenterol Hepatol. 2008 Dec; 23 Suppl 2:S205-9.
  View in: PubMed
 
5. Utsunomiya T, Okamoto M, Wakiyama S, Hashimoto M, Fukuzawa K, Ezaki T, Aishima S, Yoshikawa Y, Hanai T, Inoue H, Barnard GF, Mori M. A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease. World J Gastroenterol. 2007 Jan 21; 13(3):383-90.
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6. Eckardt AJ, Barnard GF. Endoscopic diagnosis and removal of Ascaris lumbricoides during colonoscopy for polyp surveillance (with video). Gastrointest Endosc. 2006 Apr; 63(4):708-9, discussion 709.
  View in: PubMed
 
7. Mimori K, Ishii H, Nagahara H, Sudo T, Yamashita K, Inoue H, Barnard GF, Mori M. FHIT is up-regulated by inflammatory stimuli and inhibits prostaglandin E2-mediated cancer progression. Cancer Res. 2006 Mar 1; 66(5):2683-90.
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8. Mimori K, Nagahara H, Sudo T, Ishii H, Yamashita K, Barnard GF, Mori M. The epidermal growth factor receptor gene sequence is highly conserved in primary gastric cancers. J Surg Oncol. 2006 Jan 1; 93(1):44-6.
  View in: PubMed
 
9. Haraguchi N, Utsunomiya T, Inoue H, Tanaka F, Mimori K, Barnard GF, Mori M. Characterization of a side population of cancer cells from human gastrointestinal system. Stem Cells. 2006 Mar; 24(3):506-13.
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10. Mimori K, Nagahara H, Barnard GF, Mori M. Epidermal growth factor receptor gene is highly conserved in pancreatic cancer cells. Pancreas. 2005 Oct; 31(3):299.
  View in: PubMed
 
11. Nagahara H, Mimori K, Utsunomiya T, Barnard GF, Ohira M, Hirakawa K, Mori M. Clinicopathologic and biological significance of kallikrein 6 overexpression in human gastric cancer. Clin Cancer Res. 2005 Oct 1; 11(19 Pt 1):6800-6.
  View in: PubMed
 
12. Inoue H, Shibuta K, Matsuyama A, Yoshinaga K, Sadanaga N, Ueo H, Barnard GF, Mori M. Genetic susceptibility of catechol-O-methyltransferase polymorphism in Japanese patients with breast cancer. Oncol Rep. 2005 Sep; 14(3):707-12.
  View in: PubMed
 
13. Do K, Barnard GF. Effect of concomitant polyethylene glycol and celecoxib on colonic aberrant crypt foci and tumors in F344 rats. Dig Dis Sci. 2005 Jul; 50(7):1304-11.
  View in: PubMed
 
14. Nagahara H, Mimori K, Ohta M, Utsunomiya T, Inoue H, Barnard GF, Ohira M, Hirakawa K, Mori M. Somatic mutations of epidermal growth factor receptor in colorectal carcinoma. Clin Cancer Res. 2005 Feb 15; 11(4):1368-71.
  View in: PubMed
 
15. Mimori K, Kataoka A, Yoshinaga K, Ohta M, Sagara Y, Yoshikawa Y, Ohno S, Barnard GF, Mori M. Identification of molecular markers for metastasis-related genes in primary breast cancer cells. Clin Exp Metastasis. 2005; 22(1):59-67.
  View in: PubMed
 
16. Mimori K, Yamashita K, Ohta M, Yoshinaga K, Ishikawa K, Ishii H, Utsunomiya T, Barnard GF, Inoue H, Mori M. Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells. Clin Cancer Res. 2004 Dec 15; 10(24):8243-9.
  View in: PubMed
 
17. Utsunomiya T, Okamoto M, Hashimoto M, Yoshinaga K, Shiraishi T, Tanaka F, Mimori K, Inoue H, Watanabe G, Barnard GF, Mori M. A gene-expression signature can quantify the degree of hepatic fibrosis in the rat. J Hepatol. 2004 Sep; 41(3):399-406.
  View in: PubMed
 
18. Zivny J, Banner BF, Agrawal S, Pihan G, Barnard GF. CD4+ T-cell lymphoproliferative disorder of the gut clinically mimicking celiac sprue. Dig Dis Sci. 2004 Apr; 49(4):551-5.
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19. Shibuta K, Mori M, Shimoda K, Inoue H, Mitra P, Barnard GF. Regional expression of CXCL12/CXCR4 in liver and hepatocellular carcinoma and cell-cycle variation during in vitro differentiation. Jpn J Cancer Res. 2002 Jul; 93(7):789-97.
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20. Shibuta J, Eto T, Kataoka A, Inoue H, Ueo H, Suzuki T, Barnard GF, Mori M. Genetic polymorphism of N-acetyltransferase 2 in patients with esophageal cancer. Am J Gastroenterol. 2001 Dec; 96(12):3419-24.
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21. Kataoka A, Sadanaga N, Mimori K, Ueo H, Barnard GF, Sugimachi K, Auclair D, Chen LB, Mori M. Overexpression of HRad17 mRNA in human breast cancer: correlation with lymph node metastasis. Clin Cancer Res. 2001 Sep; 7(9):2815-20.
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22. Matsuyama A, Inoue H, Shibuta K, Tanaka Y, Barnard GF, Sugimachi K, Mori M. Hepatoma-derived growth factor is associated with reduced sensitivity to irradiation in esophageal cancer. Cancer Res. 2001 Aug 1; 61(15):5714-7.
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23. Etoh T, Ueo H, Inoue H, Sato K, Utsunomiya T, Barnard GF, Kitano S, Mori M. Clinical significance of K-Ras mutations in intraoperative tumor drainage blood from patients with colorectal carcinoma. Ann Surg Oncol. 2001 Jun; 8(5):407-12.
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24. Inoue H, Mimori K, Utsunomiya T, Sadanaga N, Barnard GF, Ueo H, Mori M. Heparanase expression in clinical digestive malignancies. Oncol Rep. 2001 May-Jun; 8(3):539-42.
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25. Mitra P, De A, Ethier MF, Mimori K, Kodys K, Shibuta K, Mori M, Madison JM, Miller-Graziano C, Barnard GF. Loss of chemokine SDF-1alpha-mediated CXCR4 signalling and receptor internalization in human hepatoma cell line HepG2. Cell Signal. 2001 May; 13(5):311-9.
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26. Etoh T, Inoue H, Tanaka S, Barnard GF, Kitano S, Mori M. Angiopoietin-2 is related to tumor angiogenesis in gastric carcinoma: possible in vivo regulation via induction of proteases. Cancer Res. 2001 Mar 1; 61(5):2145-53.
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27. Mori M, Mimori K, Sadanaga N, Inoue H, Tanaka Y, Mafune K, Ueo H, Barnard GF. Prognostic impact of tissue inhibitor of matrix metalloproteinase-1 in esophageal carcinoma. Int J Cancer. 2000 Nov 15; 88(4):575-8.
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28. Katsuta T, Lim C, Shimoda K, Shibuta K, Mitra P, Banner BF, Mori M, Barnard GF. Interleukin-8 and SDF1-alpha mRNA expression in colonic biopsies from patients with inflammatory bowel disease. Am J Gastroenterol. 2000 Nov; 95(11):3157-64.
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29. Etoh T, Shibuta K, Barnard GF, Kitano S, Mori M. Angiogenin expression in human colorectal cancer: the role of focal macrophage infiltration. Clin Cancer Res. 2000 Sep; 6(9):3545-51.
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30. Inoue H, Mimori K, Shiraishi T, Kataoka A, Sadanaga N, Ueo H, Barnard GF, Mori M. Expression of tissue inhibitor of matrix metalloproteinase-1 in human breast carcinoma. Oncol Rep. 2000 Jul-Aug; 7(4):871-4.
  View in: PubMed
 
31. Etoh T, Inoue H, Yoshikawa Y, Barnard GF, Kitano S, Mori M. Increased expression of collagenase-3 (MMP-13) and MT1-MMP in oesophageal cancer is related to cancer aggressiveness. Gut. 2000 Jul; 47(1):50-6.
  View in: PubMed
 
32. Kataoka A, Mori M, Sadanaga N, Ueo H, Tsuji K, Rai Y, Barnard GF, Sugimachi K. RT-PCR detection of breast cancer cells in sentinel lymph modes. Int J Oncol. 2000 Jun; 16(6):1147-52.
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33. Tanaka Y, Mimori K, Shiraishi T, Ohkura Y, Takubo K, Mafune K, Barnard GF, Mori M. alpha6 integrin expression in esophageal carcinoma. Int J Oncol. 2000 Apr; 16(4):725-9.
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34. Shibuta K, Inoue H, Sato K, Matsuyama A, Ueo H, Tanaka Y, Mafune K, Barnard GF, Mori M. L-myc restriction fragment length polymorphism in Japanese patients with esophageal cancer. Jpn J Cancer Res. 2000 Feb; 91(2):199-203.
  View in: PubMed
 
35. Mathai J, Shimoda K, Banner BF, Mori M, Bonkovsky HL, Barnard GF. IFN-alpha receptor mRNA expression in a United States sample with predominantly genotype 1a/I chronic hepatitis C liver biopsies correlates with response to IFN therapy. J Interferon Cytokine Res. 1999 Sep; 19(9):1011-8.
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36. Mitra P, Shibuta K, Mathai J, Shimoda K, Banner BF, Mori M, Barnard GF. CXCR4 mRNA expression in colon, esophageal and gastric cancers and hepatitis C infected liver. Int J Oncol. 1999 May; 14(5):917-25.
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37. Begum NA, Shibuta K, Mori M, Barnard GF. Reduced expression of the CXCR4 receptor mRNA in hepatocellular carcinoma and lack of inducibility of its ligand alpha-chemokine hIRH/SDF1alpha/PBSF in vitro. Int J Oncol. 1999 May; 14(5):927-34.
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38. Shimoda K, Mori M, Shibuta K, Banner BF, Barnard GF. Vascular endothelial growth factor/vascular permeability factor mRNA expression in patients with chronic hepatitis C and hepatocellular carcinoma. Int J Oncol. 1999 Feb; 14(2):353-9.
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39. Mori M, Shiraishi T, Tanaka S, Yamagata M, Mafune K, Tanaka Y, Ueo H, Barnard GF, Sugimachi K. Lack of DMBT1 expression in oesophageal, gastric and colon cancers. Br J Cancer. 1999 Jan; 79(2):211-3.
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40. Shimoda K, Begum NA, Shibuta K, Mori M, Bonkovsky HL, Banner BF, Barnard GF. Interleukin-8 and hIRH (SDF1-alpha/PBSF) mRNA expression and histological activity index in patients with chronic hepatitis C. Hepatology. 1998 Jul; 28(1):108-15.
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41. Mori M, Mimori K, Shiraishi T, Haraguchi M, Ueo H, Barnard GF, Akiyoshi T. Motility related protein 1 (MRP1/CD9) expression in colon cancer. Clin Cancer Res. 1998 Jun; 4(6):1507-10.
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42. Yamagata M, Mori M, Begum NA, Shibuta K, Shimoda K, Barnard GF. Glyceraldehyde-3-phosphate dehydrogenase mRNA expression in hepatocellular carcinoma. Int J Oncol. 1998 Mar; 12(3):677-83.
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43. Bonkovsky HL, Barnard GF. Diagnosis of porphyric syndromes: a practical approach in the era of molecular biology. Semin Liver Dis. 1998; 18(1):57-65.
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44. Mori M, Mimori K, Ueo H, Tsuji K, Shiraishi T, Barnard GF, Sugimachi K, Akiyoshi T. Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcription-polymerase chain reaction in patients with gastrointestinal or breast carcinomas. J Clin Oncol. 1998 Jan; 16(1):128-32.
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45. Shibuta K, Begum NA, Mori M, Shimoda K, Akiyoshi T, Barnard GF. Reduced expression of the CXC chemokine hIRH/SDF-1alpha mRNA in hepatoma and digestive tract cancer. Int J Cancer. 1997 Nov 27; 73(5):656-62.
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46. Cai YC, Barnard G, Hiestand L, Woda B, Colby J, Banner B. Florid angiogenesis in mucosa surrounding an ileal carcinoid tumor expressing transforming growth factor-alpha. Am J Surg Pathol. 1997 Nov; 21(11):1373-7.
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47. Mimori K, Mori M, Begum N, Tanaka S, Haraguchi M, Ueo H, Karimine N, Akiyoshi T, Barnard G. Clinical significance of integrin alpha 6 mRNA expression in gastric carcinoma. Int J Oncol. 1997 Nov; 11(5):959-64.
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48. Barnard GF, Mori M. Quantitation of liver RNA. Hepatology. 1997 Sep; 26(3):803.
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49. Banner BF, Allan C, Savas L, Baker S, Barnard G, Bonkovsky HL. Inflammatory markers in chronic hepatitis C. Virchows Arch. 1997 Sep; 431(3):181-7.
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50. Smith GS, Barnard GF. Massive volume paracentesis (up to 41 liters) for the outpatient management of ascites. J Clin Gastroenterol. 1997 Jul; 25(1):402-3.
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51. Kalman DR, Banner BF, Barnard GF. Rectal Dieulafoy's or angiodysplasia? Gastrointest Endosc. 1997 Jul; 46(1):91-2.
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52. Begum NA, Coker A, Shibuta K, Swanson RS, Chen LB, Mori M, Barnard GF. Loss of hIRH mRNA expression from premalignant adenomas and malignant cell lines. Biochem Biophys Res Commun. 1996 Dec 24; 229(3):864-8.
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53. Mori M, Mimori K, Ueo H, Karimine N, Barnard GF, Sugimachi K, Akiyoshi T. Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease. Int J Cancer. 1996 Dec 11; 68(6):739-43.
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54. Mori M, Inoue H, Shiraishi T, Mimori K, Shibuta K, Nakashima H, Mafune K, Tanaka Y, Ueo H, Barnard GF, Sugimachi K, Akiyoshi T. Relaxation of insulin-like growth factor 2 gene imprinting in esophageal cancer. Int J Cancer. 1996 Nov 15; 68(4):441-6.
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55. Mori M, Inoue H, Mimori K, Shibuta K, Baba K, Nakashima H, Haraguchi M, Tsuji K, Ueo H, Barnard GF, Akiyoshi T. Expression of MAGE genes in human colorectal carcinoma. Ann Surg. 1996 Aug; 224(2):183-8.
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56. Barnard GF, Cyrus D, Banner BF. Dysplasia and carcinoma in small colorectal polyps. Am J Gastroenterol. 1996 Mar; 91(3):618-9.
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57. Barnard GF, Mori M, Staniunas RJ, Begum NA, Bao S, Puder M, Cobb J, Redman KL, Steele GD, Chen LB. Ubiquitin fusion proteins are overexpressed in colon cancer but not in gastric cancer. Biochim Biophys Acta. 1995 Dec 12; 1272(3):147-53.
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58. Begum NA, Mori M, Matsumata T, Takenaka K, Sugimachi K, Barnard GF. Differential display and integrin alpha 6 messenger RNA overexpression in hepatocellular carcinoma. Hepatology. 1995 Nov; 22(5):1447-55.
  View in: PubMed
 
59. Mori M, Mimori K, Inoue H, Barnard GF, Tsuji K, Nanbara S, Ueo H, Akiyoshi T. Detection of cancer micrometastases in lymph nodes by reverse transcriptase-polymerase chain reaction. Cancer Res. 1995 Aug 1; 55(15):3417-20.
  View in: PubMed
 
60. Li J, Mori M, Yang Y, Inoue H, Mimori K, Shibuta K, Nakashima H, Mafune K, Shimada Y, Barnard G, Sugimachi K, Akiyoshi T. Multiple tumor-suppressor-1 gene and esophageal-carcinoma. Int J Oncol. 1995 Aug; 7(2):257-60.
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61. Kalman DR, Barnard GF, Massimi GJ, Swanson RS. Primary aortoduodenal fistula after radiotherapy. Am J Gastroenterol. 1995 Jul; 90(7):1148-50.
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62. Mori M, Barnard GF, Mimori K, Ueo H, Akiyoshi T, Sugimachi K. Overexpression of matrix metalloproteinase-7 mRNA in human colon carcinomas. Cancer. 1995 Mar 15; 75(6 Suppl):1516-9.
  View in: PubMed
 
63. Barnard GF, Colby JM, Saltzman JR, Krims PE, Li L, Banner BF. Endoscopic ultrasound appearance of watermelon stomach. Abdom Imaging. 1995 Jan-Feb; 20(1):26-8.
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64. Barnard GF, Scharf MJ, Dagher RK. Sulfone syndrome in a patient receiving steroids for pemphigus. Am J Gastroenterol. 1994 Nov; 89(11):2057-9.
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65. Barnard GF, Jafri IH, Banner BF, Bonkovsky HL. Colonic mucosal appearance of Tangier disease in a new patient. Gastrointest Endosc. 1994 Sep-Oct; 40(5):628-30.
  View in: PubMed
 
66. Barnard GF, Staniunas RJ, Puder M, Steele GD, Chen LB. Human ribosomal protein L37 has motifs predicting serine/threonine phosphorylation and a zinc-finger domain. Biochim Biophys Acta. 1994 Aug 2; 1218(3):425-8.
  View in: PubMed
 
67. Barnard GF, Puder M, Begum NA, Chen LB. PCR product sequencing with [alpha-33P] and [alpha-32P]dATP. Biotechniques. 1994 Apr; 16(4):572-3.
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68. Barnard GF, Banner BF. T- and B-cell markers in colonic nodular lymphoid hyperplasia in HIV infection. Am J Gastroenterol. 1993 Dec; 88(12):2144-5.
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69. Puder M, Barnard GF, Staniunas RJ, Steele GD, Chen LB. Nucleotide and deduced amino acid sequence of human ribosomal protein L18. Biochim Biophys Acta. 1993 Oct 19; 1216(1):134-6.
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70. Mori M, Barnard GF, Staniunas RJ, Jessup JM, Steele GD, Chen LB. Prothymosin-alpha mRNA expression correlates with that of c-myc in human colon cancer. Oncogene. 1993 Oct; 8(10):2821-6.
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71. Barnard GF, Staniunas RJ, Mori M, Puder M, Jessup MJ, Steele GD, Chen LB. Gastric and hepatocellular carcinomas do not overexpress the same ribosomal protein messenger RNAs as colonic carcinoma. Cancer Res. 1993 Sep 1; 53(17):4048-52.
  View in: PubMed
 
72. Mori M, Staniunas RJ, Barnard GF, Jessup JM, Steele GD, Chen LB. The significance of carbonic anhydrase expression in human colorectal cancer. Gastroenterology. 1993 Sep; 105(3):820-6.
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73. Barnard GF, Staniunas RJ, Bao S, Mafune K, Steele GD, Gollan JL, Chen LB. Increased expression of human ribosomal phosphoprotein P0 messenger RNA in hepatocellular carcinoma and colon carcinoma. Cancer Res. 1992 Jun 1; 52(11):3067-72.
  View in: PubMed
 
74. Barnard GF, Erickson SK, Nagata Y, Cooper AD. Reduced binding and removal of chylomicron remnants by ethionine-induced premalignant liver. Hepatology. 1989 May; 9(5):731-9.
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75. Barnard GF, Erickson SK, Cooper AD. Lipoprotein metabolism by rat hepatomas. Studies on the etiology of defective dietary feedback inhibition of cholesterol synthesis. J Clin Invest. 1984 Jul; 74(1):173-84.
  View in: PubMed
 
76. Barnard GF, Langton B, Popják G. Pseudo-isoenzyme forms of liver prenyl transferase. Biochem Biophys Res Commun. 1978 Dec 14; 85(3):1097-103.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Liver Neoplasms
Carcinoma, Hepatocellular
Chemokines, CXC
RNA, Messenger
Colonic Neoplasms
See all (370) keywords
Co-Authors  
Madison, John
Scharf, Mark
Swanson, Richard
Woda, Bruce
Zivny, Jaroslav
See all (5) people
Physical Neighbors  
Basil, Anjali
Donahue, Daniel
Zivny, Jaroslav
Zawacki, John
Levey, John

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