1) Autonomic neuropathy in Parkinson’s disease and multiple system atrophy and dysautonomia in general. We are exploring a variety of approaches to the dynamic analysis of the autonomic nervous system and cerebral blood flow in dysautonomia.  Another research interest includes evaluation of dermal innervation in autonomic neuropathy using markers of neurodegeneration. We also designed a single-center open label pilot study to evaluate  the effect of  IVIg in multiple system atrophy. The study is ongoing.

2) Mechanisms of deep brain stimulation (DBS) in Parkinson disease. The purpose of this project is to clarify how the deep brain stimulation of the subthalamic nucleus (STN) interacts with underlying neuronal activity and how these changes affect the function of basal ganglia.  This project utilizes computer modeling, and direct recordings of the neuronal activity during DBS to clarify the proposed mechanisms of DBS - inhibition, excitation or modulation of the STH activity.