Marcus P Cooper MD
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Title Assistant Professor
Institution University of Massachusetts Medical School
Department Medicine
Division Cardiovascular Medicine
Address University of Massachusetts Medical School
 381 Plantation Street
 Worcester MA 01605
Telephone 508-856-6916
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Interdisciplinary Graduate Program

Institution UMMS - Graduate School of Biomedical Sciences
Department MD/PhD Program

Institution UMMS - Graduate School of Biomedical Sciences
Department Millennium MD/PhD Program
Narrative

PROFESSIONAL TRAINING INTERNSHIP AND RESIDENCY

Osler Medical Service Department of Medicine (Baltimore, MD)


FELLOWSHIPS

Division of Cardiovascular Medicine
Brigham and Women’s Hospital/Massachusetts General Hospital


HONORS AND AWARDS

Alpha Omega Alpha (1999)
Phi Beta Kappa (1999)
Four Schools Physician-Scientist Program, (1999)
Magna Cum Laude (1990)
Who's Who Among American College Students (1990)
Outstanding Biology Senior Award (1990)
Alpha Chi Honor Society (1988)
Freshman Chemistry Award (1987)
Tri-Beta Biological Honor Society (1987)

Current Research

Our mission is to discern and manipulate transcriptional pathways that reduce obesity. Obesity predisposes to heart disease and diabetes. Humans have two types of fat cells— white and brown fat cells. Though not prevalent, brown fat cells burn fat as heat and protect against obesity. We are interested in the subset of co-regulators and transcription factors that afford this “fat burning” capacity. Our goal is to activate these pathways in white fat and safely promote weight loss.
Publications
1. Zhang Z, Zhang W, Jung DY, Ko HJ, Lee Y, Friedline RH, Lee E, Jun J, Ma Z, Kim F, Tsitsilianos N, Chapman K, Morrison A, Cooper MP, Miller BA, Kim JK. TRPM2 Ca2+ channel regulates energy balance and glucose metabolism. Am J Physiol Endocrinol Metab. 2012 Apr; 302(7):E807-16.
  View in: PubMed
 
2. Liu L, Sanosaka M, Lei S, Bestwick ML, Frey JH, Surovtseva YV, Shadel GS, Cooper MP. LRP130 Protein Remodels Mitochondria and Stimulates Fatty Acid Oxidation. J Biol Chem. 2011 Dec 2; 286(48):41253-64.
  View in: PubMed
 
3. Cooper MP, Keaney JF. Epigenetic Control of Angiogenesis via DNA Methylation. Circulation. 2011 Jun 28; 123(25):2916-8.
  View in: PubMed
 
4. Xu J, Lai KK, Verlinsky A, Lugea A, French SW, Cooper MP, Ji C, Tsukamoto H. Synergistic steatohepatitis by moderate obesity and alcohol in mice despite increased adiponectin and p-AMPK. J Hepatol. 2011 Sep; 55(3):673-82.
  View in: PubMed
 
5. Estall JL, Kahn M, Cooper MP, Fisher FM, Wu MK, Laznik D, Qu L, Cohen DE, Shulman GI, Spiegelman BM. Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression. Diabetes. 2009 Jul; 58(7):1499-508.
  View in: PubMed
 
6. Cooper MP, Uldry M, Kajimura S, Arany Z, Spiegelman BM. Modulation of PGC-1 coactivator pathways in brown fat differentiation through LRP130. J Biol Chem. 2008 Nov 14; 283(46):31960-7.
  View in: PubMed
 
7. Kajimura S, Seale P, Tomaru T, Erdjument-Bromage H, Cooper MP, Ruas JL, Chin S, Tempst P, Lazar MA, Spiegelman BM. Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex. Genes Dev. 2008 May 15; 22(10):1397-409.
  View in: PubMed
 
8. Cooper MP, Qu L, Rohas LM, Lin J, Yang W, Erdjument-Bromage H, Tempst P, Spiegelman BM. Defects in energy homeostasis in Leigh syndrome French Canadian variant through PGC-1alpha/LRP130 complex. Genes Dev. 2006 Nov 1; 20(21):2996-3009.
  View in: PubMed
 
9. Lin J, Wu PH, Tarr PT, Lindenberg KS, St-Pierre J, Zhang CY, Mootha VK, Jäger S, Vianna CR, Reznick RM, Cui L, Manieri M, Donovan MX, Wu Z, Cooper MP, Fan MC, Rohas LM, Zavacki AM, Cinti S, Shulman GI, Lowell BB, Krainc D, Spiegelman BM. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004 Oct 1; 119(1):121-35.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Neoplasm Proteins
Adipose Tissue, Brown
Gluconeogenesis
Trans-Activators
Leigh Disease
See all (68) keywords
Co-Authors  
Friedline, Randall
Jung, Dae
Keaney, John
Kim, Jason
See all (4) people
Physical Neighbors  
Trivedi, Chinmay
Li, Chunying
Tanriverdi, Kahraman
Pechhold, Klaus
Beaulieu, Lea

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