Hardy Kornfeld MD
Title Professor
Institution University of Massachusetts Medical School
Department Medicine
Division Pulmonary, Allergy And Critical Care Medicine
Address University of Massachusetts Medical School
364 Plantation Street, LRB
Worcester MA 01605
Telephone 508-856-2646
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Immunology & Virology

Institution UMMS - Graduate School of Biomedical Sciences
Department Interdisciplinary Graduate Program

Institution UMMS - Graduate School of Biomedical Sciences
Department MD/PhD Program

Institution UMMS - Graduate School of Biomedical Sciences
Department Millennium MD/PhD Program

Institution UMMS - Programs, Centers and Institutes
Department Center for AIDS Research
Narrative

The Kornfeld Laboratory Link

Education

Medical School:  Boston University School of Medicine, Boston, MA, 1978.
Medical Residency:  University Hospital, Boston, MA, 1980.
    St Luke's Hospital, NY, NY, 1981.
Infectious Disease Fellowship:  St Luke's-Roosevelt Hospital Center, NY, NY, 1982.
Pulmonary Fellowship:  Boston University School of Medicine, Boston, MA, 1985.
Molecular virology Fellowship: Harvard School of Public Health,  Boston, MA, 1987.

Clinical, educational, scientific interests

Tuberculosis
Immunology
Host defense against respiratory pathogens
Impact of metabolic disorders on host defense
Critical care

Research Activities:

1. Role of macrophage apoptosis in TB defense
2. Impact of diabetes and hyperlipidemia on TB defense
3. Role of IL-16 in protective immunity
4. Heterologous immunity between viruses and mycobacteria

Publications
1. Reed GW, Choi H, Lee SY, Lee M, Kim Y, Park H, Lee J, Zhan X, Kang H, Hwang S, Carroll M, Cai Y, Cho SN, Barry CE, Via LE, Kornfeld H. Impact of diabetes and smoking on mortality in tuberculosis. PLoS One. 2013; 8(2):e58044.
  View in: PubMed
 
2. Repasy T, Lee J, Marino S, Martinez N, Kirschner DE, Hendricks G, Baker S, Wilson AA, Kotton DN, Kornfeld H. Intracellular Bacillary Burden Reflects a Burst Size for Mycobacterium tuberculosis In Vivo. PLoS Pathog. 2013 Feb; 9(2):e1003190.
  View in: PubMed
 
3. Mishra BB, Rathinam VA, Martens GW, Martinot AJ, Kornfeld H, Fitzgerald KA, Sassetti CM. Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1ß. Nat Immunol. 2013 Jan; 14(1):52-60.
  View in: PubMed
 
4. Richmond JM, Lee J, Green DS, Kornfeld H, Cruikshank WW. Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Preferentially Inhibits Sphingosine-1-Phosphate-Induced Migration of Th1 Cells. J Immunol. 2012 Dec 15; 189(12):5886-95.
  View in: PubMed
 
5. Richmond JM, Duffy ER, Lee J, Kaboli K, Remick DG, Kornfeld H, Cruikshank WW. Mannose-Capped Lipoarabinomannan from Mycobacterium tuberculosis Induces Soluble Tumor Necrosis Factor Receptor Production through Tumor Necrosis Factor Alpha-Converting Enzyme Activation. Infect Immun. 2012 Nov; 80(11):3858-68.
  View in: PubMed
 
6. Narayan K, Sylvia KE, Malhotra N, Yin CC, Martens G, Vallerskog T, Kornfeld H, Xiong N, Cohen NR, Brenner MB, Berg LJ, Kang J. Intrathymic programming of effector fates in three molecularly distinct ?d T cell subtypes. Nat Immunol. 2012 May; 13(5):511-8.
  View in: PubMed
 
7. Martens GW, Vallerskog T, Kornfeld H. Hypercholesterolemic LDL receptor-deficient mice mount a neutrophilic response to tuberculosis despite the timely expression of protective immunity. J Leukoc Biol. 2012 Jun; 91(6):849-57.
  View in: PubMed
 
8. Kimura N, Itoh S, Nakae S, Axtell RC, Velotta JB, Bos EJ, Merk DR, Gong Y, Okamura H, Nagamine CM, Adachi H, Kornfeld H, Robbins RC, Fischbein MP. Interleukin-16 deficiency suppresses the development of chronic rejection in murine cardiac transplantation model. J Heart Lung Transplant. 2011 Dec; 30(12):1409-17.
  View in: PubMed
 
9. Hartman ML, Kornfeld H. Interactions between Naïve and Infected Macrophages Reduce Mycobacterium tuberculosis Viability. PLoS One. 2011; 6(11):e27972.
  View in: PubMed
 
10. Lee J, Repasy T, Papavinasasundaram K, Sassetti C, Kornfeld H. Mycobacterium tuberculosis Induces an Atypical Cell Death Mode to Escape from Infected Macrophages. PLoS One. 2011; 6(3):e18367.
  View in: PubMed
 
11. Harris J, Hartman M, Roche C, Zeng SG, O'Shea A, Sharp FA, Lambe EM, Creagh EM, Golenbock DT, Tschopp J, Kornfeld H, Fitzgerald KA, Lavelle EC. Autophagy Controls IL-1{beta} Secretion by Targeting Pro-IL-1{beta} for Degradation. J Biol Chem. 2011 Mar 18; 286(11):9587-97.
  View in: PubMed
 
12. Ghigo E, Barry AO, Pretat L, Al Moussawi K, Desnues B, Capo C, Kornfeld H, Mege JL. IL-16 promotes T. whipplei replication by inhibiting phagosome conversion and modulating macrophage activation. PLoS One. 2010; 5(10):e13561.
  View in: PubMed
 
13. Vallerskog T, Martens GW, Kornfeld H. Diabetic mice display a delayed adaptive immune response to Mycobacterium tuberculosis. J Immunol. 2010 Jun 1; 184(11):6275-82.
  View in: PubMed
 
14. Kashino SS, Vallerskog T, Martens G, Troudt J, Keyser A, Taylor J, Izzo A, Kornfeld H, Campos-Neto A. Initiation of acquired immunity in the lungs of mice lacking lymph nodes after infection with aerosolized Mycobacterium tuberculosis. Am J Pathol. 2010 Jan; 176(1):198-204.
  View in: PubMed
 
15. Han R, Kornfeld H, Martens G. Is hypercholesterolemia a friend or a foe of tuberculosis? Infect Immun. 2009 Aug; 77(8):3514; author reply 3514-5.
  View in: PubMed
 
16. Lee J, Hartman M, Kornfeld H. Macrophage apoptosis in tuberculosis. Yonsei Med J. 2009 Feb 28; 50(1):1-11.
  View in: PubMed
 
17. Mathurin KS, Martens GW, Kornfeld H, Welsh RM. CD4 T-cell-mediated heterologous immunity between mycobacteria and poxviruses. J Virol. 2009 Apr; 83(8):3528-39.
  View in: PubMed
 
18. Friedline RH, Brown DS, Nguyen H, Kornfeld H, Lee J, Zhang Y, Appleby M, Der SD, Kang J, Chambers CA. CD4+ regulatory T cells require CTLA-4 for the maintenance of systemic tolerance. J Exp Med. 2009 Feb 16; 206(2):421-34.
  View in: PubMed
 
19. Gan H, Lee J, Ren F, Chen M, Kornfeld H, Remold HG. Mycobacterium tuberculosis blocks crosslinking of annexin-1 and apoptotic envelope formation on infected macrophages to maintain virulence. Nat Immunol. 2008 Oct; 9(10):1189-97.
  View in: PubMed
 
20. Martens GW, Arikan MC, Lee J, Ren F, Vallerskog T, Kornfeld H. Hypercholesterolemia impairs immunity to tuberculosis. Infect Immun. 2008 Aug; 76(8):3464-72.
  View in: PubMed
 
21. Moise L, McMurry J, Rivera DS, Carter EJ, Lee J, Kornfeld H, Martin WD, De Groot AS. Progress towards a genome-derived, epitope-driven vaccine for latent TB infection. Med Health R I. 2007 Oct; 90(10):301-3.
  View in: PubMed
 
22. Martens GW, Arikan MC, Lee J, Ren F, Greiner D, Kornfeld H. Tuberculosis susceptibility of diabetic mice. Am J Respir Cell Mol Biol. 2007 Nov; 37(5):518-24.
  View in: PubMed
 
23. Morgan RK, McAllister B, Cross L, Green DS, Kornfeld H, Center DM, Cruikshank WW. Histamine 4 receptor activation induces recruitment of FoxP3+ T cells and inhibits allergic asthma in a murine model. J Immunol. 2007 Jun 15; 178(12):8081-9.
  View in: PubMed
 
24. McMurry JA, Kimball S, Lee JH, Rivera D, Martin W, Weiner DB, Kutzler M, Sherman DR, Kornfeld H, De Groot AS. Epitope-driven TB vaccine development: a streamlined approach using immuno-informatics, ELISpot assays, and HLA transgenic mice. Curr Mol Med. 2007 Jun; 7(4):351-68.
  View in: PubMed
 
25. Lee J, Remold HG, Ieong MH, Kornfeld H. Macrophage apoptosis in response to high intracellular burden of Mycobacterium tuberculosis is mediated by a novel caspase-independent pathway. J Immunol. 2006 Apr 1; 176(7):4267-74.
  View in: PubMed
 
26. El Bassam S, Pinsonneault S, Kornfeld H, Ren F, Menezes J, Laberge S. Interleukin-16 inhibits interleukin-13 production by allergen-stimulated blood mononuclear cells. Immunology. 2006 Jan; 117(1):89-96.
  View in: PubMed
 
27. Stabile E, Kinnaird T, la Sala A, Hanson SK, Watkins C, Campia U, Shou M, Zbinden S, Fuchs S, Kornfeld H, Epstein SE, Burnett MS. CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16. Circulation. 2006 Jan 3; 113(1):118-24.
  View in: PubMed
 
28. Wilson KC, Cattel DJ, Wan Z, Rahangdale S, Ren F, Kornfeld H, Sullivan BA, Cruikshank WW, Center DM. Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes. Cell Immunol. 2005 Sep; 237(1):17-27.
  View in: PubMed
 
29. Gan H, He X, Duan L, Mirabile-Levens E, Kornfeld H, Remold HG. Enhancement of antimycobacterial activity of macrophages by stabilization of inner mitochondrial membrane potential. J Infect Dis. 2005 Apr 15; 191(8):1292-300.
  View in: PubMed
 
30. Ren F, Zhan X, Martens G, Lee J, Center D, Hanson SK, Kornfeld H. Pro-IL-16 regulation in activated murine CD4+ lymphocytes. J Immunol. 2005 Mar 1; 174(5):2738-45.
  View in: PubMed
 
31. Spira A, Carroll JD, Liu G, Aziz Z, Shah V, Kornfeld H, Keane J. Apoptosis genes in human alveolar macrophages infected with virulent or attenuated Mycobacterium tuberculosis: a pivotal role for tumor necrosis factor. Am J Respir Cell Mol Biol. 2003 Nov; 29(5):545-51.
  View in: PubMed
 
32. Little FF, de Bie J, van Oosterhout A, Kornfeld H, Center DM, Cruikshank WW. Immunomodulatory effect of interleukin-16 on allergic airway inflammation. Chest. 2003 Mar; 123(3 Suppl):431S-2S.
  View in: PubMed
 
33. Riendeau CJ, Kornfeld H. THP-1 cell apoptosis in response to Mycobacterial infection. Infect Immun. 2003 Jan; 71(1):254-9.
  View in: PubMed
 
34. Saukkonen JJ, Bazydlo B, Thomas M, Strieter RM, Keane J, Kornfeld H. Beta-chemokines are induced by Mycobacterium tuberculosis and inhibit its growth. Infect Immun. 2002 Apr; 70(4):1684-93.
  View in: PubMed
 
35. Maciaszek JW, Parada NA, Cruikshank WW, Center DM, Kornfeld H, Viglianti GA. IL-16 represses HIV-1 promoter activity. J Immunol. 1997 Jan 1; 158(1):5-8.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Mycobacterium tuberculosis
Tuberculosis, Pulmonary
Macrophages
Interleukin-16
Apoptosis
See all (163) keywords
Co-Authors  
Fitzgerald, Katherine
Friedline, Randall
Kang, Joonsoo
Martens, Gregory
Sassetti, Christopher
See all (12) people
Physical Neighbors  
Wang, Donghai
Martens, Gregory
Sluss, Hayla
Lee, Jinhee
Mandrekar, Pranoti

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