Hira Lal Goel PHD
Title Research Assistant Professor
Institution University of Massachusetts Medical School
Department Cancer Biology
Address University of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Telephone 508-856-1936
Email
Other Positions
Institution UMMS - School of Medicine
Department Radiation Oncology
Publications
1. Goel HL, Pursell B, Chang C, Shaw LM, Mao J, Simin K, Kumar P, Kooi CW, Shultz LD, Greiner DL, Norum JH, Toftgard R, Kuperwasser C, Mercurio AM. GLI1 regulates a novel neuropilin-2/a6ß1 integrin based autocrine pathway that contributes to breast cancer initiation. EMBO Mol Med. 2013 Feb 21.
  View in: PubMed
 
2. Goel HL, Mercurio AM. Enhancing integrin function by VEGF/neuropilin signaling: Implications for tumor biology. Cell Adh Migr. 2012 Oct 17; 6(6).
  View in: PubMed
 
3. Goel HL, Chang C, Pursell B, Leav I, Lyle S, Xi HS, Hsieh CC, Adisetiyo H, Roy-Burman P, Coleman IM, Nelson PS, Vessella RL, Davis RJ, Plymate SR, Mercurio AM. VEGF/Neuropilin-2 Regulation of Bmi-1 and Consequent Repression of IGF-IR Define a Novel Mechanism of Aggressive Prostate Cancer. Cancer Discov. 2012 Oct; 2(10):906-921.
  View in: PubMed
 
4. Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM. Neuropilin-2 regulates a6ß1 integrin in the formation of focal adhesions and signaling. J Cell Sci. 2012 Feb 2.
  View in: PubMed
 
5. Goel HL, Bae D, Pursell B, Gouvin LM, Lu S, Mercurio AM. Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland. Development. 2011 Jul; 138(14):2969-76.
  View in: PubMed
 
6. Kang BH, Tavecchio M, Goel HL, Hsieh CC, Garlick DS, Raskett CM, Lian JB, Stein GS, Languino LR, Altieri DC. Targeted inhibition of mitochondrial Hsp90 suppresses localised and metastatic prostate cancer growth in a genetic mouse model of disease. Br J Cancer. 2011 Feb 15; 104(4):629-34.
  View in: PubMed
 
7. Goel HL, Underwood JM, Nickerson JA, Hsieh CC, Languino LR. Beta1 integrins mediate cell proliferation in three-dimensional cultures by regulating expression of the sonic hedgehog effector protein, GLI1. J Cell Physiol. 2010 Jul; 224(1):210-7.
  View in: PubMed
 
8. Trerotola M, Rathore S, Goel HL, Li J, Alberti S, Piantelli M, Adams D, Jiang Z, Languino LR. CD133, Trop-2 and alpha2beta1 integrin surface receptors as markers of putative human prostate cancer stem cells. Am J Transl Res. 2010; 2(2):135-44.
  View in: PubMed
 
9. Goel H, Arora A, Tiwary AK, Rana V. Development and evaluation of mathematical model to predict disintegration time of fast disintegrating tablets using powder characteristics. Pharm Dev Technol. 2011 Feb; 16(1):57-64.
  View in: PubMed
 
10. Leav I, Plescia J, Goel HL, Li J, Jiang Z, Cohen RJ, Languino LR, Altieri DC. Cytoprotective mitochondrial chaperone TRAP-1 as a novel molecular target in localized and metastatic prostate cancer. Am J Pathol. 2010 Jan; 176(1):393-401.
  View in: PubMed
 
11. Goel HL, Moro L, Murphy-Ullrich JE, Hsieh CC, Wu CL, Jiang Z, Languino LR. Beta1 integrin cytoplasmic variants differentially regulate expression of the antiangiogenic extracellular matrix protein thrombospondin 1. Cancer Res. 2009 Jul 1; 69(13):5374-82.
  View in: PubMed
 
12. Goel HL, Alam N, Johnson IN, Languino LR. Integrin signaling aberrations in prostate cancer. Am J Transl Res. 2009; 1(3):211-20.
  View in: PubMed
 
13. Wang T, Alavian MR, Goel HL, Languino LR, Fitzgerald TJ. Bicalutamide inhibits androgen-mediated adhesion of prostate cancer cells exposed to ionizing radiation. Prostate. 2008 Dec 1; 68(16):1734-42.
  View in: PubMed
 
14. Goel HL, Li J, Kogan S, Languino LR. Integrins in prostate cancer progression. Endocr Relat Cancer. 2008 Sep; 15(3):657-64.
  View in: PubMed
 
15. Fitzgerald TJ, Wang T, Goel HL, Huang J, Stein G, Lian J, Davis RJ, Doxsey S, Balaji KC, Aronowitz J, Languino LR. Prostate carcinoma and radiation therapy: therapeutic treatment resistance and strategies for targeted therapeutic intervention. Expert Rev Anticancer Ther. 2008 Jun; 8(6):967-74.
  View in: PubMed
 
16. Alam N, Goel HL, Zarif MJ, Butterfield JE, Perkins HM, Sansoucy BG, Sawyer TK, Languino LR. The integrin-growth factor receptor duet. J Cell Physiol. 2007 Dec; 213(3):649-53.
  View in: PubMed
 
17. Bisht B, Goel HL, Dey CS. Focal adhesion kinase regulates insulin resistance in skeletal muscle. Diabetologia. 2007 May; 50(5):1058-69.
  View in: PubMed
 
18. Vaira V, Lee CW, Goel HL, Bosari S, Languino LR, Altieri DC. Regulation of survivin expression by IGF-1/mTOR signaling. Oncogene. 2007 Apr 26; 26(19):2678-84.
  View in: PubMed
 
19. Goel HL, Moro L, King M, Teider N, Centrella M, McCarthy TL, Holgado-Madruga M, Wong AJ, Marra E, Languino LR. Beta1 integrins modulate cell adhesion by regulating insulin-like growth factor-II levels in the microenvironment. Cancer Res. 2006 Jan 1; 66(1):331-42.
  View in: PubMed
 
20. Goel HL, Breen M, Zhang J, Das I, Aznavoorian-Cheshire S, Greenberg NM, Elgavish A, Languino LR. beta1A integrin expression is required for type 1 insulin-like growth factor receptor mitogenic and transforming activities and localization to focal contacts. Cancer Res. 2005 Aug 1; 65(15):6692-700.
  View in: PubMed
 
21. Simon EL, Goel HL, Teider N, Wang T, Languino LR, Fitzgerald TJ. High dose fractionated ionizing radiation inhibits prostate cancer cell adhesion and beta(1) integrin expression. Prostate. 2005 Jun 15; 64(1):83-91.
  View in: PubMed
 
22. Goel HL, Fornaro M, Moro L, Teider N, Rhim JS, King M, Languino LR. Selective modulation of type 1 insulin-like growth factor receptor signaling and functions by beta1 integrins. J Cell Biol. 2004 Aug 2; 166(3):407-18.
  View in: PubMed
 
23. Goel HL, Languino LR. Integrin signaling in cancer. Cancer Treat Res. 2004; 119:15-31.
  View in: PubMed
 
24. Goel HL, Dey CS. Insulin stimulates spreading of skeletal muscle cells involving the activation of focal adhesion kinase, phosphatidylinositol 3-kinase and extracellular signal regulated kinases. J Cell Physiol. 2002 Nov; 193(2):187-98.
  View in: PubMed
 
25. Goel HL, Dey CS. PKC-regulated myogenesis is associated with increased tyrosine phosphorylation of FAK, Cas, and paxillin, formation of Cas-CRK complex, and JNK activation. Differentiation. 2002 Aug; 70(6):257-71.
  View in: PubMed
 
26. Goel HL, Dey CS. Focal adhesion kinase tyrosine phosphorylation is associated with myogenesis and modulated by insulin. Cell Prolif. 2002 Jun; 35(3):131-42.
  View in: PubMed
 
27. Goel HL, Dey CS. Insulin-mediated tyrosine phosphorylation of myosin heavy chain and concomitant enhanced association of C-terminal SRC kinase during skeletal muscle differentiation. Cell Biol Int. 2002; 26(6):557-61.
  View in: PubMed
 
28. Goel HL, Dey CS. Role of protein kinase C during insulin mediated skeletal muscle cell spreading. J Muscle Res Cell Motil. 2002; 23(4):269-77.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Antigens, CD29
Prostatic Neoplasms
Muscle, Skeletal
Protein-Tyrosine Kinases
Integrins
See all (151) keywords
Co-Authors  
FitzGerald, Thomas
Jiang, Zhong
Lian, Jane
Mercurio, Arthur
Wang, Tao
See all (18) people
Physical Neighbors  
Baehrecke, Eric
Simin, Karl
Shaw, Leslie
Mak, Paul
Lyle, Stephen

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