David Ayers MD
Title Chair and Professor
Institution University of Massachusetts Medical School
Department Orthopedics & Physical Rehabilitation
Division Arthroscopy
Address University of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Telephone 508-334-7928
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Cell Biology

Institution UMMS - Graduate School of Biomedical Sciences
Department Clinical Population Health Research
Narrative
TitlesArthur M. Pappas, Chair, Orthopedics and Physical Rehabilitation, UMass Memorial Medical Center
Professor of Orthopedics and Physical Rehabilitation, University of Massachusetts Medical School
Clinical InterestsArthritis of the hip and knee, avascular necrosis of the hip, hip and knee replacement
Practice LocationUMass Memorial Medical Center - Memorial Campus
119 Belmont Street
Worcester, MA 01605
Appointments: 508-334-1955   Fax: 508-334-9762
Primary HospitalUMass Memorial Medical Center   
Board CertifiedOrthopedic Surgery
Medical SchoolUniversity of Rochester School of Medicine 1982
ResidencyStrong Memorial Hospital University of Rochester
FellowshipNuffield Orthopedic Center, University of Oxford (Joint Replacement)
Research Interests
  • Radiostereometric (RSA) Imaging of Hip Prostheses and Spine Fusion
  • Total Knee Replacement (TKR) (in collaboration with Prof. P. Franklin)
  • Link to David Ayers research page

    Publications
    1. Franklin PD, Allison JJ, Ayers DC. Beyond joint implant registries: a patient-centered research consortium for comparative effectiveness in total joint replacement. JAMA. 2012 Sep 26; 308(12):1217-8.
      View in: PubMed
     
    2. Rosal MC, Ayers D, Li W, Oatis C, Borg A, Zheng H, Franklin P. A randomized clinical trial of a peri-operative behavioral intervention to improve physical activity adherence and functional outcomes following total knee replacement. BMC Musculoskelet Disord. 2011; 12:226.
      View in: PubMed
     
    3. Liu P, Smits J, Ayers DC, Song J. Surface mineralization of Ti6Al4V substrates with calcium apatites for the retention and local delivery of recombinant human bone morphogenetic protein-2. Acta Biomater. 2011 Sep; 7(9):3488-95.
      View in: PubMed
     
    4. St Pierre CA, Chan M, Iwakura Y, Ayers DC, Kurt-Jones EA, Finberg RW. Periprosthetic osteolysis: characterizing the innate immune response to titanium wear-particles. J Orthop Res. 2010 Nov; 28(11):1418-24.
      View in: PubMed
     
    5. Filion TM, Li X, Mason-Savas A, Kreider JM, Goldstein SA, Ayers DC, Song J. Elastomeric osteoconductive synthetic scaffolds with acquired osteoinductivity expedite the repair of critical femoral defects in rats. Tissue Eng Part A. 2011 Feb; 17(3-4):503-11.
      View in: PubMed
     
    6. Jones MD, Liu JC, Barthel TK, Hussain S, Lovria E, Cheng D, Schoonmaker JA, Mulay S, Ayers DC, Bouxsein ML, Stein GS, Mukherjee S, Lian JB. A proteasome inhibitor, bortezomib, inhibits breast cancer growth and reduces osteolysis by downregulating metastatic genes. Clin Cancer Res. 2010 Oct 15; 16(20):4978-89.
      View in: PubMed
     
    7. Franklin PD, Karbassi JA, Li W, Yang W, Ayers DC. Reduction in narcotic use after primary total knee arthroplasty and association with patient pain relief and satisfaction. J Arthroplasty. 2010 Sep; 25(6 Suppl):12-6.
      View in: PubMed
     
    8. Xu J, Li X, Lian JB, Ayers DC, Song J. Sustained and localized in vitro release of BMP-2/7, RANKL, and tetracycline from FlexBone, an elastomeric osteoconductive bone substitute. J Orthop Res. 2009 Oct; 27(10):1306-11.
      View in: PubMed
     
    9. Wixted JJ, Fanning PJ, Gaur T, O'Connell SL, Silva J, Mason-Savas A, Ayers DC, Stein GS, Lian JB. Enhanced fracture repair by leukotriene antagonism is characterized by increased chondrocyte proliferation and early bone formation: a novel role of the cysteinyl LT-1 receptor. J Cell Physiol. 2009 Oct; 221(1):31-9.
      View in: PubMed
     
    10. Ayers DC, Hays PL, Drew JM, Eskander MS, Osuch D, Bragdon CR. Two-year radiostereometric analysis evaluation of femoral head penetration in a challenging population of young total hip arthroplasty patients. J Arthroplasty. 2009 Sep; 24(6 Suppl):9-14.
      View in: PubMed
     
    11. Gaur T, Wixted JJ, Hussain S, O'Connell SL, Morgan EF, Ayers DC, Komm BS, Bodine PV, Stein GS, Lian JB. Secreted frizzled related protein 1 is a target to improve fracture healing. J Cell Physiol. 2009 Jul; 220(1):174-81.
      View in: PubMed
     
    12. Song J, Xu J, Filion T, Saiz E, Tomsia AP, Lian JB, Stein GS, Ayers DC, Bertozzi CR. Elastomeric high-mineral content hydrogel-hydroxyapatite composites for orthopedic applications. J Biomed Mater Res A. 2009 Jun 15; 89(4):1098-107.
      View in: PubMed
     
    13. Franklin PD, Li W, Ayers DC. The Chitranjan Ranawat Award: functional outcome after total knee replacement varies with patient attributes. Clin Orthop Relat Res. 2008 Nov; 466(11):2597-604.
      View in: PubMed
     
    14. Jäger M, Fischer J, Dohrn W, Li X, Ayers DC, Czibere A, Prall WC, Lensing-Höhn S, Krauspe R. Dexamethasone modulates BMP-2 effects on mesenchymal stem cells in vitro. J Orthop Res. 2008 Nov; 26(11):1440-8.
      View in: PubMed
     
    15. Jäger M, Urselmann F, Witte F, Zanger K, Li X, Ayers DC, Krauspe R. Osteoblast differentiation onto different biometals with an endoprosthetic surface topography in vitro. J Biomed Mater Res A. 2008 Jul; 86(1):61-75.
      View in: PubMed
     
    16. Franklin PD, McLaughlin J, Boisvert CB, Li W, Ayers DC. Pilot study of methods to document quantity and variation of independent patient exercise and activity after total knee arthroplasty. J Arthroplasty. 2006 Sep; 21(6 Suppl 2):157-63.
      View in: PubMed
     
    17. Gaur T, Rich L, Lengner CJ, Hussain S, Trevant B, Ayers D, Stein JL, Bodine PV, Komm BS, Stein GS, Lian JB. Secreted frizzled related protein 1 regulates Wnt signaling for BMP2 induced chondrocyte differentiation. J Cell Physiol. 2006 Jul; 208(1):87-96.
      View in: PubMed
     
    18. Ayers DC, Franklin PD, Ploutz-Snyder R, Boisvert CB. Total knee replacement outcome and coexisting physical and emotional illness. Clin Orthop Relat Res. 2005 Nov; 440:157-61.
      View in: PubMed
     
    19. Werner FW, Ayers DC, Maletsky LP, Rullkoetter PJ. The effect of valgus/varus malalignment on load distribution in total knee replacements. J Biomech. 2005 Feb; 38(2):349-55.
      View in: PubMed
     
    20. Ayers DC, Franklin PD, Trief PM, Ploutz-Snyder R, Freund D. Psychological attributes of preoperative total joint replacement patients: implications for optimal physical outcome. J Arthroplasty. 2004 Oct; 19(7 Suppl 2):125-30.
      View in: PubMed
     
    21. Mann KA, Gupta S, Race A, Miller MA, Cleary RJ, Ayers DC. Cement microcracks in thin-mantle regions after in vitro fatigue loading. J Arthroplasty. 2004 Aug; 19(5):605-12.
      View in: PubMed
     
    22. Mann KA, Damron LA, Race A, Ayers DC. Early cementing does not increase debond energy of grit blasted interfaces. J Orthop Res. 2004 Jul; 22(4):822-7.
      View in: PubMed
     
    23. Ayers D, Mann K. The importance of proximal cement filling of the calcar region: a biomechanical justification. J Arthroplasty. 2003 Oct; 18(7 Suppl 1):103-9.
      View in: PubMed
     
    24. Mann KA, Mocarski R, Damron LA, Allen MJ, Ayers DC. Mixed-mode failure response of the cement-bone interface. J Orthop Res. 2001 Nov; 19(6):1153-61.
      View in: PubMed
     
    25. Ayers DC. Maximizing ultra high molecular weight polyethylene performance in total knee replacement. Instr Course Lect. 2001; 50:421-9.
      View in: PubMed
     
    26. Mann KA, Allen MJ, Ayers DC. Pre-yield and post-yield shear behavior of the cement-bone interface. J Orthop Res. 1998 May; 16(3):370-8.
      View in: PubMed
     
    27. Francis CW, Pellegrini VD, Totterman S, Boyd AD, Marder VJ, Liebert KM, Stulberg BN, Ayers DC, Rosenberg A, Kessler C, Johanson NA. Prevention of deep-vein thrombosis after total hip arthroplasty. Comparison of warfarin and dalteparin. J Bone Joint Surg Am. 1997 Sep; 79(9):1365-72.
      View in: PubMed
     
    28. Mann KA, Bartel DL, Ayers DC. Influence of stem geometry on mechanics of cemented femoral hip components with a proximal bond. J Orthop Res. 1997 Sep; 15(5):700-6.
      View in: PubMed
     
    29. Mann KA, Ayers DC, Damron TA. Effects of stem length on mechanics of the femoral hip component after cemented revision. J Orthop Res. 1997 Jan; 15(1):62-8.
      View in: PubMed
     
    30. Ayers DC. Supracondylar fracture of the distal femur proximal to a total knee replacement. Instr Course Lect. 1997; 46:197-203.
      View in: PubMed
     
    31. Ayers DC. Polyethylene wear and osteolysis following total knee replacement. Instr Course Lect. 1997; 46:205-13.
      View in: PubMed
     
    32. Riebel GD, Werner FW, Ayers DC, Bromka J, Murray DG. Early failure of the femoral component in unicompartmental knee arthroplasty. J Arthroplasty. 1995 Oct; 10(5):615-21.
      View in: PubMed
     
    33. Ayers DC, Murray DG, Duerr DM. Blood salvage after total hip arthroplasty. J Bone Joint Surg Am. 1995 Sep; 77(9):1347-51.
      View in: PubMed
     
    34. Ayers DC, Athanasou NA, Woods CG, Duthie RB. Dialysis arthropathy of the hip. Clin Orthop Relat Res. 1993 May; (290):216-24.
      View in: PubMed
     
    35. Ayers DC, Pellegrini VD, Evarts CM. Prevention of heterotopic ossification in high-risk patients by radiation therapy. Clin Orthop Relat Res. 1991 Feb; (263):87-93.
      View in: PubMed
     
    36. Evarts CM, Ayers DC, Puzas JE. Prevention of heterotopic bone formation in high-risk patients by postoperative irradiation. Hip. 1987; 70-83.
      View in: PubMed
     
    37. Ayers DC, Evarts CM, Parkinson JR. The prevention of heterotopic ossification in high-risk patients by low-dose radiation therapy after total hip arthroplasty. J Bone Joint Surg Am. 1986 Dec; 68(9):1423-30.
      View in: PubMed
     
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    Keyword
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    Institution
        
     
     
     
    Co-Authors  
    Franklin, Patricia
    Li, Wenjun
    Lian, Jane
    Song, Jie
    Stein, Gary
    See all (14) people
    Physical Neighbors  
    Pappas, Arthur
    Mortimer, Errol
    Gaebe, Glen
    Kraus, Mark
    Brown, Trista

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