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Erik J Sontheimer PhD

Endowed TitlePillar Chair in Biomedical Research
InstitutionUMass Chan Medical School
DepartmentRNA Therapeutics Institute
AddressUMass Chan Medical School
368 Plantation Street AS5.2051
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentProgram in Molecular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    Collapse Biography 
    Collapse education and training
    Pennsylvania State University, College Park, PA, United StatesBSMolecular & Cell Biology
    Yale University, New Haven, CT, United StatesPHDMolecular Biophysics & Biochem

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu B, Dong X, Zheng C, Keener D, Chen Z, Cheng H, Watts JK, Xue W, Sontheimer EJ. Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates. Nat Biotechnol. 2023 Sep 14. PMID: 37709915.
      Citations:    Fields:    
    2. Zheng C, Liu B, Dong X, Gaston N, Sontheimer EJ, Xue W. Template-jumping prime editing enables large insertion and exon rewriting in vivo. Nat Commun. 2023 Jun 08; 14(1):3369. PMID: 37291100.
      Citations:    Fields:    Translation:Animals
    3. Liang SQ, Liu P, Ponnienselvan K, Suresh S, Chen Z, Kramme C, Chatterjee P, Zhu LJ, Sontheimer EJ, Xue W, Wolfe SA. Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag. Nat Methods. 2023 Jun; 20(6):898-907. PMID: 37156841.
      Citations: 3     Fields:    Translation:AnimalsCells
    4. Kraus C, Sontheimer EJ. Applications of Anti-CRISPR Proteins in Genome Editing and Biotechnology. J Mol Biol. 2023 07 01; 435(13):168120. PMID: 37100169.
      Citations: 1     Fields:    
    5. Bamidele N, Zhang H, Dong X, Gaston N, Cheng H, Kelly K, Watts JK, Xie J, Gao G, Sontheimer EJ. Engineering Nme2Cas9 Adenine Base Editors with Improved Activity and Targeting Scope. bioRxiv. 2023 Apr 18. PMID: 37131611.
    6. Zhang H, Kelly K, Lee J, Echeverria D, Cooper D, Panwala R, Chen Z, Gaston N, Newby GA, Xie J, Liu DR, Gao G, Wolfe SA, Khvorova A, Watts JK, Sontheimer EJ. Self-delivering CRISPR RNAs for AAV Co-delivery and Genome Editing in vivo. bioRxiv. 2023 Mar 23. PMID: 36993169.
    7. Koseki S, Hong L, Yudistyra V, Stan T, Tysinger E, Silverstein R, Kramme C, Amrani N, Savic N, Pacesa M, Rodriguez TS, Ponnapati M, Jacobson J, Church G, Truant R, Jinek M, Kleinstiver B, Sontheimer E, Chatterjee P. PAM-Flexible Genome Editing with an Engineered Chimeric Cas9. Res Sq. 2023 Mar 07. PMID: 36945419.
    8. Meijboom KE, Abdallah A, Fordham NP, Nagase H, Rodriguez T, Kraus C, Gendron TF, Krishnan G, Esanov R, Andrade NS, Rybin MJ, Ramic M, Stephens ZD, Edraki A, Blackwood MT, Kahriman A, Henninger N, Kocher JA, Benatar M, Brodsky MH, Petrucelli L, Gao FB, Sontheimer EJ, Brown RH, Zeier Z, Mueller C. CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro. Nat Commun. 2022 10 21; 13(1):6286. PMID: 36271076.
      Citations: 10     Fields:    Translation:AnimalsCells
    9. Rodr?guez TC, Kwan SY, Smith JL, Dadafarin S, Wu CH, Sontheimer EJ, Xue W. Multiomics characterization of mouse hepatoblastoma identifies yes-associated protein 1 target genes. Hepatology. 2023 07 01; 78(1):58-71. PMID: 35932276.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Iyer S, Mir A, Vega-Badillo J, Roscoe BP, Ibraheim R, Zhu LJ, Lee J, Liu P, Luk K, Mintzer E, Guo D, Soares de Brito J, Emerson CP, Zamore PD, Sontheimer EJ, Wolfe SA. Efficient Homology-Directed Repair with Circular Single-Stranded DNA Donors. CRISPR J. 2022 Oct; 5(5):685-701. PMID: 36070530.
      Citations: 5     Fields:    Translation:HumansCells
    11. Shin M, Chan IL, Cao Y, Gruntman AM, Lee J, Sousa J, Rodr?guez TC, Echeverria D, Devi G, Debacker AJ, Moazami MP, Krishnamurthy PM, Rembetsy-Brown JM, Kelly K, Yukselen O, Donnard E, Parsons TJ, Khvorova A, Sontheimer EJ, Maehr R, Garber M, Watts JK. Intratracheally administered LNA gapmer antisense oligonucleotides induce robust gene silencing in mouse lung fibroblasts. Nucleic Acids Res. 2022 08 26; 50(15):8418-8430. PMID: 35920332.
      Citations: 4     Fields:    Translation:AnimalsCells
    12. Zhang H, Bamidele N, Liu P, Ojelabi O, Gao XD, Rodriguez T, Cheng H, Kelly K, Watts JK, Xie J, Gao G, Wolfe SA, Xue W, Sontheimer EJ. Adenine Base Editing In Vivo with a Single Adeno-Associated Virus Vector. GEN Biotechnol. 2022 Jun 01; 1(3):285-299. PMID: 35811581.
    13. Chen Z, Devi G, Arif A, Zamore PD, Sontheimer EJ, Watts JK. Tetrazine-Ligated CRISPR sgRNAs for Efficient Genome Editing. ACS Chem Biol. 2022 05 20; 17(5):1045-1050. PMID: 35446558.
      Citations: 2     Fields:    Translation:Humans
    14. Liu B, Dong X, Cheng H, Zheng C, Chen Z, Rodr?guez TC, Liang SQ, Xue W, Sontheimer EJ. A split prime editor with untethered reverse transcriptase and circular RNA template. Nat Biotechnol. 2022 09; 40(9):1388-1393. PMID: 35379962.
      Citations: 29     Fields:    Translation:Animals
    15. Liang SQ, Liu P, Smith JL, Mintzer E, Maitland S, Dong X, Yang Q, Lee J, Haynes CM, Zhu LJ, Watts JK, Sontheimer EJ, Wolfe SA, Xue W. Genome-wide detection of CRISPR editing in vivo using GUIDE-tag. Nat Commun. 2022 01 21; 13(1):437. PMID: 35064134.
      Citations: 10     Fields:    Translation:AnimalsCells
    16. Takasugi PR, Wang S, Truong KT, Drage EP, Kanishka SN, Higbee MA, Bamidele N, Ojelabi O, Sontheimer EJ, Gagnon JA. Orthogonal CRISPR-Cas tools for genome editing, inhibition, and CRISPR recording in zebrafish embryos. Genetics. 2022 01 04; 220(1). PMID: 34735006.
      Citations: 3     Fields:    
    17. Tsagkaraki E, Nicoloro SM, DeSouza T, Solivan-Rivera J, Desai A, Lifshitz LM, Shen Y, Kelly M, Guilherme A, Henriques F, Amrani N, Ibraheim R, Rodriguez TC, Luk K, Maitland S, Friedline RH, Tauer L, Hu X, Kim JK, Wolfe SA, Sontheimer EJ, Corvera S, Czech MP. CRISPR-enhanced human adipocyte browning as cell therapy for metabolic disease. Nat Commun. 2021 11 26; 12(1):6931. PMID: 34836963.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    18. Ibraheim R, Tai PWL, Mir A, Javeed N, Wang J, Rodr?guez TC, Namkung S, Nelson S, Khokhar ES, Mintzer E, Maitland S, Chen Z, Cao Y, Tsagkaraki E, Wolfe SA, Wang D, Pai AA, Xue W, Gao G, Sontheimer EJ. Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo. Nat Commun. 2021 11 01; 12(1):6267. PMID: 34725353.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    19. Ghanta KS, Chen Z, Mir A, Dokshin GA, Krishnamurthy PM, Yoon Y, Gallant J, Xu P, Zhang XO, Ozturk AR, Shin M, Idrizi F, Liu P, Gneid H, Edraki A, Lawson ND, Rivera-P?rez JA, Sontheimer EJ, Watts JK, Mello CC. 5'-Modifications improve potency and efficacy of DNA donors for precision genome editing. Elife. 2021 10 19; 10. PMID: 34665130.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    20. Liu P, Liang SQ, Zheng C, Mintzer E, Zhao YG, Ponnienselvan K, Mir A, Sontheimer EJ, Gao G, Flotte TR, Wolfe SA, Xue W. Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice. Nat Commun. 2021 04 09; 12(1):2121. PMID: 33837189.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    21. Saha K, Sontheimer EJ, Brooks PJ, Dwinell MR, Gersbach CA, Liu DR, Murray SA, Tsai SQ, Wilson RC, Anderson DG, Asokan A, Banfield JF, Bankiewicz KS, Bao G, Bulte JWM, Bursac N, Campbell JM, Carlson DF, Chaikof EL, Chen ZY, Cheng RH, Clark KJ, Curiel DT, Dahlman JE, Deverman BE, Dickinson ME, Doudna JA, Ekker SC, Emborg ME, Feng G, Freedman BS, Gamm DM, Gao G, Ghiran IC, Glazer PM, Gong S, Heaney JD, Hennebold JD, Hinson JT, Khvorova A, Kiani S, Lagor WR, Lam KS, Leong KW, Levine JE, Lewis JA, Lutz CM, Ly DH, Maragh S, McCray PB, McDevitt TC, Mirochnitchenko O, Morizane R, Murthy N, Prather RS, Ronald JA, Roy S, Roy S, Sabbisetti V, Saltzman WM, Santangelo PJ, Segal DJ, Shimoyama M, Skala MC, Tarantal AF, Tilton JC, Truskey GA, Vandsburger M, Watts JK, Wells KD, Wolfe SA, Xu Q, Xue W, Yi G, Zhou J. The NIH Somatic Cell Genome Editing program. Nature. 2021 04; 592(7853):195-204. PMID: 33828315.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    22. Smith JL, Rodr?guez TC, Mou H, Kwan SY, Pratt H, Zhang XO, Cao Y, Liang S, Ozata DM, Yu T, Yin Q, Hazeltine M, Weng Z, Sontheimer EJ, Xue W. YAP1 Withdrawal in Hepatoblastoma Drives Therapeutic Differentiation of Tumor Cells to Functional Hepatocyte-Like Cells. Hepatology. 2021 03; 73(3):1011-1027. PMID: 32452550.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    23. Chatterjee P, Jakimo N, Lee J, Amrani N, Rodr?guez T, Koseki SRT, Tysinger E, Qing R, Hao S, Sontheimer EJ, Jacobson J. Publisher Correction: An engineered ScCas9 with broad PAM range and high specificity and activity. Nat Biotechnol. 2020 Oct; 38(10):1212. PMID: 32561876.
      Citations: 1     Fields:    
    24. Barrangou R, Sontheimer EJ. Shutting down RNA-targeting CRISPR. Science. 2020 07 03; 369(6499):31-32. PMID: 32631881.
      Citations:    Fields:    Translation:Cells
    25. Chatterjee P, Lee J, Nip L, Koseki SRT, Tysinger E, Sontheimer EJ, Jacobson JM, Jakimo N. A Cas9 with PAM recognition for adenine dinucleotides. Nat Commun. 2020 05 18; 11(1):2474. PMID: 32424114.
      Citations: 41     Fields:    Translation:HumansCells
    26. Chatterjee P, Jakimo N, Lee J, Amrani N, Rodr?guez T, Koseki SRT, Tysinger E, Qing R, Hao S, Sontheimer EJ, Jacobson J. An engineered ScCas9 with broad PAM range and high specificity and activity. Nat Biotechnol. 2020 10; 38(10):1154-1158. PMID: 32393822.
      Citations: 40     Fields:    Translation:Cells
    27. Davidson AR, Lu WT, Stanley SY, Wang J, Mejdani M, Trost CN, Hicks BT, Lee J, Sontheimer EJ. Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems. Annu Rev Biochem. 2020 06 20; 89:309-332. PMID: 32186918.
      Citations: 44     Fields:    Translation:HumansCells
    28. Barrangou R, Sontheimer EJ. CRISPR Shields: Fending Off Diverse Cas Nucleases with Nucleus-like Structures. Mol Cell. 2020 03 05; 77(5):934-936. PMID: 32142691.
      Citations:    Fields:    Translation:Cells
    29. Garcia B, Lee J, Edraki A, Hidalgo-Reyes Y, Erwood S, Mir A, Trost CN, Seroussi U, Stanley SY, Cohn RD, Claycomb JM, Sontheimer EJ, Maxwell KL, Davidson AR. Anti-CRISPR AcrIIA5 Potently Inhibits All Cas9 Homologs Used for Genome Editing. Cell Rep. 2019 11 12; 29(7):1739-1746.e5. PMID: 31722192.
      Citations: 15     Fields:    Translation:HumansCells
    30. Sun W, Yang J, Cheng Z, Amrani N, Liu C, Wang K, Ibraheim R, Edraki A, Huang X, Wang M, Wang J, Liu L, Sheng G, Yang Y, Lou J, Sontheimer EJ, Wang Y. Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol Cell. 2019 12 19; 76(6):938-952.e5. PMID: 31668930.
      Citations: 42     Fields:    Translation:Cells
    31. Lee J, Mou H, Ibraheim R, Liang SQ, Liu P, Xue W, Sontheimer EJ. Tissue-restricted genome editing in vivo specified by microRNA-repressible anti-CRISPR proteins. RNA. 2019 11; 25(11):1421-1431. PMID: 31439808.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    32. Thavalingam A, Cheng Z, Garcia B, Huang X, Shah M, Sun W, Wang M, Harrington L, Hwang S, Hidalgo-Reyes Y, Sontheimer EJ, Doudna J, Davidson AR, Moraes TF, Wang Y, Maxwell KL. Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2. Nat Commun. 2019 06 26; 10(1):2806. PMID: 31243272.
      Citations: 26     Fields:    Translation:Cells
    33. Sontheimer EJ. X-Tracting a New CRISPR-Cas Genome-Editing Platform from Metagenomic Data Sets. CRISPR J. 2019 06; 2:148-150. PMID: 31225753.
      Citations:    Fields:    Translation:Cells
    34. Edraki A, Mir A, Ibraheim R, Gainetdinov I, Yoon Y, Song CQ, Cao Y, Gallant J, Xue W, Rivera-P?rez JA, Sontheimer EJ. A Compact, High-Accuracy Cas9 with a Dinucleotide PAM for In?Vivo Genome Editing. Mol Cell. 2019 02 21; 73(4):714-726.e4. PMID: 30581144.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    35. Gao XD, Rodr?guez TC, Sontheimer EJ. Adapting dCas9-APEX2 for subnuclear proteomic profiling. Methods Enzymol. 2019; 616:365-383. PMID: 30691651.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    36. Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Publisher Correction: Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018 12 10; 9(1):5294. PMID: 30531933.
      Citations:    Fields:    
    37. Amrani N, Gao XD, Liu P, Edraki A, Mir A, Ibraheim R, Gupta A, Sasaki KE, Wu T, Donohoue PD, Settle AH, Lied AM, McGovern K, Fuller CK, Cameron P, Fazzio TG, Zhu LJ, Wolfe SA, Sontheimer EJ. NmeCas9 is an intrinsically high-fidelity genome-editing platform. Genome Biol. 2018 12 05; 19(1):214. PMID: 30518407.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    38. Lee J, Mir A, Edraki A, Garcia B, Amrani N, Lou HE, Gainetdinov I, Pawluk A, Ibraheim R, Gao XD, Liu P, Davidson AR, Maxwell KL, Sontheimer EJ. Potent Cas9 Inhibition in Bacterial and Human Cells by AcrIIC4 and AcrIIC5 Anti-CRISPR Proteins. mBio. 2018 12 04; 9(6). PMID: 30514786.
      Citations: 41     Fields:    Translation:HumansCells
    39. Bolukbasi MF, Liu P, Luk K, Kwok SF, Gupta A, Amrani N, Sontheimer EJ, Zhu LJ, Wolfe SA. Orthogonal Cas9-Cas9 chimeras provide a versatile platform for genome editing. Nat Commun. 2018 11 19; 9(1):4856. PMID: 30451839.
      Citations: 18     Fields:    Translation:HumansCells
    40. Ibraheim R, Song CQ, Mir A, Amrani N, Xue W, Sontheimer EJ. All-in-one adeno-associated virus delivery and genome editing by Neisseria meningitidis Cas9 in vivo. Genome Biol. 2018 09 19; 19(1):137. PMID: 30231914.
      Citations: 49     Fields:    Translation:AnimalsCells
    41. Mir A, Alterman JF, Hassler MR, Debacker AJ, Hudgens E, Echeverria D, Brodsky MH, Khvorova A, Watts JK, Sontheimer EJ. Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing. Nat Commun. 2018 07 06; 9(1):2641. PMID: 29980686.
      Citations: 30     Fields:    Translation:HumansCells
    42. Stone NP, Hilbert BJ, Hidalgo D, Halloran KT, Lee J, Sontheimer EJ, Kelch BA. A Hyperthermophilic Phage Decoration Protein Suggests Common Evolutionary Origin with Herpesvirus Triplex Proteins and an Anti-CRISPR Protein. Structure. 2018 07 03; 26(7):936-947.e3. PMID: 29779790.
      Citations: 12     Fields:    Translation:Cells
    43. Gao XD, Tu LC, Mir A, Rodriguez T, Ding Y, Leszyk J, Dekker J, Shaffer SA, Zhu LJ, Wolfe SA, Sontheimer EJ. C-BERST: defining subnuclear proteomic landscapes at genomic elements with dCas9-APEX2. Nat Methods. 2018 06; 15(6):433-436. PMID: 29735996.
      Citations: 58     Fields:    Translation:HumansCells
    44. Edraki A, Sontheimer EJ. CRISPRs from scratch. Nat Microbiol. 2018 03; 3(3):261-262. PMID: 29463924.
      Citations:    Fields:    Translation:Cells
    45. Mir A, Edraki A, Lee J, Sontheimer EJ. Type II-C CRISPR-Cas9 Biology, Mechanism, and Application. ACS Chem Biol. 2018 02 16; 13(2):357-365. PMID: 29202216.
      Citations: 48     Fields:    Translation:Cells
    46. Harrington LB, Doxzen KW, Ma E, Liu JJ, Knott GJ, Edraki A, Garcia B, Amrani N, Chen JS, Cofsky JC, Kranzusch PJ, Sontheimer EJ, Davidson AR, Maxwell KL, Doudna JA. A Broad-Spectrum Inhibitor of CRISPR-Cas9. Cell. 2017 Sep 07; 170(6):1224-1233.e15. PMID: 28844692.
      Citations: 106     Fields:    Translation:HumansCells
    47. Sontheimer EJ, Davidson AR. Inhibition of CRISPR-Cas systems by mobile genetic elements. Curr Opin Microbiol. 2017 Jun; 37:120-127. PMID: 28668720.
      Citations: 16     Fields:    Translation:Cells
    48. Mou H, Smith JL, Peng L, Yin H, Moore J, Zhang XO, Song CQ, Sheel A, Wu Q, Ozata DM, Li Y, Anderson DG, Emerson CP, Sontheimer EJ, Moore MJ, Weng Z, Xue W. CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion. Genome Biol. 2017 06 14; 18(1):108. PMID: 28615073.
      Citations: 80     Fields:    Translation:HumansCells
    49. Pawluk A, Amrani N, Zhang Y, Garcia B, Hidalgo-Reyes Y, Lee J, Edraki A, Shah M, Sontheimer EJ, Maxwell KL, Davidson AR. Naturally Occurring Off-Switches for CRISPR-Cas9. Cell. 2016 Dec 15; 167(7):1829-1838.e9. PMID: 27984730.
      Citations: 175     Fields:    Translation:HumansCells
    50. Sontheimer EJ, Marraffini LA. RNA. CRISPR goes retro. Science. 2016 Feb 26; 351(6276):920-1. PMID: 26917756.
      Citations:    Fields:    Translation:Cells
    51. Sontheimer EJ, Wolfe SA. Cas9 gets a classmate. Nat Biotechnol. 2015 Dec 09; 33(12):1240-1241. PMID: 26650011.
      Citations: 2     Fields:    
    52. Zhang Y, Rajan R, Seifert HS, Mondrag?n A, Sontheimer EJ. DNase H Activity of Neisseria meningitidis Cas9. Mol Cell. 2015 Oct 15; 60(2):242-55. PMID: 26474066.
      Citations: 32     Fields:    Translation:Cells
    53. Wakefield N, Rajan R, Sontheimer EJ. Primary processing of CRISPR RNA by the endonuclease Cas6 in Staphylococcus epidermidis. FEBS Lett. 2015 Oct 07; 589(20 Pt B):3197-204. PMID: 26364721.
      Citations: 4     Fields:    Translation:Cells
    54. Wang D, Mou H, Li S, Li Y, Hough S, Tran K, Li J, Yin H, Anderson DG, Sontheimer EJ, Weng Z, Gao G, Xue W. Adenovirus-Mediated Somatic Genome Editing of Pten by CRISPR/Cas9 in Mouse Liver in Spite of Cas9-Specific Immune Responses. Hum Gene Ther. 2015 Jul; 26(7):432-42. PMID: 26086867.
      Citations: 158     Fields:    Translation:HumansAnimalsCells
    55. Sontheimer EJ, Barrangou R. The Bacterial Origins of the CRISPR Genome-Editing Revolution. Hum Gene Ther. 2015 Jul; 26(7):413-24. PMID: 26078042.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    56. Sontheimer E. Accelerating expansion. RNA. 2015 Apr; 21(4):510. PMID: 25780117.
      Citations:    Fields:    
    57. Zhang Y, Sontheimer EJ. Structural biology. Cascading into focus. Science. 2014 Sep 19; 345(6203):1452-3. PMID: 25237089.
      Citations: 2     Fields:    Translation:Cells
    58. Hurtado S, Kim Guisbert KS, Sontheimer EJ. SPO24 is a transcriptionally dynamic, small ORF-encoding locus required for efficient sporulation in Saccharomyces cerevisiae. PLoS One. 2014; 9(8):e105058. PMID: 25127041.
      Citations: 6     Fields:    Translation:AnimalsCells
    59. Doudna JA, Sontheimer EJ. Methods in Enzymology. The use of CRISPR/Cas9, ZFNs, and TALENs in generating site-specific genome alterations. Preface. Methods Enzymol. 2014; 546:xix-xx. PMID: 25398356.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    60. Hou Z, Zhang Y, Propson NE, Howden SE, Chu LF, Sontheimer EJ, Thomson JA. Efficient genome engineering in human pluripotent stem cells using Cas9 from Neisseria meningitidis. Proc Natl Acad Sci U S A. 2013 Sep 24; 110(39):15644-9. PMID: 23940360.
      Citations: 339     Fields:    Translation:HumansAnimalsCells
    61. Zhang Y, Heidrich N, Ampattu BJ, Gunderson CW, Seifert HS, Schoen C, Vogel J, Sontheimer EJ. Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis. Mol Cell. 2013 May 23; 50(4):488-503. PMID: 23706818.
      Citations: 136     Fields:    Translation:HumansCells
    62. Kim Guisbert KS, Sontheimer EJ. Quit stalling or you'll be silenced. Cell. 2013 Feb 28; 152(5):938-9. PMID: 23452843.
      Citations: 1     Fields:    
    63. Sontheimer EJ. Small RNAs of opposite sign? but same absolute value. Cell. 2012 Dec 07; 151(6):1157-8. PMID: 23217700.
      Citations:    Fields:    
    64. Kim Guisbert KS, Zhang Y, Flatow J, Hurtado S, Staley JP, Lin S, Sontheimer EJ. Meiosis-induced alterations in transcript architecture and noncoding RNA expression in S. cerevisiae. RNA. 2012 Jun; 18(6):1142-53. PMID: 22539527.
      Citations: 14     Fields:    Translation:AnimalsCells
    65. Gerbasi VR, Preall JB, Golden DE, Powell DW, Cummins TD, Sontheimer EJ. Blanks, a nuclear siRNA/dsRNA-binding complex component, is required for Drosophila spermiogenesis. Proc Natl Acad Sci U S A. 2011 Feb 22; 108(8):3204-9. PMID: 21300896.
      Citations: 16     Fields:    Translation:AnimalsCells
    66. Sontheimer EJ, Marraffini LA. Microbiology: slicer for DNA. Nature. 2010 Nov 04; 468(7320):45-6. PMID: 21048757.
      Citations: 8     Fields:    Translation:Cells
    67. Gerbasi VR, Golden DE, Hurtado SB, Sontheimer EJ. Proteomics identification of Drosophila small interfering RNA-associated factors. Mol Cell Proteomics. 2010 Sep; 9(9):1866-72. PMID: 20472918.
      Citations: 4     Fields:    Translation:AnimalsCells
    68. Marraffini LA, Sontheimer EJ. CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea. Nat Rev Genet. 2010 Mar; 11(3):181-90. PMID: 20125085.
      Citations: 419     Fields:    Translation:Cells
    69. Marraffini LA, Sontheimer EJ. Self versus non-self discrimination during CRISPR RNA-directed immunity. Nature. 2010 Jan 28; 463(7280):568-71. PMID: 20072129.
      Citations: 292     Fields:    Translation:Cells
    70. Lee YS, Pressman S, Andress AP, Kim K, White JL, Cassidy JJ, Li X, Lubell K, Lim DH, Cho IS, Nakahara K, Preall JB, Bellare P, Sontheimer EJ, Carthew RW. Silencing by small RNAs is linked to endosomal trafficking. Nat Cell Biol. 2009 Sep; 11(9):1150-6. PMID: 19684574.
      Citations: 180     Fields:    Translation:HumansAnimalsCells
    71. Marraffini LA, Sontheimer EJ. Invasive DNA, chopped and in the CRISPR. Structure. 2009 Jun 10; 17(6):786-8. PMID: 19523896.
      Citations: 13     Fields:    Translation:Cells
    72. Carthew RW, Sontheimer EJ. Origins and Mechanisms of miRNAs and siRNAs. Cell. 2009 Feb 20; 136(4):642-55. PMID: 19239886.
      Citations: 2096     Fields:    Translation:HumansAnimals
    73. Marraffini LA, Sontheimer EJ. CRISPR interference limits horizontal gene transfer in staphylococci by targeting DNA. Science. 2008 Dec 19; 322(5909):1843-5. PMID: 19095942.
      Citations: 729     Fields:    Translation:Cells
    74. Golden DE, Gerbasi VR, Sontheimer EJ. An inside job for siRNAs. Mol Cell. 2008 Aug 08; 31(3):309-12. PMID: 18691963.
      Citations: 47     Fields:    Translation:AnimalsCells
    75. Bellare P, Small EC, Huang X, Wohlschlegel JA, Staley JP, Sontheimer EJ. A role for ubiquitin in the spliceosome assembly pathway. Nat Struct Mol Biol. 2008 May; 15(5):444-51. PMID: 18425143.
      Citations: 72     Fields:    Translation:AnimalsCells
    76. Bellare P, Sontheimer EJ. A fork in the road for microRNAs. Nat Struct Mol Biol. 2007 Aug; 14(8):684-6. PMID: 17676029.
      Citations: 1     Fields:    Translation:Animals
    77. Preall JB, He Z, Gorra JM, Sontheimer EJ. Short interfering RNA strand selection is independent of dsRNA processing polarity during RNAi in Drosophila. Curr Biol. 2006 Mar 07; 16(5):530-5. PMID: 16527750.
      Citations: 19     Fields:    Translation:AnimalsCells
    78. Bellare P, Kutach AK, Rines AK, Guthrie C, Sontheimer EJ. Ubiquitin binding by a variant Jab1/MPN domain in the essential pre-mRNA splicing factor Prp8p. RNA. 2006 Feb; 12(2):292-302. PMID: 16428608.
      Citations: 49     Fields:    Translation:Cells
    79. Preall JB, Sontheimer EJ. RNAi: RISC gets loaded. Cell. 2005 Nov 18; 123(4):543-5. PMID: 16286001.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    80. Pham JW, Sontheimer EJ. Molecular requirements for RNA-induced silencing complex assembly in the Drosophila RNA interference pathway. J Biol Chem. 2005 Nov 25; 280(47):39278-83. PMID: 16179342.
      Citations: 34     Fields:    Translation:AnimalsCells
    81. Pellino JL, Jaskiewicz L, Filipowicz W, Sontheimer EJ. ATP modulates siRNA interactions with an endogenous human Dicer complex. RNA. 2005 Nov; 11(11):1719-24. PMID: 16177131.
      Citations: 11     Fields:    Translation:HumansCells
    82. Sontheimer EJ, Carthew RW. Silence from within: endogenous siRNAs and miRNAs. Cell. 2005 Jul 15; 122(1):9-12. PMID: 16009127.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    83. Sontheimer EJ. Assembly and function of RNA silencing complexes. Nat Rev Mol Cell Biol. 2005 Feb; 6(2):127-38. PMID: 15654322.
      Citations: 138     Fields:    Translation:HumansAnimalsCells
    84. Pham JW, Sontheimer EJ. Separation of Drosophila RNA silencing complexes by native gel electrophoresis. Methods Mol Biol. 2005; 309:11-6. PMID: 15990394.
      Citations: 1     Fields:    Translation:Animals
    85. Sontheimer EJ, Carthew RW. Molecular biology. Argonaute journeys into the heart of RISC. Science. 2004 Sep 03; 305(5689):1409-10. PMID: 15353786.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    86. He Z, Sontheimer EJ. "siRNAs and miRNAs": a meeting report on RNA silencing. RNA. 2004 Aug; 10(8):1165-73. PMID: 15272116.
      Citations: 4     Fields:    Translation:HumansAnimals
    87. Pham JW, Sontheimer EJ. The Making of an siRNA. Mol Cell. 2004 Jul 23; 15(2):163-4. PMID: 15260964.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    88. Pham JW, Radhakrishnan I, Sontheimer EJ. Thermodynamic and structural characterization of 2'-nitrogen-modified RNA duplexes. Nucleic Acids Res. 2004; 32(11):3446-55. PMID: 15247335.
      Citations: 1     Fields:    Translation:Cells
    89. Pham JW, Pellino JL, Lee YS, Carthew RW, Sontheimer EJ. A Dicer-2-dependent 80s complex cleaves targeted mRNAs during RNAi in Drosophila. Cell. 2004 Apr 02; 117(1):83-94. PMID: 15066284.
      Citations: 166     Fields:    Translation:AnimalsCells
    90. Lee YS, Nakahara K, Pham JW, Kim K, He Z, Sontheimer EJ, Carthew RW. Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways. Cell. 2004 Apr 02; 117(1):69-81. PMID: 15066283.
      Citations: 562     Fields:    Translation:AnimalsCells
    91. Pellino JL, Sontheimer EJ. R2D2 leads the silencing trigger to mRNA's death star. Cell. 2003 Oct 17; 115(2):132-3. PMID: 14567910.
      Citations: 3     Fields:    Translation:AnimalsCells
    92. Sontheimer EJ. The spliceosome shows its metal. Nat Struct Biol. 2001 Jan; 8(1):11-3. PMID: 11135658.
      Citations: 3     Fields:    Translation:AnimalsCells
    93. Gordon PM, Sontheimer EJ, Piccirilli JA. Kinetic characterization of the second step of group II intron splicing: role of metal ions and the cleavage site 2'-OH in catalysis. Biochemistry. 2000 Oct 24; 39(42):12939-52. PMID: 11041859.
      Citations: 13     Fields:    Translation:Cells
    94. Warnecke JM, Sontheimer EJ, Piccirilli JA, Hartmann RK. Active site constraints in the hydrolysis reaction catalyzed by bacterial RNase P: analysis of precursor tRNAs with a single 3'-S-phosphorothiolate internucleotide linkage. Nucleic Acids Res. 2000 Feb 01; 28(3):720-7. PMID: 10637323.
      Citations: 14     Fields:    Translation:Cells
    95. Gordon PM, Sontheimer EJ, Piccirilli JA. Metal ion catalysis during the exon-ligation step of nuclear pre-mRNA splicing: extending the parallels between the spliceosome and group II introns. RNA. 2000 Feb; 6(2):199-205. PMID: 10688359.
      Citations: 46     Fields:    Translation:HumansCells
    96. Sontheimer EJ, Gordon PM, Piccirilli JA. Metal ion catalysis during group II intron self-splicing: parallels with the spliceosome. Genes Dev. 1999 Jul 01; 13(13):1729-41. PMID: 10398685.
      Citations: 46     Fields:    Translation:AnimalsCells
    97. Sontheimer EJ. Bridging sulfur substitutions in the analysis of pre-mRNA splicing. Methods. 1999 May; 18(1):29-37. PMID: 10208814.
      Citations: 3     Fields:    Translation:Cells
    98. Sontheimer EJ, Sun S, Piccirilli JA. Metal ion catalysis during splicing of premessenger RNA. Nature. 1997 Aug 21; 388(6644):801-5. PMID: 9285595.
      Citations: 57     Fields:    Translation:HumansCells
    99. Sontheimer EJ. Site-specific RNA crosslinking with 4-thiouridine. Mol Biol Rep. 1994 Jul; 20(1):35-44. PMID: 7531281.
      Citations: 27     Fields:    Translation:Cells
    100. Sontheimer EJ, Steitz JA. The U5 and U6 small nuclear RNAs as active site components of the spliceosome. Science. 1993 Dec 24; 262(5142):1989-96. PMID: 8266094.
      Citations: 162     Fields:    Translation:Cells
    101. Cortes JJ, Sontheimer EJ, Seiwert SD, Steitz JA. Mutations in the conserved loop of human U5 snRNA generate use of novel cryptic 5' splice sites in vivo. EMBO J. 1993 Dec 15; 12(13):5181-9. PMID: 8262061.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    102. Wyatt JR, Sontheimer EJ, Steitz JA. Site-specific cross-linking of mammalian U5 snRNP to the 5' splice site before the first step of pre-mRNA splicing. Genes Dev. 1992 Dec; 6(12B):2542-53. PMID: 1340469.
      Citations: 131     Fields:    Translation:HumansCells
    103. Gelpi C, Sontheimer EJ, Rodriguez-Sanchez JL. Autoantibodies against a serine tRNA-protein complex implicated in cotranslational selenocysteine insertion. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9739-43. PMID: 1409691.
      Citations: 39     Fields:    Translation:HumansCells
    104. Sontheimer EJ, Steitz JA. Three novel functional variants of human U5 small nuclear RNA. Mol Cell Biol. 1992 Feb; 12(2):734-46. PMID: 1310151.
      Citations: 21     Fields:    Translation:HumansCells
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