David Paydarfar MD
Title Professor
Institution University of Massachusetts Medical School
Department Neurology
Address University of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01655
Telephone 508/856-1658
Email
Other Positions
Institution UMMS - School of Medicine
Department Physiology

Institution UMMS - Graduate School of Biomedical Sciences
Department Biomedical Engineering & Medical Physiology

Institution UMMS - Graduate School of Biomedical Sciences
Department Cell & Molecular Physiology

Institution UMMS - Graduate School of Biomedical Sciences
Department MD/PhD Program

Institution UMMS - Graduate School of Biomedical Sciences
Department Neuroscience
Narrative

My research is devoted to understanding the neural control of autonomic functions.  Specific areas of interest are the genesis of respiratory rhythm, the coordination of breathing and swallowing, and the maintenance of circulation during upright posture. The major goal is to understand how normal control mechanisms break down and lead to certain common disease states: central apnea, neurogenic aspiration, and neurally mediated syncope. 

More Information Coming Soon

Publications
1. Paydarfar D. Protecting the airway during swallowing: What is the role for afferent surveillance? Head Neck. 2011 Oct; 33 Suppl 1:S26-9.
  View in: PubMed
 
2. McFarland DH, Paydarfar D. Proceedings of the Integrative Neural Systems Underlying Vital Aerodigestive Tract Functions Conference, June 17-19, 2010: Work group summary and call to action. Head Neck. 2011 Oct; 33 Suppl 1:S54-7.
  View in: PubMed
 
3. Forger DB, Paydarfar D, Clay JR. Optimal stimulus shapes for neuronal excitation. PLoS Comput Biol. 2011 Jul; 7(7):e1002089.
  View in: PubMed
 
4. Paydarfar D, Schwartz WJ. A piece of my mind. Dear provider. JAMA. 2011 May 25; 305(20):2046-7.
  View in: PubMed
 
5. Indic P, Bloch-Salisbury E, Bednarek F, Brown EN, Paydarfar D, Barbieri R. Assessment of cardio-respiratory interactions in preterm infants by bivariate autoregressive modeling and surrogate data analysis. Early Hum Dev. 2011 Jul; 87(7):477-87.
  View in: PubMed
 
6. Gaspari RJ, Paydarfar D. Dichlorvos-induced central apnea: Effects of selective brainstem exposure in the rat. Neurotoxicology. 2011 Mar; 32(2):206-14.
  View in: PubMed
 
7. Bloch-Salisbury E, Hall MH, Sharma P, Boyd T, Bednarek F, Paydarfar D. Heritability of apnea of prematurity: a retrospective twin study. Pediatrics. 2010 Oct; 126(4):e779-87.
  View in: PubMed
 
8. Marcus CL, Smith RJ, Mankarious LA, Arens R, Mitchell GS, Elluru RG, Forte V, Goudy S, Jabs EW, Kane AA, Katz E, Paydarfar D, Pereira K, Reeves RH, Richtsmeier JT, Ruiz RL, Thach BT, Tunkel DE, Whitsett JA, Wootton D, Blaisdell CJ. Developmental aspects of the upper airway: report from an NHLBI Workshop, March 5-6, 2009. Proc Am Thorac Soc. 2009 Sep 15; 6(6):513-20.
  View in: PubMed
 
9. Bloch-Salisbury E, Indic P, Bednarek F, Paydarfar D. Stabilizing immature breathing patterns of preterm infants using stochastic mechanosensory stimulation. J Appl Physiol. 2009 Oct; 107(4):1017-27.
  View in: PubMed
 
10. Adams L, Lansing RW, O'Donnell CR, Paydarfar D, Banzett RB. No evidence for reduction in dyspnea following lesions of the right insula. Am J Respir Crit Care Med. 2009 Apr 1; 179(7):623; author reply 623-4.
  View in: PubMed
 
11. Gaspari RJ, Paydarfar D. Respiratory failure induced by acute organophosphate poisoning in rats: effects of vagotomy. Neurotoxicology. 2009 Mar; 30(2):298-304.
  View in: PubMed
 
12. Clay JR, Paydarfar D, Forger DB. A simple modification of the Hodgkin and Huxley equations explains type 3 excitability in squid giant axons. J R Soc Interface. 2008 Dec 6; 5(29):1421-8.
  View in: PubMed
 
13. Indic P, Schwartz WJ, Paydarfar D. Design principles for phase-splitting behaviour of coupled cellular oscillators: clues from hamsters with 'split' circadian rhythms. J R Soc Interface. 2008 Aug 6; 5(25):873-83.
  View in: PubMed
 
14. Gaspari RJ, Paydarfar D. Pathophysiology of respiratory failure following acute dichlorvos poisoning in a rodent model. Neurotoxicology. 2007 May; 28(3):664-71.
  View in: PubMed
 
15. Paydarfar D, Forger DB, Clay JR. Noisy inputs and the induction of on-off switching behavior in a neuronal pacemaker. J Neurophysiol. 2006 Dec; 96(6):3338-48.
  View in: PubMed
 
16. Forger DB, Paydarfar D. Starting, stopping, and resetting biological oscillators: in search of optimum perturbations. J Theor Biol. 2004 Oct 21; 230(4):521-32.
  View in: PubMed
 
17. Jafari S, Prince RA, Kim DY, Paydarfar D. Sensory regulation of swallowing and airway protection: a role for the internal superior laryngeal nerve in humans. J Physiol. 2003 Jul 1; 550(Pt 1):287-304.
  View in: PubMed
 
18. Binks AP, Paydarfar D, Schachter SC, Guz A, Banzett RB. High strength stimulation of the vagus nerve in awake humans: a lack of cardiorespiratory effects. Respir Physiol. 2001 Sep; 127(2-3):125-33.
  View in: PubMed
 
19. Paydarfar D, Schwartz WJ. An algorithm for discovery. Science. 2001 Apr 6; 292(5514):13.
  View in: PubMed
 
20. Paydarfar D, Krieger D, Dib N, Blair RH, Pastore JO, Stetz JJ, Symes JF. In vivo magnetic resonance imaging and surgical histopathology of intracardiac masses: distinct features of subacute thrombi. Cardiology. 2001; 95(1):40-7.
  View in: PubMed
 
21. Banzett RB, Guz A, Paydarfar D, Shea SA, Schachter SC, Lansing RW. Cardiorespiratory variables and sensation during stimulation of the left vagus in patients with epilepsy. Epilepsy Res. 1999 May; 35(1):1-11.
  View in: PubMed
 
22. Paydarfar D, Eldridge FL, Paydarfar JA. Phase resetting of the respiratory oscillator by carotid sinus nerve stimulation in cats. J Physiol. 1998 Jan 15; 506 ( Pt 2):515-28.
  View in: PubMed
 
23. Paydarfar D, Buerkel DM. Sporadic apnea: paradoxical transformation to eupnea by perturbations that inhibit inspiration. Med Hypotheses. 1997 Jul; 49(1):19-26.
  View in: PubMed
 
24. Paydarfar D, de la Monte SM. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 12-1997. A 50-year-old woman with multiple sclerosis and an enlarging frontal-lobe mass. N Engl J Med. 1997 Apr 17; 336(16):1163-71.
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25. Paydarfar D, Gilbert RJ, Poppel CS, Nassab PF. Respiratory phase resetting and airflow changes induced by swallowing in humans. J Physiol. 1995 Feb 15; 483 ( Pt 1):273-88.
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26. Shea SA, Andres LP, Paydarfar D, Banzett RB, Shannon DC. Effect of mental activity on breathing in congenital central hypoventilation syndrome. Respir Physiol. 1993 Dec; 94(3):251-63.
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27. Paydarfar D, Eldridge FL, Wagner PG, Dowell RT. Neural respiratory responses to cortically induced seizures in cats. Respir Physiol. 1992 Aug; 89(2):225-37.
  View in: PubMed
 
28. Paydarfar D, Eldridge FL, Scott SC, Dowell RT, Wagner PG. Respiratory responses to focal and generalized seizures in cats. Am J Physiol. 1991 May; 260(5 Pt 2):R934-40.
  View in: PubMed
 
29. Harris AK, Pryer NK, Paydarfar D. Effects of electric fields on fibroblast contractility and cytoskeleton. J Exp Zool. 1990 Feb; 253(2):163-76.
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30. Gominak S, Cros D, Paydarfar D. Herpes simplex labialis and trigeminal neuropathy. Neurology. 1990 Jan; 40(1):151-2.
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31. Eldridge FL, Paydarfar D, Wagner PG, Dowell RT. Phase resetting of respiratory rhythm: effect of changing respiratory "drive". Am J Physiol. 1989 Aug; 257(2 Pt 2):R271-7.
  View in: PubMed
 
32. Eldridge FL, Paydarfar D. Desynchronized respiratory rhythms and their interactions in cats with split brain stems. J Physiol. 1989 Mar; 410:513-32.
  View in: PubMed
 
33. Eldridge FL, Paydarfar D, Scott SC, Dowell RT. Role of endogenous adenosine in recurrent generalized seizures. Exp Neurol. 1989 Feb; 103(2):179-85.
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34. Eldridge FL, Kiley JP, Paydarfar D. Dynamics of medullary hydrogen ion and respiratory responses to square-wave change of arterial carbon dioxide in cats. J Physiol. 1987 Apr; 385:627-42.
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35. Paydarfar D, Eldridge FL. Phase resetting and dysrhythmic responses of the respiratory oscillator. Am J Physiol. 1987 Jan; 252(1 Pt 2):R55-62.
  View in: PubMed
 
36. Paydarfar D, Eldridge FL, Kiley JP. Resetting of mammalian respiratory rhythm: existence of a phase singularity. Am J Physiol. 1986 Apr; 250(4 Pt 2):R721-7.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Respiration
Biological Clocks
Apnea
Respiratory Mechanics
Respiratory Insufficiency
See all (181) keywords
Co-Authors  
Gaspari, Romolo
Indic, Premananda Pai
Kim, Daniel
Salisbury, Elisabeth
Schwartz, William
See all (5) people
Physical Neighbors  
Pollen, Daniel
Sodha, Naren
Novak, Peter
Carandang, Raphael
Milner, Robert

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