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    John F Keaney MD

    TitleProfessor
    InstitutionUniversity of Massachusetts Medical School
    DepartmentMedicine
    AddressUniversity of Massachusetts Medical School
    55 Lake Avenue North
    Worcester MA 01655
    Phone508-334-2266
      Other Positions
      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentInterdisciplinary Graduate Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMD/PhD Program

      InstitutionUMMS - Graduate School of Biomedical Sciences
      DepartmentMillennium MD/PhD Program

        Overview 
        Narrative

        Education:

        • 1983 A.B. Harvard College
        • 1987 M.D. Yale University School of Medicine

        Postdoctoral Training

        Internship and Residency:
        • 1987-1988 Intern in Medicine, Brigham & Women's Hospital, Boston, MA
        • 1988-1989 Junior Assistant Resident, Brigham & Women's Hospital, Boston, MA
        Fellowship:
        • 1989-1990 Clinical Fellow, Cardiology, Brigham & Women's Hospital, Boston, MA
        • 1990-1992 Clinical and Research Fellow in Cardiology, Brigham & Women's Hospital, Boston, MA

        Licensure and Certification

        • 1988 Diplomate, National Board of Medical Examiners
        • 1989 Massachusetts Medical License, No. 70338
        • 1991 Diplomate, American Board of Internal Medicine
        • 1993 Diplomate, Subspecialty in Cardiovascular Diseases
        • 1995 Certification: Palmaz-Schatz stent implantation
        • 1999 ABIM Certification in Interventional Cardiology
        • 2001 ABIM Recertification in Internal Medicine and Cardiology

        Memberships in Professional Societies

        • 1984- Massachusetts Medical Society
        • 1984- Norfolk County Medical Society
        • 1992- American Association for the Advancement of Science
        • 1992- American Federation for Clinical Research
        • 1992- American College of Physicians
        • 1996- Fellow, American College of Cardiology
        • 1996- American Physiological Society
        • 1996- Fellow, American Heart Association, Council on Arteriosclerosis.
        • 1997- Fellow, American Heart Association, Council on Circulation
        • 1998- Society for Free Radical Biology in Medicine
        • 2001- Fellow, American Heart Association
        • 2001- American Society of Biochemistry and Molecular Biology
        • 2006- American Society of Clinical Investigation
        • 2007- Association of University Cardiologists

        John F Keaney,  JrJohn F. Keaney, Jr, MD

        Division Chief, Cardiovascular Medicine
        Department of Medicine
        University of Massachusetts Medical School

        Research Grants

        • 1992-1994 F32HL08635, National Research Service Award, NIH
        • 1994-1995 Pfizer Fellowship Award, Pfizer Pharmaceutical Inc.
        • 1994-1996 Grant-in-Aid, American Heart Association, Mass. Affiliate
        • 1995-2000 K08HL03195, Clinical Investigator Development Award, NIH
        • 1995-1998 Research Grant, Council for Tobacco Research, USA #4073
        • 1996-1999 Grant-in-Aid, American Heart Association, National Center
        • 1996-2001 P01HL55854, Project Leader, Mechanism(s) of Excess LDL Oxidation in Diabetes, NIH
        • 1997-2000 R01HL59634, Vitamin C, GSH, and Endothelium-Derived NO, NIH
        • 1997-2001 R01HL58936, Homocysteine, Oxidative Stress, and Nitric Oxide, NIH
        • 2000-2004 R01DK55656, Cellular Vitamin E Status and Integrin Function, NIH
        • 2000-2004 Established Investigator Award, American Heart Association
        • 2000-2005 P01HL60886, Project Leader, Vitamin C, GSH, and EDNO, NIH
        • 2001-2006 T32HL07224-30, Basic Science Cardiovascular Training Program
        • 2002-2005 Oxidative Stress, AMP kinase, and EDNO (Project 2), NIH/NHLBI and JDRF Center for Study of Diabetic Complications
        • 2003-2008 R01HL61766, HOCl-Mediated Impairment of Endothelial Function, NIH
        • 2005-2010 R01AG027081, Nox Isoforms in the Control of Endothelial Cell Phenotype
        • 2005-2010 P01HL81587, Endothelial Redox State and Phenotype in Health and Disease
        • 2009-2012 RO1HL09122, Mitochondrial Biogenesis and Endothelial Cell Phenotype, NIH
        • 2010-2014 RO1HL098407, Nox4 and Vascular Homeostasis

        Awards and Honors

        • 1983Magna Cum Laude, Harvard College
        • 1987Cum Laude, Yale University School of Medicine
        • 1987Alpha Omega Alpha
        • 1987Norma Bailey Berniker Prize, Yale University School of Medicine
        • 1987Merck Merit Award, Yale University School of Medicine
        • 1992Merck/ACC Research Fellow Award, American College of Cardiology
        • 1992National Research Service Award, National Institutes of Health.
        • 1992Ignacio Chavez Young Investigator Award, XIV InterAmerican Congress of Cardiology, Orlando, FL
        • 1994Pfizer Fellowship Award, Pfizer Pharmaceutical Inc.
        • 1995Clinical Investigator Development Award, National Institutes of Health
        • 1997Ad Hoc Member, Experimental Cardiovascular Sciences Study Section, NIH
        • 1998Ad Hoc Member, Nutrition Study Section, NIH
        • 2000Established Investigator Award, American Heart Association
        • 2001Co-Chair, Cardiorenal Grant Review Panel, AHA New England Affiliate
        • 2002Chair, Cardiorenal Review Panel, AHA Northeast Region
        • 2003Young Investigator Award Review Panel, The Medical Foundation, Boston, MA
        • 2004Ad Hoc Member, Atherosclerosis and Inflammation Study Section, NIH
        • 2004-2007 Charter Member, Vascular Cell and Molecular Biology Study Section, NIH
        • 2004-Associate Editor, Circulation
        • 2005Outstanding Medical Student Mentor, Boston University School of Medicine
        • 2006American Society for Clinical Investigation
        • 2006-Charter Member and Chair, Molecular Signaling Review Panel, AHA National Center
        • 2007-Association of University Cardiologists
        • 2012-Deputy Editor, Journal of the American Heart Association
        • 2012-Chair, Research Committee, AHA Founder's Affiliate


        Bibliographic 
        selected publications
        List All   |   Timeline
        1. Keaney JF, Curfman GD, Jarcho JA. The new cholesterol treatment guidelines. N Engl J Med. 2014 May 15; 370(20):1957.
          View in: PubMed
        2. Liu L, Nam M, Fan W, Akie TE, Hoaglin DC, Gao G, Keaney JF, Cooper MP. Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation. J Clin Invest. 2014 Feb 3; 124(2):768-84.
          View in: PubMed
        3. Roy AK, McCullagh BN, Segurado R, McGorrian C, Keane E, Keaney J, Fitzgibbon MN, Mahon NG, Murray PT, Gaine SP. Detection of high-sensitivity troponin in outpatients with stable pulmonary hypertension identifies a subgroup at higher risk of adverse outcomes. J Card Fail. 2014 Jan; 20(1):31-7.
          View in: PubMed
        4. Keaney JF, Curfman GD, Jarcho JA. A pragmatic view of the new cholesterol treatment guidelines. N Engl J Med. 2014 Jan 16; 370(3):275-8.
          View in: PubMed
        5. Hong SN, Gona P, Fontes JD, Oyama N, Chan RH, Kenchaiah S, Tsao CW, Yeon SB, Schnabel RB, Keaney JF, O'Donnell CJ, Benjamin EJ, Manning WJ. Atherosclerotic biomarkers and aortic atherosclerosis by cardiovascular magnetic resonance imaging in the framingham heart study. J Am Heart Assoc. 2013; 2(6):e000307.
          View in: PubMed
        6. Keaney JF. P2Y12 inhibition in patients with NSTEMI--can later be better? N Engl J Med. 2013 Sep 12; 369(11):1056-7.
          View in: PubMed
        7. McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF, Benjamin EJ, Freedman JE. Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2666-73.
          View in: PubMed
        8. Shimasaki Y, Pan N, Messina LM, Li C, Chen K, Liu L, Cooper MP, Vita JA, Keaney JF. Uncoupling protein 2 impacts endothelial phenotype via p53-mediated control of mitochondrial dynamics. Circ Res. 2013 Sep 13; 113(7):891-901.
          View in: PubMed
        9. Schnabel RB, Yin X, Larson MG, Yamamoto JF, Fontes JD, Kathiresan S, Rong J, Levy D, Keaney JF, Wang TJ, Murabito JM, Vasan RS, Benjamin EJ. Multiple inflammatory biomarkers in relation to cardiovascular events and mortality in the community. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1728-33.
          View in: PubMed
        10. Chami HA, Fontes JD, Vasan RS, Keaney JF, O'Connor GT, Larson MG, Benjamin EJ, Gottlieb DJ. Vascular inflammation and sleep disordered breathing in a community-based cohort. Sleep. 2013 May; 36(5):763-768C.
          View in: PubMed
        11. Fontes JD, Yamamoto JF, Larson MG, Wang N, Dallmeier D, Rienstra M, Schnabel RB, Vasan RS, Keaney JF, Benjamin EJ. Clinical correlates of change in inflammatory biomarkers: The Framingham Heart Study. Atherosclerosis. 2013 May; 228(1):217-23.
          View in: PubMed
        12. Chen K, Keaney JF. Evolving concepts of oxidative stress and reactive oxygen species in cardiovascular disease. Curr Atheroscler Rep. 2012 Oct; 14(5):476-83.
          View in: PubMed
        13. Kaess BM, Enserro DM, McManus DD, Xanthakis V, Chen MH, Sullivan LM, Ingram C, O'Donnell CJ, Keaney JF, Vasan RS, Glazer NL. Cardiometabolic correlates and heritability of fetuin-A, retinol-binding protein 4, and fatty-acid binding protein 4 in the Framingham Heart Study. J Clin Endocrinol Metab. 2012 Oct; 97(10):E1943-7.
          View in: PubMed
        14. Dallmeier D, Larson MG, Vasan RS, Keaney JF, Fontes JD, Meigs JB, Fox CS, Benjamin EJ. Metabolic syndrome and inflammatory biomarkers: a community-based cross-sectional study at the Framingham Heart Study. Diabetol Metab Syndr. 2012; 4(1):28.
          View in: PubMed
        15. Sugamura K, Keaney JF. Nicotine: linking smoking to abdominal aneurysms. Nat Med. 2012 Jun; 18(6):856-8.
          View in: PubMed
        16. Kröller-Schön S, Jansen T, Hauptmann F, Schüler A, Heeren T, Hausding M, Oelze M, Viollet B, Keaney JF, Wenzel P, Daiber A, Münzel T, Schulz E. a1AMP-activated protein kinase mediates vascular protective effects of exercise. Arterioscler Thromb Vasc Biol. 2012 Jul; 32(7):1632-41.
          View in: PubMed
        17. Tabit CE, Holbrook M, Shenouda SM, Dohadwala MM, Widlansky ME, Frame AA, Kim BH, Duess MA, Kluge MA, Levit A, Keaney JF, Vita JA, Hamburg NM. Effect of sulfasalazine on inflammation and endothelial function in patients with established coronary artery disease. Vasc Med. 2012 Apr; 17(2):101-7.
          View in: PubMed
        18. Keaney JF. Immune modulation of atherosclerosis. Circulation. 2011 Nov 29; 124(22):e559-60.
          View in: PubMed
        19. Grallert H, Dupuis J, Bis JC, Dehghan A, Barbalic M, Baumert J, Lu C, Smith NL, Uitterlinden AG, Roberts R, Khuseyinova N, Schnabel RB, Rice KM, Rivadeneira F, Hoogeveen RC, Fontes JD, Meisinger C, Keaney JF, Lemaitre R, Aulchenko YS, Vasan RS, Ellis S, Hazen SL, van Duijn CM, Nelson JJ, März W, Schunkert H, McPherson RM, Stirnadel-Farrant HA, Psaty BM, Gieger C, Siscovick D, Hofman A, Illig T, Cushman M, Yamamoto JF, Rotter JI, Larson MG, Stewart AF, Boerwinkle E, Witteman JC, Tracy RP, Koenig W, Benjamin EJ, Ballantyne CM. Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies. Eur Heart J. 2012 Jan; 33(2):238-51.
          View in: PubMed
        20. Aurigemma GP, Keaney JF. Renin-angiotensin system inhibition for aortic stenosis "A II, Bruté?". J Am Coll Cardiol. 2011 Aug 2; 58(6):577-80.
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        21. Craige SM, Chen K, Pei Y, Li C, Huang X, Chen C, Shibata R, Sato K, Walsh K, Keaney JF. NADPH oxidase 4 promotes endothelial angiogenesis through endothelial nitric oxide synthase activation. Circulation. 2011 Aug 9; 124(6):731-40.
          View in: PubMed
        22. Cooper MP, Keaney JF. Epigenetic control of angiogenesis via DNA methylation. Circulation. 2011 Jun 28; 123(25):2916-8.
          View in: PubMed
        23. Sugamura K, Keaney JF. Reactive oxygen species in cardiovascular disease. Free Radic Biol Med. 2011 Sep 1; 51(5):978-92.
          View in: PubMed
        24. Ward NC, Chen K, Li C, Croft KD, Keaney JF. Chronic activation of AMP-activated protein kinase prevents 20-hydroxyeicosatetraenoic acid-induced endothelial dysfunction. Clin Exp Pharmacol Physiol. 2011 May; 38(5):328-33.
          View in: PubMed
        25. Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, Baumert J, Strachan DP, Fuchsberger C, Vitart V, Wilson JF, Paré G, Naitza S, Rudock ME, Surakka I, de Geus EJ, Alizadeh BZ, Guralnik J, Shuldiner A, Tanaka T, Zee RY, Schnabel RB, Nambi V, Kavousi M, Ripatti S, Nauck M, Smith NL, Smith AV, Sundvall J, Scheet P, Liu Y, Ruokonen A, Rose LM, Larson MG, Hoogeveen RC, Freimer NB, Teumer A, Tracy RP, Launer LJ, Buring JE, Yamamoto JF, Folsom AR, Sijbrands EJ, Pankow J, Elliott P, Keaney JF, Sun W, Sarin AP, Fontes JD, Badola S, Astor BC, Hofman A, Pouta A, Werdan K, Greiser KH, Kuss O, Meyer zu Schwabedissen HE, Thiery J, Jamshidi Y, Nolte IM, Soranzo N, Spector TD, Völzke H, Parker AN, Aspelund T, Bates D, Young L, Tsui K, Siscovick DS, Guo X, Rotter JI, Uda M, Schlessinger D, Rudan I, Hicks AA, Penninx BW, Thorand B, Gieger C, Coresh J, Willemsen G, Harris TB, Uitterlinden AG, Järvelin MR, Rice K, Radke D, Salomaa V, Willems van Dijk K, Boerwinkle E, Vasan RS, Ferrucci L, Gibson QD, Bandinelli S, Snieder H, Boomsma DI, Xiao X, Campbell H, Hayward C, Pramstaller PP, van Duijn CM, Peltonen L, Psaty BM, Gudnason V, Ridker PM, Homuth G, Koenig W, Ballantyne CM, Witteman JC, Benjamin EJ, Perola M, Chasman DI. Meta-analysis of genome-wide association studies in >80 000 subjects identifies multiple loci for C-reactive protein levels. Circulation. 2011 Feb 22; 123(7):731-8.
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        26. Schuhmacher S, Foretz M, Knorr M, Jansen T, Hortmann M, Wenzel P, Oelze M, Kleschyov AL, Daiber A, Keaney JF, Wegener G, Lackner K, Münzel T, Viollet B, Schulz E. a1AMP-activated protein kinase preserves endothelial function during chronic angiotensin II treatment by limiting Nox2 upregulation. Arterioscler Thromb Vasc Biol. 2011 Mar; 31(3):560-6.
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        27. Cheng S, Lyass A, Massaro JM, O'Connor GT, Keaney JF, Vasan RS. Exhaled carbon monoxide and risk of metabolic syndrome and cardiovascular disease in the community. Circulation. 2010 Oct 12; 122(15):1470-7.
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        28. Dohadwala MM, Hamburg NM, Holbrook M, Kim BH, Duess MA, Levit A, Titas M, Chung WB, Vincent FB, Caiano TL, Frame AA, Keaney JF, Vita JA. Effects of Concord grape juice on ambulatory blood pressure in prehypertension and stage 1 hypertension. Am J Clin Nutr. 2010 Nov; 92(5):1052-9.
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        29. Upadhyay A, Larson MG, Guo CY, Vasan RS, Lipinska I, O'Donnell CJ, Kathiresan S, Meigs JB, Keaney JF, Rong J, Benjamin EJ, Fox CS. Inflammation, kidney function and albuminuria in the Framingham Offspring cohort. Nephrol Dial Transplant. 2011 Mar; 26(3):920-6.
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        30. Lieb W, Gona P, Larson MG, Massaro JM, Lipinska I, Keaney JF, Rong J, Corey D, Hoffmann U, Fox CS, Vasan RS, Benjamin EJ, O'Donnell CJ, Kathiresan S. Biomarkers of the osteoprotegerin pathway: clinical correlates, subclinical disease, incident cardiovascular disease, and mortality. Arterioscler Thromb Vasc Biol. 2010 Sep; 30(9):1849-54.
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        31. Lian BQ, Keaney JF. Predicting ischemic heart disease in women: the value of endothelial function. J Am Coll Cardiol. 2010 Apr 20; 55(16):1697-9.
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        32. Wang Y, Liu H, McKenzie G, Witting PK, Stasch JP, Hahn M, Changsirivathanathamrong D, Wu BJ, Ball HJ, Thomas SR, Kapoor V, Celermajer DS, Mellor AL, Keaney JF, Hunt NH, Stocker R. Kynurenine is an endothelium-derived relaxing factor produced during inflammation. Nat Med. 2010 Mar; 16(3):279-85.
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        33. Barbalic M, Dupuis J, Dehghan A, Bis JC, Hoogeveen RC, Schnabel RB, Nambi V, Bretler M, Smith NL, Peters A, Lu C, Tracy RP, Aleksic N, Heeriga J, Keaney JF, Rice K, Lip GY, Vasan RS, Glazer NL, Larson MG, Uitterlinden AG, Yamamoto J, Durda P, Haritunians T, Psaty BM, Boerwinkle E, Hofman A, Koenig W, Jenny NS, Witteman JC, Ballantyne C, Benjamin EJ. Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels. Hum Mol Genet. 2010 May 1; 19(9):1863-72.
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        34. Li C, Keaney JF. AMP-activated protein kinase: a stress-responsive kinase with implications for cardiovascular disease. Curr Opin Pharmacol. 2010 Apr; 10(2):111-5.
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        35. Schnabel RB, Baumert J, Barbalic M, Dupuis J, Ellinor PT, Durda P, Dehghan A, Bis JC, Illig T, Morrison AC, Jenny NS, Keaney JF, Gieger C, Tilley C, Yamamoto JF, Khuseyinova N, Heiss G, Doyle M, Blankenberg S, Herder C, Walston JD, Zhu Y, Vasan RS, Klopp N, Boerwinkle E, Larson MG, Psaty BM, Peters A, Ballantyne CM, Witteman JC, Hoogeveen RC, Benjamin EJ, Koenig W, Tracy RP. Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators. Blood. 2010 Jul 1; 115(26):5289-99.
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        36. Tadros TM, Massaro JM, Rosito GA, Hoffmann U, Vasan RS, Larson MG, Keaney JF, Lipinska I, Meigs JB, Kathiresan S, O'Donnell CJ, Fox CS, Benjamin EJ. Pericardial fat volume correlates with inflammatory markers: the Framingham Heart Study. Obesity (Silver Spring). 2010 May; 18(5):1039-45.
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        37. Chen K, Craige SE, Keaney JF. Downstream targets and intracellular compartmentalization in Nox signaling. Antioxid Redox Signal. 2009 Oct; 11(10):2467-80.
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        38. Schnabel RB, Larson MG, Yamamoto JF, Kathiresan S, Rong J, Levy D, Keaney JF, Wang TJ, Vasan RS, Benjamin EJ. Relation of multiple inflammatory biomarkers to incident atrial fibrillation. Am J Cardiol. 2009 Jul 1; 104(1):92-6.
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        39. Schnabel RB, Lunetta KL, Larson MG, Dupuis J, Lipinska I, Rong J, Chen MH, Zhao Z, Yamamoto JF, Meigs JB, Nicaud V, Perret C, Zeller T, Blankenberg S, Tiret L, Keaney JF, Vasan RS, Benjamin EJ. The relation of genetic and environmental factors to systemic inflammatory biomarker concentrations. Circ Cardiovasc Genet. 2009 Jun; 2(3):229-37.
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        40. Craige SE, Keaney JF. Polyploidy and dysregulated ROS signaling: the school of hard Nox? Cell Cycle. 2009 Mar 15; 8(6):797.
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        41. Keaney JF, Weaver DR. Vascular rhythms and adaptation: do your arteries know what time it is? Circulation. 2009 Mar 24; 119(11):1463-6.
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        42. Schnabel R, Dupuis J, Larson MG, Lunetta KL, Robins SJ, Zhu Y, Rong J, Yin X, Stirnadel HA, Nelson JJ, Wilson PW, Keaney JF, Vasan RS, Benjamin EJ. Clinical and genetic factors associated with lipoprotein-associated phospholipase A2 in the Framingham Heart Study. Atherosclerosis. 2009 Jun; 204(2):601-7.
          View in: PubMed
        43. Keaney JF, Lipinska I, Larson MG, Dupuis J, Freedman JE, Hamburg NM, Massaro JM, Rong J, Sutherland P, Vita JA, Vasan RS, Benjamin EJ. Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study. Am Heart J. 2008 Nov; 156(5):1003-1009.e1.
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        44. Schulz E, Dopheide J, Schuhmacher S, Thomas SR, Chen K, Daiber A, Wenzel P, Münzel T, Keaney JF. Suppression of the JNK pathway by induction of a metabolic stress response prevents vascular injury and dysfunction. Circulation. 2008 Sep 23; 118(13):1347-57.
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        45. Murabito JM, Keyes MJ, Guo CY, Keaney JF, Vasan RS, D'Agostino RB, Benjamin EJ. Cross-sectional relations of multiple inflammatory biomarkers to peripheral arterial disease: The Framingham Offspring Study. Atherosclerosis. 2009 Apr; 203(2):509-14.
          View in: PubMed
        46. Chen K, Kirber MT, Xiao H, Yang Y, Keaney JF. Regulation of ROS signal transduction by NADPH oxidase 4 localization. J Cell Biol. 2008 Jun 30; 181(7):1129-39.
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        47. Ingelsson E, Larson MG, Yin X, Wang TJ, Meigs JB, Lipinska I, Benjamin EJ, Keaney JF, Vasan RS. Circulating ghrelin, leptin, and soluble leptin receptor concentrations and cardiometabolic risk factors in a community-based sample. J Clin Endocrinol Metab. 2008 Aug; 93(8):3149-57.
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        48. Schnabel R, Larson MG, Dupuis J, Lunetta KL, Lipinska I, Meigs JB, Yin X, Rong J, Vita JA, Newton-Cheh C, Levy D, Keaney JF, Vasan RS, Mitchell GF, Benjamin EJ. Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection. Hypertension. 2008 Jun; 51(6):1651-7.
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        49. Levitzky YS, Guo CY, Rong J, Larson MG, Walter RE, Keaney JF, Sutherland PA, Vasan A, Lipinska I, Evans JC, Benjamin EJ. Relation of smoking status to a panel of inflammatory markers: the framingham offspring. Atherosclerosis. 2008 Nov; 201(1):217-24.
          View in: PubMed
        50. Shea MK, Booth SL, Massaro JM, Jacques PF, D'Agostino RB, Dawson-Hughes B, Ordovas JM, O'Donnell CJ, Kathiresan S, Keaney JF, Vasan RS, Benjamin EJ. Vitamin K and vitamin D status: associations with inflammatory markers in the Framingham Offspring Study. Am J Epidemiol. 2008 Feb 1; 167(3):313-20.
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        51. Lee DS, Larson MG, Lunetta KL, Dupuis J, Rong J, Keaney JF, Lipinska I, Baldwin CT, Vasan RS, Benjamin EJ. Clinical and genetic correlates of soluble P-selectin in the community. J Thromb Haemost. 2008 Jan; 6(1):20-31.
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        52. Hamburg NM, McMackin CJ, Huang AL, Shenouda SM, Widlansky ME, Schulz E, Gokce N, Ruderman NB, Keaney JF, Vita JA. Physical inactivity rapidly induces insulin resistance and microvascular dysfunction in healthy volunteers. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2650-6.
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        53. Kirber MT, Chen K, Keaney JF. YFP photoconversion revisited: confirmation of the CFP-like species. Nat Methods. 2007 Oct; 4(10):767-8.
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        54. Walter RE, Wilk JB, Larson MG, Vasan RS, Keaney JF, Lipinska I, O'Connor GT, Benjamin EJ. Systemic inflammation and COPD: the Framingham Heart Study. Chest. 2008 Jan; 133(1):19-25.
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        55. Benjamin EJ, Dupuis J, Larson MG, Lunetta KL, Booth SL, Govindaraju DR, Kathiresan S, Keaney JF, Keyes MJ, Lin JP, Meigs JB, Robins SJ, Rong J, Schnabel R, Vita JA, Wang TJ, Wilson PW, Wolf PA, Vasan RS. Genome-wide association with select biomarker traits in the Framingham Heart Study. BMC Med Genet. 2007; 8 Suppl 1:S11.
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        56. Huang AL, Silver AE, Shvenke E, Schopfer DW, Jahangir E, Titas MA, Shpilman A, Menzoian JO, Watkins MT, Raffetto JD, Gibbons G, Woodson J, Shaw PM, Dhadly M, Eberhardt RT, Keaney JF, Gokce N, Vita JA. Predictive value of reactive hyperemia for cardiovascular events in patients with peripheral arterial disease undergoing vascular surgery. Arterioscler Thromb Vasc Biol. 2007 Oct; 27(10):2113-9.
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        57. Pou KM, Massaro JM, Hoffmann U, Vasan RS, Maurovich-Horvat P, Larson MG, Keaney JF, Meigs JB, Lipinska I, Kathiresan S, Murabito JM, O'Donnell CJ, Benjamin EJ, Fox CS. Visceral and subcutaneous adipose tissue volumes are cross-sectionally related to markers of inflammation and oxidative stress: the Framingham Heart Study. Circulation. 2007 Sep 11; 116(11):1234-41.
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        58. Meigs JB, Larson MG, Fox CS, Keaney JF, Vasan RS, Benjamin EJ. Association of oxidative stress, insulin resistance, and diabetes risk phenotypes: the Framingham Offspring Study. Diabetes Care. 2007 Oct; 30(10):2529-35.
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        59. Thakore AH, Guo CY, Larson MG, Corey D, Wang TJ, Vasan RS, D'Agostino RB, Lipinska I, Keaney JF, Benjamin EJ, O'Donnell CJ. Association of multiple inflammatory markers with carotid intimal medial thickness and stenosis (from the Framingham Heart Study). Am J Cardiol. 2007 Jun 1; 99(11):1598-602.
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        60. McMackin CJ, Widlansky ME, Hamburg NM, Huang AL, Weller S, Holbrook M, Gokce N, Hagen TM, Keaney JF, Vita JA. Effect of combined treatment with alpha-Lipoic acid and acetyl-L-carnitine on vascular function and blood pressure in patients with coronary artery disease. J Clin Hypertens (Greenwich). 2007 Apr; 9(4):249-55.
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        61. Widlansky ME, Hamburg NM, Anter E, Holbrook M, Kahn DF, Elliott JG, Keaney JF, Vita JA. Acute EGCG supplementation reverses endothelial dysfunction in patients with coronary artery disease. J Am Coll Nutr. 2007 Apr; 26(2):95-102.
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        62. Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan RS, Larson MG, Meigs JB, Keaney JF, Lipinska I, Kathiresan S, Benjamin EJ, DeCarli C. Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. Neurology. 2007 Mar 27; 68(13):1032-8.
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        63. Ingelsson E, Larson MG, Fox CS, Yin X, Wang TJ, Lipinska I, Pou KM, Hoffmann U, Benjamin EJ, Keaney JF, Vasan RS. Clinical correlates of circulating visfatin levels in a community-based sample. Diabetes Care. 2007 May; 30(5):1278-80.
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        64. Demissie S, Levy D, Benjamin EJ, Cupples LA, Gardner JP, Herbert A, Kimura M, Larson MG, Meigs JB, Keaney JF, Aviv A. Insulin resistance, oxidative stress, hypertension, and leukocyte telomere length in men from the Framingham Heart Study. Aging Cell. 2006 Aug; 5(4):325-30.
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        65. Thomas SR, Schulz E, Keaney JF. Hydrogen peroxide restrains endothelium-derived nitric oxide bioactivity -- role for iron-dependent oxidative stress. Free Radic Biol Med. 2006 Aug 15; 41(4):681-8.
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        66. Fox CS, Guo CY, Larson MG, Vasan RS, Parise H, O'Donnell CJ, D'Agostino RB, Keaney JF, Benjamin EJ. Relations of inflammation and novel risk factors to valvular calcification. Am J Cardiol. 2006 May 15; 97(10):1502-5.
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        67. Kathiresan S, Larson MG, Vasan RS, Guo CY, Gona P, Keaney JF, Wilson PW, Newton-Cheh C, Musone SL, Camargo AL, Drake JA, Levy D, O'Donnell CJ, Hirschhorn JN, Benjamin EJ. Contribution of clinical correlates and 13 C-reactive protein gene polymorphisms to interindividual variability in serum C-reactive protein level. Circulation. 2006 Mar 21; 113(11):1415-23.
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        68. Kotlyar E, Vita JA, Winter MR, Awtry EH, Siwik DA, Keaney JF, Sawyer DB, Cupples LA, Colucci WS, Sam F. The relationship between aldosterone, oxidative stress, and inflammation in chronic, stable human heart failure. J Card Fail. 2006 Mar; 12(2):122-7.
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        69. Dhingra R, Larson MG, Benjamin EJ, Lipinska I, Gona P, Corey D, Keaney JF, Vasan RS. Cross-sectional correlates of serum heat shock protein 70 in the community. Am J Hypertens. 2006 Feb; 19(2):227-31; discussion 232-3.
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        70. Shapira OM, Eskenazi BR, Anter E, Joseph L, Christensen TG, Hunter CT, Lazar HL, Vita JA, Shemin RJ, Keaney JF. Endoscopic versus conventional radial artery harvest for coronary artery bypass grafting: functional and histologic assessment of the conduit. J Thorac Cardiovasc Surg. 2006 Feb; 131(2):388-94.
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        72. McDermott DH, Yang Q, Kathiresan S, Cupples LA, Massaro JM, Keaney JF, Larson MG, Vasan RS, Hirschhorn JN, O'Donnell CJ, Murphy PM, Benjamin EJ. CCL2 polymorphisms are associated with serum monocyte chemoattractant protein-1 levels and myocardial infarction in the Framingham Heart Study. Circulation. 2005 Aug 23; 112(8):1113-20.
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        77. Anter E, Chen K, Shapira OM, Karas RH, Keaney JF. p38 mitogen-activated protein kinase activates eNOS in endothelial cells by an estrogen receptor alpha-dependent pathway in response to black tea polyphenols. Circ Res. 2005 May 27; 96(10):1072-8.
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        78. Wendt MC, Daiber A, Kleschyov AL, Mülsch A, Sydow K, Schulz E, Chen K, Keaney JF, Lassègue B, Walter U, Griendling KK, Münzel T. Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4. Free Radic Biol Med. 2005 Aug 1; 39(3):381-91.
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        79. Dupuis J, Larson MG, Vasan RS, Massaro JM, Wilson PW, Lipinska I, Corey D, Vita JA, Keaney JF, Benjamin EJ. Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study: evidence for susceptibility loci on 1q. Atherosclerosis. 2005 Oct; 182(2):307-14.
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        80. Nuntharatanapong N, Chen K, Sinhaseni P, Keaney JF. EGF receptor-dependent JNK activation is involved in arsenite-induced p21Cip1/Waf1 upregulation and endothelial apoptosis. Am J Physiol Heart Circ Physiol. 2005 Jul; 289(1):H99-H107.
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        81. Widlansky ME, Duffy SJ, Hamburg NM, Gokce N, Warden BA, Wiseman S, Keaney JF, Frei B, Vita JA. Effects of black tea consumption on plasma catechins and markers of oxidative stress and inflammation in patients with coronary artery disease. Free Radic Biol Med. 2005 Feb 15; 38(4):499-506.
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        82. Gokce N, Vita JA, McDonnell M, Forse AR, Istfan N, Stoeckl M, Lipinska I, Keaney JF, Apovian CM. Effect of medical and surgical weight loss on endothelial vasomotor function in obese patients. Am J Cardiol. 2005 Jan 15; 95(2):266-8.
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        83. Huang A, Zhang YY, Chen K, Hatakeyama K, Keaney JF. Cytokine-stimulated GTP cyclohydrolase I expression in endothelial cells requires coordinated activation of nuclear factor-kappaB and Stat1/Stat3. Circ Res. 2005 Feb 4; 96(2):164-71.
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        84. Vita JA, Keaney JF, Larson MG, Keyes MJ, Massaro JM, Lipinska I, Lehman BT, Fan S, Osypiuk E, Wilson PW, Vasan RS, Mitchell GF, Benjamin EJ. Brachial artery vasodilator function and systemic inflammation in the Framingham Offspring Study. Circulation. 2004 Dec 7; 110(23):3604-9.
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        85. Cacicedo JM, Yagihashi N, Keaney JF, Ruderman NB, Ido Y. AMPK inhibits fatty acid-induced increases in NF-kappaB transactivation in cultured human umbilical vein endothelial cells. Biochem Biophys Res Commun. 2004 Nov 26; 324(4):1204-9.
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        86. Stocker R, Keaney JF. Role of oxidative modifications in atherosclerosis. Physiol Rev. 2004 Oct; 84(4):1381-478.
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        88. Stocker R, Huang A, Jeranian E, Hou JY, Wu TT, Thomas SR, Keaney JF. Hypochlorous acid impairs endothelium-derived nitric oxide bioactivity through a superoxide-dependent mechanism. Arterioscler Thromb Vasc Biol. 2004 Nov; 24(11):2028-33.
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        89. Vita JA, Brennan ML, Gokce N, Mann SA, Goormastic M, Shishehbor MH, Penn MS, Keaney JF, Hazen SL. Serum myeloperoxidase levels independently predict endothelial dysfunction in humans. Circulation. 2004 Aug 31; 110(9):1134-9.
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        90. Chen Z, Keaney JF, Schulz E, Levison B, Shan L, Sakuma M, Zhang X, Shi C, Hazen SL, Simon DI. Decreased neointimal formation in Nox2-deficient mice reveals a direct role for NADPH oxidase in the response to arterial injury. Proc Natl Acad Sci U S A. 2004 Aug 31; 101(35):13014-9.
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        91. Mitchell GF, Parise H, Vita JA, Larson MG, Warner E, Keaney JF, Keyes MJ, Levy D, Vasan RS, Benjamin EJ. Local shear stress and brachial artery flow-mediated dilation: the Framingham Heart Study. Hypertension. 2004 Aug; 44(2):134-9.
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        92. Keaney JF, Massaro JM, Larson MG, Vasan RS, Wilson PW, Lipinska I, Corey D, Sutherland P, Vita JA, Benjamin EJ. Heritability and correlates of intercellular adhesion molecule-1 in the Framingham Offspring Study. J Am Coll Cardiol. 2004 Jul 7; 44(1):168-73.
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        93. Chen K, Thomas SR, Albano A, Murphy MP, Keaney JF. Mitochondrial function is required for hydrogen peroxide-induced growth factor receptor transactivation and downstream signaling. J Biol Chem. 2004 Aug 13; 279(33):35079-86.
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        94. Schulz E, Anter E, Keaney JF. Oxidative stress, antioxidants, and endothelial function. Curr Med Chem. 2004 May; 11(9):1093-104.
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        95. Chen K, Keaney J. Reactive oxygen species-mediated signal transduction in the endothelium. Endothelium. 2004 Mar-Apr; 11(2):109-21.
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        96. Heydrick SJ, Weiss N, Thomas SR, Cap AP, Pimentel DR, Loscalzo J, Keaney JF. L-Homocysteine and L-homocystine stereospecifically induce endothelial nitric oxide synthase-dependent lipid peroxidation in endothelial cells. Free Radic Biol Med. 2004 Mar 1; 36(5):632-40.
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        97. Benjamin EJ, Larson MG, Keyes MJ, Mitchell GF, Vasan RS, Keaney JF, Lehman BT, Fan S, Osypiuk E, Vita JA. Clinical correlates and heritability of flow-mediated dilation in the community: the Framingham Heart Study. Circulation. 2004 Feb 10; 109(5):613-9.
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        98. Sydow K, Daiber A, Oelze M, Chen Z, August M, Wendt M, Ullrich V, Mülsch A, Schulz E, Keaney JF, Stamler JS, Münzel T. Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance. J Clin Invest. 2004 Feb; 113(3):482-9.
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        99. Widlansky ME, Biegelsen ES, Hamburg NM, Duffy SJ, Keaney JF, Vita JA. Coronary endothelial dysfunction is not rapidly reversible with ascorbic acid. Free Radic Biol Med. 2004 Jan 1; 36(1):123-30.
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        100. Weiss N, Heydrick SJ, Postea O, Keller C, Keaney JF, Loscalzo J. Influence of hyperhomocysteinemia on the cellular redox state--impact on homocysteine-induced endothelial dysfunction. Clin Chem Lab Med. 2003 Nov; 41(11):1455-61.
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        101. Widlansky ME, Gokce N, Keaney JF, Vita JA. The clinical implications of endothelial dysfunction. J Am Coll Cardiol. 2003 Oct 1; 42(7):1149-60.
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        102. Chen K, Albano A, Ho A, Keaney JF. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. J Biol Chem. 2003 Oct 10; 278(41):39527-33.
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        103. Beckman JA, Goldfine AB, Gordon MB, Garrett LA, Keaney JF, Creager MA. Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol. 2003 Dec; 285(6):H2392-8.
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        104. Widlansky ME, Price DT, Gokce N, Eberhardt RT, Duffy SJ, Holbrook M, Maxwell C, Palmisano J, Keaney JF, Morrow JD, Vita JA. Short- and long-term COX-2 inhibition reverses endothelial dysfunction in patients with hypertension. Hypertension. 2003 Sep; 42(3):310-5.
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        105. Chen K, Thomas SR, Keaney JF. Beyond LDL oxidation: ROS in vascular signal transduction. Free Radic Biol Med. 2003 Jul 15; 35(2):117-32.
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        106. Gokce N, Keaney JF, Hunter LM, Watkins MT, Nedeljkovic ZS, Menzoian JO, Vita JA. Predictive value of noninvasively determined endothelial dysfunction for long-term cardiovascular events in patients with peripheral vascular disease. J Am Coll Cardiol. 2003 May 21; 41(10):1769-75.
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        107. Shishehbor MH, Aviles RJ, Brennan ML, Fu X, Goormastic M, Pearce GL, Gokce N, Keaney JF, Penn MS, Sprecher DL, Vita JA, Hazen SL. Association of nitrotyrosine levels with cardiovascular disease and modulation by statin therapy. JAMA. 2003 Apr 2; 289(13):1675-80.
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        108. Thomas SR, Chen K, Keaney JF. Oxidative stress and endothelial nitric oxide bioactivity. Antioxid Redox Signal. 2003 Apr; 5(2):181-94.
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        110. Kuvin JT, Gokce N, Holbrook M, Hunter LM, Patel AR, Sliney KA, Craven DE, Grayston JT, Keaney JF, Karas RH, Vita JA. Effect of short-term antibiotic treatment on Chlamydia pneumoniae and peripheral endothelial function. Am J Cardiol. 2003 Mar 15; 91(6):732-5.
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        111. Ruderman NB, Cacicedo JM, Itani S, Yagihashi N, Saha AK, Ye JM, Chen K, Zou M, Carling D, Boden G, Cohen RA, Keaney J, Kraegen EW, Ido Y. Malonyl-CoA and AMP-activated protein kinase (AMPK): possible links between insulin resistance in muscle and early endothelial cell damage in diabetes. Biochem Soc Trans. 2003 Feb; 31(Pt 1):202-6.
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        113. Gokce N, Holbrook M, Hunter LM, Palmisano J, Vigalok E, Keaney JF, Vita JA. Acute effects of vasoactive drug treatment on brachial artery reactivity. J Am Coll Cardiol. 2002 Aug 21; 40(4):761-5.
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        114. Kim HS, Skurk C, Thomas SR, Bialik A, Suhara T, Kureishi Y, Birnbaum M, Keaney JF, Walsh K. Regulation of angiogenesis by glycogen synthase kinase-3beta. J Biol Chem. 2002 Nov 1; 277(44):41888-96.
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        120. Gupta S, Chough E, Daley J, Oates P, Tornheim K, Ruderman NB, Keaney JF. Hyperglycemia increases endothelial superoxide that impairs smooth muscle cell Na+-K+-ATPase activity. Am J Physiol Cell Physiol. 2002 Mar; 282(3):C560-6.
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        121. Zhang YY, Walker JL, Huang A, Keaney JF, Clish CB, Serhan CN, Loscalzo J. Expression of 5-lipoxygenase in pulmonary artery endothelial cells. Biochem J. 2002 Jan 15; 361(Pt 2):267-76.
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        122. Visioli F, Smith A, Zhang W, Keaney JF, Hagen T, Frei B. Lipoic acid and vitamin C potentiate nitric oxide synthesis in human aortic endothelial cells independently of cellular glutathione status. Redox Rep. 2002; 7(4):223-7.
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        123. Huang A, Thomas SR, Keaney JF. Measurements of redox control of nitric oxide bioavailability. Methods Enzymol. 2002; 359:209-16.
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        124. Thomas SR, Chen K, Keaney JF. Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway. J Biol Chem. 2002 Feb 22; 277(8):6017-24.
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        125. Vita JA, Keaney JF. Hormone replacement therapy and endothelial function: the exception that proves the rule? Arterioscler Thromb Vasc Biol. 2001 Dec; 21(12):1867-9.
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        126. Gokce N, Holbrook M, Duffy SJ, Demissie S, Cupples LA, Biegelsen E, Keaney JF, Loscalzo J, Vita JA. Effects of race and hypertension on flow-mediated and nitroglycerin-mediated dilation of the brachial artery. Hypertension. 2001 Dec 1; 38(6):1349-54.
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        127. Upston JM, Witting PK, Brown AJ, Stocker R, Keaney JF. Effect of vitamin E on aortic lipid oxidation and intimal proliferation after arterial injury in cholesterol-fed rabbits. Free Radic Biol Med. 2001 Nov 15; 31(10):1245-53.
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        128. Münzel T, Keaney JF. Are ACE inhibitors a "magic bullet" against oxidative stress? Circulation. 2001 Sep 25; 104(13):1571-4.
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        129. Huang A, Xiao H, Samii JM, Vita JA, Keaney JF. Contrasting effects of thiol-modulating agents on endothelial NO bioactivity. Am J Physiol Cell Physiol. 2001 Aug; 281(2):C719-25.
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        130. Gokce N, Duffy SJ, Hunter LM, Keaney JF, Vita JA. Acute hypertriglyceridemia is associated with peripheral vasodilation and increased basal flow in healthy young adults. Am J Cardiol. 2001 Jul 15; 88(2):153-9.
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        131. Duffy SJ, Keaney JF, Holbrook M, Gokce N, Swerdloff PL, Frei B, Vita JA. Short- and long-term black tea consumption reverses endothelial dysfunction in patients with coronary artery disease. Circulation. 2001 Jul 10; 104(2):151-6.
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        132. Duffy SJ, Biegelsen ES, Holbrook M, Russell JD, Gokce N, Keaney JF, Vita JA. Iron chelation improves endothelial function in patients with coronary artery disease. Circulation. 2001 Jun 12; 103(23):2799-804.
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        133. Duffy SJ, Vita JA, Holbrook M, Swerdloff PL, Keaney JF. Effect of acute and chronic tea consumption on platelet aggregation in patients with coronary artery disease. Arterioscler Thromb Vasc Biol. 2001 Jun; 21(6):1084-9.
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        134. Kuohung W, Shwaery GT, Keaney JF. Tamoxifen, esterified estradiol, and physiologic concentrations of estradiol inhibit oxidation of low-density lipoprotein by endothelial cells. Am J Obstet Gynecol. 2001 May; 184(6):1060-3.
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        135. Chen K, Vita JA, Berk BC, Keaney JF. c-Jun N-terminal kinase activation by hydrogen peroxide in endothelial cells involves SRC-dependent epidermal growth factor receptor transactivation. J Biol Chem. 2001 May 11; 276(19):16045-50.
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        136. Duffy SJ, Gokce N, Holbrook M, Hunter LM, Biegelsen ES, Huang A, Keaney JF, Vita JA. Effect of ascorbic acid treatment on conduit vessel endothelial dysfunction in patients with hypertension. Am J Physiol Heart Circ Physiol. 2001 Feb; 280(2):H528-34.
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        137. Freedman JE, Keaney JF. Vitamin E inhibition of platelet aggregation is independent of antioxidant activity. J Nutr. 2001 Feb; 131(2):374S-7S.
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        138. Mowri HO, Frei B, Keaney JF. Glucose enhancement of LDL oxidation is strictly metal ion dependent. Free Radic Biol Med. 2000 Nov 1; 29(9):814-24.
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        139. Shapira OM, Alkon JD, Macron DS, Keaney JF, Vita JA, Aldea GS, Shemin RJ. Nitroglycerin is preferable to diltiazem for prevention of coronary bypass conduit spasm. Ann Thorac Surg. 2000 Sep; 70(3):883-8; discussion 888-9.
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        140. Visioli F, Keaney JF, Halliwell B. Antioxidants and cardiovascular disease; panaceas or tonics for tired sheep? Cardiovasc Res. 2000 Aug 18; 47(3):409.
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        141. Tomasian D, Keaney JF, Vita JA. Antioxidants and the bioactivity of endothelium-derived nitric oxide. Cardiovasc Res. 2000 Aug 18; 47(3):426-35.
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        142. Xu A, Vita JA, Keaney JF. Ascorbic acid and glutathione modulate the biological activity of S-nitrosoglutathione. Hypertension. 2000 Aug; 36(2):291-5.
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        143. Keaney JF. Atherosclerosis: from lesion formation to plaque activation and endothelial dysfunction. Mol Aspects Med. 2000 Aug-Oct; 21(4-5):99-166.
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        145. Sherman DL, Keaney JF, Biegelsen ES, Duffy SJ, Coffman JD, Vita JA. Pharmacological concentrations of ascorbic acid are required for the beneficial effect on endothelial vasomotor function in hypertension. Hypertension. 2000 Apr; 35(4):936-41.
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        146. Vita JA, Keaney JF. Exercise--toning up the endothelium? N Engl J Med. 2000 Feb 17; 342(7):503-5.
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        148. Price DT, Vita JA, Keaney JF. Redox control of vascular nitric oxide bioavailability. Antioxid Redox Signal. 2000; 2(4):919-35.
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        150. Shapira OM, Xu A, Aldea GS, Vita JA, Shemin RJ, Keaney JF. Enhanced nitric oxide-mediated vascular relaxation in radial artery compared with internal mammary artery or saphenous vein. Circulation. 1999 Nov 9; 100(19 Suppl):II322-7.
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        151. Gokce N, Keaney JF, Frei B, Holbrook M, Olesiak M, Zachariah BJ, Leeuwenburgh C, Heinecke JW, Vita JA. Long-term ascorbic acid administration reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 1999 Jun 29; 99(25):3234-40.
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        152. Keaney JF, Simon DI, Freedman JE. Vitamin E and vascular homeostasis: implications for atherosclerosis. FASEB J. 1999 Jun; 13(9):965-75.
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        153. Shapira OM, Xu A, Vita JA, Aldea GS, Shah N, Shemin RJ, Keaney JF. Nitroglycerin is superior to diltiazem as a coronary bypass conduit vasodilator. J Thorac Cardiovasc Surg. 1999 May; 117(5):906-11.
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        154. Ceriello A, Keaney JF, Vita JA. Vitamin C and endothelial dysfunction: what is new? Circulation. 1999 Mar 9; 99(9):1273-4.
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        155. Keaney JF, Loscalzo J. Diabetes, oxidative stress, and platelet activation. Circulation. 1999 Jan 19; 99(2):189-91.
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        156. Shwaery GT, Samii JM, Frei B, Keaney JF. Determination of phospholipid oxidation in cultured cells. Methods Enzymol. 1999; 300:51-7.
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        157. Freedman JE, Keaney JF. Nitric oxide and superoxide detection in human platelets. Methods Enzymol. 1999; 301:61-70.
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        158. Shwaery GT, Mowri H, Keaney JF, Frei B. Preparation of lipid hydroperoxide-free low-density lipoproteins. Methods Enzymol. 1999; 300:17-23.
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        159. Jackson TS, Xu A, Vita JA, Keaney JF. Ascorbate prevents the interaction of superoxide and nitric oxide only at very high physiological concentrations. Circ Res. 1998 Nov 2; 83(9):916-22.
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        161. Polidori MC, Frei B, Cherubini A, Nelles G, Rordorf G, Keaney JF, Schwamm L, Mecocci P, Koroshetz WJ, Beal MF. Increased plasma levels of lipid hydroperoxides in patients with ischemic stroke. Free Radic Biol Med. 1998 Sep; 25(4-5):561-7.
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        163. Shwaery GT, Vita JA, Keaney JF. Antioxidant protection of LDL by physiologic concentrations of estrogens is specific for 17-beta-estradiol. Atherosclerosis. 1998 Jun; 138(2):255-62.
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        169. Dabbagh AJ, Shwaery GT, Keaney JF, Frei B. Effect of iron overload and iron deficiency on atherosclerosis in the hypercholesterolemic rabbit. Arterioscler Thromb Vasc Biol. 1997 Nov; 17(11):2638-45.
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        170. Diaz MN, Frei B, Vita JA, Keaney JF. Antioxidants and atherosclerotic heart disease. N Engl J Med. 1997 Aug 7; 337(6):408-16.
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        171. Upchurch GR, Welch GN, Fabian AJ, Pigazzi A, Keaney JF, Loscalzo J. Stimulation of endothelial nitric oxide production by homocyst(e)ine. Atherosclerosis. 1997 Jul 25; 132(2):177-85.
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        174. Upchurch GR, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF, Loscalzo J. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation. 1997 Apr 15; 95(8):2115-21.
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        175. Shwaery GT, Vita JA, Keaney JF. Antioxidant protection of LDL by physiological concentrations of 17 beta-estradiol. Requirement for estradiol modification. Circulation. 1997 Mar 18; 95(6):1378-85.
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        176. Keaney JF, Hare JM, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Inhibition of nitric oxide synthase augments myocardial contractile responses to beta-adrenergic stimulation. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2646-52.
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        177. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation. 1996 Nov 15; 94(10):2434-40.
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        178. Jackson TS, Lerner E, Weisbrod RM, Tajima M, Loscalzo J, Keaney JF. Vasodilatory properties of recombinant maxadilan. Am J Physiol. 1996 Sep; 271(3 Pt 2):H924-30.
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        179. Afridi N, Keaney JF. Animal studies on antioxidants. J Cardiovasc Risk. 1996 Aug; 3(4):358-62.
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        180. Keaney JF, Guo Y, Cunningham D, Shwaery GT, Xu A, Vita JA. Vascular incorporation of alpha-tocopherol prevents endothelial dysfunction due to oxidized LDL by inhibiting protein kinase C stimulation. J Clin Invest. 1996 Jul 15; 98(2):386-94.
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        181. Zhang YY, Xu AM, Nomen M, Walsh M, Keaney JF, Loscalzo J. Nitrosation of tryptophan residue(s) in serum albumin and model dipeptides. Biochemical characterization and bioactivity. J Biol Chem. 1996 Jun 14; 271(24):14271-9.
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        182. Burchenal JE, Keaney JF, Curran-Celentano J, Gaziano JM, Vita JA. The lack of effect of beta-carotene on restenosis in cholesterol-fed rabbits. Atherosclerosis. 1996 Jun; 123(1-2):157-67.
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        183. Levine GN, Frei B, Koulouris SN, Gerhard MD, Keaney JF, Vita JA. Ascorbic acid reverses endothelial vasomotor dysfunction in patients with coronary artery disease. Circulation. 1996 Mar 15; 93(6):1107-13.
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        184. Frei B, Keaney JF, Retsky KL, Chen K. Vitamins C and E and LDL oxidation. Vitam Horm. 1996; 52:1-34.
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        185. Marks DS, Vita JA, Folts JD, Keaney JF, Welch GN, Loscalzo J. Inhibition of neointimal proliferation in rabbits after vascular injury by a single treatment with a protein adduct of nitric oxide. J Clin Invest. 1995 Dec; 96(6):2630-8.
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        186. Keaney JF, Vita JA. Atherosclerosis, oxidative stress, and antioxidant protection in endothelium-derived relaxing factor action. Prog Cardiovasc Dis. 1995 Sep-Oct; 38(2):129-54.
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        187. Keaney JF, Xu A, Cunningham D, Jackson T, Frei B, Vita JA. Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation. J Clin Invest. 1995 Jun; 95(6):2520-9.
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        188. Levine GN, Keaney JF, Vita JA. Cholesterol reduction in cardiovascular disease. Clinical benefits and possible mechanisms. N Engl J Med. 1995 Feb 23; 332(8):512-21.
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        189. Hare JM, Keaney JF, Balligand JL, Loscalzo J, Smith TW, Colucci WS. Role of nitric oxide in parasympathetic modulation of beta-adrenergic myocardial contractility in normal dogs. J Clin Invest. 1995 Jan; 95(1):360-6.
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        190. Scharfstein JS, Keaney JF, Slivka A, Welch GN, Vita JA, Stamler JS, Loscalzo J. In vivo transfer of nitric oxide between a plasma protein-bound reservoir and low molecular weight thiols. J Clin Invest. 1994 Oct; 94(4):1432-9.
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        191. Keaney JF, Puyana JC, Francis S, Loscalzo JF, Stamler JS, Loscalzo J. Methylene blue reverses endotoxin-induced hypotension. Circ Res. 1994 Jun; 74(6):1121-5.
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        192. Keaney JF, Shwaery GT, Xu A, Nicolosi RJ, Loscalzo J, Foxall TL, Vita JA. 17 beta-estradiol preserves endothelial vasodilator function and limits low-density lipoprotein oxidation in hypercholesterolemic swine. Circulation. 1994 May; 89(5):2251-9.
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        193. Keaney JF, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA. Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits. J Clin Invest. 1994 Feb; 93(2):844-51.
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        194. Keaney JF, Gaziano JM, Xu A, Frei B, Curran-Celentano J, Shwaery GT, Loscalzo J, Vita JA. Dietary antioxidants preserve endothelium-dependent vessel relaxation in cholesterol-fed rabbits. Proc Natl Acad Sci U S A. 1993 Dec 15; 90(24):11880-4.
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        195. Simon DI, Stamler JS, Jaraki O, Keaney JF, Osborne JA, Francis SA, Singel DJ, Loscalzo J. Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor. Arterioscler Thromb. 1993 Jun; 13(6):791-9.
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        196. Keaney JF, Simon DI, Stamler JS, Jaraki O, Scharfstein J, Vita JA, Loscalzo J. NO forms an adduct with serum albumin that has endothelium-derived relaxing factor-like properties. J Clin Invest. 1993 Apr; 91(4):1582-9.
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        197. Bittl JA, Ryan TJ, Keaney JF, Tcheng JE, Ellis SG, Isner JM, Sanborn TA. Coronary artery perforation during excimer laser coronary angioplasty. The percutaneous Excimer Laser Coronary Angioplasty Registry. J Am Coll Cardiol. 1993 Apr; 21(5):1158-65.
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        198. Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR, Loscalzo J. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7674-7.
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