Satoshi Komatsu PHD
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Title Research Assistant Professor
Institution University of Massachusetts Medical School
Department Microbiology & Physiological Systems
Address University of Massachusetts Medical School
 55 Lake Avenue North
 Worcester MA 01655
Telephone 508-856-2338
Email
Narrative

Academic Background:

1992, B.S., Tokyo University of Agriculture
1994, M.S., Tokyo University of Agriculture
1997, Ph.D., Hiroshima University

Regulation of Cell Motility and Contractility

Komatsu New Pic

Cell motility and contractility play a key role in both normal physiology and disease, including development, wound healing, immunity, angiogenesis, atherosclerosis and metastasis.  Reorganization of actomyosin filaments is an essential process for these cell behaviors, and phosphorylation of the regulatory light chain of myosin II (MLC) plays a key role in cell motile processes.  Multiple kinases within nonmuscle cells regulates cell motility and contractility through the phosphorylation of MLC, understanding the contribution of MLC kinases to cell motile processes is important to understanding the regulatory mechanism of cell motility and contractility.  My objective is to elucidate how signaling pathways regulate the myosin phosphorylation in cell motile process. 
Publications
1. Komatsu S, Dobson JG, Ikebe M, Shea LG, Fenton RA. Crosstalk between adenosine A(1) and ß(1) -adrenergic receptors regulates translocation of PKCe in isolated rat cardiomyocytes. J Cell Physiol. 2012 Sep; 227(9):3201-7.
  View in: PubMed
 
2. Fenton RA, Komatsu S, Ikebe M, Shea LG, Dobson JG. Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse. Am J Physiol Heart Circ Physiol. 2009 Aug; 297(2):H718-25.
  View in: PubMed
 
3. Jung HS, Komatsu S, Ikebe M, Craig R. Head-head and head-tail interaction: a general mechanism for switching off myosin II activity in cells. Mol Biol Cell. 2008 Aug; 19(8):3234-42.
  View in: PubMed
 
4. Komatsu S, Ikebe M. The phosphorylation of myosin II at the Ser1 and Ser2 is critical for normal platelet-derived growth factor induced reorganization of myosin filaments. Mol Biol Cell. 2007 Dec; 18(12):5081-90.
  View in: PubMed
 
5. Takamoto N, Komatsu S, Komaba S, Niiro N, Ikebe M. Novel ZIP kinase isoform lacks leucine zipper. Arch Biochem Biophys. 2006 Dec 15; 456(2):194-203.
  View in: PubMed
 
6. Miyazaki K, Komatsu S, Ikebe M. Dynamics of RhoA and ROKalpha translocation in single living cells. Cell Biochem Biophys. 2006; 45(3):243-54.
  View in: PubMed
 
7. Miyazaki K, Komatsu S, Ikebe M, Fenton RA, Dobson JG. Protein kinase Cepsilon and the antiadrenergic action of adenosine in rat ventricular myocytes. Am J Physiol Heart Circ Physiol. 2004 Oct; 287(4):H1721-9.
  View in: PubMed
 
8. Komatsu S, Ikebe M. ZIP kinase is responsible for the phosphorylation of myosin II and necessary for cell motility in mammalian fibroblasts. J Cell Biol. 2004 Apr 26; 165(2):243-54.
  View in: PubMed
 
9. Komatsu S, Miyazaki K, Tuft RA, Ikebe M. Translocation of telokin by cGMP signaling in smooth muscle cells. Am J Physiol Cell Physiol. 2002 Sep; 283(3):C752-61.
  View in: PubMed
 
10. Ikebe M, Komatsu S, Woodhead JL, Mabuchi K, Ikebe R, Saito J, Craig R, Higashihara M. The tip of the coiled-coil rod determines the filament formation of smooth muscle and nonmuscle myosin. J Biol Chem. 2001 Aug 10; 276(32):30293-300.
  View in: PubMed
 
11. Komatsu S, Yano T, Shibata M, Tuft RA, Ikebe M. Effects of the regulatory light chain phosphorylation of myosin II on mitosis and cytokinesis of mammalian cells. J Biol Chem. 2000 Nov 3; 275(44):34512-20.
  View in: PubMed
 
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Co-Authors  
Craig, Roger
Dobson, James
Ikebe, Mitsuo
Tuft, Richard
Woodhead, John
See all (5) people
Physical Neighbors  
Poteete, Anthony
Schrader, Carol
Baker, Richard
Honeyman, Thomas
Morrison, Trudy

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