David Grunwald PHD
Title Assistant Professor
Institution University of Massachusetts Medical School
Department Biochemistry & Molecular Pharmacology
Address Albert Sherman Center
368 Plantation Street
Worcester MA 01605
Telephone 508/856-6241
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Biochemistry & Molecular Pharmacology

Institution UMMS - Programs, Centers and Institutes
Department RNA Therapeutics Institute
Publications
1. Grunwald DJ. A revolution coming to a classic model organism. Nat Methods. 2013 Apr; 10(4):303-6.
  View in: PubMed
 
2. Singer S, Zhao R, Barsotti AM, Ouwehand A, Fazollahi M, Coutavas E, Breuhahn K, Neumann O, Longerich T, Pusterla T, Powers MA, Giles KM, Leedman PJ, Hess J, Grunwald D, Bussemaker HJ, Singer RH, Schirmacher P, Prives C. Nuclear Pore Component Nup98 Is a Potential Tumor Suppressor and Regulates Posttranscriptional Expression of Select p53 Target Genes. Mol Cell. 2012 Dec 14; 48(5):799-810.
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3. Wang X, Kopinke D, Lin J, McPherson AD, Duncan RN, Otsuna H, Moro E, Hoshijima K, Grunwald DJ, Argenton F, Chien CB, Murtaugh LC, Dorsky RI. Wnt signaling regulates postembryonic hypothalamic progenitor differentiation. Dev Cell. 2012 Sep 11; 23(3):624-36.
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4. Xing L, Hoshijima K, Grunwald DJ, Fujimoto E, Quist TS, Sneddon J, Chien CB, Stevenson TJ, Bonkowsky JL. Zebrafish foxP2 Zinc Finger Nuclease Mutant Has Normal Axon Pathfinding. PLoS One. 2012; 7(8):e43968.
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5. Dahlem TJ, Hoshijima K, Jurynec MJ, Gunther D, Starker CG, Locke AS, Weis AM, Voytas DF, Grunwald DJ. Simple Methods for Generating and Detecting Locus-Specific Mutations Induced with TALENs in the Zebrafish Genome. PLoS Genet. 2012 Aug; 8(8):e1002861.
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6. Wythe JD, Jurynec MJ, Urness LD, Jones CA, Sabeh MK, Werdich AA, Sato M, Yost HJ, Grunwald DJ, Macrae CA, Li DY. Hadp1, a newly identified pleckstrin homology domain protein, is required for cardiac contractility in zebrafish. Dis Model Mech. 2011 Sep-Oct; 4(5):607-21.
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7. Demarest BL, Horsley WH, Locke EE, Boucher K, Grunwald DJ, Trede NS. Trans-centromere effects on meiotic recombination in the zebrafish. Genetics. 2011 Jan; 187(1):333-6.
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8. Bai X, Kim J, Yang Z, Jurynec MJ, Akie TE, Lee J, LeBlanc J, Sessa A, Jiang H, DiBiase A, Zhou Y, Grunwald DJ, Lin S, Cantor AB, Orkin SH, Zon LI. TIF1gamma controls erythroid cell fate by regulating transcription elongation. Cell. 2010 Jul 9; 142(1):133-43.
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9. Jurynec MJ, Grunwald DJ. SHIP2, a factor associated with diet-induced obesity and insulin sensitivity, attenuates FGF signaling in vivo. Dis Model Mech. 2010 Nov-Dec; 3(11-12):733-42.
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10. Jurynec MJ, Xia R, Mackrill JJ, Gunther D, Crawford T, Flanigan KM, Abramson JJ, Howard MT, Grunwald DJ. Selenoprotein N is required for ryanodine receptor calcium release channel activity in human and zebrafish muscle. Proc Natl Acad Sci U S A. 2008 Aug 26; 105(34):12485-90.
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11. Vasquez SX, Hansen MS, Bahadur AN, Hockin MF, Kindlmann GL, Nevell L, Wu IQ, Grunwald DJ, Weinstein DM, Jones GM, Johnson CR, Vandeberg JL, Capecchi MR, Keller C. Optimization of volumetric computed tomography for skeletal analysis of model genetic organisms. Anat Rec (Hoboken). 2008 May; 291(5):475-87.
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12. Lamason RL, Mohideen MA, Mest JR, Wong AC, Norton HL, Aros MC, Jurynec MJ, Mao X, Humphreville VR, Humbert JE, Sinha S, Moore JL, Jagadeeswaran P, Zhao W, Ning G, Makalowska I, McKeigue PM, O'donnell D, Kittles R, Parra EJ, Mangini NJ, Grunwald DJ, Shriver MD, Canfield VA, Cheng KC. SLC24A5, a putative cation exchanger, affects pigmentation in zebrafish and humans. Science. 2005 Dec 16; 310(5755):1782-6.
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13. Goering LM, Hoshijima K, Hug B, Bisgrove B, Kispert A, Grunwald DJ. An interacting network of T-box genes directs gene expression and fate in the zebrafish mesoderm. Proc Natl Acad Sci U S A. 2003 Aug 5; 100(16):9410-5.
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14. Hoshijima K, Metherall JE, Grunwald DJ. A protein disulfide isomerase expressed in the embryonic midline is required for left/right asymmetries. Genes Dev. 2002 Oct 1; 16(19):2518-29.
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15. Grunwald DJ, Eisen JS. Headwaters of the zebrafish -- emergence of a new model vertebrate. Nat Rev Genet. 2002 Sep; 3(9):717-24.
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16. Korzh V, Grunwald D. Nadine Dobrovolskaïa-Zavadskaïa and the dawn of developmental genetics. Bioessays. 2001 Apr; 23(4):365-71.
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17. Albrieux M, Moutin MJ, Grunwald D, Villaz M. Calmodulin and immunophilin are required as functional partners of a ryanodine receptor in ascidian oocytes at fertilization. Dev Biol. 2000 Sep 1; 225(1):101-11.
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18. Marty I, Thevenon D, Scotto C, Groh S, Sainnier S, Robert M, Grunwald D, Villaz M. Cloning and characterization of a new isoform of skeletal muscle triadin. J Biol Chem. 2000 Mar 17; 275(11):8206-12.
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19. Dorsky RI, Snyder A, Cretekos CJ, Grunwald DJ, Geisler R, Haffter P, Moon RT, Raible DW. Maternal and embryonic expression of zebrafish lef1. Mech Dev. 1999 Aug; 86(1-2):147-50.
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20. Cretekos CJ, Grunwald DJ. alyron, an insertional mutation affecting early neural crest development in zebrafish. Dev Biol. 1999 Jun 15; 210(2):322-38.
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21. Appel B, Fritz A, Westerfield M, Grunwald DJ, Eisen JS, Riley BB. Delta-mediated specification of midline cell fates in zebrafish embryos. Curr Biol. 1999 Mar 11; 9(5):247-56.
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22. Bisgrove BW, Raible DW, Walter V, Eisen JS, Grunwald DJ. Expression of c-ret in the zebrafish embryo: potential roles in motoneuronal development. J Neurobiol. 1997 Nov 20; 33(6):749-68.
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23. Hug B, Walter V, Grunwald DJ. tbx6, a Brachyury-related gene expressed by ventral mesendodermal precursors in the zebrafish embryo. Dev Biol. 1997 Mar 1; 183(1):61-73.
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24. Arnoult C, Albrieux M, Antoine AF, Grunwald D, Marty I, Villaz M. A ryanodine-sensitive calcium store in ascidian eggs monitored by whole-cell patch-clamp recordings. Cell Calcium. 1997 Feb; 21(2):93-101.
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25. Liao W, Bisgrove BW, Sawyer H, Hug B, Bell B, Peters K, Grunwald DJ, Stainier DY. The zebrafish gene cloche acts upstream of a flk-1 homologue to regulate endothelial cell differentiation. Development. 1997 Jan; 124(2):381-9.
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26. Grunwald DJ. A fin-de siècle achievement: charting new waters in vertebrate biology. Science. 1996 Dec 6; 274(5293):1634-5.
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27. Riley BB, Grunwald DJ. A mutation in zebrafish affecting a localized cellular function required for normal ear development. Dev Biol. 1996 Nov 1; 179(2):427-35.
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28. Weinberg ES, Allende ML, Kelly CS, Abdelhamid A, Murakami T, Andermann P, Doerre OG, Grunwald DJ, Riggleman B. Developmental regulation of zebrafish MyoD in wild-type, no tail and spadetail embryos. Development. 1996 Jan; 122(1):271-80.
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29. Riley BB, Grunwald DJ. Efficient induction of point mutations allowing recovery of specific locus mutations in zebrafish. Proc Natl Acad Sci U S A. 1995 Jun 20; 92(13):5997-6001.
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30. Helde KA, Wilson ET, Cretekos CJ, Grunwald DJ. Contribution of early cells to the fate map of the zebrafish gastrula. Science. 1994 Jul 22; 265(5171):517-20.
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31. Wilson ET, Helde KA, Grunwald DJ. Something's fishy here--rethinking cell movements and cell fate in the zebrafish embryo. Trends Genet. 1993 Oct; 9(10):348-52.
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32. Helde KA, Grunwald DJ. The DVR-1 (Vg1) transcript of zebrafish is maternally supplied and distributed throughout the embryo. Dev Biol. 1993 Oct; 159(2):418-26.
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33. Stachel SE, Grunwald DJ, Myers PZ. Lithium perturbation and goosecoid expression identify a dorsal specification pathway in the pregastrula zebrafish. Development. 1993 Apr; 117(4):1261-74.
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34. Baudier J, Delphin C, Grunwald D, Khochbin S, Lawrence JJ. Characterization of the tumor suppressor protein p53 as a protein kinase C substrate and a S100b-binding protein. Proc Natl Acad Sci U S A. 1992 Dec 1; 89(23):11627-31.
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35. Grunwald DJ, Streisinger G. Induction of recessive lethal and specific locus mutations in the zebrafish with ethyl nitrosourea. Genet Res. 1992 Apr; 59(2):103-16.
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36. Grunwald DJ, Streisinger G. Induction of mutations in the zebrafish with ultraviolet light. Genet Res. 1992 Apr; 59(2):93-101.
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37. Streisinger G, Coale F, Taggart C, Walker C, Grunwald DJ. Clonal origins of cells in the pigmented retina of the zebrafish eye. Dev Biol. 1989 Jan; 131(1):60-9.
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38. Grunwald DJ, Kimmel CB, Westerfield M, Walker C, Streisinger G. A neural degeneration mutation that spares primary neurons in the zebrafish. Dev Biol. 1988 Mar; 126(1):115-28.
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