Gang Han PHD
Title Assistant Professor
Institution University of Massachusetts Medical School
Department Biochemistry & Molecular Pharmacology
Address University of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Biochemistry & Molecular Pharmacology

Institution UMMS - Graduate School of Biomedical Sciences
Department Interdisciplinary Graduate Program

Institution UMMS - Programs, Centers and Institutes
Department RNA Therapeutics Institute
Awards and Honors
2011 Worcester Foundation Mel Cutler Award
Narrative

Synthetic Nanomaterials for siRNA Delivery and Biomolecule Imaging

My research focuses on developing both small and bright tools for biomedical applications, that is, designing synthetic/semi-synthetic nanomaterials with unique programmable physical properties for basic science and biomedical applications.  These nanomaterials will be developed using a synergetic multidisciplinary approach, including synthetic chemistry, materials science, biochemistry, and cell biology.  In particular, we are most interested in developing optically active nanomaterials for probing signal transduction pathways, single-molecule imaging, synthesizing functional nanoscale scaffolds for targeted and traceable delivery of small molecules to cells and organelles, as well as for accurately detecting biomarkers in early stage disease.

Publications
1. Ostrowski AD, Chan EM, Gargas DJ, Katz EM, Han G, Schuck PJ, Milliron DJ, Cohen BE. Controlled Synthesis and Single-Particle Imaging of Bright, Sub-10 nm Lanthanide-Doped Upconverting Nanocrystals. ACS Nano. 2012 Feb 22.
  View in: PubMed
 
2. Zhang X, Jing X, Liu T, Han G, Li H, Duan C. Dual-Functional Gadolinium-Based Copper(II) Probe for Selective Magnetic Resonance Imaging and Fluorescence Sensing. Inorg Chem. 2012 Feb 20; 51(4):2325-31.
  View in: PubMed
 
3. Qiu, H., Chen, Sun,L., Hao, S., Han, G * and Yang, C.* .(* co- corresponding authors). J Mater Chem. Ethylenediaminetetraacetic acid (EDTA)-Controlled Synthesis of Multicolor Lanthanide Doped BaYF5 Upconversion Nanocrystals. 2011; (21):17202-17208.
 
4. Liang X, Chen T, Jung YS, Miyamoto Y, Han G, Cabrini S, Ma B, Olynick DL. Nanoimprint-induced molecular stacking and pattern stabilization in a solution-processed subphthalocyanine film. ACS Nano. 2010 May 25; 4(5):2627-34.
  View in: PubMed
 
5. Chan EM, Xu C, Mao AW, Han G, Owen JS, Cohen BE, Milliron DJ. Reproducible, high-throughput synthesis of colloidal nanocrystals for optimization in multidimensional parameter space. Nano Lett. 2010 May 12; 10(5):1874-85.
  View in: PubMed
 
6. Kim B, Han G, Toley BJ, Kim CK, Rotello VM, Forbes NS. Tuning payload delivery in tumour cylindroids using gold nanoparticles. Nat Nanotechnol. 2010 Jun; 5(6):465-72.
  View in: PubMed
 
7. Jordan BJ, Hong R, Han G, Rana S, Rotello VM. Modulation of enzyme-substrate selectivity using tetraethylene glycol functionalized gold nanoparticles. Nanotechnology. 2009 Oct 28; 20(43):434004.
  View in: PubMed
 
8. Wu S*, Han G*, Milliron DJ, Aloni S, Altoe V, Talapin DV, Cohen BE, Schuck PJ. (co-first authors) . Proc Natl Acad Sci U S A. Non-blinking and photostable upconverted luminescence from single lanthanide-doped nanocrystals. 2009; 106(27):10917-21.
 
9. Han G, Mokari T, Ajo-Franklin C, Cohen BE. Caged quantum dots. J Am Chem Soc. 2008 Nov 26; 130(47):15811-3.
  View in: PubMed
 
10. Ghosh PS, Kim CK, Han G, Forbes NS, Rotello VM. Efficient gene delivery vectors by tuning the surface charge density of amino acid-functionalized gold nanoparticles. ACS Nano. 2008 Nov 25; 2(11):2213-8.
  View in: PubMed
 
11. Chompoosor A, Han G, Rotello VM. Charge dependence of ligand release and monolayer stability of gold nanoparticles by biogenic thiols. Bioconjug Chem. 2008 Jul; 19(7):1342-5.
  View in: PubMed
 
12. Ghosh P, Han G, De M, Kim CK, Rotello VM. Gold nanoparticles in delivery applications. Adv Drug Deliv Rev. 2008 Aug 17; 60(11):1307-15.
  View in: PubMed
 
13. Ghosh PS, Han G, Erdogan B, Rosado O, Rotello VM. Binding of nanoparticle receptors to peptide alpha-helices using amino acid-functionalized nanoparticles. J Pept Sci. 2008 Feb; 14(2):134-8.
  View in: PubMed
 
14. Leroueil PR, Berry SA, Duthie K, Han G, Rotello VM, McNerny DQ, Baker JR, Orr BG, Holl MM. Wide varieties of cationic nanoparticles induce defects in supported lipid bilayers. Nano Lett. 2008 Feb; 8(2):420-4.
  View in: PubMed
 
15. Ghosh PS, Han G, Erdogan B, Rosado O, Krovi SA, Rotello VM. Nanoparticles featuring amino acid-functionalized side chains as DNA receptors. Chem Biol Drug Des. 2007 Jul; 70(1):13-8.
  View in: PubMed
 
16. Han G, Ghosh P, Rotello VM. Functionalized gold nanoparticles for drug delivery. Nanomedicine (Lond). 2007 Feb; 2(1):113-23.
  View in: PubMed
 
17. Han G, Ghosh P, Rotello VM. Multi-functional gold nanoparticles for drug delivery. Adv Exp Med Biol. 2007; 620:48-56.
  View in: PubMed
 
18. Srivastava, S.; Samanta, B.; Arumugam, P.; Han, G. Rotello, V. M. . Journal of Material chemistry. Influence of DNA on Spacing and Magnetic Properties of Iron Platinum (Fe-Pt) Nanoparticles. 2007; 17(1):52-55.
 
19. Nakade H, Jordan BJ, Xu H, Han G, Srivastava S, Arvizo RR, Cooke G, Rotello VM. Chiral translation and cooperative self-assembly of discrete helical structures using molecular recognition dyads. J Am Chem Soc. 2006 Nov 22; 128(46):14924-9.
  View in: PubMed
 
20. Vanderpuije BN, Han G, Rotello VM, Vachet RW. Mixed monolayer-protected gold nanoclusters as selective peptide extraction agents for MALDI-MS analysis. Anal Chem. 2006 Aug 1; 78(15):5491-6.
  View in: PubMed
 
21. Han G, You CC, Kim BJ, Turingan RS, Forbes NS, Martin CT, Rotello VM. Light-regulated release of DNA and its delivery to nuclei by means of photolabile gold nanoparticles. Angew Chem Int Ed Engl. 2006 May 5; 45(19):3165-9.
  View in: PubMed
 
22. Goodman CM, Chari NS, Han G, Hong R, Ghosh P, Rotello VM. DNA-binding by functionalized gold nanoparticles: mechanism and structural requirements. Chem Biol Drug Des. 2006 Apr; 67(4):297-304.
  View in: PubMed
 
23. Hong R, Han G, Fernández JM, Kim BJ, Forbes NS, Rotello VM. Glutathione-mediated delivery and release using monolayer protected nanoparticle carriers. J Am Chem Soc. 2006 Feb 1; 128(4):1078-9.
  View in: PubMed
 
24. Han G, Martin CT, Rotello VM. Stability of gold nanoparticle-bound DNA toward biological, physical, and chemical agents. Chem Biol Drug Des. 2006 Jan; 67(1):78-82.
  View in: PubMed
 
25. Han G, Chari NS, Verma A, Hong R, Martin CT, Rotello VM. Controlled recovery of the transcription of nanoparticle-bound DNA by intracellular concentrations of glutathione. Bioconjug Chem. 2005 Nov-Dec; 16(6):1356-9.
  View in: PubMed
 
26. You CC, De M, Han G, Rotello VM. Tunable inhibition and denaturation of alpha-chymotrypsin with amino acid-functionalized gold nanoparticles. J Am Chem Soc. 2005 Sep 21; 127(37):12873-81.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Gold
Nanostructures
DNA
Drug Carriers
Metal Nanoparticles
See all (111) keywords
Physical Neighbors  
Schiffer, Celia
Nichols, Jeffry
Peng, Lingtao
Yilmaz, Lutfu
Xu, Zuoshang

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