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Yvonne J.K. Edwards PhD

TitleAssistant Professor
InstitutionUniversity of Massachusetts Medical School
DepartmentProgram in Molecular Medicine
Phone508-856-8167
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentProgram in Molecular Medicine


    Collapse Biography 
    Collapse education and training
    King's College London, London, , United KingdomBSPharmacology & Biochemistry
    Birkbeck, University of London, London, , United KingdomMSBioinformatics
    Birkbeck, University of London, London, , United KingdomPHDBioinformatics

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shen Y, Cohen JL, Nicoloro SM, Kelly M, Yenilmez B, Henriques F, Tsagkaraki E, Edwards YJK, Hu X, Friedline RH, Kim JK, Czech MP. CRISPR delivery particles targeting nuclear receptor-interacting protein 1 (Nrip1) in adipose cells to enhance energy expenditure. J Biol Chem. 2018 Sep 06. PMID: 30190322.
      View in: PubMed
    2. Girnius N, Edwards YJ, Garlick DS, Davis RJ. The cJUN NH2-terminal kinase (JNK) signaling pathway promotes genome stability and prevents tumor initiation. Elife. 2018 Jun 01; 7. PMID: 29856313.
      View in: PubMed
    3. Girnius N, Edwards YJK, Davis RJ. The cJUN NH2-terminal kinase (JNK) pathway contributes to mouse mammary gland remodeling during involution. Cell Death Differ. 2018 Mar 06. PMID: 29511338.
      View in: PubMed
    4. Venkatesan AM, Vyas R, Gramann AK, Dresser K, Gujja S, Bhatnagar S, Chhangawala S, Gomes CBF, Xi HS, Lian CG, Houvras Y, Edwards YJK, Deng A, Green M, Ceol CJ. Ligand-activated BMP signaling inhibits cell differentiation and death to promote melanoma. J Clin Invest. 2017 Dec 04. PMID: 29202482.
      View in: PubMed
    5. Sanchez-Gurmaches J, Tang Y, Jespersen NZ, Wallace M, Martinez Calejman C, Gujja S, Li H, Edwards YJK, Wolfrum C, Metallo CM, Nielsen S, Scheele C, Guertin DA. Brown Fat AKT2 Is a Cold-Induced Kinase that Stimulates ChREBP-Mediated De Novo Lipogenesis to Optimize Fuel Storage and Thermogenesis. Cell Metab. 2017 Nov 15. PMID: 29153407.
      View in: PubMed
    6. Fitzgibbons TP, Edwards YJK, Shaw P, Iskandar A, Ahmed M, Bote J, Shah T, Sinha S, Gerszten RE, Keaney JF, Zile MR, Aurigemma GP. Activation of Inflammatory and Pro-Thrombotic Pathways in Acute Stress Cardiomyopathy. Front Cardiovasc Med. 2017; 4:49. PMID: 28824923.
      View in: PubMed
    7. Vernia S, Edwards YJ, Han MS, Cavanagh-Kyros J, Barrett T, Kim JK, Davis RJ. An alternative splicing program promotes adipose tissue thermogenesis. Elife. 2016 Sep 16; 5. PMID: 27635635.
      View in: PubMed
    8. Mansur F, Ivshina M, Gu W, Schaevitz L, Stackpole E, Gujja S, Edwards YJ, Richter JD. Gld2-catalyzed 3' monoadenylation of miRNAs in the hippocampus has no detectable effect on their stability or on animal behavior. RNA. 2016 Oct; 22(10):1492-9. PMID: 27495319.
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    9. Smulan LJ, Ding W, Freinkman E, Gujja S, Edwards YJ, Walker AK. Cholesterol-Independent SREBP-1 Maturation Is Linked to ARF1 Inactivation. Cell Rep. 2016 Jun 28; 16(1):9-18. PMID: 27320911.
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    10. Roth Flach RJ, Guo CA, Danai LV, Yawe JC, Gujja S, Edwards YJ, Czech MP. Endothelial Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Is Critical for Lymphatic Vascular Development and Function. Mol Cell Biol. 2016 Jun 15; 36(12):1740-9. PMID: 27044870.
      View in: PubMed
    11. Abrams N, Stephens R, Collins R, Edwards YJ, Stahlberg E. Journal of Proteomics & Bioinformatics. The effect of experimental design and analysis tool parameter optimization in RNA-Seq data analysis. 2013.
    12. Diaz-Horta O, Duman D, Foster J, Sirmaci A, Gonzalez M, Mahdieh N, Fotouhi N, Bonyadi M, Cengiz FB, Menendez I, Ulloa RH, Edwards YJ, Züchner S, Blanton S, Tekin M. Whole-exome sequencing efficiently detects rare mutations in autosomal recessive nonsyndromic hearing loss. PLoS One. 2012; 7(11):e50628. PMID: 23226338.
      View in: PubMed
    13. Yariz KO, Duman D, Seco CZ, Dallman J, Huang M, Peters TA, Sirmaci A, Lu N, Schraders M, Skromne I, Oostrik J, Diaz-Horta O, Young JI, Tokgoz-Yilmaz S, Konukseven O, Shahin H, Hetterschijt L, Kanaan M, Oonk AM, Edwards YJ, Li H, Atalay S, Blanton S, Desmidt AA, Liu XZ, Pennings RJ, Lu Z, Chen ZY, Kremer H, Tekin M. Mutations in OTOGL, encoding the inner ear protein otogelin-like, cause moderate sensorineural hearing loss. Am J Hum Genet. 2012 Nov 2; 91(5):872-82. PMID: 23122586.
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    14. Sirmaci A, Edwards YJ, Akay H, Tekin M. Challenges in whole exome sequencing: an example from hereditary deafness. PLoS One. 2012; 7(2):e32000. PMID: 22363784.
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    15. Hedges DJ, Guettouche T, Yang S, Bademci G, Diaz A, Andersen A, Hulme WF, Linker S, Mehta A, Edwards YJ, Beecham GW, Martin ER, Pericak-Vance MA, Zuchner S, Vance JM, Gilbert JR. Comparison of three targeted enrichment strategies on the SOLiD sequencing platform. PLoS One. 2011 Apr 29; 6(4):e18595. PMID: 21559511.
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    16. Edwards YJ, Beecham GW, Scott WK, Khuri S, Bademci G, Tekin D, Martin ER, Jiang Z, Mash DC, ffrench-Mullen J, Pericak-Vance MA, Tsinoremas N, Vance JM. Identifying consensus disease pathways in Parkinson's disease using an integrative systems biology approach. PLoS One. 2011 Feb 22; 6(2):e16917. PMID: 21364952.
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    17. Züchner S, Dallman J, Wen R, Beecham G, Naj A, Farooq A, Kohli MA, Whitehead PL, Hulme W, Konidari I, Edwards YJ, Cai G, Peter I, Seo D, Buxbaum JD, Haines JL, Blanton S, Young J, Alfonso E, Vance JM, Lam BL, Pericak-Vance MA. Whole-exome sequencing links a variant in DHDDS to retinitis pigmentosa. Am J Hum Genet. 2011 Feb 11; 88(2):201-6. PMID: 21295283.
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    18. Montenegro G, Powell E, Huang J, Speziani F, Edwards YJ, Beecham G, Hulme W, Siskind C, Vance J, Shy M, Züchner S. Exome sequencing allows for rapid gene identification in a Charcot-Marie-Tooth family. Ann Neurol. 2011 Mar; 69(3):464-70. PMID: 21254193.
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    19. Williams SL, Huang J, Edwards YJ, Ulloa RH, Dillon LM, Prolla TA, Vance JM, Moraes CT, Züchner S. The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers. Cell Metab. 2010 Dec 1; 12(6):675-82. PMID: 21109200.
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    20. Cengiz FB, Duman D, Sirmaci A, Tokgöz-Yilmaz S, Erbek S, Oztürkmen-Akay H, Incesulu A, Edwards YJ, Ozdag H, Liu XZ, Tekin M. Recurrent and private MYO15A mutations are associated with deafness in the Turkish population. Genet Test Mol Biomarkers. 2010 Aug; 14(4):543-50. PMID: 20642360.
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    21. Edwards YJ, Lobley AE, Pentony MM, Jones DT. Insights into the regulation of intrinsically disordered proteins in the human proteome by analyzing sequence and gene expression data. Genome Biol. 2009; 10(5):R50. PMID: 19432952.
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    22. Edwards YJ, Bryson K, Jones DT. A meta-analysis of microarray gene expression in mouse stem cells: redefining stemness. PLoS One. 2008 Jul 16; 3(7):e2712. PMID: 18628962.
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    23. Ikeda D, Ono Y, Snell P, Edwards YJ, Elgar G, Watabe S. Divergent evolution of the myosin heavy chain gene family in fish and tetrapods: evidence from comparative genomic analysis. Physiol Genomics. 2007 Dec 19; 32(1):1-15. PMID: 17940200.
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    24. Edwards YJ, Walter K, McEwen G, Vavouri T, Kelly KA, Abnizova I, Woolfe A, Goode DK, Goodson M, North P, Snell P, Callaway H, Smith SF, Gilks WR, Cooke JE, Elgar G. Characterisation of conserved non-coding sequences in vertebrate genomes using bioinformatics, statistics and functional studies. Comp Biochem Physiol Part D Genomics Proteomics. 2006 Mar; 1(1):46-58. PMID: 20483234.
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    25. Woolfe A, Goodson M, Goode DK, Snell P, McEwen GK, Vavouri T, Smith SF, North P, Callaway H, Kelly K, Walter K, Abnizova I, Gilks W, Edwards YJ, Cooke JE, Elgar G. Highly conserved non-coding sequences are associated with vertebrate development. PLoS Biol. 2005 Jan; 3(1):e7. PMID: 15630479.
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    26. Halling-Brown M, Sansom C, Moss DS, Elgar G, Edwards YJ. A Fugu-Human Genome Synteny Viewer: web software for graphical display and annotation reports of synteny between Fugu genomic sequence and human genes. Nucleic Acids Res. 2004; 32(8):2618-22. PMID: 15141032.
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    27. Cottage A, Mullan L, Portela MB, Hellen E, Carver T, Patel S, Vavouri T, Elgar G, Edwards YJ. Molecular characterisation of the SAND protein family: a study based on comparative genomics, structural bioinformatics and phylogeny. Cell Mol Biol Lett. 2004; 9(4A):739-53. PMID: 15647795.
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    28. Clark MS, Edwards YJ, Peterson D, Clifton SW, Thompson AJ, Sasaki M, Suzuki Y, Kikuchi K, Watabe S, Kawakami K, Sugano S, Elgar G, Johnson SL. Fugu ESTs: new resources for transcription analysis and genome annotation. Genome Res. 2003 Dec; 13(12):2747-53. PMID: 14613980.
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    29. Cottage AJ, Edwards YJ, Elgar G. AP1 genes in Fugu indicate a divergent transcriptional control to that of mammals. Mamm Genome. 2003 Aug; 14(8):514-25. PMID: 12925884.
      View in: PubMed
    30. Edwards YJ, Carver TJ, Vavouri T, Frith M, Bishop MJ, Elgar G. Theatre: A software tool for detailed comparative analysis and visualization of genomic sequence. Nucleic Acids Res. 2003 Jul 1; 31(13):3510-7. PMID: 12824356.
      View in: PubMed
    31. Edwards YJ, Cottage A. Bioinformatics methods to predict protein structure and function. A practical approach. Mol Biotechnol. 2003 Feb; 23(2):139-66. PMID: 12632698.
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    32. Aparicio S, Chapman J, Stupka E, Putnam N, Chia JM, Dehal P, Christoffels A, Rash S, Hoon S, Smit A, Gelpke MD, Roach J, Oh T, Ho IY, Wong M, Detter C, Verhoef F, Predki P, Tay A, Lucas S, Richardson P, Smith SF, Clark MS, Edwards YJ, Doggett N, Zharkikh A, Tavtigian SV, Pruss D, Barnstead M, Evans C, Baden H, Powell J, Glusman G, Rowen L, Hood L, Tan YH, Elgar G, Hawkins T, Venkatesh B, Rokhsar D, Brenner S. Whole-genome shotgun assembly and analysis of the genome of Fugu rubripes. Science. 2002 Aug 23; 297(5585):1301-10. PMID: 12142439.
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    33. Sambrook JG, Russell R, Umrania Y, Edwards YJ, Campbell RD, Elgar G, Clark MS. Fugu orthologues of human major histocompatibility complex genes: a genome survey. Immunogenetics. 2002 Sep; 54(6):367-80. PMID: 12242588.
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    34. Cottage A, Edwards YJ, Elgar G. SAND, a new protein family: from nucleic acid to protein structure and function prediction. Comp Funct Genomics. 2001; 2(4):226-35. PMID: 18628914.
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    35. Edwards YJ, Cottage A. Prediction of protein structure and function by using bioinformatics. Methods Mol Biol. 2001; 175:341-75. PMID: 11462846.
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    36. Edwards YJ, Brocklehurst SM. Finding genes in genomic nucleotide sequences by using bioinformatics. Methods Mol Biol. 2001; 175:235-47. PMID: 11462838.
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    37. Perkins SJ, Hinshelwood J, Edwards YJ, Jenkins PV. Structural and functional modelling of von Willebrand factor type A domains in complement and coagulation. Biochem Soc Trans. 1999 Dec; 27(6):815-20. PMID: 10830108.
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    38. Hinshelwood J, Spencer DI, Edwards YJ, Perkins SJ. Identification of the C3b binding site in a recombinant vWF-A domain of complement factor B by surface-enhanced laser desorption-ionisation affinity mass spectrometry and homology modelling: implications for the activity of factor B. J Mol Biol. 1999 Nov 26; 294(2):587-99. PMID: 10610782.
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    39. Elgar G, Clark MS, Meek S, Smith S, Warner S, Edwards YJ, Bouchireb N, Cottage A, Yeo GS, Umrania Y, Williams G, Brenner S. Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning. Genome Res. 1999 Oct; 9(10):960-71. PMID: 10523524.
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    40. Clark MS, Edwards YJ, McQueen HA, Meek SE, Smith S, Umrania Y, Warner S, Williams G, Elgar G. Sequence scanning chicken cosmids: a methodology for genome screening. Gene. 1999 Feb 18; 227(2):223-30. PMID: 10023066.
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    41. Edwards YJ, Elgar G, Clark MS, Bishop MJ. The identification and characterization of microsatellites in the compact genome of the Japanese pufferfish, Fugu rubripes: perspectives in functional and comparative genomic analyses. J Mol Biol. 1998 May 15; 278(4):843-54. PMID: 9614946.
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    42. Edwards YJ, Perkins SJ. Assessment of protein fold predictions from sequence information: the predicted alpha/beta doubly wound fold of the von Willebrand factor type A domain is similar to its crystal structure. J Mol Biol. 1996 Jul 12; 260(2):277-85. PMID: 8764406.
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    43. Edwards YJ, Perkins SJ. The protein fold of the von Willebrand factor type A domain is predicted to be similar to the open twisted beta-sheet flanked by alpha-helices found in human ras-p21. FEBS Lett. 1995 Jan 30; 358(3):283-6. PMID: 7843416.
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