Jeanne B Lawrence PHD
Title Professor
Institution University of Massachusetts Medical School
Department Cell Biology
Address University of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Telephone 508-856-6015
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Cell Biology

Institution UMMS - Graduate School of Biomedical Sciences
Department Interdisciplinary Graduate Program

Institution UMMS - Graduate School of Biomedical Sciences
Department MD/PhD Program
Narrative

Cell Biology Department Website

Lawrence Lab Website

Academic Background

1977-1982  Brown University, Providence, Rhode Island
Program in Molecular and Cell Biology
Degree:  Ph.D.
Discipline:  Developmental Biology

1974-1975  Rutgers University, New Brunswick, New Jersey
Degree:  M.S.
Discipline:  Human Genetics and Genetic Counseling

1971-1973  Stephens College, Columbia, Missouri
Degree:  B.A., Summa Cum Laude 
Double Major:  Biology and Music

1969-197l  Simmons College
Boston, Massachusetts

Genome Organization and the Functional Relationship of DNA/RNA with Nuclear Structure

Research Interests

  • Nuclear architecture and genome organization in human cells.
  • Epigenetic instability of heterochromatin in cancer.
  • The role of non-coding RNAs in chromatin regulation, particularly XIST RNA.
  • Nuclear programming and X-chromosome inactivation in embryonic and induced pluripotent stem cells.
  • Human genetic mutations impacting nuclear RNA metabolism (myotonic dystrophy) or dosage compensation (Down Syndrome).
  • Novel genetic engineering approaches for gene therapy.
  • Heterochromatic changes in cell senescence and aging.

Course Information

In addition to her research, Jeanne B. Lawrence Ph.D.,is also the co-director of the Human Genetics Course at UMass Medical School ,which focuses on the genetic knowledge and concepts which underlies almost every aspect of human health, both in normal function and disease. The course covers chromosomal, single gene, and multifactorial disorders, including quantitative analysis of Mendelian and non-Mendelian inheritance, human cancer genetics, epigenomic regulation and recent developments in human genome research.

Figure

Lawrence Nucleus Figure

Publications
1. Jiao B, Ma H, Shokhirev MN, Drung A, Yang Q, Shin J, Lu S, Byron M, Kalantry S, Mercurio AM, Lawrence JB, Hoffmann A, Bach I. Paternal RLIM/Rnf12 Is a Survival Factor for Milk-Producing Alveolar Cells. Cell. 2012 Apr 27; 149(3):630-41.
  View in: PubMed
 
2. Shin J, Bossenz M, Chung Y, Ma H, Byron M, Taniguchi-Ishigaki N, Zhu X, Jiao B, Hall LL, Green MR, Jones SN, Hermans-Borgmeyer I, Lawrence JB, Bach I. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature. 2010 Oct 21; 467(7318):977-81.
  View in: PubMed
 
3. Hall LL, Byron M, Pageau G, Lawrence JB. AURKB-mediated effects on chromatin regulate binding versus release of XIST RNA to the inactive chromosome. J Cell Biol. 2009 Aug 24; 186(4):491-507.
  View in: PubMed
 
4. Butler JT, Hall LL, Smith KP, Lawrence JB. Changing nuclear landscape and unique PML structures during early epigenetic transitions of human embryonic stem cells. J Cell Biochem. 2009 Jul 1; 107(4):609-21.
  View in: PubMed
 
5. Clemson CM, Hutchinson JN, Sara SA, Ensminger AW, Fox AH, Chess A, Lawrence JB. An architectural role for a nuclear noncoding RNA: NEAT1 RNA is essential for the structure of paraspeckles. Mol Cell. 2009 Mar 27; 33(6):717-26.
  View in: PubMed
 
6. Lawrence JB, Clemson CM. Gene associations: true romance or chance meeting in a nuclear neighborhood? J Cell Biol. 2008 Sep 22; 182(6):1035-8.
  View in: PubMed
 
7. Hall LL, Byron M, Butler J, Becker KA, Nelson A, Amit M, Itskovitz-Eldor J, Stein J, Stein G, Ware C, Lawrence JB. X-inactivation reveals epigenetic anomalies in most hESC but identifies sublines that initiate as expected. J Cell Physiol. 2008 Aug; 216(2):445-52.
  View in: PubMed
 
8. Mudhasani R, Zhu Z, Hutvagner G, Eischen CM, Lyle S, Hall LL, Lawrence JB, Imbalzano AN, Jones SN. Loss of miRNA biogenesis induces p19Arf-p53 signaling and senescence in primary cells. J Cell Biol. 2008 Jun 30; 181(7):1055-63.
  View in: PubMed
 
9. Smith KP, Byron M, Johnson C, Xing Y, Lawrence JB. Defining early steps in mRNA transport: mutant mRNA in myotonic dystrophy type I is blocked at entry into SC-35 domains. J Cell Biol. 2007 Sep 10; 178(6):951-64.
  View in: PubMed
 
10. Pageau GJ, Hall LL, Ganesan S, Livingston DM, Lawrence JB. The disappearing Barr body in breast and ovarian cancers. Nat Rev Cancer. 2007 Aug; 7(8):628-33.
  View in: PubMed
 
11. Pageau GJ, Hall LL, Lawrence JB. BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin. J Cell Biochem. 2007 Mar 1; 100(4):835-50.
  View in: PubMed
 
12. Pageau GJ, Lawrence JB. BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin. J Cell Biol. 2006 Dec 4; 175(5):693-701.
  View in: PubMed
 
13. Hall LL, Smith KP, Byron M, Lawrence JB. Molecular anatomy of a speckle. Anat Rec A Discov Mol Cell Evol Biol. 2006 Jul; 288(7):664-75.
  View in: PubMed
 
14. Clemson CM, Hall LL, Byron M, McNeil J, Lawrence JB. The X chromosome is organized into a gene-rich outer rim and an internal core containing silenced nongenic sequences. Proc Natl Acad Sci U S A. 2006 May 16; 103(20):7688-93.
  View in: PubMed
 
15. McNeil JA, Smith KP, Hall LL, Lawrence JB. Word frequency analysis reveals enrichment of dinucleotide repeats on the human X chromosome and [GATA]n in the X escape region. Genome Res. 2006 Apr; 16(4):477-84.
  View in: PubMed
 
16. Smith KP, Byron M, O'Connell BC, Tam R, Schorl C, Guney I, Hall LL, Agrawal P, Sedivy JM, Lawrence JB. c-Myc localization within the nucleus: evidence for association with the PML nuclear body. J Cell Biochem. 2004 Dec 15; 93(6):1282-96.
  View in: PubMed
 
17. Smith KP, Byron M, Clemson CM, Lawrence JB. Ubiquitinated proteins including uH2A on the human and mouse inactive X chromosome: enrichment in gene rich bands. Chromosoma. 2004 Dec; 113(6):324-35.
  View in: PubMed
 
18. Tam R, Smith KP, Lawrence JB. The 4q subtelomere harboring the FSHD locus is specifically anchored with peripheral heterochromatin unlike most human telomeres. J Cell Biol. 2004 Oct 25; 167(2):269-79.
  View in: PubMed
 
19. Hall LL, Lawrence JB. The cell biology of a novel chromosomal RNA: chromosome painting by XIST/Xist RNA initiates a remodeling cascade. Semin Cell Dev Biol. 2003 Dec; 14(6):369-78.
  View in: PubMed
 
20. Moen PT, Johnson CV, Byron M, Shopland LS, de la Serna IL, Imbalzano AN, Lawrence JB. Repositioning of muscle-specific genes relative to the periphery of SC-35 domains during skeletal myogenesis. Mol Biol Cell. 2004 Jan; 15(1):197-206.
  View in: PubMed
 
21. Shopland LS, Johnson CV, Byron M, McNeil J, Lawrence JB. Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains: evidence for local euchromatic neighborhoods. J Cell Biol. 2003 Sep 15; 162(6):981-90.
  View in: PubMed
 
22. Oh SW, Pope RK, Smith KP, Crowley JL, Nebl T, Lawrence JB, Luna EJ. Archvillin, a muscle-specific isoform of supervillin, is an early expressed component of the costameric membrane skeleton. J Cell Sci. 2003 Jun 1; 116(Pt 11):2261-75.
  View in: PubMed
 
23. Hall LL, Clemson CM, Byron M, Wydner K, Lawrence JB. Unbalanced X;autosome translocations provide evidence for sequence specificity in the association of XIST RNA with chromatin. Hum Mol Genet. 2002 Dec 1; 11(25):3157-65.
  View in: PubMed
 
24. Shopland LS, Johnson CV, Lawrence JB. Evidence that all SC-35 domains contain mRNAs and that transcripts can be structurally constrained within these domains. J Struct Biol. 2002 Oct-Dec; 140(1-3):131-9.
  View in: PubMed
 
25. Hall LL, Byron M, Sakai K, Carrel L, Willard HF, Lawrence JB. An ectopic human XIST gene can induce chromosome inactivation in postdifferentiation human HT-1080 cells. Proc Natl Acad Sci U S A. 2002 Jun 25; 99(13):8677-82.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
RNA, Untranslated
Chromosomes, Human, X
Cell Nucleus
Heterochromatin
X Chromosome Inactivation
See all (169) keywords
Co-Authors  
Bach, Ingolf
Hall-Anderson, Lisa
Imbalzano, Anthony
Jones, Stephen
Smith, Kelly
See all (11) people
Physical Neighbors  
Hall, Christopher
Rivera Perez, Jaime
Keller, Jeanne
Ghule, Prachi
Zhang, Ying

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