Philimon Gona PHD
Title Associate Professor
Institution University of Massachusetts Medical School
Department Quantitative Health Sciences
Division Biostatistics And Health Services Research
Address University of Massachusetts Medical School
55 Lake Avenue North
Worcester MA 01655
Telephone 508/856-8959
Email
Other Positions
Institution UMMS - Graduate School of Biomedical Sciences
Department Clinical Population Health Research

Institution UMMS - Programs, Centers and Institutes
Department Center for AIDS Research
Awards and Honors
1991 Boston University MPH (Epidemiology)
1993 Boston University MA (Biostatistics)
1999 Boston University PhD (Biostatistics)
2010 Boston University MSc (Actuarial Science)
Narrative
Dr. Gona is an Associate Professor of Quantitative Health Sciences at UMass. His research interest interests are survival analysis applied to epidemiology, semi-Markov models with missing data, statistical genetics & genomics, clinical trials and global health. . In addition to teaching biostatistics in the Clinical and Population Health Research PhD Program at UMMS, Dr. Gona is member of UMass Center for Clinical and Translational Science’s Biostatistics, Epidemiology, Research and Design (BERD) within the national Clinical and Translational Science Award (CTSA) consortium created to accelerate laboratory discoveries into treatments for patients. He represents UMMS in the Association of Clinical Translational Statisticians. Previously, as a Research Scientist at Harvard School of Public Health Center for Biostatistics in AIDS Research, he lead the design and analyses of HIV/AIDS clinical trials for the AIDS Clinical Trials Group and chaired the Pediatric ACTG’s Surveillance Working Group on HIV-related opportunistic infections. As an investigator at the Framingham Heart Study, Dr. Gona has conducted statistical design and analyses of nutritional epidemiological studies and numerous studies relating biomarkers to incident heart diseases. He is the Data Safety Monitoring Board biostatistician for the NIH-funded Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) and a statistical consultant for the John Snow Institute. He was recently appointed Visiting Scientist at North-West University, South Africa to work with the Hypertension in Africa Research Team (HART) on "Early detection of cardiovascular disease in black South Africans" study.
Publications
1. Michael L Chuang, Philimon Gona, Gilion L T F Hautvast, Carol J Salton, Susan J Blease, Susan B Yeon, Marcel Breeuwer, Christopher J O'Donnell, Warren J Manning. Correlation of Trabeculae and Papillary Muscles With Clinical and Cardiac Characteristics. JACC. Cardiovascular imaging. 2012; 5(11)(11/2012):1115-23.
 
2. Chuang ML, Gona P, Hautvast GL, Salton CJ, Blease SJ, Yeon SB, Breeuwer M, O'Donnell CJ, Manning WJ. Correlation of Trabeculae and Papillary Muscles With Clinical and Cardiac Characteristics and Impact on CMR Measures of LV Anatomy and Function. JACC Cardiovasc Imaging. 2012 Nov; 5(11):1115-23.
  View in: PubMed
 
3. Kimokoti RW, Gona P, Zhu L, Newby PK, Millen BE, Brown LS, D'Agostino RB, Fung TT. Dietary patterns of women are associated with incident abdominal obesity but not metabolic syndrome. J Nutr. 2012 Sep; 142(9):1720-7.
  View in: PubMed
 
4. Ruth W. Kimokoti, Philimon Gona, Lei Zhu, P. K. Newby, Barbara E. Millen, Lisa S. Brown, Ralph B. D’Agostino and Teresa T. Fung. Dietary Patterns of Women Are Associated with Incident Abdominal Obesity but Not Metabolic Syndrome. The Journal of Nutrition. 2012.
 
5. Ho JE, Gona P, Pencina MJ, Tu JV, Austin PC, Vasan RS, Kannel WB, D'Agostino RB, Lee DS, Levy D. Discriminating clinical features of heart failure with preserved vs. reduced ejection fraction in the community. Eur Heart J. 2012 Jul; 33(14):1734-41.
  View in: PubMed
 
6. Chuang ML, Gona P, Salton CJ, Yeon SB, Kissinger KV, Blease SJ, Levy D, O'Donnell CJ, Manning WJ. Usefulness of the left ventricular myocardial contraction fraction in healthy men and women to predict cardiovascular morbidity and mortality. Am J Cardiol. 2012 May 15; 109(10):1454-8.
  View in: PubMed
 
7. Prushik SG, Farber A, Gona P, Shrader P, Pencina MJ, D'Agostino RB, Murabito JM. Parental intermittent claudication as risk factor for claudication in adults. Am J Cardiol. 2012 Mar 1; 109(5):736-41.
  View in: PubMed
 
8. Kimokoti RW, Newby PK, Gona P, Zhu L, Campbell WR, D'Agostino RB, Millen BE. Stability of the Framingham Nutritional Risk Score and its component nutrients over 8 years: the Framingham Nutrition Studies. Eur J Clin Nutr. 2012 Mar; 66(3):336-44.
  View in: PubMed
 
9. Tsao CW, Gona P, Salton C, Murabito JM, Oyama N, Danias PG, O'Donnell CJ, Manning WJ, Yeon SB. Relationship between central and peripheral atherosclerosis and left ventricular dysfunction in a community population. Vasc Med. 2011 Aug; 16(4):253-9.
  View in: PubMed
 
10. Tsao CW, Gona P, Salton C, Danias PG, Blease S, Hoffmann U, Fox CS, Albert M, Levy D, O'Donnell CJ, Manning WJ, Yeon SB. Subclinical and clinical correlates of left ventricular wall motion abnormalities in the community. Am J Cardiol. 2011 Mar 15; 107(6):949-55.
  View in: PubMed
 
11. Lee DS, Gona P, Albano I, Larson MG, Benjamin EJ, Levy D, Kannel WB, Vasan RS. A systematic assessment of causes of death after heart failure onset in the community: impact of age at death, time period, and left ventricular systolic dysfunction. Circ Heart Fail. 2011 Jan 1; 4(1):36-43.
  View in: PubMed
 
12. Fox CS, Gona P, Larson MG, Selhub J, Tofler G, Hwang SJ, Meigs JB, Levy D, Wang TJ, Jacques PF, Benjamin EJ, Vasan RS. A Multi-Marker Approach to Predict Incident CKD and Microalbuminuria. J Am Soc Nephrol. 2010 Dec; 21(12):2143-9.
  View in: PubMed
 
13. Velagaleti RS, Gona P, Larson MG, Wang TJ, Levy D, Benjamin EJ, Selhub J, Jacques PF, Meigs JB, Tofler GH, Vasan RS. Multimarker approach for the prediction of heart failure incidence in the community. Circulation. 2010 Oct 26; 122(17):1700-6.
  View in: PubMed
 
14. Velagaleti RS, Gona P, Sundström J, Larson MG, Siwik D, Colucci WS, Benjamin EJ, Vasan RS. Relations of biomarkers of extracellular matrix remodeling to incident cardiovascular events and mortality. Arterioscler Thromb Vasc Biol. 2010 Nov; 30(11):2283-8.
  View in: PubMed
 
15. Jefferson AL, Himali JJ, Beiser AS, Au R, Massaro JM, Seshadri S, Gona P, Salton CJ, DeCarli C, O'Donnell CJ, Benjamin EJ, Wolf PA, Manning WJ. Cardiac index is associated with brain aging: the Framingham Heart Study. Circulation. 2010 Aug 17; 122(7):690-7.
  View in: PubMed
 
16. Dhingra R, Gona P, Benjamin EJ, Wang TJ, Aragam J, D'Agostino RB, Kannel WB, Vasan RS. Relations of serum phosphorus levels to echocardiographic left ventricular mass and incidence of heart failure in the community. Eur J Heart Fail. 2010 Aug; 12(8):812-8.
  View in: PubMed
 
17. Dhingra R, Gona P, Wang TJ, Fox CS, D'Agostino RB, Vasan RS. Serum gamma-glutamyl transferase and risk of heart failure in the community. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1855-60.
  View in: PubMed
 
18. Makadzange AT, Ndhlovu CE, Takarinda K, Reid M, Kurangwa M, Gona P, Hakim JG. Early versus delayed initiation of antiretroviral therapy for concurrent HIV infection and cryptococcal meningitis in sub-saharan Africa. Clin Infect Dis. 2010 Jun 1; 50(11):1532-8.
  View in: PubMed
 
19. Kimokoti RW, Newby PK, Gona P, Zhu L, Jasuja GK, Pencina MJ, McKeon-O'Malley C, Fox CS, D'Agostino RB, Millen BE. Diet quality, physical activity, smoking status, and weight fluctuation are associated with weight change in women and men. J Nutr. 2010 Jul; 140(7):1287-93.
  View in: PubMed
 
20. Lieb W, Gona P, Larson MG, Massaro JM, Lipinska I, Keaney JF, Rong J, Corey D, Hoffmann U, Fox CS, Vasan RS, Benjamin EJ, O'Donnell CJ, Kathiresan S. Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1849-54.
  View in: PubMed
 
21. Velagaleti RS, Gona P, Chuang ML, Salton CJ, Fox CS, Blease SJ, Yeon SB, Manning WJ, O'Donnell CJ. Relations of insulin resistance and glycemic abnormalities to cardiovascular magnetic resonance measures of cardiac structure and function: the Framingham Heart Study. Circ Cardiovasc Imaging. 2010 May; 3(3):257-63.
  View in: PubMed
 
22. Weinberg A, Huang S, Fenton T, Patterson-Bartlett J, Gona P, Read JS, Dankner WM, Nachman S. Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment. J Acquir Immune Defic Syndr. 2009 Sep 1; 52(1):17-24.
  View in: PubMed
 
23. Andiman WA, Chernoff MC, Mitchell C, Purswani M, Oleske J, Williams PL, Spiegel H, Gona P, Seage GR. Incidence of persistent renal dysfunction in human immunodeficiency virus-infected children: associations with the use of antiretrovirals, and other nephrotoxic medications and risk factors. Pediatr Infect Dis J. 2009 Jul; 28(7):619-25.
  View in: PubMed
 
24. Lee DS, Gona P, Vasan RS, Larson MG, Benjamin EJ, Wang TJ, Tu JV, Levy D. Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the framingham heart study of the national heart, lung, and blood institute. Circulation. 2009 Jun 23; 119(24):3070-7.
  View in: PubMed
 
25. Fox CS, Gona P, Hoffmann U, Porter SA, Salton CJ, Massaro JM, Levy D, Larson MG, D'Agostino RB, O'Donnell CJ, Manning WJ. Pericardial fat, intrathoracic fat, and measures of left ventricular structure and function: the Framingham Heart Study. Circulation. 2009 Mar 31; 119(12):1586-91.
  View in: PubMed
 
26. Parikh NI, Gona P, Larson MG, Fox CS, Benjamin EJ, Murabito JM, O'Donnell CJ, Vasan RS, Levy D. Long-term trends in myocardial infarction incidence and case fatality in the National Heart, Lung, and Blood Institute's Framingham Heart study. Circulation. 2009 Mar 10; 119(9):1203-10.
  View in: PubMed
 
27. Nachman SA, Chernoff M, Gona P, Van Dyke RB, Dankner WM, Seage GR, Oleske J, Williams PL. Incidence of noninfectious conditions in perinatally HIV-infected children and adolescents in the HAART era. Arch Pediatr Adolesc Med. 2009 Feb; 163(2):164-71.
  View in: PubMed
 
28. Chen TH, Gona P, Sutherland PA, Benjamin EJ, Wilson PW, Larson MG, Vasan RS, Robins SJ. Long-term C-reactive protein variability and prediction of metabolic risk. Am J Med. 2009 Jan; 122(1):53-61.
  View in: PubMed
 
29. Velagaleti RS, Gona P, Levy D, Aragam J, Larson MG, Tofler GH, Lieb W, Wang TJ, Benjamin EJ, Vasan RS. Relations of biomarkers representing distinct biological pathways to left ventricular geometry. Circulation. 2008 Nov 25; 118(22):2252-8, 5p following 2258.
  View in: PubMed
 
30. Ingelsson E, Gona P, Larson MG, Lloyd-Jones DM, Kannel WB, Vasan RS, Levy D. Altered blood pressure progression in the community and its relation to clinical events. Arch Intern Med. 2008 Jul 14; 168(13):1450-7.
  View in: PubMed
 
31. Ndebele K, Gona P, Jin TG, Benhaga N, Chalah A, Degli-Esposti M, Khosravi-Far R. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) induced mitochondrial pathway to apoptosis and caspase activation is potentiated by phospholipid scramblase-3. Apoptosis. 2008 Jul; 13(7):845-56.
  View in: PubMed
 
32. Lewis GD, Gona P, Larson MG, Plehn JF, Benjamin EJ, O'Donnell CJ, Levy D, Vasan RS, Wang TJ. Exercise blood pressure and the risk of incident cardiovascular disease (from the Framingham Heart Study). Am J Cardiol. 2008 Jun 1; 101(11):1614-20.
  View in: PubMed
 
33. Dhingra R, Gona P, Nam BH, D'Agostino RB, Wilson PW, Benjamin EJ, O'Donnell CJ. C-reactive protein, inflammatory conditions, and cardiovascular disease risk. Am J Med. 2007 Dec; 120(12):1054-62.
  View in: PubMed
 
34. Oyama N, Gona P, Salton CJ, Chuang ML, Jhaveri RR, Blease SJ, Manning AR, Lahiri M, Botnar RM, Levy D, Larson MG, O'Donnell CJ, Manning WJ. Differential impact of age, sex, and hypertension on aortic atherosclerosis: the Framingham Heart Study. Arterioscler Thromb Vasc Biol. 2008 Jan; 28(1):155-9.
  View in: PubMed
 
35. Parikh NI, Gona P, Larson MG, Wang TJ, Newton-Cheh C, Levy D, Benjamin EJ, Kannel WB, Vasan RS. Plasma renin and risk of cardiovascular disease and mortality: the Framingham Heart Study. Eur Heart J. 2007 Nov; 28(21):2644-52.
  View in: PubMed
 
36. Newton-Cheh C, Guo CY, Gona P, Larson MG, Benjamin EJ, Wang TJ, Kathiresan S, O'Donnell CJ, Musone SL, Camargo AL, Drake JA, Levy D, Hirschhorn JN, Vasan RS. Clinical and genetic correlates of aldosterone-to-renin ratio and relations to blood pressure in a community sample. Hypertension. 2007 Apr; 49(4):846-56.
  View in: PubMed
 
37. Wang TJ, Gona P, Larson MG, Levy D, Benjamin EJ, Tofler GH, Jacques PF, Meigs JB, Rifai N, Selhub J, Robins SJ, Newton-Cheh C, Vasan RS. Multiple biomarkers and the risk of incident hypertension. Hypertension. 2007 Mar; 49(3):432-8.
  View in: PubMed
 
38. Wang TJ, Gona P, Larson MG, Tofler GH, Levy D, Newton-Cheh C, Jacques PF, Rifai N, Selhub J, Robins SJ, Benjamin EJ, D'Agostino RB, Vasan RS. Multiple biomarkers for the prediction of first major cardiovascular events and death. N Engl J Med. 2006 Dec 21; 355(25):2631-9.
  View in: PubMed
 
39. Gona P, Van Dyke RB, Williams PL, Dankner WM, Chernoff MC, Nachman SA, Seage GR. Incidence of opportunistic and other infections in HIV-infected children in the HAART era. JAMA. 2006 Jul 19; 296(3):292-300.
  View in: PubMed
 
40. Kathiresan S, Larson MG, Vasan RS, Guo CY, Gona P, Keaney JF, Wilson PW, Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation. 2006 Mar 21; 113(11):1415-23.
  View in: PubMed
 
41. Kathiresan S, Gona P, Larson MG, Vita JA, Mitchell GF, Tofler GH, Levy D, Newton-Cheh C, Wang TJ, Benjamin EJ, Vasan RS. Cross-sectional relations of multiple biomarkers from distinct biological pathways to brachial artery endothelial function. Circulation. 2006 Feb 21; 113(7):938-45.
  View in: PubMed
 
42. Dhingra R, Larson MG, Benjamin EJ, Lipinska I, Gona P, Corey D, Keaney JF, Vasan RS. Cross-sectional correlates of serum heat shock protein 70 in the community. Am J Hypertens. 2006 Feb; 19(2):227-31; discussion 232-3.
  View in: PubMed
 
43. Weinberg A, Gona P, Nachman SA, Defechereux P, Yogev R, Hughes W, Wara D, Spector SA, Read J, Elgie C, Cooper M, Dankner W. Antibody responses to hepatitis A virus vaccine in HIV-infected children with evidence of immunologic reconstitution while receiving highly active antiretroviral therapy. J Infect Dis. 2006 Jan 15; 193(2):302-11.
  View in: PubMed
 
44. Sandra F, Degli Esposti M, Ndebele K, Gona P, Knight D, Rosenquist M, Khosravi-Far R. Tumor necrosis factor-related apoptosis-inducing ligand alters mitochondrial membrane lipids. Cancer Res. 2005 Sep 15; 65(18):8286-97.
  View in: PubMed
 
45. Farley J, Gona P, Crain M, Cervia J, Oleske J, Seage G, Lindsey J. Prevalence of elevated cholesterol and associated risk factors among perinatally HIV-infected children (4-19 years old) in Pediatric AIDS Clinical Trials Group 219C. J Acquir Immune Defic Syndr. 2005 Apr 1; 38(4):480-7.
  View in: PubMed
 
46. Nachman S, Gona P, Dankner W, Weinberg A, Yogev R, Gershon A, Rathore M, Read JS, Huang S, Elgie C, Hudgens K, Hughes W. The rate of serious bacterial infections among HIV-infected children with immune reconstitution who have discontinued opportunistic infection prophylaxis. Pediatrics. 2005 Apr; 115(4):e488-94.
  View in: PubMed
 
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