Guangping Gao PHD
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Title Professor
Institution University of Massachusetts Medical School
Department Microbiology & Physiological Systems
Address University of Massachusetts Medical School
 381 Plantation Street
 Worcester MA 01605
Telephone 508-856-3563
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Immunology & Virology

Institution UMMS - Graduate School of Biomedical Sciences
Department Interdisciplinary Graduate Program

Institution UMMS - Graduate School of Biomedical Sciences
Department MD/PhD Program

Institution UMMS - Graduate School of Biomedical Sciences
Department Molecular Genetics & Microbiology

Institution UMMS - Programs, Centers and Institutes
Department Gene Therapy Center

Institution UMMS - Programs, Centers and Institutes
Department RNA Therapeutics Institute
Narrative

Academic Background

B.A. West China Univ. of Med. Sciences, Chengdu, China
M.S. Florida International University, Miami, FL
Ph.D. Florida International University, Miami, FL
Postdoctoral training at the University of Pennsylvania - School of Medicine

Overview:

Research in the Gao Lab primarily involves the discovery, development and use of adeno-associated virus vectors for gene therapy of genetic diseases and the study of miRNA functions in mammals. The lab works on isolation, characterization and vectorology of novel AAV vectors from primate tissues, molecular mechanisms of AAV evolution and diversity, and molecular interactions between endogenous AAV, AAV vector, host genomes and innate RNAi defense pathways. We also develop novel strategies for rAAV gene therapy of an inherited neurodegenerative disease, Canavan Disease, using novel AAVs that can cross the blood-brain-barrier for efficient CNS gene delivery and endogenous miRNA-mediated posttranscriptional de-targeting. Another area of research interest in the lab is to explore AAV vectors for delivery of denovo synthesized biological miRNA antagonists or over expression of microRNAs to elucidate micro RNA functions in adult mammals.
Publications
1. Xie J, Ameres SL, Friedline R, Hung JH, Zhang Y, Xie Q, Zhong L, Su Q, He R, Li M, Li H, Mu X, Zhang H, Broderick JA, Kim JK, Weng Z, Flotte TR, Zamore PD, Gao G. Long-term, efficient inhibition of microRNA function in mice using rAAV vectors. Nat Methods. 2012; 9(4):403-9.
  View in: PubMed
 
2. Gao G, Bish LT, Sleeper MM, Mu X, Sun L, Lou Y, Duan J, Hu C, Wang L, Sweeney HL. Transendocardial Delivery of AAV6 Results in Highly Efficient and Global Cardiac Gene Transfer in Rhesus Macaques. Hum Gene Ther. 2011 Aug; 22(8):979-84.
  View in: PubMed
 
3. Zhang H, Yang B, Mu X, Ahmed SS, Su Q, He R, Wang H, Mueller C, Sena-Esteves M, Brown R, Xu Z, Gao G. Several rAAV Vectors Efficiently Cross the Blood-brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System. Mol Ther. 2011 Aug; 19(8):1440-8.
  View in: PubMed
 
4. Gao G, Zhong L, Danos O. Exploiting natural diversity of AAV for the design of vectors with novel properties. Methods Mol Biol. 2011; 807:93-118.
  View in: PubMed
 
5. Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q, He R, Mu X, Seher Ahmed S, Park S, Kato H, Li C, Mueller C, Mello CC, Weng Z, Flotte TR, Zamore PD, Gao G. MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression. Mol Ther. 2011 Mar; 19(3):526-35.
  View in: PubMed
 
6. Jakovcevski M, Guo Y, Su Q, Gao G, Akbarian S. rAAV9--a human-derived adeno-associated virus vector for efficient transgene expression in mouse cingulate cortex. Cold Spring Harb Protoc. 2010 Apr; 2010(4):pdb.prot5417.
  View in: PubMed
 
7. Zhang H, Xie J, Xie Q, Wilson JM, Gao G. Adenovirus-adeno-associated virus hybrid for large-scale recombinant adeno-associated virus production. Hum Gene Ther. 2009 Sep; 20(9):922-9.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Dependovirus
Recombination, Genetic
Gene Therapy
Genetic Vectors
Gyrus Cinguli
See all (15) keywords
Co-Authors  
Flotte, Terence
Mueller, Christian
Weng, Zhiping
Zamore, Phillip
Zhong, Li
See all (10) people
Physical Neighbors  
Punzo, Claudio
Velez, Gisela
Zou, Hui
Zhong, Li
Friedline, Randall

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