1992, B.S., Tokyo University of Agriculture
1994, M.S., Tokyo University of Agriculture
1997, Ph.D., Hiroshima University
Regulation of Cell Motility and Contractility
Cell motility and contractility play a key role in both normal physiology and disease, including development, wound healing, immunity, angiogenesis, atherosclerosis and metastasis. Reorganization of actomyosin filaments is an essential process for these cell behaviors, and phosphorylation of the regulatory light chain of myosin II (MLC) plays a key role in cell motile processes. Multiple kinases within nonmuscle cells regulates cell motility and contractility through the phosphorylation of MLC, understanding the contribution of MLC kinases to cell motile processes is important to understanding the regulatory mechanism of cell motility and contractility. My objective is to elucidate how signaling pathways regulate the myosin phosphorylation in cell motile process.