Christian P Mueller MD
Title Assistant Professor
Institution University of Massachusetts Medical School
Department Anesthesiology
Address University of Massachusetts Medical School
381 Plantation Street
Worcester MA
Telephone 508-856-4358
Email
Narrative

Photo: Christian Müller, M.D. My grandfather, who was a successful surgeon, was a little disappointed about my desire to go into anesthesia.  "Fifty years ago," he said, "your job was done by a nurse!" "That's not bad", I replied, "considering 200 years ago your job was done by a barber!"

I am very happy that I have chosen a career in anesthesiology.   I enjoy working with people and getting patients through the operation comfortably.   I like the hands-on approach and the relatively limited number of patients I have, thereby giving me more time to focus on a particular patient.

My special interests are cardiac anesthesia, anesthesia for the trauma patient and the difficult airway.   The reason I went into cardiac anesthesia is the challenge of getting a severely sick patient through the surgery and therefore making a difference in that patient's quality of life.   Furthermore I enjoy spending time with my family and (as you can see in the picture) post-call days.

I have been working with and teaching residents since 2001.   I enjoy seeing residents making progress and developing into good physicians.   My teaching interests are the practical approach to deliver a good anesthetic, to perform a safe anesthetic for a patient with severe cardiac disease, and a practical approach to manage a difficult airway.   My goal is to "translate" the information my residents read in textbooks into good clinical skills.

I am looking forward to future residents coming through and sharing with them Chinese, Indian or Middle Eastern food when we are on call.


Academic Background

M.D., Rostock University Medical School, Rostock, Germany, 1993.


Postdoctoral Training

Rostock University Hospitals, Rostock, Germany, Residency in Anesthesiology, 1993-1995.
UMass Memorial Medical Center, Residency in Anesthesiology, 1996-2000.
UMass Memorial Medical Center, Fellowship in Cardiovascular Anesthesiology, 2000-2001.


Publications
1. Mueller C, Tang Q, Gruntman A, Blomenkamp K, Teckman J, Song L, Zamore PD, Flotte TR. Sustained miRNA-mediated Knockdown of Mutant AAT With Simultaneous Augmentation of Wild-type AAT Has Minimal Effect on Global Liver miRNA Profiles. Mol Ther. 2012 Jan 17.
  View in: PubMed
 
2. Flotte TR, Trapnell BC, Humphries M, Carey B, Calcedo R, Rouhani F, Campbell-Thompson M, Yachnis AT, Sandhaus RA, McElvaney NG, Mueller C, Messina LM, Wilson JM, Brantly M, Knop DR, Ye GJ, Chulay JD. Phase 2 clinical trial of a recombinant adeno-associated viral vector expressing a1-antitrypsin: interim results. Hum Gene Ther. 2011 Oct; 22(10):1239-47.
  View in: PubMed
 
3. Zhang H, Yang B, Mu X, Ahmed SS, Su Q, He R, Wang H, Mueller C, Sena-Esteves M, Brown R, Xu Z, Gao G. Several rAAV Vectors Efficiently Cross the Blood-brain Barrier and Transduce Neurons and Astrocytes in the Neonatal Mouse Central Nervous System. Mol Ther. 2011 Aug; 19(8):1440-8.
  View in: PubMed
 
4. Nath B, Levin I, Csak T, Petrasek J, Mueller C, Kodys K, Catalano D, Mandrekar P, Szabo G. Hepatocyte-specific hypoxia-inducible factor-1a is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice. Hepatology. 2011 May; 53(5):1526-37.
  View in: PubMed
 
5. Flotte TR, Frederickson RM, Lowenstein PR, Mueller C. Moving Forward Toward a Cure for Parkinson's: Neuropathology of the Nigrostriatal Pathway Determines the Location of Growth Factor Delivery. Mol Ther. 2011 May; 19(5):827-9.
  View in: PubMed
 
6. Flotte TR, Mueller C. Gene therapy for alpha-1 antitrypsin deficiency. Hum Mol Genet. 2011 Apr 15; 20(R1):R87-92.
  View in: PubMed
 
7. Flotte TR, Conlon TJ, Mueller C. Preclinical study design for rAAV. Methods Mol Biol. 2011; 807:317-37.
  View in: PubMed
 
8. Xie J, Xie Q, Zhang H, Ameres SL, Hung JH, Su Q, He R, Mu X, Seher Ahmed S, Park S, Kato H, Li C, Mueller C, Mello CC, Weng Z, Flotte TR, Zamore PD, Gao G. MicroRNA-regulated, Systemically Delivered rAAV9: A Step Closer to CNS-restricted Transgene Expression. Mol Ther. 2011 Mar; 19(3):526-35.
  View in: PubMed
 
9. Mueller C, Braag SA, Keeler A, Hodges C, Drumm M, Flotte TR. Lack of Cystic Fibrosis Transmembrane Conductance Regulator in CD3+ Lymphocytes Leads to Aberrant Cytokine Secretion and Hyperinflammatory Adaptive Immune Responses. Am J Respir Cell Mol Biol. 2011 Jun; 44(6):922-9.
  View in: PubMed
 
10. Mueller C, Keeler A, Braag S, Menz T, Tang Q, Flotte TR. Modulation of exaggerated-IgE allergic responses by gene transfer-mediated antagonism of IL-13 and IL-17e. Mol Ther. 2010 Mar; 18(3):511-8.
  View in: PubMed
 
11. Mueller C, Strayer MS, Sirninger J, Braag S, Branco F, Louboutin JP, Flotte TR, Strayer DS. In vitro and in vivo functional characterization of gutless recombinant SV40-derived CFTR vectors. Gene Ther. 2010 Feb; 17(2):227-37.
  View in: PubMed
 
12. Flotte TR, Fischer AC, Goetzmann J, Mueller C, Cebotaru L, Yan Z, Wang L, Wilson JM, Guggino WB, Engelhardt JF. Dual reporter comparative indexing of rAAV pseudotyped vectors in chimpanzee airway. Mol Ther. 2010 Mar; 18(3):594-600.
  View in: PubMed
 
13. Mueller C, Flotte TR. Gene therapy for cystic fibrosis. Clin Rev Allergy Immunol. 2008 Dec; 35(3):164-78.
  View in: PubMed
 
14. Mueller C, Braag SA, Martino AT, Tang Q, Campbell-Thompson M, Flotte TR. The pros and cons of immunomodulatory IL-10 gene therapy with recombinant AAV in a Cftr-/- -dependent allergy mouse model. Gene Ther. 2009 Feb; 16(2):172-83.
  View in: PubMed
 
15. Stalvey MS, Brusko TM, Mueller C, Wasserfall CH, Schatz DA, Atkinson MA, Flotte TR. CFTR mutations impart elevated immune reactivity in a murine model of cystic fibrosis related diabetes. Cytokine. 2008 Oct; 44(1):154-9.
  View in: PubMed
 
16. Flotte TR, Goetzmann J, Caridi J, Paolillo J, Conlon TJ, Potter M, Mueller C, Byrne BJ. Apparently nonspecific enzyme elevations after portal vein delivery of recombinant adeno-associated virus serotype 2 vector in hepatitis C virus-infected chimpanzees. Hum Gene Ther. 2008 Jul; 19(7):681-9.
  View in: PubMed
 
17. Mueller C, Flotte TR. Clinical gene therapy using recombinant adeno-associated virus vectors. Gene Ther. 2008 Jun; 15(11):858-63.
  View in: PubMed
 
For assistance with using Profiles, please refer to the online tutorials at http://inside.umassmed.edu/is/profiles.aspx or contact the UMMS Help Desk at UMWHelpDesk@umassmed.edu or 508-856-8643.
 
Keyword
Last Name
Institution
    
 
 
 
Co-Authors  
Flotte, Terence
Gao, Guangping
Muller, Christian
Tang, Qiushi
Zamore, Phillip
See all (11) people
Physical Neighbors  
Almeda, Arnel
Negroiu, Costin
Maltais, Eileen
Zanconato, Rebecca
Shaikh, Shaheen

UMMS Home

Intranet

This is an official Page/Publication of the University of Massachusetts Worcester Campus
Office of the Vice Provost for Research, 55 Lake Ave North, Worcester, Massachusetts 01655
Questions or Comments? Email: publicaffairs@umassmed.edu Phone: 508-856-1572