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1.
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Cheng SY, Leonard JL, Davis PJ. Molecular aspects of thyroid hormone actions. Endocr Rev. 2010 Apr; 31(2):139-70.
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2.
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Farwell AP, Leonard JL. Effect of methyl iodide on deiodinase activity. Inhal Toxicol. 2009 May; 21(6):497-504.
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3.
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Leonard JL. Non-genomic actions of thyroid hormone in brain development. Steroids. 2008 Oct; 73(9-10):1008-12.
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4.
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Davis PJ, Leonard JL, Davis FB. Mechanisms of nongenomic actions of thyroid hormone. Front Neuroendocrinol. 2008 May; 29(2):211-8.
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5.
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Simpson GI, Leonard DM, Leonard JL. Identification of the key residues responsible for the assembly of selenodeiodinases. J Biol Chem. 2006 May 26; 281(21):14615-21.
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6.
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Farwell AP, Dubord-Tomasetti SA, Pietrzykowski AZ, Leonard JL. Dynamic nongenomic actions of thyroid hormone in the developing rat brain. Endocrinology. 2006 May; 147(5):2567-74.
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7.
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Alkemade A, Friesema EC, Unmehopa UA, Fabriek BO, Kuiper GG, Leonard JL, Wiersinga WM, Swaab DF, Visser TJ, Fliers E. Neuroanatomical pathways for thyroid hormone feedback in the human hypothalamus. J Clin Endocrinol Metab. 2005 Jul; 90(7):4322-34.
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8.
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Leonard JL, Simpson G, Leonard DM. Characterization of the protein dimerization domain responsible for assembly of functional selenodeiodinases. J Biol Chem. 2005 Mar 25; 280(12):11093-100.
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9.
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Farwell AP, Dubord-Tomasetti SA, Pietrzykowski AZ, Stachelek SJ, Leonard JL. Regulation of cerebellar neuronal migration and neurite outgrowth by thyroxine and 3,3',5'-triiodothyronine. Brain Res Dev Brain Res. 2005 Jan 1; 154(1):121-35.
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10.
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Dobson JG, Fray J, Leonard JL, Pratt RE. Molecular mechanisms of reduced beta-adrenergic signaling in the aged heart as revealed by genomic profiling. Physiol Genomics. 2003 Oct 17; 15(2):142-7.
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11.
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Diano S, Leonard JL, Meli R, Esposito E, Schiavo L. Hypothalamic type II iodothyronine deiodinase: a light and electron microscopic study. Brain Res. 2003 Jun 20; 976(1):130-4.
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12.
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Verhoelst CH, Vandenborne K, Severi T, Bakker O, Zandieh Doulabi B, Leonard JL, Kühn ER, van der Geyten S, Darras VM. Specific detection of type III iodothyronine deiodinase protein in chicken cerebellar purkinje cells. Endocrinology. 2002 Jul; 143(7):2700-7.
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13.
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Stachelek SJ, Tuft RA, Lifschitz LM, Leonard DM, Farwell AP, Leonard JL. Real-time visualization of processive myosin 5a-mediated vesicle movement in living astrocytes. J Biol Chem. 2001 Sep 21; 276(38):35652-9.
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14.
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Vacanti MP, Leonard JL, Dore B, Bonassar LJ, Cao Y, Stachelek SJ, Vacanti JP, O'Connell F, Yu CS, Farwell AP, Vacanti CA. Tissue-engineered spinal cord. Transplant Proc. 2001 Feb-Mar; 33(1-2):592-8.
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15.
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Leonard JL, Visser TJ, Leonard DM. Characterization of the subunit structure of the catalytically active type I iodothyronine deiodinase. J Biol Chem. 2001 Jan 26; 276(4):2600-7.
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16.
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Stachelek SJ, Kowalik TF, Farwell AP, Leonard JL. Myosin V plays an essential role in the thyroid hormone-dependent endocytosis of type II iodothyronine 5'-deiodinase. J Biol Chem. 2000 Oct 13; 275(41):31701-7.
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17.
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Leonard DM, Stachelek SJ, Safran M, Farwell AP, Kowalik TF, Leonard JL. Cloning, expression, and functional characterization of the substrate binding subunit of rat type II iodothyronine 5'-deiodinase. J Biol Chem. 2000 Aug 18; 275(33):25194-201.
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18.
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Dowling AL, Martz GU, Leonard JL, Zoeller RT. Acute changes in maternal thyroid hormone induce rapid and transient changes in gene expression in fetal rat brain. J Neurosci. 2000 Mar 15; 20(6):2255-65.
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19.
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Sanders JP, Van der Geyten S, Kaptein E, Darras VM, Kühn ER, Leonard JL, Visser TJ. Cloning and characterization of type III iodothyronine deiodinase from the fish Oreochromis niloticus. Endocrinology. 1999 Aug; 140(8):3666-73.
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20.
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Leonard JL, Leonard DM, Safran M, Wu R, Zapp ML, Farwell AP. The mammalian homolog of the frog type II selenodeiodinase does not encode a functional enzyme in the rat. Endocrinology. 1999 May; 140(5):2206-15.
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21.
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Shen Q, Wu R, Leonard JL, Newburger PE. Identification and molecular cloning of a human selenocysteine insertion sequence-binding protein. A bifunctional role for DNA-binding protein B. J Biol Chem. 1998 Mar 6; 273(10):5443-6.
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22.
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Van der Geyten S, Sanders JP, Kaptein E, Darras VM, Kühn ER, Leonard JL, Visser TJ. Expression of chicken hepatic type I and type III iodothyronine deiodinases during embryonic development. Endocrinology. 1997 Dec; 138(12):5144-52.
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23.
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Sanders JP, Van der Geyten S, Kaptein E, Darras VM, Kühn ER, Leonard JL, Visser TJ. Characterization of a propylthiouracil-insensitive type I iodothyronine deiodinase. Endocrinology. 1997 Dec; 138(12):5153-60.
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24.
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Leonard JL, Farwell AP. Thyroid hormone-regulated actin polymerization in brain. Thyroid. 1997 Feb; 7(1):147-51.
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25.
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Safran M, Farwell AP, Leonard JL. Catalytic activity of type II iodothyronine 5'-deiodinase polypeptide is dependent upon a cyclic AMP activation factor. J Biol Chem. 1996 Jul 5; 271(27):16363-8.
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26.
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Farwell AP, Safran M, Dubord S, Leonard JL. Degradation and recycling of the substrate-binding subunit of type II iodothyronine 5'-deiodinase in astrocytes. J Biol Chem. 1996 Jul 5; 271(27):16369-74.
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27.
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Leonard JL, Leonard DM, Shen Q, Farwell AP, Newburger PE. Selenium-regulated translation control of heterologous gene expression: normal function of selenocysteine-substituted gene products. J Cell Biochem. 1996 Jun 1; 61(3):410-9.
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28.
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Farwell AP, Tranter MP, Leonard JL. Thyroxine-dependent regulation of integrin-laminin interactions in astrocytes. Endocrinology. 1995 Sep; 136(9):3909-15.
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29.
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Shen Q, Leonard JL, Newburger PE. Structure and function of the selenium translation element in the 3'-untranslated region of human cellular glutathione peroxidase mRNA. RNA. 1995 Jul; 1(5):519-25.
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30.
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Leonard JL, Farwell AP, Yen PM, Chin WW, Stula M. Differential expression of thyroid hormone receptor isoforms in neurons and astroglial cells. Endocrinology. 1994 Aug; 135(2):548-55.
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31.
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Bick T, Frick GP, Leonard D, Leonard JL, Goodman HM. Overexpression of the short form of the growth hormone receptor in 3T3-L1 mouse preadipocytes. Proc Soc Exp Biol Med. 1994 Jul; 206(3):185-9.
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32.
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Heard SO, Toth IE, Perkins MW, Leonard JL. The role of protein kinase C in lipopolysaccharide-induced myocardial depression in guinea pigs. Shock. 1994 Jun; 1(6):419-24.
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33.
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Chanoine JP, Veronikis I, Alex S, Stone S, Fang SL, Leonard JL, Braverman LE. The postnatal serum 3,5,3'-triiodothyronine (T3) surge in the rat is largely independent of extrathyroidal 5'-deiodination of thyroxine to T3. Endocrinology. 1993 Dec; 133(6):2604-9.
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34.
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Chanoine JP, Alex S, Stone S, Fang SL, Veronikis I, Leonard JL, Braverman LE. Placental 5-deiodinase activity and fetal thyroid hormone economy are unaffected by selenium deficiency in the rat. Pediatr Res. 1993 Sep; 34(3):288-92.
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35.
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Safran M, Farwell AP, Rokos H, Leonard JL. Structural requirements of iodothyronines for the rapid inactivation and internalization of type II iodothyronine 5'-deiodinase in glial cells. J Biol Chem. 1993 Jul 5; 268(19):14224-9.
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36.
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Chanoine JP, Braverman LE, Farwell AP, Safran M, Alex S, Dubord S, Leonard JL. The thyroid gland is a major source of circulating T3 in the rat. J Clin Invest. 1993 Jun; 91(6):2709-13.
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37.
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Farwell AP, DiBenedetto DJ, Leonard JL. Thyroxine targets different pathways of internalization of type II iodothyronine 5'-deiodinase in astrocytes. J Biol Chem. 1993 Mar 5; 268(7):5055-62.
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38.
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Safran M, Farwell AP, Leonard JL. Thyroid hormone-dependent redistribution of the 55-kilodalton monomer of protein disulfide isomerase in cultured glial cells. Endocrinology. 1992 Nov; 131(5):2413-8.
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39.
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Chanoine JP, Safran M, Farwell AP, Dubord S, Alex S, Stone S, Arthur JR, Braverman LE, Leonard JL. Effects of selenium deficiency on thyroid hormone economy in rats. Endocrinology. 1992 Oct; 131(4):1787-92.
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40.
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Farwell AP, Leonard JL. Dissociation of actin polymerization and enzyme inactivation in the hormonal regulation of type II iodothyronine 5'-deiodinase activity in astrocytes. Endocrinology. 1992 Aug; 131(2):721-8.
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41.
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Chanoine JP, Alex S, Fang SL, Stone S, Leonard JL, Körhle J, Braverman LE. Role of transthyretin in the transport of thyroxine from the blood to the choroid plexus, the cerebrospinal fluid, and the brain. Endocrinology. 1992 Feb; 130(2):933-8.
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42.
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Leonard JL. Regulation of T3 production in the brain. Acta Med Austriaca. 1992; 19 Suppl 1:5-8.
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43.
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Safran M, Leonard JL. Characterization of a N-bromoacetyl-L-thyroxine affinity-labeled 55-kilodalton protein as protein disulfide isomerase in cultured glial cells. Endocrinology. 1991 Oct; 129(4):2011-6.
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44.
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Abend SL, Fang SL, Alex S, Braverman LE, Leonard JL. Rapid alteration in circulating free thyroxine modulates pituitary type II 5' deiodinase and basal thyrotropin secretion in the rat. J Clin Invest. 1991 Sep; 88(3):898-903.
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45.
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Safran M, Farwell AP, Leonard JL. Evidence that type II 5'-deiodinase is not a selenoprotein. J Biol Chem. 1991 Jul 25; 266(21):13477-80.
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46.
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Leonard JL, Ekenbarger DM, Frank SJ, Farwell AP, Koehrle J. Localization of type I iodothyronine 5'-deiodinase to the basolateral plasma membrane in renal cortical epithelial cells. J Biol Chem. 1991 Jun 15; 266(17):11262-9.
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47.
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Safran M, Leonard JL. Comparison of the physicochemical properties of type I and type II iodothyronine 5'-deiodinase. J Biol Chem. 1991 Feb 15; 266(5):3233-8.
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48.
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Farwell AP, Lynch RM, Okulicz WC, Comi AM, Leonard JL. The actin cytoskeleton mediates the hormonally regulated translocation of type II iodothyronine 5'-deiodinase in astrocytes. J Biol Chem. 1990 Oct 25; 265(30):18546-53.
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49.
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Frick GP, Leonard JL, Goodman HM. Effect of hypophysectomy on growth hormone receptor gene expression in rat tissues. Endocrinology. 1990 Jun; 126(6):3076-82.
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50.
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Köhrle J, Rasmussen UB, Ekenbarger DM, Alex S, Rokos H, Hesch RD, Leonard JL. Affinity labeling of rat liver and kidney type I 5'-deiodinase. Identification of the 27-kDa substrate binding subunit. J Biol Chem. 1990 Apr 15; 265(11):6155-63.
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51.
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Köhrle J, Rasmussen UB, Rokos H, Leonard JL, Hesch RD. Selective affinity labeling of a 27-kDa integral membrane protein in rat liver and kidney with N-bromoacetyl derivatives of L-thyroxine and 3,5,3'-triiodo-L-thyronine. J Biol Chem. 1990 Apr 15; 265(11):6146-54.
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52.
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Siegrist-Kaiser CA, Juge-Aubry C, Tranter MP, Ekenbarger DM, Leonard JL. Thyroxine-dependent modulation of actin polymerization in cultured astrocytes. A novel, extranuclear action of thyroid hormone. J Biol Chem. 1990 Mar 25; 265(9):5296-302.
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53.
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Safran M, Köhrle J, Braverman LE, Leonard JL. Effect of biological alterations of type I 5'deiodinase activity on affinity labeled membrane proteins in rat liver and kidney. Endocrinology. 1990 Feb; 126(2):826-31.
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54.
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Leonard JL, Siegrist-Kaiser CA, Zuckerman CJ. Regulation of type II iodothyronine 5'-deiodinase by thyroid hormone. Inhibition of actin polymerization blocks enzyme inactivation in cAMP-stimulated glial cells. J Biol Chem. 1990 Jan 15; 265(2):940-6.
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55.
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Farwell AP, Leonard JL. Identification of a 27-kDa protein with the properties of type II iodothyronine 5'-deiodinase in dibutyryl cyclic AMP-stimulated glial cells. J Biol Chem. 1989 Dec 5; 264(34):20561-7.
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56.
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Leonard JL. Dibutyryl cAMP induction of type II 5'deiodinase activity in rat brain astrocytes in culture. Biochem Biophys Res Commun. 1988 Mar 30; 151(3):1164-72.
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57.
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Kolodny JM, Leonard JL, Larsen PR, Silva JE. Studies of nuclear 3,5,3'-triiodothyronine binding in primary cultures of rat brain. Endocrinology. 1985 Nov; 117(5):1848-57.
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58.
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Watson AY, Leonard JL, Radie KA, Mellen SA, Murphy RA. Alterations in the pituitary-thyroid axis and 5'-deiodinase activity in mice with muscular dystrophy. Endocrinology. 1985 Jun; 116(6):2201-8.
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59.
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Silva JE, Leonard JL. Regulation of rat cerebrocortical and adenohypophyseal type II 5'-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine. Endocrinology. 1985 Apr; 116(4):1627-35.
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60.
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Leonard JL, Larsen PR. Thyroid hormone metabolism in primary cultures of fetal rat brain cells. Brain Res. 1985 Feb 18; 327(1-2):1-13.
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61.
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Koenig RJ, Leonard JL, Senator D, Rappaport N, Watson AY, Larsen PR. Regulation of thyroxine 5'-deiodinase activity by 3,5,3'-triiodothyronine in cultured rat anterior pituitary cells. Endocrinology. 1984 Jul; 115(1):324-9.
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62.
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Leonard JL, Visser TJ. Selective modification of the active center of renal iodothyronine 5'-deiodinase by iodoacetate. Biochim Biophys Acta. 1984 Jun 14; 787(2):122-30.
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63.
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Silva JE, Gordon MB, Crantz FR, Leonard JL, Larsen PR. Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest. 1984 Apr; 73(4):898-907.
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64.
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Leonard JL, Silva JE, Kaplan MM, Mellen SA, Visser TJ, Larsen PR. Acute posttranscriptional regulation of cerebrocortical and pituitary iodothyronine 5'-deiodinases by thyroid hormone. Endocrinology. 1984 Mar; 114(3):998-1004.
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65.
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Visser TJ, Frank S, Leonard JL. Differential sensitivity of brain iodothyronine 5'-deiodinases to sulfhydryl-blocking reagents. Mol Cell Endocrinol. 1983 Dec; 33(2-3):321-7.
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66.
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Visser TJ, Kaplan MM, Leonard JL, Larsen PR. Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest. 1983 Apr; 71(4):992-1002.
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67.
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Leonard JL, Mellen SA, Larsen PR. Thyroxine 5'-deiodinase activity in brown adipose tissue. Endocrinology. 1983 Mar; 112(3):1153-5.
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68.
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Kaplan MM, Visser TJ, Yaskoski KA, Leonard JL. Characteristics of iodothyronine tyrosyl ring deiodination by rat cerebral cortical microsomes. Endocrinology. 1983 Jan; 112(1):35-42.
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69.
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Leonard JL, Rennke H, Kaplan MM, Larsen PR. Subcellular distribution of iodothyronine 5'-deiodinase in cerebral cortex from hypothyroid rats. Biochim Biophys Acta. 1982 Sep 17; 718(1):109-19.
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70.
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Visser TJ, Leonard JL, Kaplan MM, Larsen PR. Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex. Proc Natl Acad Sci U S A. 1982 Aug; 79(16):5080-4.
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71.
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Silva JE, Leonard JL, Crantz FR, Larsen PR. Evidence for two tissue-specific pathways for in vivo thyroxine 5'-deiodination in the rat. J Clin Invest. 1982 May; 69(5):1176-84.
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72.
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Goswami A, Leonard JL, Rosenberg IN. Inhibition by coumadin anticoagulants of enzymatic outer ring monodeiodination of iodothyronines. Biochem Biophys Res Commun. 1982 Feb 26; 104(4):1231-8.
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73.
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Leonard JL, Kaplan MM, Visser TJ, Silva JE, Larsen PR. Cerebral cortex responds rapidly to thyroid hormones. Science. 1981 Oct 30; 214(4520):571-3.
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74.
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Visser TJ, Leonard JL, Kaplan MM, Larsen PR. Different pathways of iodothyronine 5'-deiodination in rat cerebral cortex. Biochem Biophys Res Commun. 1981 Aug 31; 101(4):1297-304.
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75.
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Kaplan MM, McCann UD, Yaskoski KA, Larsen PR, Leonard JL. Anatomical distribution of phenolic and tyrosyl ring iodothyronine deiodinases in the nervous system of normal and hypothyroid rats. Endocrinology. 1981 Aug; 109(2):397-402.
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76.
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Leonard JL, Rosenberg IN. Solubilization of a phospholipid-requiring enzyme, iodothyronine 5'-deiodinase, from rat kidney membranes. Biochim Biophys Acta. 1981 May 14; 659(1):205-18.
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77.
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Leonard JL, Rosenberg IN. Iodothyronine 5'-deiodinase from rat kidney: substrate specificity and the 5'-deiodination of reverse triiodothyronine. Endocrinology. 1980 Nov; 107(5):1376-83.
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78.
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Leonard JL, Rosenberg IN. Characterization of essential enzyme sulfhydryl groups of thyroxine 5'-deiodinase from rat kidney. Endocrinology. 1980 Feb; 106(2):444-51.
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79.
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Leonard JL, Rosenberg IN. Thyroxine 5'-deiodinase activity of rat kidney: observations on activation by thiols and inhibition by propylthiouracil. Endocrinology. 1978 Dec; 103(6):2137-44.
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80.
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Leonard JL, Rosenberg IN. Subcellular distribution of thyroxine 5'-deiodinase in the rat kidney: a plasma membrane location. Endocrinology. 1978 Jul; 103(1):274-80.
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81.
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Leonard JL, Rosenberg LL. Studies on a cyclic AMP-dependent protein kinase from rat thyroid gland. Biochim Biophys Acta. 1977 Oct 13; 484(2):336-47.
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