Michael J Mitchell MD
Title Clinical Associate Professor
Institution University of Massachusetts Medical School
Department Pathology
Division Academic Pathology
Address UMass Memorial Health Care, Inc.
365 Plantation Street, Biotech One
Worcester MA 01605
Email
Narrative

Academic Background

    Present Position:
    Director, Microbiology Services
    Department of Hospital Laboratories
    Address:
    89 Puritan Road
    Waban, MA 02468
    Medical School:
    Yale University School of Medicine, MD (1978)

Graduate Medical Education:

    1978-1981 Resident in Pediatrics, Yale-New Haven Hospital
    1981-1984 Fellow, Pediatric Infectious Diseases, Johns Hopkins Hospital
    1984-1987 Fellow, Microbiology Service, National Institutes of Health
    1990-1992 Fellow, Combined Program in Human Genetics, Harvard Medical School

Certification:

    National Board of Medical Examiners (#201579), 1980.
    American Academy of Pediatrics, (#29383), 1983.
    American Board of Pathology, Medical Microbiology, 1986.
    American Board of Medical Genetics, Clinical Cytogenetics, 1993

Licensure:

    The Board of Medical Examiners of the State of Maryland, D33781 (expired 1987).
    Commonwealth of Massachusetts Board of Registration in Medicine, (Reg.#: 58562, Expires 6/18/03).

Current Academic Appointment(s):

    Assistant Professor, Department of Pathology, University of Massachusetts School of Medicine

Current Medical Staff Appointment(s):

    Staff Physician, UMass Memorial Group Practice

Interests

I oversee laboratory and clinical aspects of the microbiology laboratories, including aerobic michael Mitchell and anaerobic bacteriology, mycobacteriology, mycology, parasitology, and virology. I am involved with teaching and training of Medical Students, Pathology Residents, and Infectious Diseases Fellows (Department of Medicine). I am a member of the Steering Committee in the Department of Hospital Labs. I sit on the UMMMC Clinical Process Improvement Committee, and chair its Laboratory Advisory subcommittee. I also sit on the UMMMC Pharmacy and Therapeutics Antimicrobial Subcommittee, the UMMMC Infection Control Committee, and the UMMMC Disaster Committee.

Publications
1. Vernet N, Mahadevaiah SK, Ojarikre OA, Longepied G, Prosser HM, Bradley A, Mitchell MJ, Burgoyne PS. The y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011 May 10; 21(9):787-93.
  View in: PubMed
 
2. Hayden RT, Wick MT, Rodriguez AB, Caliendo AM, Mitchell MJ, Ginocchio CC. A survey-based assessment of United States clinical laboratory response to the 2009 H1N1 influenza outbreak. Arch Pathol Lab Med. 2010 Nov; 134(11):1671-8.
  View in: PubMed
 
3. Cutler JA, Patel R, Rangarajan S, Tait RC, Mitchell MJ. Molecular characterization of 11 novel mutations in patients with heterozygous and homozygous FV deficiency. Haemophilia. 2010 Nov; 16(6):937-42.
  View in: PubMed
 
4. Wagar EA, Mitchell MJ, Carroll KC, Beavis KG, Petti CA, Schlaberg R, Yasin B. A review of sentinel laboratory performance: identification and notification of bioterrorism agents. Arch Pathol Lab Med. 2010 Oct; 134(10):1490-503.
  View in: PubMed
 
5. Longepied G, Saut N, Aknin-Seifer I, Levy R, Frances AM, Metzler-Guillemain C, Guichaoua MR, Mitchell MJ. Complete deletion of the AZFb interval from the Y chromosome in an oligozoospermic man. Hum Reprod. 2010 Oct; 25(10):2655-63.
  View in: PubMed
 
6. Msaidie S, Ducourneau A, Boetsch G, Longepied G, Papa K, Allibert C, Yahaya AA, Chiaroni J, Mitchell MJ. Genetic diversity on the Comoros Islands shows early seafaring as major determinant of human biocultural evolution in the Western Indian Ocean. Eur J Hum Genet. 2011 Jan; 19(1):89-94.
  View in: PubMed
 
7. Chiaroni J, King RJ, Myres NM, Henn BM, Ducourneau A, Mitchell MJ, Boetsch G, Sheikha I, Lin AA, Nik-Ahd M, Ahmad J, Lattanzi F, Herrera RJ, Ibrahim ME, Brody A, Semino O, Kivisild T, Underhill PA. The emergence of Y-chromosome haplogroup J1e among Arabic-speaking populations. Eur J Hum Genet. 2010 Mar; 18(3):348-53.
  View in: PubMed
 
8. Mitchell MJ, Stubbs BA, Eisenberg MS. Socioeconomic status is associated with provision of bystander cardiopulmonary resuscitation. Prehosp Emerg Care. 2009 Oct-Dec; 13(4):478-86.
  View in: PubMed
 
9. Metzler-Guillemain C, Depetris D, Luciani JJ, Mignon-Ravix C, Mitchell MJ, Mattei MG. In human pachytene spermatocytes, SUMO protein is restricted to the constitutive heterochromatin. Chromosome Res. 2008; 16(5):761-82.
  View in: PubMed
 
10. Kichine E, Msaidie S, Bokilo AD, Ducourneau A, Navarro A, Levy N, Terriou P, Collignon P, Boetsch G, Chiaroni J, Mitchell MJ. Low-frequency protamine 1 gene transversions c.102G->T and c.-107G->C do not correlate with male infertility. J Med Genet. 2008 Apr; 45(4):255-6.
  View in: PubMed
 
11. Mitchell MJ, Montgomery M, Reiter CG, Culp WC. Pericardial tamponade following CT-guided lung biopsy. Cardiovasc Intervent Radiol. 2008 Jul; 31 Suppl 2:S227-30.
  View in: PubMed
 
12. Dai L, Cutler JA, Savidge GF, Mitchell MJ. Characterization of a causative mutation of hemophilia A identified in the promoter region of the factor VIII gene (F8). J Thromb Haemost. 2008 Jan; 6(1):193-5.
  View in: PubMed
 
13. Mitchell MJ, Dai L, Clarke JB, Bolton-Maggs PH, Savidge GF, Alhaq A. Characterisation of five factor XI mutations. Thromb Haemost. 2007 Jun; 97(6):884-9.
  View in: PubMed
 
14. Karcanias AC, Ichimura K, Mitchell MJ, Sargent CA, Affara NA. Analysis of sex chromosome abnormalities using X and Y chromosome DNA tiling path arrays. J Med Genet. 2007 Jul; 44(7):429-36.
  View in: PubMed
 
15. Bolton-Maggs PH, Hay CR, Shanks D, Mitchell MJ, McVey JH. The importance of tissue factor source in the management of Factor VII deficiency. Thromb Haemost. 2007 Jan; 97(1):151-2.
  View in: PubMed
 
16. Turner JM, Mahadevaiah SK, Ellis PJ, Mitchell MJ, Burgoyne PS. Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell. 2006 Apr; 10(4):521-9.
  View in: PubMed
 
17. Perrin J, Metzler-Guillemain C, Karsenty G, Grillo JM, Mitchell MJ, Guichaoua MR. Meiotic arrest at the midpachytene stage in a patient with complete azoospermia factor b deletion of the Y chromosome. Fertil Steril. 2006 Feb; 85(2):494.e5-8.
  View in: PubMed
 
18. Giachini C, Guarducci E, Longepied G, Degl'Innocenti S, Becherini L, Forti G, Mitchell MJ, Krausz C. The gr/gr deletion(s): a new genetic test in male infertility? J Med Genet. 2005 Jun; 42(6):497-502.
  View in: PubMed
 
19. Cutler JA, Patel R, Mitchell MJ, Savidge GF. The significance of published polymorphisms in 14 cases of mild factor VII deficiency. Blood Coagul Fibrinolysis. 2005 Mar; 16(2):91-5.
  View in: PubMed
 
20. Machev N, Saut N, Longepied G, Terriou P, Navarro A, Levy N, Guichaoua M, Metzler-Guillemain C, Collignon P, Frances AM, Belougne J, Clemente E, Chiaroni J, Chevillard C, Durand C, Ducourneau A, Pech N, McElreavey K, Mattei MG, Mitchell MJ. Sequence family variant loss from the AZFc interval of the human Y chromosome, but not gene copy loss, is strongly associated with male infertility. J Med Genet. 2004 Nov; 41(11):814-25.
  View in: PubMed
 
21. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. Germline mosaicism resulting in the transmission of severe hemophilia B from a grandfather with a mild deficiency. Am J Med Genet A. 2004 Aug 15; 129A(1):13-5.
  View in: PubMed
 
22. Cutler JA, Mitchell MJ, Savidge GF. More on: unusual expression of the F9 gene in peripheral lymphocytes hinders investigation of F9 mRNA in hemophilia B patients. J Thromb Haemost. 2004 Jun; 2(6):1021.
  View in: PubMed
 
23. Delbridge ML, Longepied G, Depetris D, Mattei MG, Disteche CM, Marshall Graves JA, Mitchell MJ. TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution. Chromosome Res. 2004; 12(4):345-56.
  View in: PubMed
 
24. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. The identification and classification of 41 novel mutations in the factor VIII gene (F8C). Hum Mutat. 2002 Mar; 19(3):274-8.
  View in: PubMed
 
25. McElreavey K, Mitchell MJ. The sexually transmitted genome. Trends Genet. 2002 Jan; 18(1):13-4.
  View in: PubMed
 
26. Mazeyrat S, Saut N, Grigoriev V, Mahadevaiah SK, Ojarikre OA. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Nat Genet. 2001 Sep; 29(1):49-53.
  View in: PubMed
 
27. Lingenfelter PA, Delbridge ML, Thomas S, Hoekstra HE, Mitchell MJ, Graves JA, Disteche CM. Expression and conservation of processed copies of the RBMX gene. Mamm Genome. 2001 Jul; 12(7):538-45.
  View in: PubMed
 
28. Cutler JA, Mitchell MJ, Greenslade K, Smith MP, Savidge GF. A rapid and cost-effective method for analysis of three common genetic risk factors for thrombosis. Blood Coagul Fibrinolysis. 2001 Jan; 12(1):33-6.
  View in: PubMed
 
29. Affara NA, Mitchell MJ. The role of human and mouse Y chromosome genes in male infertility. J Endocrinol Invest. 2000 Nov; 23(10):630-45.
  View in: PubMed
 
30. Saut N, Terriou P, Navarro A, Lévy N, Mitchell MJ. The human Y chromosome genes BPY2, CDY1 and DAZ are not essential for sustained fertility. Mol Hum Reprod. 2000 Sep; 6(9):789-93.
  View in: PubMed
 
31. Scott D, Addey C, Ellis P, James E, Mitchell MJ, Saut N, Jurcevic S, Simpson E. Dendritic cells permit identification of genes encoding MHC class II-restricted epitopes of transplantation antigens. Immunity. 2000 Jun; 12(6):711-20.
  View in: PubMed
 
32. Lévy N, Navarro A, Bishop CE, Mitchell MJ. The ubiquitin-activating enzyme E1 homologous genes on the mouse Y chromosome (Ube1y) represent one functional gene and six partial pseudogenes. Mamm Genome. 2000 Feb; 11(2):164-8.
  View in: PubMed
 
33. Mitchell MJ. Spermatogenesis and the mouse Y chromosome: specialisation out of decay. Results Probl Cell Differ. 2000; 28:233-70.
  View in: PubMed
 
34. Bishop CE, Mitchell MJ. Mouse Y chromosome. Mamm Genome. 1999 Oct; 10(10):962.
  View in: PubMed
 
35. Mazeyrat S, Saut N, Mattei MG, Mitchell MJ. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Nat Genet. 1999 Jul; 22(3):224-6.
  View in: PubMed
 
36. Smith MP, Spence KJ, Waters EL, Beresford-Webb R, Mitchell MJ, Cuttler J, Alhaq A, Brown SA, Savidge GF. Immune tolerance therapy for haemophilia A patients with acquired factor VIII alloantibodies: comprehensive analysis of experience at a single institution. Thromb Haemost. 1999 Jan; 81(1):35-8.
  View in: PubMed
 
37. Mazeyrat S, Saut N, Sargent CA, Grimmond S, Longepied G, Ehrmann IE, Ellis PS, Greenfield A, Affara NA, Mitchell MJ. The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Hum Mol Genet. 1998 Oct; 7(11):1713-24.
  View in: PubMed
 
38. Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998 Oct; 7(11):1725-37.
  View in: PubMed
 
39. Mitchell MJ, Wilcox SA, Watson JM, Lerner JL, Woods DR, Scheffler J, Hearn JP, Bishop CE, Graves JA. The origin and loss of the ubiquitin activating enzyme gene on the mammalian Y chromosome. Hum Mol Genet. 1998 Mar; 7(3):429-34.
  View in: PubMed
 
40. Mazeyrat S, Mitchell MJ. Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse. Hum Mol Genet. 1998 Mar; 7(3):557-62.
  View in: PubMed
 
41. Bishop CE, Mitchell MJ. Encyclopedia of the mouse genome VII. Mouse chromosome Y. Mamm Genome. 1998; 8 Spec No:S378-81.
  View in: PubMed
 
42. Levy N, de Boer P, Mattei J, Mitchell MJ. Molecular analysis of an isoYq chromosome in a sterile male mouse. Mamm Genome. 1996 Aug; 7(8):608-9.
  View in: PubMed
 
43. Laval SH, Blair HJ, Mitchell MJ, Boyd Y. Smcx lies distal to DXHX674 and DXHX679 on the mouse X chromosome. Mamm Genome. 1996 Jul; 7(7):552.
  View in: PubMed
 
44. Bishop CE, Mitchell MJ. Encyclopedia of the mouse genome V. Mouse Y chromosome. Mamm Genome. 1996; 6 Spec No:S331-3.
  View in: PubMed
 
45. Scott DM, Ehrmann IE, Ellis PS, Bishop CE, Agulnik AI, Simpson E, Mitchell MJ. Identification of a mouse male-specific transplantation antigen, H-Y. Nature. 1995 Aug 24; 376(6542):695-8.
  View in: PubMed
 
46. King TR, Christianson GJ, Mitchell MJ, Bishop CE, Scott D, Ehrmann I, Simpson E, Eicher EM, Roopenian DC. Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus. Genomics. 1994 Nov 1; 24(1):159-68.
  View in: PubMed
 
47. Agulnik AI, Mitchell MJ, Mattei MG, Borsani G, Avner PA, Lerner JL, Bishop CE. A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human. Hum Mol Genet. 1994 Jun; 3(6):879-84.
  View in: PubMed
 
48. Agulnik AI, Mitchell MJ, Lerner JL, Woods DR, Bishop CE. A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens. Hum Mol Genet. 1994 Jun; 3(6):873-8.
  View in: PubMed
 
49. McLaren A, Simpson E, Bishop CE, Mitchell MJ, Darling SM. Recombination between the X and Y chromosomes and the Sxr region of the mouse. Genet Res. 1992 Dec; 60(3):175-84.
  View in: PubMed
 
50. Mitchell MJ, Woods DR, Wilcox SA, Graves JA, Bishop CE. Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y. Nature. 1992 Oct 8; 359(6395):528-31.
  View in: PubMed
 
51. Zwelling LA, Mitchell MJ, Satitpunwaycha P, Mayes J, Altschuler E, Hinds M, Baguley BC. Relative activity of structural analogues of amsacrine against human leukemia cell lines containing amsacrine-sensitive or -resistant forms of topoisomerase II: use of computer simulations in new drug development. Cancer Res. 1992 Jan 1; 52(1):209-17.
  View in: PubMed
 
52. Mitchell MJ, Woods DR, Tucker PK, Opp JS, Bishop CE. Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme E1. Nature. 1991 Dec 12; 354(6353):483-6.
  View in: PubMed
 
53. Tiersch TR, Mitchell MJ, Wachtel SS. Studies on the phylogenetic conservation of the SRY gene. Hum Genet. 1991 Sep; 87(5):571-3.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Y Chromosome
Chromosomes, Human, Y
Infertility, Male
Chromosome Mapping
Spermatogenesis
See all (265) keywords
Physical Neighbors  
Higgins, Anne
Kiefer, Charles
Rao, Lokinendi
Al-Turkmani, M.
Yu, Neng

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