Marc Fisher MD
Title Professor
Institution University of Massachusetts Medical School
Department Neurology
Address UMass Memorial Medical Center
108 Belmont Street
Worcester MA 01605
Telephone 508-334-6641
Email
Other Positions
Institution UMMS - School of Medicine
Department Radiology
Publications
1. Albers GW, Fisher M. Improving the accuracy of perfusion imaging in acute ischemic stroke. Ann Neurol. 2011 Sep; 70(3):347-9.
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2. Shuaib A, Bornstein NM, Diener HC, Dillon W, Fisher M, Hammer MD, Molina CA, Rutledge JN, Saver JL, Schellinger PD, Shownkeen H. Partial aortic occlusion for cerebral perfusion augmentation: safety and efficacy of NeuroFlo in Acute Ischemic Stroke trial. Stroke. 2011 Jun; 42(6):1680-90.
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3. Walvick RP, Bråtane BT, Henninger N, Sicard KM, Bouley J, Yu Z, Lo E, Wang X, Fisher M. Visualization of clot lysis in a rat embolic stroke model: application to comparative lytic efficacy. Stroke. 2011 Apr; 42(4):1110-5.
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4. Fisher M, Loscalzo J. The perils of combination antithrombotic therapy and potential resolutions. Stroke. 2011 Feb; 42(2):278-81.
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5. Fisher M, Loscalzo J. The perils of combination antithrombotic therapy and potential resolutions. Circulation. 2011 Jan 25; 123(3):232-5.
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6. Fisher M. New approaches to neuroprotective drug development. Stroke. 2011 Jan; 42(1 Suppl):S24-7.
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7. Morris JG, Singh S, Fisher M. Testing for inherited thrombophilias in arterial stroke: can it cause more harm than good? Stroke. 2010 Dec; 41(12):2985-90.
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8. Schäbitz WR, Laage R, Vogt G, Koch W, Kollmar R, Schwab S, Schneider D, Hamann GF, Rosenkranz M, Veltkamp R, Fiebach JB, Hacke W, Grotta JC, Fisher M, Schneider A. AXIS: a trial of intravenous granulocyte colony-stimulating factor in acute ischemic stroke. Stroke. 2010 Nov; 41(11):2545-51.
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9. Henninger N, Kumar R, Fisher M. Acute ischemic stroke therapy. Expert Rev Cardiovasc Ther. 2010 Oct; 8(10):1389-98.
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10. Zhou X, Sun Y, Mazzanti M, Henninger N, Mansour J, Fisher M, Albert M. MRI of stroke using hyperpolarized (129) Xe. NMR Biomed. 2011 Feb; 24(2):170-5.
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11. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Int J Stroke. 2010 Aug; 5(4):238-56.
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12. El Khoury R, Fisher M, Savitz SI. Current practice versus willingness to enroll in clinical trials: paradox among vascular neurologists about treatment for acute ischemic stroke. Stroke. 2010 Sep; 41(9):2038-43.
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13. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Stroke. 2010 Jun; 41(6):1084-99.
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14. Hachinski V, Donnan GA, Gorelick PB, Hacke W, Cramer SC, Kaste M, Fisher M, Brainin M, Buchan AM, Lo EH, Skolnick BE, Furie KL, Hankey GJ, Kivipelto M, Morris J, Rothwell PM, Sacco RL, Smith SC, Wang Y, Bryer A, Ford GA, Iadecola C, Martins SC, Saver J, Skvortsova V, Bayley M, Bednar MM, Duncan P, Enney L, Finklestein S, Jones TA, Kalra L, Kleim J, Nitkin R, Teasell R, Weiller C, Desai B, Goldberg MP, Heiss WD, Saarelma O, Schwamm LH, Shinohara Y, Trivedi B, Wahlgren N, Wong LK, Hakim A, Norrving B, Prudhomme S, Bornstein NM, Davis SM, Goldstein LB, Leys D, Tuomilehto J. Stroke: working toward a prioritized world agenda. Cerebrovasc Dis. 2010; 30(2):127-47.
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15. Fisher M. Introduction to advances in stroke 2009. Stroke. 2010 Feb; 41(2):e62.
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16. Sicard KM, Fisher M. Animal models of focal brain ischemia. Exp Transl Stroke Med. 2009; 1:7.
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17. Bråtane BT, Walvick RP, Corot C, Lancelot E, Fisher M. Characterization of gadolinium-based dynamic susceptibility contrast perfusion measurements in permanent and transient MCAO models with volumetric based validation by CASL. J Cereb Blood Flow Metab. 2010 Feb; 30(2):336-42.
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18. Bråtane BT, Bouley J, Schneider A, Bastan B, Henninger N, Fisher M. Granulocyte-colony stimulating factor delays PWI/DWI mismatch evolution and reduces final infarct volume in permanent-suture and embolic focal cerebral ischemia models in the rat. Stroke. 2009 Sep; 40(9):3102-6.
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19. Henninger N, Chowdhury N, Fisher M, Moonis M. Use of telemedicine to increase thrombolysis and advance care in acute ischemic stroke. Cerebrovasc Dis. 2009; 27 Suppl 4:9-14.
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20. Saver JL, Albers GW, Dunn B, Johnston KC, Fisher M. Stroke Therapy Academic Industry Roundtable (STAIR) recommendations for extended window acute stroke therapy trials. Stroke. 2009 Jul; 40(7):2594-600.
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21. Morris JG, Duffis EJ, Fisher M. Cardiac workup of ischemic stroke: can we improve our diagnostic yield? Stroke. 2009 Aug; 40(8):2893-8.
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22. Bråtane BT, Bastan B, Fisher M, Bouley J, Henninger N. Ischemic lesion volume determination on diffusion weighted images vs. apparent diffusion coefficient maps. Brain Res. 2009 Jul 7; 1279:182-8.
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23. Fisher M, Hachinski V. European Cooperative Acute Stroke Study III: support for and questions about a truly emerging therapy. Stroke. 2009 Jun; 40(6):2262-3.
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24. Fisher M. Does the combination of warfarin and aspirin have a place in secondary stroke prevention? No. Stroke. 2009 May; 40(5):1944-5.
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25. Sicard KM, Fisher M. Emerging drugs for acute ischemic stroke. Expert Opin Emerg Drugs. 2009 Mar; 14(1):33-42.
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26. Fisher M, Feuerstein G, Howells DW, Hurn PD, Kent TA, Savitz SI, Lo EH. Update of the stroke therapy academic industry roundtable preclinical recommendations. Stroke. 2009 Jun; 40(6):2244-50.
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27. Zivin JA, Albers GW, Bornstein N, Chippendale T, Dahlof B, Devlin T, Fisher M, Hacke W, Holt W, Ilic S, Kasner S, Lew R, Nash M, Perez J, Rymer M, Schellinger P, Schneider D, Schwab S, Veltkamp R, Walker M, Streeter J. Effectiveness and safety of transcranial laser therapy for acute ischemic stroke. Stroke. 2009 Apr; 40(4):1359-64.
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28. Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman RJ, Minematsu K, Donnan GA, Howells DW. Reprint: Good laboratory practice: preventing introduction of bias at the bench. Int J Stroke. 2009 Feb; 4(1):3-5.
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29. Reinecke H, Brand E, Mesters R, Schäbitz WR, Fisher M, Pavenstädt H, Breithardt G. Dilemmas in the management of atrial fibrillation in chronic kidney disease. J Am Soc Nephrol. 2009 Apr; 20(4):705-11.
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30. Philip M, Benatar M, Fisher M, Savitz SI. Methodological quality of animal studies of neuroprotective agents currently in phase II/III acute ischemic stroke trials. Stroke. 2009 Feb; 40(2):577-81.
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31. Henninger N, Bouley J, Bråtane BT, Bastan B, Shea M, Fisher M. Laser Doppler flowmetry predicts occlusion but not tPA-mediated reperfusion success after rat embolic stroke. Exp Neurol. 2009 Feb; 215(2):290-7.
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32. Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, Buchan A, van der Worp HB, Traystman RJ, Minematsu K, Donnan GA, Howells DW. Reprint: Good laboratory practice: preventing introduction of bias at the bench. J Cereb Blood Flow Metab. 2009 Feb; 29(2):221-3.
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33. Henninger N, Bratane BT, Bastan B, Bouley J, Fisher M. Normobaric hyperoxia and delayed tPA treatment in a rat embolic stroke model. J Cereb Blood Flow Metab. 2009 Jan; 29(1):119-29.
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34. Fisher M, Bastan B. Treating acute ischemic stroke. Curr Opin Drug Discov Devel. 2008 Sep; 11(5):626-32.
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35. Macleod MR, Fisher M, O'Collins V, Sena ES, Dirnagl U, Bath PM, Buchan A, van der Worp HB, Traystman R, Minematsu K, Donnan GA, Howells DW. Good laboratory practice: preventing introduction of bias at the bench. Stroke. 2009 Mar; 40(3):e50-2.
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36. Savitz SI, Benatar M, Saver JL, Fisher M. Outcome analysis in clinical trial design for acute stroke: physicians' attitudes and choices. Cerebrovasc Dis. 2008; 26(2):156-62.
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37. Fisher M. Stroke and TIA: epidemiology, risk factors, and the need for early intervention. Am J Manag Care. 2008 Jun; 14(6 Suppl 2):S204-11.
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38. Donnan GA, Fisher M, Macleod M, Davis SM. Stroke. Lancet. 2008 May 10; 371(9624):1612-23.
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39. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. AJNR Am J Neuroradiol. 2008 May; 29(5):e23-30.
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40. Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, Davis S, Demaerschalk BM, Derdeyn CP, Donnan GA, Eastwood JD, Fiebach JB, Fisher M, Furie KL, Goldmakher GV, Hacke W, Kidwell CS, Kloska SP, Köhrmann M, Koroshetz W, Lee TY, Lees KR, Lev MH, Liebeskind DS, Ostergaard L, Powers WJ, Provenzale J, Schellinger P, Silbergleit R, Sorensen AG, Wardlaw J, Wu O, Warach S. Acute stroke imaging research roadmap. Stroke. 2008 May; 39(5):1621-8.
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41. Fisher M, Folland E. Acute ischemic coronary artery disease and ischemic stroke: similarities and differences. Am J Ther. 2008 Mar-Apr; 15(2):137-49.
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42. Fisher M. Advances in Stroke 2007: introduction. Stroke. 2008 Feb; 39(2):250-1.
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43. Langley B, D'Annibale MA, Suh K, Ayoub I, Tolhurst A, Bastan B, Yang L, Ko B, Fisher M, Cho S, Beal MF, Ratan RR. Pulse inhibition of histone deacetylases induces complete resistance to oxidative death in cortical neurons without toxicity and reveals a role for cytoplasmic p21(waf1/cip1) in cell cycle-independent neuroprotection. J Neurosci. 2008 Jan 2; 28(1):163-76.
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44. Savitz SI, Fisher M. NXY-059 for the treatment of stroke. N Engl J Med. 2007 Nov 22; 357(21):2198; author reply 2198-9.
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45. Henninger N, Sicard KM, Li Z, Kulkarni P, Dützmann S, Urbanek C, Schwab S, Fisher M. Differential recovery of behavioral status and brain function assessed with functional magnetic resonance imaging after mild traumatic brain injury in the rat. Crit Care Med. 2007 Nov; 35(11):2607-14.
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46. Fisher M, Hess DC, Lees K. Issues pertaining to the critiques of the SAINT-I Trial. Stroke. 2007 Nov; 38(11):e126-7; author reply e128.
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47. Savitz SI, Lew R, Bluhmki E, Hacke W, Fisher M. Shift analysis versus dichotomization of the modified Rankin scale outcome scores in the NINDS and ECASS-II trials. Stroke. 2007 Dec; 38(12):3205-12.
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48. Henninger N, Fisher M. Stimulating circle of Willis nerve fibers preserves the diffusion-perfusion mismatch in experimental stroke. Stroke. 2007 Oct; 38(10):2779-86.
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49. Tatlisumak T, Rantanen K, Fisher M. Stroke prevention: a challenging but rewarding task. Curr Drug Targets. 2007 Jul; 8(7):784-5.
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50. Savitz SI, Fisher M. Prophylactic neuroprotection. Curr Drug Targets. 2007 Jul; 8(7):846-9.
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51. Savitz SI, Fisher M. Future of neuroprotection for acute stroke: in the aftermath of the SAINT trials. Ann Neurol. 2007 May; 61(5):396-402.
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52. Lampl Y, Zivin JA, Fisher M, Lew R, Welin L, Dahlof B, Borenstein P, Andersson B, Perez J, Caparo C, Ilic S, Oron U. Infrared laser therapy for ischemic stroke: a new treatment strategy: results of the NeuroThera Effectiveness and Safety Trial-1 (NEST-1). Stroke. 2007 Jun; 38(6):1843-9.
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53. Ali M, Bath PM, Curram J, Davis SM, Diener HC, Donnan GA, Fisher M, Gregson BA, Grotta J, Hacke W, Hennerici MG, Hommel M, Kaste M, Marler JR, Sacco RL, Teal P, Wahlgren NG, Warach S, Weir CJ, Lees KR. The Virtual International Stroke Trials Archive. Stroke. 2007 Jun; 38(6):1905-10.
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54. Henninger N, Sicard KM, Fisher M. Spectacular shrinking deficit: insights from multimodal magnetic resonance imaging after embolic middle cerebral artery occlusion in Sprague-Dawley rats. J Cereb Blood Flow Metab. 2007 Oct; 27(10):1756-63.
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55. Bardutzky J, Shen Q, Henninger N, Schwab S, Duong TQ, Fisher M. Characterizing tissue fate after transient cerebral ischemia of varying duration using quantitative diffusion and perfusion imaging. Stroke. 2007 Apr; 38(4):1336-44.
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56. Henninger N, Bouley J, Nelligan JM, Sicard KM, Fisher M. Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2007 Sep; 27(9):1632-42.
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57. Fisher M, Hanley DF, Howard G, Jauch EC, Warach S. Recommendations from the STAIR V meeting on acute stroke trials, technology and outcomes. Stroke. 2007 Feb; 38(2):245-8.
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58. Fisher M, Henninger N. Translational research in stroke: taking advances in the pathophysiology and treatment of stroke from the experimental setting to clinical trials. Curr Neurol Neurosci Rep. 2007 Jan; 7(1):35-41.
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59. Bouley J, Fisher M, Henninger N. Comparison between coated vs. uncoated suture middle cerebral artery occlusion in the rat as assessed by perfusion/diffusion weighted imaging. Neurosci Lett. 2007 Feb 2; 412(3):185-90.
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60. Fisher M. Is penumbral imaging useful for extending the treatment window for intravenous tissue plasminogen activator? Ann Neurol. 2006 Nov; 60(5):499-501.
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61. Fisher M. NXY-059 for acute ischemic stroke: the promise of neuroprotection is finally realized? Stroke. 2006 Oct; 37(10):2651-2.
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62. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Long-term changes of functional MRI-based brain function, behavioral status, and histopathology after transient focal cerebral ischemia in rats. Stroke. 2006 Oct; 37(10):2593-600.
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63. Fisher M, Lees K, Papadakis M, Buchan AM. NXY-059: brain or vessel protection. Stroke. 2006 Aug; 37(8):2189-90.
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64. Fisher M. Does neuroprotection with NXY-059 improve patient outcome after acute ischemic stroke? Nat Clin Pract Cardiovasc Med. 2006 Jun; 3(6):302-3.
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65. Fisher M. The ischemic penumbra: a new opportunity for neuroprotection. Cerebrovasc Dis. 2006; 21 Suppl 2:64-70.
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66. Padma V, Fisher M, Moonis M. Role of heparin and low-molecular-weight heparins in the management of acute ischemic stroke. Expert Rev Cardiovasc Ther. 2006 May; 4(3):405-15.
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67. Fisher M, Cheung K, Howard G, Warach S. New pathways for evaluating potential acute stroke therapies. Int J Stroke. 2006 May; 1(2):52-8.
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68. Henninger N, Sicard KM, Schmidt KF, Bardutzky J, Fisher M. Comparison of ischemic lesion evolution in embolic versus mechanical middle cerebral artery occlusion in Sprague Dawley rats using diffusion and perfusion imaging. Stroke. 2006 May; 37(5):1283-7.
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69. Sicard KM, Henninger N, Fisher M, Duong TQ, Ferris CF. Differential recovery of multimodal MRI and behavior after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 2006 Nov; 26(11):1451-62.
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70. Henninger N, Sicard KM, Bouley J, Fisher M, Stagliano NE. The proteasome inhibitor VELCADE reduces infarction in rat models of focal cerebral ischemia. Neurosci Lett. 2006 May 8; 398(3):300-5.
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71. Fisher M. Results of the management of atherothrombosis with clopidogrel in high-risk patients trial: implications for the neurologist. Arch Neurol. 2006 Jan; 63(1):20-4.
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72. Henninger N, Fisher M. Normobaric hyperoxia - a promising approach to expand the time window for acute stroke treatment. Cerebrovasc Dis. 2006; 21(1-2):134-6.
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73. Warach S, Kaufman D, Chiu D, Devlin T, Luby M, Rashid A, Clayton L, Kaste M, Lees KR, Sacco R, Fisher M. Effect of the Glycine Antagonist Gavestinel on cerebral infarcts in acute stroke patients, a randomized placebo-controlled trial: The GAIN MRI Substudy. Cerebrovasc Dis. 2006; 21(1-2):106-11.
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74. Fisher M. Developing and implementing future stroke therapies: the potential of telemedicine. Ann Neurol. 2005 Nov; 58(5):666-71.
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75. Shen Q, Ren H, Fisher M, Duong TQ. Statistical prediction of tissue fate in acute ischemic brain injury. J Cereb Blood Flow Metab. 2005 Oct; 25(10):1336-45.
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76. Shen Q, Ren H, Cheng H, Fisher M, Duong TQ. Functional, perfusion and diffusion MRI of acute focal ischemic brain injury. J Cereb Blood Flow Metab. 2005 Oct; 25(10):1265-79.
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77. Fisher M, Tatlisumak T. Use of animal models has not contributed to development of acute stroke therapies: con. Stroke. 2005 Oct; 36(10):2324-5.
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78. Bardutzky J, Meng X, Bouley J, Duong TQ, Ratan R, Fisher M. Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model. J Cereb Blood Flow Metab. 2005 Aug; 25(8):968-77.
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79. Bardutzky J, Shen Q, Henninger N, Bouley J, Duong TQ, Fisher M. Differences in ischemic lesion evolution in different rat strains using diffusion and perfusion imaging. Stroke. 2005 Sep; 36(9):2000-5.
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80. Fisher M, Albers GW, Donnan GA, Furlan AJ, Grotta JC, Kidwell CS, Sacco RL, Wechsler LR. Enhancing the development and approval of acute stroke therapies: Stroke Therapy Academic Industry roundtable. Stroke. 2005 Aug; 36(8):1808-13.
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81. Bardutzky J, Shen Q, Bouley J, Sotak CH, Duong TQ, Fisher M. Perfusion and diffusion imaging in acute focal cerebral ischemia: temporal vs. spatial resolution. Brain Res. 2005 May 10; 1043(1-2):155-62.
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82. Moonis M, Kane K, Schwiderski U, Sandage BW, Fisher M. HMG-CoA reductase inhibitors improve acute ischemic stroke outcome. Stroke. 2005 Jun; 36(6):1298-300.
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83. Henning EC, Meng X, Fisher M, Sotak CH. Visualization of cortical spreading depression using manganese-enhanced magnetic resonance imaging. Magn Reson Med. 2005 Apr; 53(4):851-7.
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84. Padma V, Fisher M, Moonis M. Thrombolytic therapy for acute ischemic stroke: 3 h and beyond. Expert Rev Neurother. 2005 Mar; 5(2):223-33.
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85. Furlan AJ, Fisher M. Devices, drugs, and the Food and Drug Administration: increasing implications for ischemic stroke. Stroke. 2005 Feb; 36(2):398-9.
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86. Davalos A, Fisher M. Emerging therapies for cerebrovascular disorders. Stroke. 2005 Feb; 36(2):208-10.
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87. Ren H, Shen Q, Bardutzky J, Fisher M, Duong TQ. Partial-volume effect on ischemic tissue-fate delineation using quantitative perfusion and diffusion imaging on a rat stroke model. Magn Reson Med. 2004 Dec; 52(6):1328-35.
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88. Padma V, Fisher M, Moonis M. Antihypertensive medications for risk reduction of first and recurrent ischemic stroke. Expert Rev Cardiovasc Ther. 2004 Nov; 2(6):867-76.
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89. Fisher M, Davalos A. The MATCH study results in the context of secondary stroke prevention. Stroke. 2004 Nov; 35(11):2609.
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90. Gerriets T, Stolz E, Walberer M, Müller C, Rottger C, Kluge A, Kaps M, Fisher M, Bachmann G. Complications and pitfalls in rat stroke models for middle cerebral artery occlusion: a comparison between the suture and the macrosphere model using magnetic resonance angiography. Stroke. 2004 Oct; 35(10):2372-7.
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91. Shen Q, Ren H, Fisher M, Bouley J, Duong TQ. Dynamic tracking of acute ischemic tissue fates using improved unsupervised ISODATA analysis of high-resolution quantitative perfusion and diffusion data. J Cereb Blood Flow Metab. 2004 Aug; 24(8):887-97.
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92. Duong TQ, Fisher M. Applications of diffusion/perfusion magnetic resonance imaging in experimental and clinical aspects of stroke. Curr Atheroscler Rep. 2004 Jul; 6(4):267-73.
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93. Mayzel-Oreg O, Omae T, Kazemi M, Li F, Fisher M, Cohen Y, Sotak CH. Microsphere-induced embolic stroke: an MRI study. Magn Reson Med. 2004 Jun; 51(6):1232-8.
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94. Kazemi M, Silva MD, Li F, Fisher M, Sotak CH. Investigation of techniques to quantify in vivo lesion volume based on comparison of water apparent diffusion coefficient (ADC) maps with histology in focal cerebral ischemia of rats. Magn Reson Imaging. 2004 Jun; 22(5):653-9.
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95. Shen Q, Fisher M, Sotak CH, Duong TQ. Effects of reperfusion on ADC and CBF pixel-by-pixel dynamics in stroke: characterizing tissue fates using quantitative diffusion and perfusion imaging. J Cereb Blood Flow Metab. 2004 Mar; 24(3):280-90.
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96. Moonis M, Fisher M. HMG CoA reductase inhibitors (statins): use in stroke prevention and outcome after stroke. Expert Rev Neurother. 2004 Mar; 4(2):241-7.
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97. Meng X, Fisher M, Shen Q, Sotak CH, Duong TQ. Characterizing the diffusion/perfusion mismatch in experimental focal cerebral ischemia. Ann Neurol. 2004 Feb; 55(2):207-12.
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98. Fisher M, Davalos A. Emerging therapies for cerebrovascular disorders. Stroke. 2004 Feb; 35(2):367-9.
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99. Gerriets T, Stolz E, Walberer M, Müller C, Kluge A, Kaps M, Fisher M, Bachmann G. Middle cerebral artery occlusion during MR-imaging: investigation of the hyperacute phase of stroke using a new in-bore occlusion model in rats. Brain Res Brain Res Protoc. 2004 Feb; 12(3):137-43.
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100. Fisher M. The ischemic penumbra: identification, evolution and treatment concepts. Cerebrovasc Dis. 2004; 17 Suppl 1:1-6.
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101. Shen Q, Meng X, Fisher M, Sotak CH, Duong TQ. Pixel-by-pixel spatiotemporal progression of focal ischemia derived using quantitative perfusion and diffusion imaging. J Cereb Blood Flow Metab. 2003 Dec; 23(12):1479-88.
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102. Moonis M, Fisher M. Antiplatelet treatment for secondary prevention of acute ischemic stroke and transient ischemic attacks: mechanisms, choices and possible emerging patterns of use. Expert Rev Cardiovasc Ther. 2003 Nov; 1(4):611-5.
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103. Fisher M. Stem cell transplantation for stroke: does it work, and if so, how? Stroke. 2003 Aug; 34(8):2083.
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104. Fisher M. Recommendations for advancing development of acute stroke therapies: Stroke Therapy Academic Industry Roundtable 3. Stroke. 2003 Jun; 34(6):1539-46.
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105. Shashoua VE, Adams DS, Boyer-Boiteau A, Cornell-Bell A, Li F, Fisher M. Neuroprotective effects of a new synthetic peptide, CMX-9236, in in vitro and in vivo models of cerebral ischemia. Brain Res. 2003 Feb 14; 963(1-2):214-23.
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106. Fisher M, Brott TG. Emerging therapies for acute ischemic stroke: new therapies on trial. Stroke. 2003 Feb; 34(2):359-61.
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107. Gerriets T, Li F, Silva MD, Meng X, Brevard M, Sotak CH, Fisher M. The macrosphere model: evaluation of a new stroke model for permanent middle cerebral artery occlusion in rats. J Neurosci Methods. 2003 Jan 30; 122(2):201-11.
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108. Fisher M, Ratan R. New perspectives on developing acute stroke therapy. Ann Neurol. 2003 Jan; 53(1):10-20.
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109. Fisher M. Ongoing trials and future directions for acute ischemic stroke treatment. Adv Neurol. 2003; 92:401-8.
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110. Fisher M. Reversal of diffusion abnormalities after ischemic stroke: adding difficulty and complexity to the conundrum of acute stroke imaging. Ann Neurol. 2002 Dec; 52(6):695-6.
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111. Fisher M. Developing therapy for acute ischemic stroke. Therapie. 2002 Nov-Dec; 57(6):564-8.
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112. Silva MD, Omae T, Helmer KG, Li F, Fisher M, Sotak CH. Separating changes in the intra- and extracellular water apparent diffusion coefficient following focal cerebral ischemia in the rat brain. Magn Reson Med. 2002 Nov; 48(5):826-37.
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113. Moonis M, Fisher M. Considering the role of heparin and low-molecular-weight heparins in acute ischemic stroke. Stroke. 2002 Jul; 33(7):1927-33.
  View in: PubMed
 
114. Li F, Liu KF, Silva MD, Meng X, Gerriets T, Helmer KG, Fenstermacher JD, Sotak CH, Fisher M. Acute postischemic renormalization of the apparent diffusion coefficient of water is not associated with reversal of astrocytic swelling and neuronal shrinkage in rats. AJNR Am J Neuroradiol. 2002 Feb; 23(2):180-8.
  View in: PubMed
 
115. Moonis M, Fisher M. Imaging of acute stroke. Cerebrovasc Dis. 2001; 11(3):143-50.
  View in: PubMed
 
116. Fisher M, Schaebitz W. An overview of acute stroke therapy: past, present, and future. Arch Intern Med. 2000 Nov 27; 160(21):3196-206.
  View in: PubMed
 
117. Omae T, Mayzel-Oreg O, Li F, Sotak CH, Fisher M. Inapparent hemodynamic insufficiency exacerbates ischemic damage in a rat microembolic stroke model. Stroke. 2000 Oct; 31(10):2494-9.
  View in: PubMed
 
118. Li F, Silva MD, Liu KF, Helmer KG, Omae T, Fenstermacher JD, Sotak CH, Fisher M. Secondary decline in apparent diffusion coefficient and neurological outcomes after a short period of focal brain ischemia in rats. Ann Neurol. 2000 Aug; 48(2):236-44.
  View in: PubMed
 
119. Schäbitz WR, Li F, Fisher M. The N-methyl-D-aspartate antagonist CNS 1102 protects cerebral gray and white matter from ischemic injury following temporary focal ischemia in rats. Stroke. 2000 Jul; 31(7):1709-14.
  View in: PubMed
 
120. Li F, Liu KF, Silva MD, Omae T, Sotak CH, Fenstermacher JD, Fisher M, Hsu CY, Lin W. Transient and permanent resolution of ischemic lesions on diffusion-weighted imaging after brief periods of focal ischemia in rats : correlation with histopathology. Stroke. 2000 Apr; 31(4):946-54.
  View in: PubMed
 
121. Li F, Silva MD, Sotak CH, Fisher M. Temporal evolution of ischemic injury evaluated with diffusion-, perfusion-, and T2-weighted MRI. Neurology. 2000 Feb 8; 54(3):689-96.
  View in: PubMed
 
122. Li F, Omae T, Fisher M. Spontaneous hyperthermia and its mechanism in the intraluminal suture middle cerebral artery occlusion model of rats. Stroke. 1999 Nov; 30(11):2464-70; discussion 2470-1.
  View in: PubMed
 
123. Fisher M. [The objective of acute stroke therapy and neuroprotective therapeutic approaches]. Rev Neurol. 1999 Sep 16-30; 29(6):536-44.
  View in: PubMed
 
124. Li F, Han SS, Tatlisumak T, Liu KF, Garcia JH, Sotak CH, Fisher M. Reversal of acute apparent diffusion coefficient abnormalities and delayed neuronal death following transient focal cerebral ischemia in rats. Ann Neurol. 1999 Sep; 46(3):333-42.
  View in: PubMed
 
125. Li F, Carano RA, Irie K, Tatlisumak T, Silva MD, Pschorni U, Sotak CH, Fisher M. Neuroprotective effects of a novel broad-spectrum cation channel blocker, LOE 908 MS, on experimental focal ischemia: a multispectral study. J Magn Reson Imaging. 1999 Aug; 10(2):138-45.
  View in: PubMed
 
126. Fisher M, Albers GW. Applications of diffusion-perfusion magnetic resonance imaging in acute ischemic stroke. Neurology. 1999 Jun 10; 52(9):1750-6.
  View in: PubMed
 
127. Schäbitz WR, Li F, Irie K, Sandage BW, Locke KW, Fisher M. Synergistic effects of a combination of low-dose basic fibroblast growth factor and citicoline after temporary experimental focal ischemia. Stroke. 1999 Feb; 30(2):427-31; discussion 431-2.
  View in: PubMed
 
128. Fisher M, Finklestein S. Pharmacological approaches to stroke recovery. Cerebrovasc Dis. 1999; 9 Suppl 5:29-32.
  View in: PubMed
 
129. Fisher M. The travails of neuroprotective drug development for acute ischemic stroke. Eur Neurol. 1998 Aug; 40(2):65-6.
  View in: PubMed
 
130. Li F, Han S, Tatlisumak T, Carano RA, Irie K, Sotak CH, Fisher M. A new method to improve in-bore middle cerebral artery occlusion in rats: demonstration with diffusion- and perfusion-weighted imaging. Stroke. 1998 Aug; 29(8):1715-9; discussion 1719-20.
  View in: PubMed
 
131. Fisher M, Bogousslavsky J. Further evolution toward effective therapy for acute ischemic stroke. JAMA. 1998 Apr 22-29; 279(16):1298-303.
  View in: PubMed
 
132. Takano K, Carano RA, Tatlisumak T, Meiler M, Sotak CH, Kleinert HD, Fisher M. Efficacy of intra-arterial and intravenous prourokinase in an embolic stroke model evaluated by diffusion-perfusion magnetic resonance imaging. Neurology. 1998 Apr; 50(4):870-5.
  View in: PubMed
 
133. Takano K, Tatlisumak T, Bergmann AG, Gibson DG, Fisher M. Reproducibility and reliability of middle cerebral artery occlusion using a silicone-coated suture (Koizumi) in rats. J Neurol Sci. 1997 Dec 9; 153(1):8-11.
  View in: PubMed
 
134. Fisher M. Anterior circulation ischemia. New Horiz. 1997 Nov; 5(4):299-304.
  View in: PubMed
 
135. Li F, Irie K, Anwer MS, Fisher M. Delayed triphenyltetrazolium chloride staining remains useful for evaluating cerebral infarct volume in a rat stroke model. J Cereb Blood Flow Metab. 1997 Oct; 17(10):1132-5.
  View in: PubMed
 
136. Takano K, Tatlisumak T, Formato JE, Carano RA, Bergmann AG, Pullan LM, Bare TM, Sotak CH, Fisher M. Glycine site antagonist attenuates infarct size in experimental focal ischemia. Postmortem and diffusion mapping studies. Stroke. 1997 Jun; 28(6):1255-62; discussion 1263.
  View in: PubMed
 
137. Onal MZ, Li F, Tatlisumak T, Locke KW, Sandage BW, Fisher M. Synergistic effects of citicoline and MK-801 in temporary experimental focal ischemia in rats. Stroke. 1997 May; 28(5):1060-5.
  View in: PubMed
 
138. Fisher M. Characterizing the target of acute stroke therapy. Stroke. 1997 Apr; 28(4):866-72.
  View in: PubMed
 
139. Fisher M, Garcia JH. Evolving stroke and the ischemic penumbra. Neurology. 1996 Oct; 47(4):884-8.
  View in: PubMed
 
140. Hasegawa Y, Formato JE, Latour LL, Gutierrez JA, Liu KF, Garcia JH, Sotak CH, Fisher M. Severe transient hypoglycemia causes reversible change in the apparent diffusion coefficient of water. Stroke. 1996 Sep; 27(9):1648-55; discussion 1655-6.
  View in: PubMed
 
141. Schäbitz WR, Weber J, Takano K, Sandage BW, Locke KW, Fisher M. The effects of prolonged treatment with citicoline in temporary experimental focal ischemia. J Neurol Sci. 1996 Jun; 138(1-2):21-5.
  View in: PubMed
 
142. Silver B, Weber J, Fisher M. Medical therapy for ischemic stroke. Clin Neuropharmacol. 1996 Apr; 19(2):101-28.
  View in: PubMed
 
143. Takano K, Latour LL, Formato JE, Carano RA, Helmer KG, Hasegawa Y, Sotak CH, Fisher M. The role of spreading depression in focal ischemia evaluated by diffusion mapping. Ann Neurol. 1996 Mar; 39(3):308-18.
  View in: PubMed
 
144. Anwer UE, Fisher M. Acute and atypical presentations of syringomyelia. Eur Neurol. 1996; 36(4):215-8.
  View in: PubMed
 
145. Fisher M, Meadows ME, Do T, Weise J, Trubetskoy V, Charette M, Finklestein SP. Delayed treatment with intravenous basic fibroblast growth factor reduces infarct size following permanent focal cerebral ischemia in rats. J Cereb Blood Flow Metab. 1995 Nov; 15(6):953-9.
  View in: PubMed
 
146. Fisher M, Prichard JW, Warach S. New magnetic resonance techniques for acute ischemic stroke. JAMA. 1995 Sep 20; 274(11):908-11.
  View in: PubMed
 
147. Schäbitz WR, Fisher M. Diffusion weighted imaging for acute cerebral infarction. Neurol Res. 1995 Aug; 17(4):270-4.
  View in: PubMed
 
148. Fisher M, Takano K. The penumbra, therapeutic time window and acute ischaemic stroke. Baillieres Clin Neurol. 1995 Aug; 4(2):279-95.
  View in: PubMed
 
149. Fisher M. Diffusion and perfusion imaging for acute stroke. Surg Neurol. 1995 Jun; 43(6):606-9.
  View in: PubMed
 
150. Hasegawa Y, Latour LL, Formato JE, Sotak CH, Fisher M. Spreading waves of a reduced diffusion coefficient of water in normal and ischemic rat brain. J Cereb Blood Flow Metab. 1995 Mar; 15(2):179-87.
  View in: PubMed
 
151. Reith W, Hasegawa Y, Latour LL, Dardzinski BJ, Sotak CH, Fisher M. Multislice diffusion mapping for 3-D evolution of cerebral ischemia in a rat stroke model. Neurology. 1995 Jan; 45(1):172-7.
  View in: PubMed
 
152. Fisher M. Potentially effective therapies for acute ischemic stroke. Eur Neurol. 1995; 35(1):3-7.
  View in: PubMed
 
153. Weaver JP, Fisher M. Subarachnoid hemorrhage: an update of pathogenesis, diagnosis and management. J Neurol Sci. 1994 Sep; 125(2):119-31.
  View in: PubMed
 
154. Hasegawa Y, Fisher M, Latour LL, Dardzinski BJ, Sotak CH. MRI diffusion mapping of reversible and irreversible ischemic injury in focal brain ischemia. Neurology. 1994 Aug; 44(8):1484-90.
  View in: PubMed
 
155. Hasegawa Y, Fisher M, Baron BM, Metcalf G. The competitive NMDA antagonist MDL-100,453 reduces infarct size after experimental stroke. Stroke. 1994 Jun; 25(6):1241-4; discussion 1245-6.
  View in: PubMed
 
156. Hasegawa Y, Latour LL, Sotak CH, Dardzinski BJ, Fisher M. Temperature dependent change of apparent diffusion coefficient of water in normal and ischemic brain of rats. J Cereb Blood Flow Metab. 1994 May; 14(3):383-90.
  View in: PubMed
 
157. Fisher M, Jonas S, Sacco RL, Jones S [corrected to Jonas S. Prophylactic neuroprotection for cerebral ischemia. Stroke. 1994 May; 25(5):1075-80.
  View in: PubMed
 
158. Minematsu K, Fisher M, Li L, Sotak CH. Diffusion and perfusion magnetic resonance imaging studies to evaluate a noncompetitive N-methyl-D-aspartate antagonist and reperfusion in experimental stroke in rats. Stroke. 1993 Dec; 24(12):2074-81.
  View in: PubMed
 
159. Fisher M, Plante GM, Doyle EM. Inhibition of inflammatory cell-mediated myelin oxidation and interleukin-1 beta generation by a 21-aminosteroid, U74500A. J Neurol Sci. 1993 Nov; 119(2):189-94.
  View in: PubMed
 
160. Fisher M, Bogousslavsky J. Evolving toward effective therapy for acute ischemic stroke. JAMA. 1993 Jul 21; 270(3):360-4.
  View in: PubMed
 
161. Minematsu K, Fisher M, Li L, Davis MA, Knapp AG, Cotter RE, McBurney RN, Sotak CH. Effects of a novel NMDA antagonist on experimental stroke rapidly and quantitatively assessed by diffusion-weighted MRI. Neurology. 1993 Feb; 43(2):397-403.
  View in: PubMed
 
162. Nunnari JJ, Fisher M, White SD. Inhibition of lipid deposition in the hypercholesterolemic rat by clentiazem, a calcium channel blocker. Exp Mol Pathol. 1992 Dec; 57(3):193-204.
  View in: PubMed
 
163. Fisher M, Minematsu K. Lacunar stroke: diagnosis, evaluation, and management. Heart Dis Stroke. 1992 Nov-Dec; 1(6):353-6.
  View in: PubMed
 
164. Minematsu K, Li L, Sotak CH, Davis MA, Fisher M. Reversible focal ischemic injury demonstrated by diffusion-weighted magnetic resonance imaging in rats. Stroke. 1992 Sep; 23(9):1304-10; discussion 1310-1.
  View in: PubMed
 
165. Fisher M, Sotak CH, Minematsu K, Li L. New magnetic resonance techniques for evaluating cerebrovascular disease. Ann Neurol. 1992 Aug; 32(2):115-22.
  View in: PubMed
 
166. Fisher M, Arpano MM. Inhibition of stimulated human leukocyte hydrogen peroxide generation by a novel antioxidant, OPC-14117. J Neurol Sci. 1992 May; 109(1):107-10.
  View in: PubMed
 
167. Minematsu K, Li L, Fisher M, Sotak CH, Davis MA, Fiandaca MS. Diffusion-weighted magnetic resonance imaging: rapid and quantitative detection of focal brain ischemia. Neurology. 1992 Jan; 42(1):235-40.
  View in: PubMed
 
168. Fisher M, Levine PH, Doyle EM, Arpano MM, Hoogasian JJ. A 21-aminosteroid inhibits oxidation of human low density lipoprotein by human monocytes and copper. Atherosclerosis. 1991 Oct; 90(2-3):197-202.
  View in: PubMed
 
169. Fisher M. Primary intracerebral and subarachnoid hemorrhage. An approach to diagnosis and therapy. Arq Neuropsiquiatr. 1991 Sep; 49(3):233-42.
  View in: PubMed
 
170. Fisher M. Ischemic cerebral vascular disease: an overview. Arq Neuropsiquiatr. 1991 Mar; 49(1):1-10.
  View in: PubMed
 
171. Hosley MA, Fisher M, Lingley JF. Thrombosis in a congenitally bifurcated superior sagittal sinus. Stroke. 1991 Mar; 22(3):396-400.
  View in: PubMed
 
172. Fisher M, Levine PH, Doyle EM, Arpano MM, Bergeron DA, Cohen RA, Hoogasian JJ. A 21-aminosteroid inhibits stimulated monocyte hydrogen peroxide and chemiluminescence measurements from MS patients and controls. Neurology. 1991 Feb; 41(2 ( Pt 1)):297-9.
  View in: PubMed
 
173. Fisher M. Atherosclerosis: cellular aspects and potential interventions. Cerebrovasc Brain Metab Rev. 1991; 3(2):114-33.
  View in: PubMed
 
174. Fisher M, Levine PH, Cohen RA. A 21-aminosteroid reduces hydrogen peroxide generation by and chemiluminescence of stimulated human leukocytes. Stroke. 1990 Oct; 21(10):1435-8.
  View in: PubMed
 
175. Fisher M, Levine PH, Weiner BH, Johnson MH, Doyle EM, Ellis PA, Hoogasian JJ. Dietary n-3 fatty acid supplementation reduces superoxide production and chemiluminescence in a monocyte-enriched preparation of leukocytes. Am J Clin Nutr. 1990 May; 51(5):804-8.
  View in: PubMed
 
176. Phillips DA, Fisher M, Davis MA, Smith TW, Pang RH. Delayed treatment with a t-PA analogue and streptokinase in a rabbit embolic stroke model. Stroke. 1990 Apr; 21(4):602-5.
  View in: PubMed
 
177. Young SM, Fisher M, Sigsbee A, Errichetti A. Cardiogenic brain embolism and lupus anticoagulant. Ann Neurol. 1989 Sep; 26(3):390-2.
  View in: PubMed
 
178. Fisher M, Levine PH, Leaf A. n-3 fatty acids and cellular aspects of atherosclerosis. Arch Intern Med. 1989 Aug; 149(8):1726-8.
  View in: PubMed
 
179. Cohen RA, Fisher M. Amantadine treatment of fatigue associated with multiple sclerosis. Arch Neurol. 1989 Jun; 46(6):676-80.
  View in: PubMed
 
180. Levine PH, Fisher M, Schneider PB, Whitten RH, Weiner BH, Ockene IS, Johnson BF, Johnson MH, Doyle EM, Riendeau PA, et al. Dietary supplementation with omega-3 fatty acids prolongs platelet survival in hyperlipidemic patients with atherosclerosis. Arch Intern Med. 1989 May; 149(5):1113-6.
  View in: PubMed
 
181. Phillips DA, Fisher M, Smith TW, Davis MA, Pang RH. The effects of a new tissue plasminogen activator analogue, Fb-Fb-CF, on cerebral reperfusion in a rabbit embolic stroke model. Ann Neurol. 1989 Mar; 25(3):281-5.
  View in: PubMed
 
182. Fisher M, Recht LD. Brain tumor presenting as an acute pure motor hemiparesis. Stroke. 1989 Feb; 20(2):288-91.
  View in: PubMed
 
183. Phillips DA, Davis MA, Fisher M. Selective embolization and clot dissolution with tPA in the internal carotid artery circulation of the rabbit. AJNR Am J Neuroradiol. 1988 Sep; 9(5):899-902.
  View in: PubMed
 
184. Fisher M, Kase CS, Stelle B, Mills RM. Ischemic stroke after cardiac pacemaker implantation in sick sinus syndrome. Stroke. 1988 Jun; 19(6):712-5.
  View in: PubMed
 
185. Phillips DA, Fisher M, Smith TW, Davis MA. The safety and angiographic efficacy of tissue plasminogen activator in a cerebral embolization model. Ann Neurol. 1988 Apr; 23(4):391-4.
  View in: PubMed
 
186. Fisher M, Smith TW, Jacobs R. Pure motor hemiplegia secondary to a saccular basilar artery aneurysm. Stroke. 1988 Jan; 19(1):104-7.
  View in: PubMed
 
187. Fisher M, Johnson MH, Natale AM, Levine PH. Linoleic acid levels in white blood cells, platelets, and serum of multiple sclerosis patients. Acta Neurol Scand. 1987 Oct; 76(4):241-5.
  View in: PubMed
 
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Co-Authors  
Anwer, Ursula
Davis, Maryann
Folland, Edward
Moonis, Majaz
Phillips, David
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Physical Neighbors  
Ionete, Carolina
Gibson, Mark
Ramzan, Muhammad
Garg, Neeta
Nanjundaswamy, Shashidhara

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