Tzumin Lee MD, PHD
Title Affiliate
Institution University of Massachusetts Medical School
Department Neurobiology
Address University of Massachusetts Medical School
364 Plantation Street, LRB-704
Worcester MA 01605
Telephone 571-209-4198
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Neuroscience
Publications
1. Yu HH, Awasaki T, Schroeder MD, Long F, Yang JS, He Y, Ding P, Kao JC, Wu GY, Peng H, Myers G, Lee T. Clonal development and organization of the adult Drosophila central brain. Curr Biol. 2013 Apr 22; 23(8):633-43.
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2. Kao CF, Lee T. Reverse Genetics by Loss-of-Function Mosaic Analysis in Drosophila. Cold Spring Harb Protoc. 2013; 2013(1).
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3. Kao CF, Lee T. Genetic mosaic screens in Drosophila mushroom bodies. Cold Spring Harb Protoc. 2013; 2013(1).
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4. Kao CF, Lee T. Generation of Standard Wild-Type MARCM Clones for Analysis of Drosophila Brain Development. Cold Spring Harb Protoc. 2012; 2012(12).
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5. Lin S, Kao CF, Yu HH, Huang Y, Lee T. Lineage analysis of Drosophila lateral antennal lobe neurons reveals notch-dependent binary temporal fate decisions. PLoS Biol. 2012 Nov; 10(11):e1001425.
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6. Zhu S, Wildonger J, Barshow S, Younger S, Huang Y, Lee T. The bHLH Repressor Deadpan Regulates the Self-renewal and Specification of Drosophila Larval Neural Stem Cells Independently of Notch. PLoS One. 2012; 7(10):e46724.
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7. Kao CF, Yu HH, He Y, Kao JC, Lee T. Hierarchical deployment of factors regulating temporal fate in a diverse neuronal lineage of the Drosophila central brain. Neuron. 2012 Feb 23; 73(4):677-84.
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8. Shi L, Lee T. Molecular diversity of dscam and self-recognition. Adv Exp Med Biol. 2012; 739:262-75.
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9. Lin S, Lee T. Generating neuronal diversity in the Drosophila central nervous system. Dev Dyn. 2012 Jan; 241(1):57-68.
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10. Brody T, Yavatkar AS, Kuzin A, Kundu M, Tyson LJ, Ross J, Lin TY, Lee CH, Awasaki T, Lee T, Odenwald WF. Use of a Drosophila genome-wide conserved sequence database to identify functionally related cis-regulatory enhancers. Dev Dyn. 2012 Jan; 241(1):169-89.
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11. Lee PT, Lin HW, Chang YH, Fu TF, Dubnau J, Hirsh J, Lee T, Chiang AS. Serotonin-mushroom body circuit modulating the formation of anesthesia-resistant memory in Drosophila. Proc Natl Acad Sci U S A. 2011 Aug 16; 108(33):13794-9.
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12. Awasaki T, Huang Y, O'Connor MB, Lee T. Glia instruct developmental neuronal remodeling through TGF-ß signaling. Nat Neurosci. 2011; 14(7):821-3.
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13. Xie J, Zhao T, Lee T, Myers E, Peng H. Anisotropic path searching for automatic neuron reconstruction. Med Image Anal. 2011 Oct; 15(5):680-9.
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14. Pitman JL, Huetteroth W, Burke CJ, Krashes MJ, Lai SL, Lee T, Waddell S. A pair of inhibitory neurons are required to sustain labile memory in the Drosophila mushroom body. Curr Biol. 2011 May 24; 21(10):855-61.
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15. Awasaki T, Lee T. New tools for the analysis of glial cell biology in Drosophila. Glia. 2011 Sep; 59(9):1377-86.
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16. Awasaki T, Lee T. Orphan nuclear receptors control neuronal remodeling during fly metamorphosis. Nat Neurosci. 2011 Jan; 14(1):6-7.
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17. Yu HH, Kao CF, He Y, Ding P, Kao JC, Lee T. A complete developmental sequence of a Drosophila neuronal lineage as revealed by twin-spot MARCM. PLoS Biol. 2010; 8(8).
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18. Xie J, Zhao T, Lee T, Myers E, Peng H. Automatic neuron tracing in volumetric microscopy images with anisotropic path searching. Med Image Comput Comput Assist Interv. 2010; 13(Pt 2):472-9.
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19. Lin S, Lai SL, Yu HH, Chihara T, Luo L, Lee T. Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain. Development. 2010 Jan; 137(1):43-51.
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20. Lin S, Huang Y, Lee T. Nuclear receptor unfulfilled regulates axonal guidance and cell identity of Drosophila mushroom body neurons. PLoS One. 2009; 4(12):e8392.
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21. Kao CF, Lee T. Birth time/order-dependent neuron type specification. Curr Opin Neurobiol. 2010 Feb; 20(1):14-21.
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22. Jensen PA, Zheng X, Lee T, O'Connor MB. The Drosophila Activin-like ligand Dawdle signals preferentially through one isoform of the Type-I receptor Baboon. Mech Dev. 2009 Dec; 126(11-12):950-7.
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23. Lee T. New genetic tools for cell lineage analysis in Drosophila. Nat Methods. 2009 Aug; 6(8):566-8.
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24. Yu HH, Chen CH, Shi L, Huang Y, Lee T. Twin-spot MARCM to reveal the developmental origin and identity of neurons. Nat Neurosci. 2009 Jul; 12(7):947-53.
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25. Yu HH, Yang JS, Wang J, Huang Y, Lee T. Endodomain diversity in the Drosophila Dscam and its roles in neuronal morphogenesis. J Neurosci. 2009 Feb 11; 29(6):1904-14.
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26. Awasaki T, Lai SL, Ito K, Lee T. Organization and postembryonic development of glial cells in the adult central brain of Drosophila. J Neurosci. 2008 Dec 17; 28(51):13742-53.
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27. Yang JS, Bai JM, Lee T. Dynein-dynactin complex is essential for dendritic restriction of TM1-containing Drosophila Dscam. PLoS One. 2008; 3(10):e3504.
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28. Lai SL, Awasaki T, Ito K, Lee T. Clonal analysis of Drosophila antennal lobe neurons: diverse neuronal architectures in the lateral neuroblast lineage. Development. 2008 Sep; 135(17):2883-93.
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29. Shi L, Lin S, Grinberg Y, Beck Y, Grozinger CM, Robinson GE, Lee T. Roles of Drosophila Kruppel-homolog 1 in neuronal morphogenesis. Dev Neurobiol. 2007 Oct; 67(12):1614-26.
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30. Yu HH, Lee T. Neuronal temporal identity in post-embryonic Drosophila brain. Trends Neurosci. 2007 Oct; 30(10):520-6.
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31. Shi L, Yu HH, Yang JS, Lee T. Specific Drosophila Dscam juxtamembrane variants control dendritic elaboration and axonal arborization. J Neurosci. 2007 Jun 20; 27(25):6723-8.
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32. Soba P, Zhu S, Emoto K, Younger S, Yang SJ, Yu HH, Lee T, Jan LY, Jan YN. Drosophila sensory neurons require Dscam for dendritic self-avoidance and proper dendritic field organization. Neuron. 2007 May 3; 54(3):403-16.
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33. Zhu S, Lin S, Kao CF, Awasaki T, Chiang AS, Lee T. Gradients of the Drosophila Chinmo BTB-zinc finger protein govern neuronal temporal identity. Cell. 2006 Oct 20; 127(2):409-22.
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34. Lai SL, Lee T. Genetic mosaic with dual binary transcriptional systems in Drosophila. Nat Neurosci. 2006 May; 9(5):703-9.
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35. Guétat G, Maitre M, Joly L, Lai SL, Lee T, Shinagawa Y. Automatic 3-D grayscale volume matching and shape analysis. IEEE Trans Inf Technol Biomed. 2006 Apr; 10(2):362-76.
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36. Wang J, Lee CH, Lin S, Lee T. Steroid hormone-dependent transformation of polyhomeotic mutant neurons in the Drosophila brain. Development. 2006 Apr; 133(7):1231-40.
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37. Zheng X, Zugates CT, Lu Z, Shi L, Bai JM, Lee T. Baboon/dSmad2 TGF-beta signaling is required during late larval stage for development of adult-specific neurons. EMBO J. 2006 Feb 8; 25(3):615-27.
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38. Zhu S, Perez R, Pan M, Lee T. Requirement of Cul3 for axonal arborization and dendritic elaboration in Drosophila mushroom body neurons. J Neurosci. 2005 Apr 20; 25(16):4189-97.
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39. Zugates CT, Lee T. Genetic mosaic analysis in the nervous system. Curr Opin Neurobiol. 2004 Oct; 14(5):647-53.
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40. Wang J, Ma X, Yang JS, Zheng X, Zugates CT, Lee CH, Lee T. Transmembrane/juxtamembrane domain-dependent Dscam distribution and function during mushroom body neuronal morphogenesis. Neuron. 2004 Sep 2; 43(5):663-72.
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41. Zhu S, Chiang AS, Lee T. Development of the Drosophila mushroom bodies: elaboration, remodeling and spatial organization of dendrites in the calyx. Development. 2003 Jun; 130(12):2603-10.
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42. Zheng X, Wang J, Haerry TE, Wu AY, Martin J, O'Connor MB, Lee CH, Lee T. TGF-beta signaling activates steroid hormone receptor expression during neuronal remodeling in the Drosophila brain. Cell. 2003 Feb 7; 112(3):303-15.
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43. Wang J, Zugates CT, Liang IH, Lee CH, Lee T. Drosophila Dscam is required for divergent segregation of sister branches and suppresses ectopic bifurcation of axons. Neuron. 2002 Feb 14; 33(4):559-71.
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Drosophila Proteins
Neurons
Drosophila
Brain
Mushroom Bodies
See all (150) keywords
Co-Authors  
Waddell, Scott
See all (1) people
Physical Neighbors  
Benard, Claire
Li, Hong-Sheng
Francis, Michael
Waddell, Scott
Reppert, Steven

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