Chinmay M Trivedi MD, PHD
Title Assistant Professor
Institution University of Massachusetts Medical School
Department Medicine
Division Cardiovascular Medicine
Address University of Massachusetts Medical School
368 Plantation Street
Worcester MA 01605
Telephone 508-856-6947
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Interdisciplinary Graduate Program

Institution UMMS - Graduate School of Biomedical Sciences
Department MD/PhD Program
Narrative
Congenital and adult heart diseases are the leading causes of mortality in the developed world. Improper development of cardiomyocytes leads to the devastating heart defects in newborn children and loss of diseased cardiomyocytes leads to heart failure in adults. Unfortunately, heart is one of the least regenerative organs in the body with negligible endogenous capacity to repair or replace affected cardiomyocytes. Ability of pluripotent stem cells and cardiac progenitor cells to progressively differentiate into various lineages, including cardiomyocytes, provide tantalizing promise for cell-based therapy. Our main focus is to understand regulatory functions of chromatin and epigenetic modifications during lineage commitment and differentiation of these progenitor cells to harness its therapeutic potential.
Publications
1. Singh N, Gupta M, Trivedi CM, Singh MK, Li L, Epstein JA. Murine craniofacial development requires Hdac3-mediated repression of Msx gene expression. Dev Biol. 2013 Mar 15.
  View in: PubMed
 
2. Banerjee A, Trivedi CM, Damera G, Jiang M, Jester W, Hoshi T, Epstein JA, Panettieri RA. Trichostatin a abrogates airway constriction, but not inflammation, in murine and human asthma models. Am J Respir Cell Mol Biol. 2012 Feb; 46(2):132-8.
  View in: PubMed
 
3. Singh N, Trivedi CM, Lu M, Mullican SE, Lazar MA, Epstein JA. Histone deacetylase 3 regulates smooth muscle differentiation in neural crest cells and development of the cardiac outflow tract. Circ Res. 2011 Nov 11; 109(11):1240-9.
  View in: PubMed
 
4. Anokye-Danso F, Trivedi CM, Juhr D, Gupta M, Cui Z, Tian Y, Zhang Y, Yang W, Gruber PJ, Epstein JA, Morrisey EE. Highly Efficient miRNA-Mediated Reprogramming of Mouse and Human Somatic Cells to Pluripotency. Cell Stem Cell. 2011 Apr 8; 8(4):376-88.
  View in: PubMed
 
5. Pillai VB, Sundaresan NR, Samant SA, Wolfgeher D, Trivedi CM, Gupta MP. Acetylation of a Conserved Lysine Residue in the ATP Binding Pocket of p38 Augments Its Kinase Activity during Hypertrophy of Cardiomyocytes. Mol Cell Biol. 2011 Jun; 31(11):2349-63.
  View in: PubMed
 
6. Trivedi CM, Cappola TP, Margulies KB, Epstein JA. Homeodomain Only Protein X is down-regulated in human heart failure. J Mol Cell Cardiol. 2011 Jun; 50(6):1056-8.
  View in: PubMed
 
7. Trivedi CM, Epstein JA. Heart-healthy hypertrophy. Cell Metab. 2011 Jan 5; 13(1):3-4.
  View in: PubMed
 
8. Trivedi CM, Zhu W, Wang Q, Jia C, Kee HJ, Li L, Hannenhalli S, Epstein JA. Hopx and Hdac2 interact to modulate Gata4 acetylation and embryonic cardiac myocyte proliferation. Dev Cell. 2010 Sep 14; 19(3):450-9.
  View in: PubMed
 
9. Chokas AL, Trivedi CM, Lu MM, Tucker PW, Li S, Epstein JA, Morrisey EE. Foxp1/2/4-NuRD interactions regulate gene expression and epithelial injury response in the lung via regulation of interleukin-6. J Biol Chem. 2010 Apr 23; 285(17):13304-13.
  View in: PubMed
 
10. Zhu W, Trivedi CM, Zhou D, Yuan L, Lu MM, Epstein JA. Inpp5f is a polyphosphoinositide phosphatase that regulates cardiac hypertrophic responsiveness. Circ Res. 2009 Dec 4; 105(12):1240-7.
  View in: PubMed
 
11. Kerkela R, Kockeritz L, Macaulay K, Zhou J, Doble BW, Beahm C, Greytak S, Woulfe K, Trivedi CM, Woodgett JR, Epstein JA, Force T, Huggins GS. Deletion of GSK-3beta in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation. J Clin Invest. 2008 Nov; 118(11):3609-18.
  View in: PubMed
 
12. Trivedi CM, Lu MM, Wang Q, Epstein JA. Transgenic overexpression of Hdac3 in the heart produces increased postnatal cardiac myocyte proliferation but does not induce hypertrophy. J Biol Chem. 2008 Sep 26; 283(39):26484-9.
  View in: PubMed
 
13. Trivedi CM, Patel RC, Patel CV. Differential regulation of HOXA9 expression by nuclear factor kappa B (NF-kappaB) and HOXA9. Gene. 2008 Jan 31; 408(1-2):187-95.
  View in: PubMed
 
14. Trivedi CM, Patel RC, Patel CV. Homeobox gene HOXA9 inhibits nuclear factor-kappa B dependent activation of endothelium. Atherosclerosis. 2007 Dec; 195(2):e50-60.
  View in: PubMed
 
15. Trivedi CM, Luo Y, Yin Z, Zhang M, Zhu W, Wang T, Floss T, Goettlicher M, Noppinger PR, Wurst W, Ferrari VA, Abrams CS, Gruber PJ, Epstein JA. Hdac2 regulates the cardiac hypertrophic response by modulating Gsk3 beta activity. Nat Med. 2007 Mar; 13(3):324-31.
  View in: PubMed
 
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Keyword
Last Name
Institution
    
 
 
 
Keywords   
Homeodomain Proteins
Cardiomegaly
Myocytes, Cardiac
Histone Deacetylases
Histone Deacetylase 2
See all (77) keywords
Physical Neighbors  
Tanriverdi, Kahraman
Pechhold, Klaus
Beaulieu, Lea
Cooper, Marcus
Kent, Sally

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