Kevin E Fogarty MS
Title Research Assistant Professor
Institution University of Massachusetts Medical School
Department Program in Molecular Medicine
Address University of Massachusetts Medical School
373 Plantation Street
Worcester MA 01605
Telephone 508-856-3785
Email
Other Positions
Institution UMMS - School of Medicine
Department Microbiology & Physiological Systems
Narrative

Academic Background

1975, B.S., Worcester Polytechnic Institute
1979, M.S., Worcester Polytechnic Institute

Imaging Molecular and Cellular Dynamics with Light Microscopy in Living Cells

Research in this lab is concerned with the both the development and the application of light microscopy and imaging in cell biology and biophysics. Some driving problems include imaging the molecular components driving endocytosis and exocytosis/secretion in various cell types, and the imaging of intracellular calcium signaling in excitable cells such as smooth muscle cells, chromaffin cells, and neurons. We have developed the TESM microscope that combines Total internal reflection fluorescence (TIRF) with Epi-fluorescence Structured illumination to provide new views of trafficking in the near-plasma membrane domain of cells. We have a unique, custom built, ultra-high speed microscope system for imaging the dynamics of intracellular calcium channel events, called "calcium sparks", that are being found to regulate an expanding array of cellular processes. We have a two-photon fluorescence microscope for looking deep inside tissue, completing the range from molecule to organism. Areas of on-going technology research include high-speed, high-resolution imaging of live cells and tissues, novel image processing approaches, high performance computing and computer graphics, with an emphasis on developing open source tools for the research community.

Figure

Research Figure

Publications
1. Zhang CH, Lifshitz LM, Uy KF, Ikebe M, Fogarty KE, Zhuge R. The cellular and molecular basis of bitter tastant-induced bronchodilation. PLoS Biol. 2013 Mar; 11(3):e1001501.
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2. Zhang CH, Chen C, Lifshitz LM, Fogarty KE, Zhu MS, Zhuge R. Activation of BK channels may not be required for bitter tastant-induced bronchodilation. Nat Med. 2012; 18(5):648-50.
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3. Guo D, Standley C, Bellve K, Fogarty K, Bao ZZ. Protein kinase Ca and integrin-linked kinase mediate the negative axon guidance effects of Sonic hedgehog. Mol Cell Neurosci. 2012 May; 50(1):82-92.
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4. Goel HL, Pursell B, Standley C, Fogarty K, Mercurio AM. Neuropilin-2 regulates a6ß1 integrin in the formation of focal adhesions and signaling. J Cell Sci. 2012 Feb 2.
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5. Navaroli DM, Bellvé KD, Standley C, Lifshitz LM, Cardia J, Lambright D, Leonard D, Fogarty KE, Corvera S. Rabenosyn-5 defines the fate of the transferrin receptor following clathrin-mediated endocytosis. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):E471-80.
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6. De Crescenzo V, Fogarty KE, Lefkowitz JJ, Bellve KD, Zvaritch E, Maclennan DH, Walsh JV. Type 1 ryanodine receptor knock-in mutation causing central core disease of skeletal muscle also displays a neuronal phenotype. Proc Natl Acad Sci U S A. 2012 Jan 10; 109(2):610-5.
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7. Lifshitz LM, Carmichael JD, Lai FA, Sorrentino V, Bellvé K, Fogarty KE, Zhuge R. Spatial organization of RYRs and BK channels underlying the activation of STOCs by Ca2+ sparks in airway myocytes. J Gen Physiol. 2011 Aug; 138(2):195-209.
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8. Schmolze DB, Standley C, Fogarty KE, Fischer AH. Advances in microscopy techniques. Arch Pathol Lab Med. 2011 Feb; 135(2):255-63.
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9. Jurczyk A, Pino SC, O'Sullivan-Murphy B, Addorio M, Lidstone EA, Diiorio P, Lipson KL, Standley C, Fogarty K, Lifshitz L, Urano F, Mordes JP, Greiner DL, Rossini AA, Bortell R. A novel role for the centrosomal protein, pericentrin, in regulation of insulin secretory vesicle docking in mouse pancreatic beta-cells. PLoS One. 2010; 5(7):e11812.
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10. Zhou QL, Jiang ZY, Mabardy AS, Del Campo CM, Lambright DG, Holik J, Fogarty KE, Straubhaar J, Nicoloro S, Chawla A, Czech MP. A novel pleckstrin homology domain-containing protein enhances insulin-stimulated Akt phosphorylation and GLUT4 translocation in adipocytes. J Biol Chem. 2010 Sep 3; 285(36):27581-9.
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11. Nicoli S, Standley C, Walker P, Hurlstone A, Fogarty KE, Lawson ND. MicroRNA-mediated integration of haemodynamics and Vegf signalling during angiogenesis. Nature. 2010 Apr 22; 464(7292):1196-200.
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12. Zhuge R, Bao R, Fogarty KE, Lifshitz LM. Ca2+ sparks act as potent regulators of excitation-contraction coupling in airway smooth muscle. J Biol Chem. 2010 Jan 15; 285(3):2203-10.
  View in: PubMed
 
13. McNally JM, De Crescenzo V, Fogarty KE, Walsh JV, Lemos JR. Individual calcium syntillas do not trigger spontaneous exocytosis from nerve terminals of the neurohypophysis. J Neurosci. 2009 Nov 11; 29(45):14120-6.
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14. Lefkowitz JJ, Fogarty KE, Lifshitz LM, Bellve KD, Tuft RA, ZhuGe R, Walsh JV, De Crescenzo V. Suppression of Ca2+ syntillas increases spontaneous exocytosis in mouse adrenal chromaffin cells. J Gen Physiol. 2009 Oct; 134(4):267-80.
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15. Siekmann AF, Standley C, Fogarty KE, Wolfe SA, Lawson ND. Chemokine signaling guides regional patterning of the first embryonic artery. Genes Dev. 2009 Oct 1; 23(19):2272-7.
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16. Li X, Standley C, Sapp E, Valencia A, Qin ZH, Kegel KB, Yoder J, Comer-Tierney LA, Esteves M, Chase K, Alexander J, Masso N, Sobin L, Bellve K, Tuft R, Lifshitz L, Fogarty K, Aronin N, DiFiglia M. Mutant huntingtin impairs vesicle formation from recycling endosomes by interfering with Rab11 activity. Mol Cell Biol. 2009 Nov; 29(22):6106-16.
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17. Kolpak AL, Jiang J, Guo D, Standley C, Bellve K, Fogarty K, Bao ZZ. Negative guidance factor-induced macropinocytosis in the growth cone plays a critical role in repulsive axon turning. J Neurosci. 2009 Aug 26; 29(34):10488-98.
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18. Leonard D, Hayakawa A, Lawe D, Lambright D, Bellve KD, Standley C, Lifshitz LM, Fogarty KE, Corvera S. Sorting of EGF and transferrin at the plasma membrane and by cargo-specific signaling to EEA1-enriched endosomes. J Cell Sci. 2008 Oct 15; 121(Pt 20):3445-58.
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19. Bao R, Lifshitz LM, Tuft RA, Bellvé K, Fogarty KE, ZhuGe R. A close association of RyRs with highly dense clusters of Ca2+-activated Cl- channels underlies the activation of STICs by Ca2+ sparks in mouse airway smooth muscle. J Gen Physiol. 2008 Jul; 132(1):145-60.
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20. Zhang YA, Tuft RA, Lifshitz LM, Fogarty KE, Singer JJ, Zou H. Caffeine-activated large-conductance plasma membrane cation channels in cardiac myocytes: characteristics and significance. Am J Physiol Heart Circ Physiol. 2007 Oct; 293(4):H2448-61.
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21. Huang S, Lifshitz LM, Jones C, Bellve KD, Standley C, Fonseca S, Corvera S, Fogarty KE, Czech MP. Insulin stimulates membrane fusion and GLUT4 accumulation in clathrin coats on adipocyte plasma membranes. Mol Cell Biol. 2007 May; 27(9):3456-69.
  View in: PubMed
 
22. Hayakawa A, Leonard D, Murphy S, Hayes S, Soto M, Fogarty K, Standley C, Bellve K, Lambright D, Mello C, Corvera S. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Proc Natl Acad Sci U S A. 2006 Aug 8; 103(32):11928-33.
  View in: PubMed
 
23. De Crescenzo V, Fogarty KE, Zhuge R, Tuft RA, Lifshitz LM, Carmichael J, Bellvé KD, Baker SP, Zissimopoulos S, Lai FA, Lemos JR, Walsh JV. Dihydropyridine receptors and type 1 ryanodine receptors constitute the molecular machinery for voltage-induced Ca2+ release in nerve terminals. J Neurosci. 2006 Jul 19; 26(29):7565-74.
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24. Chau MD, Tuft R, Fogarty K, Bao ZZ. Notch signaling plays a key role in cardiac cell differentiation. Mech Dev. 2006 Aug; 123(8):626-40.
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25. Follit JA, Tuft RA, Fogarty KE, Pazour GJ. The intraflagellar transport protein IFT20 is associated with the Golgi complex and is required for cilia assembly. Mol Biol Cell. 2006 Sep; 17(9):3781-92.
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26. Bellve KD, Leonard D, Standley C, Lifshitz LM, Tuft RA, Hayakawa A, Corvera S, Fogarty KE. Plasma membrane domains specialized for clathrin-mediated endocytosis in primary cells. J Biol Chem. 2006 Jun 9; 281(23):16139-46.
  View in: PubMed
 
27. ZhuGe R, DeCrescenzo V, Sorrentino V, Lai FA, Tuft RA, Lifshitz LM, Lemos JR, Smith C, Fogarty KE, Walsh JV. Syntillas release Ca2+ at a site different from the microdomain where exocytosis occurs in mouse chromaffin cells. Biophys J. 2006 Mar 15; 90(6):2027-37.
  View in: PubMed
 
28. Politz JC, Tuft RA, Prasanth KV, Baudendistel N, Fogarty KE, Lifshitz LM, Langowski J, Spector DL, Pederson T. Rapid, diffusional shuttling of poly(A) RNA between nuclear speckles and the nucleoplasm. Mol Biol Cell. 2006 Mar; 17(3):1239-49.
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29. Turvey MR, Fogarty KE, Thorn P. Inositol (1,4,5)-trisphosphate receptor links to filamentous actin are important for generating local Ca2+ signals in pancreatic acinar cells. J Cell Sci. 2005 Mar 1; 118(Pt 5):971-80.
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30. Huang S, Lifshitz L, Patki-Kamath V, Tuft R, Fogarty K, Czech MP. Phosphatidylinositol-4,5-bisphosphate-rich plasma membrane patches organize active zones of endocytosis and ruffling in cultured adipocytes. Mol Cell Biol. 2004 Oct; 24(20):9102-23.
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31. Zou H, Lifshitz LM, Tuft RA, Fogarty KE, Singer JJ. Using total fluorescence increase (signal mass) to determine the Ca2+ current underlying localized Ca2+ events. J Gen Physiol. 2004 Sep; 124(3):259-72.
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32. Zhuge R, Fogarty KE, Baker SP, McCarron JG, Tuft RA, Lifshitz LM, Walsh JV. Ca(2+) spark sites in smooth muscle cells are numerous and differ in number of ryanodine receptors, large-conductance K(+) channels, and coupling ratio between them. Am J Physiol Cell Physiol. 2004 Dec; 287(6):C1577-88.
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33. Zou H, Lifshitz LM, Tuft RA, Fogarty KE, Singer JJ. Imaging calcium entering the cytosol through a single opening of plasma membrane ion channels: SCCaFTs--fundamental calcium events. Cell Calcium. 2004 Jun; 35(6):523-33.
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34. Bose A, Robida S, Furcinitti PS, Chawla A, Fogarty K, Corvera S, Czech MP. Unconventional myosin Myo1c promotes membrane fusion in a regulated exocytic pathway. Mol Cell Biol. 2004 Jun; 24(12):5447-58.
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35. Thorn P, Fogarty KE, Parker I. Zymogen granule exocytosis is characterized by long fusion pore openings and preservation of vesicle lipid identity. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6774-9.
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36. De Crescenzo V, ZhuGe R, Velázquez-Marrero C, Lifshitz LM, Custer E, Carmichael J, Lai FA, Tuft RA, Fogarty KE, Lemos JR, Walsh JV. Ca2+ syntillas, miniature Ca2+ release events in terminals of hypothalamic neurons, are increased in frequency by depolarization in the absence of Ca2+ influx. J Neurosci. 2004 Feb 4; 24(5):1226-35.
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37. O'Reilly CM, Fogarty KE, Drummond RM, Tuft RA, Walsh JV. Spontaneous mitochondrial depolarizations are independent of SR Ca2+ release. Am J Physiol Cell Physiol. 2004 May; 286(5):C1139-51.
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38. O'Reilly CM, Fogarty KE, Drummond RM, Tuft RA, Walsh JV. Quantitative analysis of spontaneous mitochondrial depolarizations. Biophys J. 2003 Nov; 85(5):3350-7.
  View in: PubMed
 
39. Hayakawa A, Hayes SJ, Lawe DC, Sudharshan E, Tuft R, Fogarty K, Lambright D, Corvera S. Structural basis for endosomal targeting by FYVE domains. J Biol Chem. 2004 Feb 13; 279(7):5958-66.
  View in: PubMed
 
40. Lawe DC, Sitouah N, Hayes S, Chawla A, Virbasius JV, Tuft R, Fogarty K, Lifshitz L, Lambright D, Corvera S. Essential role of Ca2+/calmodulin in Early Endosome Antigen-1 localization. Mol Biol Cell. 2003 Jul; 14(7):2935-45.
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41. Femino AM, Fogarty K, Lifshitz LM, Carrington W, Singer RH. Visualization of single molecules of mRNA in situ. Methods Enzymol. 2003; 361:245-304.
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42. Rapizzi E, Pinton P, Szabadkai G, Wieckowski MR, Vandecasteele G, Baird G, Tuft RA, Fogarty KE, Rizzuto R. Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria. J Cell Biol. 2002 Nov 25; 159(4):613-24.
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43. Zhuge R, Fogarty KE, Tuft RA, Walsh JV. Spontaneous transient outward currents arise from microdomains where BK channels are exposed to a mean Ca(2+) concentration on the order of 10 microM during a Ca(2+) spark. J Gen Physiol. 2002 Jul; 120(1):15-27.
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44. Zou H, Lifshitz LM, Tuft RA, Fogarty KE, Singer JJ. Visualization of Ca2+ entry through single stretch-activated cation channels. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6404-9.
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45. Kidd JF, Pilkington MF, Schell MJ, Fogarty KE, Skepper JN, Taylor CW, Thorn P. Paclitaxel affects cytosolic calcium signals by opening the mitochondrial permeability transition pore. J Biol Chem. 2002 Feb 22; 277(8):6504-10.
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46. Lawe DC, Chawla A, Merithew E, Dumas J, Carrington W, Fogarty K, Lifshitz L, Tuft R, Lambright D, Corvera S. Sequential roles for phosphatidylinositol 3-phosphate and Rab5 in tethering and fusion of early endosomes via their interaction with EEA1. J Biol Chem. 2002 Mar 8; 277(10):8611-7.
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47. Chiesa A, Rapizzi E, Tosello V, Pinton P, de Virgilio M, Fogarty KE, Rizzuto R. Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signalling. Biochem J. 2001 Apr 1; 355(Pt 1):1-12.
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48. Frimberger AE, McAuliffe CI, Werme KA, Tuft RA, Fogarty KE, Benoit BO, Dooner MS, Quesenberry PJ. The fleet feet of haematopoietic stem cells: rapid motility, interaction and proteopodia. Br J Haematol. 2001 Mar; 112(3):644-54.
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49. Kirber MT, Etter EF, Bellve KA, Lifshitz LM, Tuft RA, Fay FS, Walsh JV, Fogarty KE. Relationship of Ca2+ sparks to STOCs studied with 2D and 3D imaging in feline oesophageal smooth muscle cells. J Physiol. 2001 Mar 1; 531(Pt 2):315-27.
  View in: PubMed
 
50. Patki V, Buxton J, Chawla A, Lifshitz L, Fogarty K, Carrington W, Tuft R, Corvera S. Insulin action on GLUT4 traffic visualized in single 3T3-l1 adipocytes by using ultra-fast microscopy. Mol Biol Cell. 2001 Jan; 12(1):129-41.
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51. ZhuGe R, Fogarty KE, Tuft RA, Lifshitz LM, Sayar K, Walsh JV. Dynamics of signaling between Ca(2+) sparks and Ca(2+)- activated K(+) channels studied with a novel image-based method for direct intracellular measurement of ryanodine receptor Ca(2+) current. J Gen Physiol. 2000 Dec; 116(6):845-64.
  View in: PubMed
 
52. Fogarty KE, Kidd JF, Tuft DA, Thorn P. Mechanisms underlying InsP3-evoked global Ca2+ signals in mouse pancreatic acinar cells. J Physiol. 2000 Aug 1; 526 Pt 3:515-26.
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53. Fogarty KE, Kidd JF, Turner A, Skepper JN, Carmichael J, Thorn P. Microtubules regulate local Ca2+ spiking in secretory epithelial cells. J Biol Chem. 2000 Jul 21; 275(29):22487-94.
  View in: PubMed
 
54. Fogarty KE, Kidd JF, Tuft RA, Thorn P. A bimodal pattern of InsP(3)-evoked elementary Ca(2+) signals in pancreatic acinar cells. Biophys J. 2000 May; 78(5):2298-306.
  View in: PubMed
 
55. Paemeleire K, Martin PE, Coleman SL, Fogarty KE, Carrington WA, Leybaert L, Tuft RA, Evans WH, Sanderson MJ. Intercellular calcium waves in HeLa cells expressing GFP-labeled connexin 43, 32, or 26. Mol Biol Cell. 2000 May; 11(5):1815-27.
  View in: PubMed
 
56. Kirber MT, Guerrero-Hernández A, Bowman DS, Fogarty KE, Tuft RA, Singer JJ, Fay FS. Multiple pathways responsible for the stretch-induced increase in Ca2+ concentration in toad stomach smooth muscle cells. J Physiol. 2000 Apr 1; 524 Pt 1:3-17.
  View in: PubMed
 
57. Zou H, Lifshitz LM, Tuft RA, Fogarty KE, Singer JJ. Imaging Ca(2+) entering the cytoplasm through a single opening of a plasma membrane cation channel. J Gen Physiol. 1999 Oct; 114(4):575-88.
  View in: PubMed
 
58. Kidd JF, Fogarty KE, Tuft RA, Thorn P. The role of Ca2+ feedback in shaping InsP3-evoked Ca2+ signals in mouse pancreatic acinar cells. J Physiol. 1999 Oct 1; 520 Pt 1:187-201.
  View in: PubMed
 
59. ZhuGe R, Tuft RA, Fogarty KE, Bellve K, Fay FS, Walsh JV. The influence of sarcoplasmic reticulum Ca2+ concentration on Ca2+ sparks and spontaneous transient outward currents in single smooth muscle cells. J Gen Physiol. 1999 Feb; 113(2):215-28.
  View in: PubMed
 
60. ZhuGe R, Sims SM, Tuft RA, Fogarty KE, Walsh JV. Ca2+ sparks activate K+ and Cl- channels, resulting in spontaneous transient currents in guinea-pig tracheal myocytes. J Physiol. 1998 Dec 15; 513 ( Pt 3):711-8.
  View in: PubMed
 
61. Rizzuto R, Pinton P, Carrington W, Fay FS, Fogarty KE, Lifshitz LM, Tuft RA, Pozzan T. Close contacts with the endoplasmic reticulum as determinants of mitochondrial Ca2+ responses. Science. 1998 Jun 12; 280(5370):1763-6.
  View in: PubMed
 
62. Femino AM, Fay FS, Fogarty K, Singer RH. Visualization of single RNA transcripts in situ. Science. 1998 Apr 24; 280(5363):585-90.
  View in: PubMed
 
63. Lynch RM, Carrington W, Fogarty KE, Fay FS. Metabolic modulation of hexokinase association with mitochondria in living smooth muscle cells. Am J Physiol. 1996 Feb; 270(2 Pt 1):C488-99.
  View in: PubMed
 
64. Carrington WA, Lynch RM, Moore ED, Isenberg G, Fogarty KE, Fay FS. Superresolution three-dimensional images of fluorescence in cells with minimal light exposure. Science. 1995 Jun 9; 268(5216):1483-7.
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65. Brundage RA, Fogarty KE, Tuft RA, Fay FS. Chemotaxis of newt eosinophils: calcium regulation of chemotactic response. Am J Physiol. 1993 Dec; 265(6 Pt 1):C1527-43.
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66. Moore ED, Etter EF, Philipson KD, Carrington WA, Fogarty KE, Lifshitz LM, Fay FS. Coupling of the Na+/Ca2+ exchanger, Na+/K+ pump and sarcoplasmic reticulum in smooth muscle. Nature. 1993 Oct 14; 365(6447):657-60.
  View in: PubMed
 
67. Carter KC, Bowman D, Carrington W, Fogarty K, McNeil JA, Fay FS, Lawrence JB. A three-dimensional view of precursor messenger RNA metabolism within the mammalian nucleus. Science. 1993 Feb 26; 259(5099):1330-5.
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68. Brundage RA, Fogarty KE, Tuft RA, Fay FS. Calcium gradients underlying polarization and chemotaxis of eosinophils. Science. 1991 Nov 1; 254(5032):703-6.
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69. Lynch RM, Fogarty KE, Fay FS. Modulation of hexokinase association with mitochondria analyzed with quantitative three-dimensional confocal microscopy. J Cell Biol. 1991 Feb; 112(3):385-95.
  View in: PubMed
 
70. Moore ED, Fogarty KE, Fay FS. Role of Na(+)-Ca2+ exchanger in beta-adrenergic relaxation of single smooth muscle cells. Ann N Y Acad Sci. 1991; 639:543-9.
  View in: PubMed
 
71. Moore ED, Becker PL, Fogarty KE, Williams DA, Fay FS. Ca2+ imaging in single living cells: theoretical and practical issues. Cell Calcium. 1990 Feb-Mar; 11(2-3):157-79.
  View in: PubMed
 
72. Fay FS, Carrington W, Fogarty KE. Three-dimensional molecular distribution in single cells analysed using the digital imaging microscope. J Microsc. 1989 Feb; 153(Pt 2):133-49.
  View in: PubMed
 
73. Cooke PH, Kargacin G, Craig R, Fogarty K, Fay FS. Molecular structure and organization of filaments in single, skinned smooth muscle cells. Prog Clin Biol Res. 1987; 245:1-25.
  View in: PubMed
 
74. Coggins JM, Fay FS, Fogarty KE. Development and application of a three-dimensional artificial visual system. Comput Methods Programs Biomed. 1986 Mar; 22(1):69-77.
  View in: PubMed
 
75. Fay FS, Fogarty KE, Coggins JM. Analysis of molecular distribution in single cells using a digital imaging microscope. Soc Gen Physiol Ser. 1986; 40:51-63.
  View in: PubMed
 
76. Williams DA, Fogarty KE, Tsien RY, Fay FS. Calcium gradients in single smooth muscle cells revealed by the digital imaging microscope using Fura-2. Nature. 1985 Dec 12-18; 318(6046):558-61.
  View in: PubMed
 
77. Rees DD, Fogarty KE, Levy LK, Fay FS. Computerized analysis of TV images for ultrasensitive monitoring of the reaction of fluorochrome with protein. Anal Biochem. 1985 Feb 1; 144(2):461-8.
  View in: PubMed
 
78. Fay FS, Fujiwara K, Rees DD, Fogarty KE. Distribution of alpha-actinin in single isolated smooth muscle cells. J Cell Biol. 1983 Mar; 96(3):783-95.
  View in: PubMed
 
79. Grigg A, Hoffman AH, Fogarty KE. Properties of Golgi-Mazzoni afferents in cat knee joint capsule, as revealed by mechanical studies of isolated joint capsule. J Neurophysiol. 1982 Jan; 47(1):31-40.
  View in: PubMed
 
80. Fay FS, Fogarty K, Fujiwara K, Tuft R. Contractile mechanism of single isolated smooth muscle cells. Soc Gen Physiol Ser. 1982; 37:143-57.
  View in: PubMed
 
81. Grigg P, Harrigan EP, Fogarty KE. Segmental reflexes mediated by joint afferent neurons in cat knee. J Neurophysiol. 1978 Jan; 41(1):9-14.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Calcium
Calcium Signaling
Muscle, Smooth
Pancreas
Calcium Channels
See all (392) keywords
Co-Authors  
Lifshitz, Lawrence
Standley, Clive
Tuft, Richard
Walsh, John
Zhuge, Ronghua
See all (39) people
Physical Neighbors  
Richter, Joel
Virbasius, Joseph
Aouadi, Myriam
Kennedy, Norman
Ip, Yicktung

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