Jon D Goguen PHD
Title Associate Professor
Institution University of Massachusetts Medical School
Department Microbiology & Physiological Systems
Address University of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Telephone 508-856-2490
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Immunology & Virology

Institution UMMS - Graduate School of Biomedical Sciences
Department Molecular Genetics & Microbiology

Institution UMMS - Programs, Centers and Institutes
Department Bacterial Genetics and Pathogenesis
Publications
1. Vladimer GI, Weng D, Paquette SW, Vanaja SK, Rathinam VA, Aune MH, Conlon JE, Burbage JJ, Proulx MK, Liu Q, Reed G, Mecsas JC, Iwakura Y, Bertin J, Goguen JD, Fitzgerald KA, Lien E. The NLRP12 Inflammasome Recognizes Yersinia pestis. Immunity. 2012 Jul 27; 37(1):96-107.
  View in: PubMed
 
2. Wang S, Goguen JD, Li F, Lu S. Involvement of CD8+ T cell-mediated immune responses in LcrV DNA vaccine induced protection against lethal Yersinia pestis challenge. Vaccine. 2011 Sep 9; 29(39):6802-9.
  View in: PubMed
 
3. Eren E, Murphy M, Goguen J, van den Berg B. An active site water network in the plasminogen activator pla from Yersinia pestis. Structure. 2010 Jul 14; 18(7):809-18.
  View in: PubMed
 
4. Wang S, Mboudjeka I, Goguen JD, Lu S. Antigen engineering can play a critical role in the protective immunity elicited by Yersinia pestis DNA vaccines. Vaccine. 2010 Feb 23; 28(8):2011-9.
  View in: PubMed
 
5. Hayward RD, Goguen JD, Leong JM. No better time to FRET: shedding light on host pathogen interactions. J Biol. 2010; 9(2):12.
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6. Pan NJ, Brady MJ, Leong JM, Goguen JD. Targeting type III secretion in Yersinia pestis. Antimicrob Agents Chemother. 2009 Feb; 53(2):385-92.
  View in: PubMed
 
7. Wang S, Joshi S, Mboudjeka I, Liu F, Ling T, Goguen JD, Lu S. Relative immunogenicity and protection potential of candidate Yersinia Pestis antigens against lethal mucosal plague challenge in Balb/C mice. Vaccine. 2008 Mar 20; 26(13):1664-74.
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8. Degen JL, Bugge TH, Goguen JD. Fibrin and fibrinolysis in infection and host defense. J Thromb Haemost. 2007 Jul; 5 Suppl 1:24-31.
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9. Sweet CR, Conlon J, Golenbock DT, Goguen J, Silverman N. YopJ targets TRAF proteins to inhibit TLR-mediated NF-kappaB, MAPK and IRF3 signal transduction. Cell Microbiol. 2007 Nov; 9(11):2700-15.
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10. Pouliot K, Pan N, Wang S, Lu S, Lien E, Goguen JD. Evaluation of the role of LcrV-Toll-like receptor 2-mediated immunomodulation in the virulence of Yersinia pestis. Infect Immun. 2007 Jul; 75(7):3571-80.
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11. Pan N, Lee C, Goguen J. High throughput screening for small-molecule inhibitors of type III secretion in Yersinia pestis. Adv Exp Med Biol. 2007; 603:367-75.
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12. Montminy SW, Khan N, McGrath S, Walkowicz MJ, Sharp F, Conlon JE, Fukase K, Kusumoto S, Sweet C, Miyake K, Akira S, Cotter RJ, Goguen JD, Lien E. Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response. Nat Immunol. 2006 Oct; 7(10):1066-73.
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13. Ngampasutadol J, Ram S, Blom AM, Jarva H, Jerse AE, Lien E, Goguen J, Gulati S, Rice PA. Human C4b-binding protein selectively interacts with Neisseria gonorrhoeae and results in species-specific infection. Proc Natl Acad Sci U S A. 2005 Nov 22; 102(47):17142-7.
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14. Wang S, Heilman D, Liu F, Giehl T, Joshi S, Huang X, Chou TH, Goguen J, Lu S. A DNA vaccine producing LcrV antigen in oligomers is effective in protecting mice from lethal mucosal challenge of plague. Vaccine. 2004 Sep 3; 22(25-26):3348-57.
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15. Leong JM, Parveen N, Goguen JD. New approaches and old problems in the shadow of bioterrorism. Trends Microbiol. 2002 Mar; 10(3):112-4.
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16. Subrahmanyam YV, Yamaga S, Prashar Y, Lee HH, Hoe NP, Kluger Y, Gerstein M, Goguen JD, Newburger PE, Weissman SM. RNA expression patterns change dramatically in human neutrophils exposed to bacteria. Blood. 2001 Apr 15; 97(8):2457-68.
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17. Goguen JD, Bugge T, Degen JL. Role of the pleiotropic effects of plasminogen deficiency in infection experiments with plasminogen-deficient mice. Methods. 2000 Jun; 21(2):179-83.
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18. Goguen JD, Hoe NP, Subrahmanyam YV. Proteases and bacterial virulence: a view from the trenches. Infect Agents Dis. 1995 Mar; 4(1):47-54.
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19. Hoe NP, Goguen JD. Temperature sensing in Yersinia pestis: translation of the LcrF activator protein is thermally regulated. J Bacteriol. 1993 Dec; 175(24):7901-9.
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20. Sodeinde OA, Subrahmanyam YV, Stark K, Quan T, Bao Y, Goguen JD. A surface protease and the invasive character of plague. Science. 1992 Nov 6; 258(5084):1004-7.
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21. Hoe NP, Minion FC, Goguen JD. Temperature sensing in Yersinia pestis: regulation of yopE transcription by lcrF. J Bacteriol. 1992 Jul; 174(13):4275-86.
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22. Sodeinde OA, Goguen JD. Nucleotide sequence of the plasminogen activator gene of Yersinia pestis: relationship to ompT of Escherichia coli and gene E of Salmonella typhimurium. Infect Immun. 1989 May; 57(5):1517-23.
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23. Sodeinde OA, Goguen JD. Genetic analysis of the 9.5-kilobase virulence plasmid of Yersinia pestis. Infect Immun. 1988 Oct; 56(10):2743-8.
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24. Sodeinde OA, Sample AK, Brubaker RR, Goguen JD. Plasminogen activator/coagulase gene of Yersinia pestis is responsible for degradation of plasmid-encoded outer membrane proteins. Infect Immun. 1988 Oct; 56(10):2749-52.
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25. Abraham SN, Goguen JD, Beachey EH. Hyperadhesive mutant of type 1-fimbriated Escherichia coli associated with formation of FimH organelles (fimbriosomes). Infect Immun. 1988 May; 56(5):1023-9.
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26. Abraham SN, Goguen JD, Sun D, Klemm P, Beachey EH. Identification of two ancillary subunits of Escherichia coli type 1 fimbriae by using antibodies against synthetic oligopeptides of fim gene products. J Bacteriol. 1987 Dec; 169(12):5530-6.
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27. Benjamin WH, Turnbough CL, Goguen JD, Posey BS, Briles DE. Genetic mapping of novel virulence determinants of Salmonella typhimurium to the region between trpD and supD. Microb Pathog. 1986 Apr; 1(2):115-24.
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28. Goguen JD, Walker WS, Hatch TP, Yother J. Plasmid-determined cytotoxicity in Yersinia pestis and Yersinia pseudotuberculosis. Infect Immun. 1986 Mar; 51(3):788-94.
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29. Minion FC, Abraham SN, Beachey EH, Goguen JD. The genetic determinant of adhesive function in type 1 fimbriae of Escherichia coli is distinct from the gene encoding the fimbrial subunit. J Bacteriol. 1986 Mar; 165(3):1033-6.
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30. Yother J, Chamness TW, Goguen JD. Temperature-controlled plasmid regulon associated with low calcium response in Yersinia pestis. J Bacteriol. 1986 Feb; 165(2):443-7.
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31. Minion FC, Goguen JD. Identification and preliminary characterization of external membrane-bound nuclease activities in Mycoplasma pulmonis. Infect Immun. 1986 Jan; 51(1):352-4.
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32. Yother J, Goguen JD. Isolation and characterization of Ca2+-blind mutants of Yersinia pestis. J Bacteriol. 1985 Nov; 164(2):704-11.
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33. Piekarowicz A, Goguen JD, Skrzypek E. The EcoDXX1 restriction and modification system of Escherichia coli ET7. Purification, subunit structure and properties of the restriction endonuclease. Eur J Biochem. 1985 Oct 15; 152(2):387-93.
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34. Minion FC, Goguen JD. Trypsin-sensitive, bovine serum albumin-dependent hemolysis activity in Mycoplasma pulmonis. Infect Immun. 1985 Aug; 49(2):440-2.
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35. Minion FC, Goguen JD. Diffusion of target cell membrane proteins allows recognition of cryptic binding sites by Mycoplasma pulmonis hemagglutinin. Infect Immun. 1985 May; 48(2):579-80.
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36. Goguen JD, Yother J, Straley SC. Genetic analysis of the low calcium response in Yersinia pestis mu d1(Ap lac) insertion mutants. J Bacteriol. 1984 Dec; 160(3):842-8.
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37. Shaw DR, Maurelli AT, Goguen JD, Straley SC, Curtiss R. Use of UV-irradiated bacteriophage T6 to kill extracellular bacteria in tissue culture infectivity assays. J Immunol Methods. 1983; 56(1):75-83.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Yersinia pestis
Plague
Antigens, Bacterial
Bacterial Outer Membrane Proteins
Virulence
See all (210) keywords
Co-Authors  
Golenbock, Douglas
Lien, Egil
Lu, Shan
Newburger, Peter
Wang, Shixia
See all (11) people
Physical Neighbors  
Cuadra, Adolfo
McCormick, Beth
Amrani, Nadia
Iorio, Ronald
Honeyman, Thomas

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