Katherine Ruiz De Luzuriaga MD
Title Professor
Institution University of Massachusetts Medical School
Department Pediatrics
Division Pediatric Immunology & Infectious Diseases
Address University of Massachusetts Medical School
373 Plantation Street
Worcester MA 01605
Telephone 508-856-6282
Email
Other Positions
Institution UMMS - School of Medicine
Department Medicine
Division Infectious Diseases And Immunology

Institution UMMS - Graduate School of Biomedical Sciences
Department Clinical Population Health Research

Institution UMMS - Graduate School of Biomedical Sciences
Department Immunology & Virology

Institution UMMS - Graduate School of Biomedical Sciences
Department Interdisciplinary Graduate Program

Institution UMMS - Graduate School of Biomedical Sciences
Department Masters in Clinical Investigation

Institution UMMS - Graduate School of Biomedical Sciences
Department MD/PhD Program

Institution UMMS - Programs, Centers and Institutes
Department Center for AIDS Research

Institution UMMS - Programs, Centers and Institutes
Department Office of Global Health
Narrative

Academic Background

S.B., S.M. - Massachusetts Institute of Technology

M.D. (1984) Tufts University

Professor,
Department of Pediatrics and Program in Molecular Medicine

 

Virus-Host Dynamics in Persistent Viral Infections

Dr. Luzuriaga

Research in my laboratory is focused on the viral and immunopathogenesis of persistent viral infections in humans, including human immunodeficiency virus (HIV), Epstein Barr virus (EBV), and cytomegalovirus (CMV). Ongoing studies are focused on: 1) examining the relationship between viral replication/viral gene expression and the development of the antiviral CD4+ and CD8+ T cell repertoires from acute through chronic infection; 2) characterization of the ontogeny of cell-mediated immune responses to viral infections in infants and children; and 3) the development of prophylactic and therapeutic vaccine strategies for HIV.

Publications
1. Tracy SI, Kakalacheva K, Lünemann JD, Luzuriaga K, Middeldorp J, Thorley-Lawson DA. Persistence of epstein-barr virus in self-reactive memory B cells. J Virol. 2012 Nov; 86(22):12330-40.
  View in: PubMed
 
2. Kishko M, Somasundaran M, Brewster F, Sullivan JL, Clapham PR, Luzuriaga K. Genotypic and functional properties of early infant HIV-1 envelopes. Retrovirology. 2011; 8:67.
  View in: PubMed
 
3. Clute SC, Naumov YN, Watkin LB, Aslan N, Sullivan JL, Thorley-Lawson DA, Luzuriaga K, Welsh RM, Puzone R, Celada F, Selin LK. Broad cross-reactive TCR repertoires recognizing dissimilar epstein-barr and influenza A virus epitopes. J Immunol. 2010 Dec 1; 185(11):6753-64.
  View in: PubMed
 
4. Greenough TC, Campellone SC, Brody R, Jain S, Sanchez-Merino V, Somasundaran M, Luzuriaga K. Programmed Death-1 expression on Epstein Barr virus specific CD8+ T cells varies by stage of infection, epitope specificity, and T-cell receptor usage. PLoS One. 2010; 5(9):e12926.
  View in: PubMed
 
5. Luzuriaga K, Sullivan JL. Infectious mononucleosis. N Engl J Med. 2010 May 27; 362(21):1993-2000.
  View in: PubMed
 
6. Mehta N, Cunningham CK, Flynn P, Pepe J, Obaro S, Kapogiannis BG, Bethel J, Luzuriaga K. Impaired generation of hepatitis B virus-specific memory B cells in HIV infected individuals following vaccination. Vaccine. 2010 May 7; 28(21):3672-8.
  View in: PubMed
 
7. Shiu C, Cunningham CK, Greenough T, Muresan P, Sanchez-Merino V, Carey V, Jackson JB, Ziemniak C, Fox L, Belzer M, Ray SC, Luzuriaga K, Persaud D. Identification of ongoing human immunodeficiency virus type 1 (HIV-1) replication in residual viremia during recombinant HIV-1 poxvirus immunizations in patients with clinically undetectable viral loads on durable suppressive highly active antiretroviral therapy. J Virol. 2009 Oct; 83(19):9731-42.
  View in: PubMed
 
8. Mehta N, Trzmielina S, Nonyane BA, Eliot MN, Lin R, Foulkes AS, McNeal K, Ammann A, Eulalievyolo V, Sullivan JL, Luzuriaga K, Somasundaran M. Low-cost HIV-1 diagnosis and quantification in dried blood spots by real time PCR. PLoS One. 2009; 4(6):e5819.
  View in: PubMed
 
9. Sanchez-Merino V, Farrow MA, Brewster F, Somasundaran M, Luzuriaga K. Identification and characterization of HIV-1 CD8+ T cell escape variants with impaired fitness. J Infect Dis. 2008 Jan 15; 197(2):300-8.
  View in: PubMed
 
10. Hadinoto V, Shapiro M, Greenough TC, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis. Blood. 2008 Feb 1; 111(3):1420-7.
  View in: PubMed
 
11. Luzuriaga K. Mother-to-child transmission of HIV: a global perspective. Curr Infect Dis Rep. 2007 Nov; 9(6):511-7.
  View in: PubMed
 
12. Duca KA, Shapiro M, Delgado-Eckert E, Hadinoto V, Jarrah AS, Laubenbacher R, Lee K, Luzuriaga K, Polys NF, Thorley-Lawson DA. A virtual look at Epstein-Barr virus infection: biological interpretations. PLoS Pathog. 2007 Oct 19; 3(10):1388-400.
  View in: PubMed
 
13. Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Influence of EBV on the peripheral blood memory B cell compartment. J Immunol. 2007 Sep 1; 179(5):3153-60.
  View in: PubMed
 
14. Luzuriaga K, Newell ML, Dabis F, Excler JL, Sullivan JL. Vaccines to prevent transmission of HIV-1 via breastmilk: scientific and logistical priorities. Lancet. 2006 Aug 5; 368(9534):511-21.
  View in: PubMed
 
15. Souza TA, Stollar BD, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Peripheral B cells latently infected with Epstein-Barr virus display molecular hallmarks of classical antigen-selected memory B cells. Proc Natl Acad Sci U S A. 2005 Dec 13; 102(50):18093-8.
  View in: PubMed
 
16. Clute SC, Watkin LB, Cornberg M, Naumov YN, Sullivan JL, Luzuriaga K, Welsh RM, Selin LK. Cross-reactive influenza virus-specific CD8+ T cells contribute to lymphoproliferation in Epstein-Barr virus-associated infectious mononucleosis. J Clin Invest. 2005 Dec; 115(12):3602-12.
  View in: PubMed
 
17. Sanchez-Merino V, Nie S, Luzuriaga K. HIV-1-specific CD8+ T cell responses and viral evolution in women and infants. J Immunol. 2005 Nov 15; 175(10):6976-86.
  View in: PubMed
 
18. Luzuriaga K, McManus M, Mofenson L, Britto P, Graham B, Sullivan JL. A trial of three antiretroviral regimens in HIV-1-infected children. N Engl J Med. 2004 Jun 10; 350(24):2471-80.
  View in: PubMed
 
19. Hochberg D, Souza T, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Acute infection with Epstein-Barr virus targets and overwhelms the peripheral memory B-cell compartment with resting, latently infected cells. J Virol. 2004 May; 78(10):5194-204.
  View in: PubMed
 
20. Hochberg D, Middeldorp JM, Catalina M, Sullivan JL, Luzuriaga K, Thorley-Lawson DA. Demonstration of the Burkitt's lymphoma Epstein-Barr virus phenotype in dividing latently infected memory cells in vivo. Proc Natl Acad Sci U S A. 2004 Jan 6; 101(1):239-44.
  View in: PubMed
 
21. Luzuriaga K, Sullivan JL. Pediatric HIV-1 infection: advances and remaining challenges. AIDS Rev. 2002 Jan-Mar; 4(1):21-6.
  View in: PubMed
 
22. Luzuriaga K, McManus M, Catalina M, Mayack S, Sharkey M, Stevenson M, Sullivan JL. Early therapy of vertical human immunodeficiency virus type 1 (HIV-1) infection: control of viral replication and absence of persistent HIV-1-specific immune responses. J Virol. 2000 Aug; 74(15):6984-91.
  View in: PubMed
 
23. Philippon J, Duplessis E, Dorwling-Carter D, Horn YE, Cornu P. [Lumboperitoneal shunt and normal pressure hydrocephalus in elderly subjects]. Rev Neurol (Paris). 1989; 145(11):776-80.
  View in: PubMed
 
24. Parkhouse RM, Almond NM. Stage-specific antigens of Trichinella spiralis. Biochem Soc Trans. 1985 Apr; 13(2):426-8.
  View in: PubMed
 
25. Green LC, Ruiz de Luzuriaga K, Wagner DA, Rand W, Istfan N, Young VR, Tannenbaum SR. Nitrate biosynthesis in man. Proc Natl Acad Sci U S A. 1981 Dec; 78(12):7764-8.
  View in: PubMed
 
26. Tannenbaum SR, Young V, Green L, Ruiz de Luzuriaga K. Intestinal formation of nitrite and N-nitroso compounds. IARC Sci Publ. 1980; (31):2819.
  View in: PubMed
 
For assistance with using Profiles, please refer to the online tutorials or contact UMMS Help Desk or call 508-856-8643.
 
Keyword
Last Name
Institution
    
 
 
 
Keywords   
Herpesvirus 4, Human
Infectious Mononucleosis
HIV Infections
HIV-1
Immunologic Memory
See all (152) keywords
Co-Authors  
Greenough, Thomas
Selin, Liisa
Somasundaran, Mohan
Sullivan, John
Welsh, Raymond
See all (7) people
Physical Neighbors  
Morel, Caroline
Conte, Darryl
Gonzalez Perez, Maria
Somasundaran, Mohan
Clapham, Paul

UMMS Home

Intranet

This is an official Page/Publication of the University of Massachusetts Worcester Campus
Office of the Vice Provost for Research, 55 Lake Ave North, Worcester, Massachusetts 01655
Questions or Comments? Email: publicaffairs@umassmed.edu Phone: 508-856-1572