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Paul R Thompson PhD

InstitutionUMass Chan Medical School
DepartmentBiochemistry and Molecular Biotechnology
AddressUniversity of Massachusetts Medical School
55 Lake Ave North
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionT.H. Chan School of Medicine
    DepartmentNeuroNexus Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentBiochemistry and Molecular Biotechnology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentCancer Biology

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentPostbaccalaureate Research Education Program

    Collapse Biography 
    Collapse education and training
    McMaster University, Hamilton, ON, CanadaBSBiochemistry
    McMaster University, Hamilton, ON, CanadaPHDBiochemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Barasa L, Chaudhuri S, Zhou JY, Jiang Z, Choudhary S, Green RM, Wiggin E, Cameron M, Humphries F, Fitzgerald KA, Thompson PR. Development of LB244, an Irreversible STING Antagonist. J Am Chem Soc. 2023 09 20; 145(37):20273-20288. PMID: 37695732.
      Citations:    Fields:    Translation:Humans
    2. Humphries F, Shmuel-Galia L, Jiang Z, Zhou JY, Barasa L, Mondal S, Wilson R, Sultana N, Shaffer SA, Ng SL, Pesiridis GS, Thompson PR, Fitzgerald KA. Targeting STING oligomerization with small-molecule inhibitors. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2305420120. PMID: 37549268.
      Citations:    Fields:    Translation:AnimalsCells
    3. Ralston BA, Khan L, DeVore SB, Bronnenberg TA, Flock JW, Sequoia AO, Thompson PR, Navratil AM, Cherrington BD. Peptidylarginine deiminase 2 regulates expression of DGCR8 affecting miRNA biogenesis in gonadotrope cells. Reproduction. 2023 08 01; 166(2):125-134. PMID: 37310889.
      Citations:    Fields:    Translation:AnimalsCells
    4. Icso JD, Barasa L, Thompson PR. SARM1, an Enzyme Involved in Axon Degeneration, Catalyzes Multiple Activities through a Ternary Complex Mechanism. Biochemistry. 2023 07 04; 62(13):2065-2078. PMID: 37307562.
      Citations:    Fields:    Translation:AnimalsCells
    5. Green RM, Thompson PR. Current insights into the role of citrullination in thrombosis. Curr Opin Chem Biol. 2023 08; 75:102313. PMID: 37148643.
      Citations:    Fields:    Translation:HumansCells
    6. Mondal S, Chen Y, Lockbaum GJ, Sen S, Chaudhuri S, Reyes AC, Lee JM, Kaur AN, Sultana N, Cameron MD, Shaffer SA, Schiffer CA, Fitzgerald KA, Thompson PR. Dual Inhibitors of Main Protease (MPro) and Cathepsin L as Potent Antivirals against SARS-CoV2. J Am Chem Soc. 2022 11 23; 144(46):21035-21045. PMID: 36356199.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    7. Ali R, Parelkar SS, Thompson PR, Mitroka-Batsford S, Yerramilli S, Scarlata SF, Mistretta KS, Coburn JM, Mattson AE. Phomoxanthone A Targets ATP Synthase. Chemistry. 2022 Dec 15; 28(70):e202202397. PMID: 36082977.
      Citations:    Fields:    
    8. Yusuf IO, Qiao T, Parsi S, Tilvawala R, Thompson PR, Xu Z. Protein citrullination marks myelin protein aggregation and disease progression in mouse ALS models. Acta Neuropathol Commun. 2022 09 08; 10(1):135. PMID: 36076282.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    9. Binder V, Chruscicka-Smaga B, Bergum B, Jaisson S, Gillery P, Sivertsen J, Hervig T, Kaminska M, Tilvawala R, Nemmara VV, Thompson PR, Potempa J, Marti HP, Mydel P. Carbamylation of Integrin aIIb?3: The Mechanistic Link to Platelet Dysfunction in ESKD. J Am Soc Nephrol. 2022 10; 33(10):1841-1856. PMID: 36038265.
      Citations:    Fields:    Translation:HumansCells
    10. Icso JD, Thompson PR. The chemical biology of NAD+ regulation in axon degeneration. Curr Opin Chem Biol. 2022 08; 69:102176. PMID: 35780654.
      Citations:    Fields:    Translation:AnimalsCells
    11. Peterson ND, Icso JD, Salisbury JE, Rodr?guez T, Thompson PR, Pukkila-Worley R. Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition. Elife. 2022 01 31; 11. PMID: 35098926.
      Citations: 11     Fields:    Translation:Animals
    12. Sen S, Sultana N, Shaffer SA, Thompson PR. Proximity-Dependent Labeling of Cysteines. J Am Chem Soc. 2021 11 24; 143(46):19257-19261. PMID: 34762412.
      Citations: 1     Fields:    Translation:HumansCells
    13. Mart?n Monreal MT, Rebak AS, Massarenti L, Mondal S, ?enolt L, ?dum N, Nielsen ML, Thompson PR, Nielsen CH, Damgaard D. Applicability of Small-Molecule Inhibitors in the Study of Peptidyl Arginine Deiminase 2 (PAD2) and PAD4. Front Immunol. 2021; 12:716250. PMID: 34737738.
      Citations: 6     Fields:    Translation:HumansCells
    14. Lockbaum GJ, Henes M, Lee JM, Timm J, Nalivaika EA, Thompson PR, Kurt Yilmaz N, Schiffer CA. Pan-3C Protease Inhibitor Rupintrivir Binds SARS-CoV-2 Main Protease in a Unique Binding Mode. Biochemistry. 2021 10 05; 60(39):2925-2931. PMID: 34506130.
      Citations: 8     Fields:    Translation:Cells
    15. Maurais AJ, Salinger AJ, Tobin M, Shaffer SA, Weerapana E, Thompson PR. A Streamlined Data Analysis Pipeline for the Identification of Sites of Citrullination. Biochemistry. 2021 09 28; 60(38):2902-2914. PMID: 34491035.
      Citations: 4     Fields:    Translation:HumansCells
    16. Tilvawala R, Nemmara VV, Reyes AC, Sorvillo N, Salinger AJ, Cherpokova D, Fukui S, Gutch S, Wagner D, Thompson PR. The role of SERPIN citrullination in thrombosis. Cell Chem Biol. 2021 12 16; 28(12):1728-1739.e5. PMID: 34352225.
      Citations: 2     Fields:    Translation:Animals
    17. Sun B, Tomita B, Salinger A, Tilvawala RR, Li L, Hakami H, Liu T, Tsoyi K, Rosas IO, Reinhardt DP, Thompson PR, Ho IC. PAD2-mediated citrullination of Fibulin-5 promotes elastogenesis. Matrix Biol. 2021 08; 102:70-84. PMID: 34274450.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    18. Young CH, Snow B, DeVore SB, Mohandass A, Nemmara VV, Thompson PR, Thyagarajan B, Navratil AM, Cherrington BD. Progesterone stimulates histone citrullination to increase IGFBP1 expression in uterine cells. Reproduction. 2021 07 08; 162(2):117-127. PMID: 34034233.
      Citations: 4     Fields:    Translation:AnimalsCells
    19. Loring HS, Czech VL, Icso JD, O'Connor L, Parelkar SS, Byrne AB, Thompson PR. A phase transition enhances the catalytic activity of SARM1, an NAD+ glycohydrolase involved in neurodegeneration. Elife. 2021 06 29; 10. PMID: 34184985.
      Citations: 11     Fields:    Translation:AnimalsCells
    20. Griffante G, Gugliesi F, Pasquero S, Dell'Oste V, Biolatti M, Salinger AJ, Mondal S, Thompson PR, Weerapana E, Lebbink RJ, Soppe JA, Stamminger T, Girault V, Pichlmair A, Oroszl?n G, Coen DM, De Andrea M, Landolfo S. Human cytomegalovirus-induced host protein citrullination is crucial for viral replication. Nat Commun. 2021 06 23; 12(1):3910. PMID: 34162877.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    21. Funabashi K, Sawata M, Nagai A, Akimoto M, Mashimo R, Takahara H, Kizawa K, Thompson PR, Ite K, Kitanishi K, Unno M. Structures of human peptidylarginine deiminase type III provide insights into substrate recognition and inhibitor design. Arch Biochem Biophys. 2021 09 15; 708:108911. PMID: 33971157.
      Citations: 4     Fields:    Translation:HumansCells
    22. Li FJ, Surolia R, Li H, Wang Z, Liu G, Kulkarni T, Massicano AVF, Mobley JA, Mondal S, de Andrade JA, Coonrod SA, Thompson PR, Wille K, Lapi SE, Athar M, Thannickal VJ, Carter AB, Antony VB. Citrullinated vimentin mediates development and progression of lung fibrosis. Sci Transl Med. 2021 03 17; 13(585). PMID: 33731433.
      Citations: 19     Fields:    Translation:AnimalsCellsPHPublic Health
    23. Mondal S, Thompson PR. Chemical biology of protein citrullination by the protein A arginine deiminases. Curr Opin Chem Biol. 2021 08; 63:19-27. PMID: 33676233.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    24. Lockbaum GJ, Reyes AC, Lee JM, Tilvawala R, Nalivaika EA, Ali A, Kurt Yilmaz N, Thompson PR, Schiffer CA. Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188. Viruses. 2021 01 25; 13(2). PMID: 33503819.
      Citations: 44     Fields:    Translation:Cells
    25. Mondal S, Wang S, Zheng Y, Sen S, Chatterjee A, Thompson PR. Site-specific incorporation of citrulline into proteins in mammalian cells. Nat Commun. 2021 01 04; 12(1):45. PMID: 33398026.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    26. Sodr? FMC, Bissenova S, Bruggeman Y, Tilvawala R, Cook DP, Berthault C, Mondal S, Callebaut A, You S, Scharfmann R, Mallone R, Thompson PR, Mathieu C, Buitinga M, Overbergh L. Peptidylarginine Deiminase Inhibition Prevents Diabetes Development in NOD Mice. Diabetes. 2021 02; 70(2):516-528. PMID: 33203696.
      Citations: 15     Fields:    Translation:AnimalsCells
    27. Tian Y, Qu S, Alam HB, Williams AM, Wu Z, Deng Q, Pan B, Zhou J, Liu B, Duan X, Ma J, Mondal S, Thompson PR, Stringer KA, Standiford TJ, Li Y. Peptidylarginine deiminase 2 has potential as both a biomarker and therapeutic target of sepsis. JCI Insight. 2020 10 15; 5(20). PMID: 33055424.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    28. Humphries F, Shmuel-Galia L, Ketelut-Carneiro N, Li S, Wang B, Nemmara VV, Wilson R, Jiang Z, Khalighinejad F, Muneeruddin K, Shaffer SA, Dutta R, Ionete C, Pesiridis S, Yang S, Thompson PR, Fitzgerald KA. Succination inactivates gasdermin D and blocks pyroptosis. Science. 2020 09 25; 369(6511):1633-1637. PMID: 32820063.
      Citations: 164     Fields:    Translation:HumansAnimalsCells
    29. Wu Z, Deng Q, Pan B, Alam HB, Tian Y, Bhatti UF, Liu B, Mondal S, Thompson PR, Li Y. Inhibition of PAD2 Improves Survival in a Mouse Model of Lethal LPS-Induced Endotoxic Shock. Inflammation. 2020 Aug; 43(4):1436-1445. PMID: 32239392.
      Citations: 18     Fields:    Translation:AnimalsCells
    30. Loring HS, Parelkar SS, Mondal S, Thompson PR. Identification of the first noncompetitive SARM1 inhibitors. Bioorg Med Chem. 2020 09 15; 28(18):115644. PMID: 32828421.
      Citations: 18     Fields:    Translation:HumansCells
    31. Li G, Young CH, Snow B, Christensen AO, Demoruelle MK, Nemmara VV, Thompson PR, Rothfuss HM, Cherrington BD. Identification and Characterization of the Lactating Mouse Mammary Gland Citrullinome. Int J Mol Sci. 2020 Apr 10; 21(7). PMID: 32290104.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    32. Uysal-Onganer P, MacLatchy A, Mahmoud R, Kraev I, Thompson PR, Inal JM, Lange S. Peptidylarginine Deiminase Isozyme-Specific PAD2, PAD3 and PAD4 Inhibitors Differentially Modulate Extracellular Vesicle Signatures and Cell Invasion in Two Glioblastoma Multiforme Cell Lines. Int J Mol Sci. 2020 Feb 22; 21(4). PMID: 32098295.
      Citations: 24     Fields:    Translation:HumansCells
    33. Loring HS, Icso JD, Nemmara VV, Thompson PR. Initial Kinetic Characterization of Sterile Alpha and Toll/Interleukin Receptor Motif-Containing Protein 1. Biochemistry. 2020 03 03; 59(8):933-942. PMID: 32049506.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    34. Loring HS, Thompson PR. Emergence of SARM1 as a Potential Therapeutic Target for Wallerian-type Diseases. Cell Chem Biol. 2020 01 16; 27(1):1-13. PMID: 31761689.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    35. Sun B, Chang HH, Salinger A, Tomita B, Bawadekar M, Holmes CL, Shelef MA, Weerapana E, Thompson PR, Ho IC. Reciprocal regulation of Th2 and Th17 cells by PAD2-mediated citrullination. JCI Insight. 2019 11 14; 4(22). PMID: 31723060.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    36. Li F, Miao L, Xue T, Qin H, Mondal S, Thompson PR, Coonrod SA, Liu X, Zhang X. Inhibiting PAD2 enhances the anti-tumor effect of docetaxel in tamoxifen-resistant breast cancer cells. J Exp Clin Cancer Res. 2019 Oct 10; 38(1):414. PMID: 31601253.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    37. Ali R, Guan Y, Leveille AN, Vaughn E, Parelkar S, Thompson PR, Mattson AE. Synthesis and Anticancer Activity of Structure Simplified Naturally-Inspired Dimeric Chromenone Derivatives. European J Org Chem. 2019 Nov 10; 2019(41):6917-6929. PMID: 33828411.
    38. Mondal S, Gong X, Zhang X, Salinger AJ, Zheng L, Sen S, Weerapana E, Zhang X, Thompson PR. Halogen Bonding Increases the Potency and Isozyme Selectivity of Protein Arginine Deiminase 1 Inhibitors. Angew Chem Int Ed Engl. 2019 09 02; 58(36):12476-12480. PMID: 31276611.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    39. Mishra N, Schwerdtner L, Sams K, Mondal S, Ahmad F, Schmidt RE, Coonrod SA, Thompson PR, Lerch MM, Bossaller L. Cutting Edge: Protein Arginine Deiminase 2 and 4 Regulate NLRP3 Inflammasome-Dependent IL-1? Maturation and ASC Speck Formation in Macrophages. J Immunol. 2019 08 15; 203(4):795-800. PMID: 31292215.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    40. Sorvillo N, Mizurini DM, Coxon C, Martinod K, Tilvawala R, Cherpokova D, Salinger AJ, Seward RJ, Staudinger C, Weerapana E, Shapiro NI, Costello CE, Thompson PR, Wagner DD. Plasma Peptidylarginine Deiminase IV Promotes VWF-Platelet String Formation and Accelerates Thrombosis After Vessel Injury. Circ Res. 2019 08 16; 125(5):507-519. PMID: 31248335.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    41. Zheng L, Nagar M, Maurais AJ, Slade DJ, Parelkar SS, Coonrod SA, Weerapana E, Thompson PR. Calcium Regulates the Nuclear Localization of Protein Arginine Deiminase 2. Biochemistry. 2019 07 09; 58(27):3042-3056. PMID: 31243954.
      Citations: 14     Fields:    Translation:HumansCells
    42. Sen S, Mondal S, Zheng L, Salinger AJ, Fast W, Weerapana E, Thompson PR. Development of a Suicide Inhibition-Based Protein Labeling Strategy for Nicotinamide N-Methyltransferase. ACS Chem Biol. 2019 04 19; 14(4):613-618. PMID: 30933557.
      Citations: 5     Fields:    Translation:HumansCells
    43. Cau L, Takahara H, Thompson PR, Serre G, M?chin MC, Simon M. Peptidylarginine Deiminase Inhibitor Cl-Amidine Attenuates Cornification and Interferes with the Regulation of Autophagy in?Reconstructed Human Epidermis. J Invest Dermatol. 2019 09; 139(9):1889-1897.e4. PMID: 30878672.
      Citations: 8     Fields:    Translation:HumansCells
    44. Mondal S, Thompson PR. Protein Arginine Deiminases (PADs): Biochemistry and Chemical Biology of Protein Citrullination. Acc Chem Res. 2019 03 19; 52(3):818-832. PMID: 30844238.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    45. Tilvawala R, Thompson PR. Peptidyl arginine deiminases: detection and functional analysis of protein citrullination. Curr Opin Struct Biol. 2019 12; 59:205-215. PMID: 30833201.
      Citations: 15     Fields:    Translation:HumansCells
    46. Nagar M, Tilvawala R, Thompson PR. Thioredoxin Modulates Protein Arginine Deiminase 4 (PAD4)-Catalyzed Citrullination. Front Immunol. 2019; 10:244. PMID: 30853960.
      Citations: 9     Fields:    Translation:HumansCells
    47. Nemmara VV, Thompson PR. Development of Activity-Based Proteomic Probes for Protein Citrullination. Curr Top Microbiol Immunol. 2019; 420:233-251. PMID: 30203394.
      Citations: 5     Fields:    Translation:HumansCells
    48. Liu Y, Lightfoot YL, Seto N, Carmona-Rivera C, Moore E, Goel R, O'Neil L, Mistry P, Hoffmann V, Mondal S, Premnath PN, Gribbons K, Dell'Orso S, Jiang K, Thompson PR, Sun HW, Coonrod SA, Kaplan MJ. Peptidylarginine deiminases 2 and 4 modulate innate and adaptive immune responses in TLR-7-dependent lupus. JCI Insight. 2018 12 06; 3(23). PMID: 30518690.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    49. DeVore SB, Young CH, Li G, Sundararajan A, Ramaraj T, Mudge J, Schilkey F, Muth A, Thompson PR, Cherrington BD. Histone Citrullination Represses MicroRNA Expression, Resulting in Increased Oncogene mRNAs in Somatolactotrope Cells. Mol Cell Biol. 2018 10 01; 38(19). PMID: 29987187.
      Citations: 16     Fields:    Translation:HumansCells
    50. Loring HS, Thompson PR. Kinetic Mechanism of Nicotinamide N-Methyltransferase. Biochemistry. 2018 09 25; 57(38):5524-5532. PMID: 30148963.
      Citations: 15     Fields:    Translation:HumansCells
    51. Nemmara VV, Tilvawala R, Salinger AJ, Miller L, Nguyen SH, Weerapana E, Thompson PR. Citrullination Inactivates Nicotinamide- N-methyltransferase. ACS Chem Biol. 2018 09 21; 13(9):2663-2672. PMID: 30044909.
      Citations: 14     Fields:    Translation:HumansCells
    52. M?ller S, Ackloo S, Arrowsmith CH, Bauser M, Baryza JL, Blagg J, B?ttcher J, Bountra C, Brown PJ, Bunnage ME, Carter AJ, Damerell D, D?tsch V, Drewry DH, Edwards AM, Edwards J, Elkins JM, Fischer C, Frye SV, Gollner A, Grimshaw CE, IJzerman A, Hanke T, Hartung IV, Hitchcock S, Howe T, Hughes TV, Laufer S, Li VM, Liras S, Marsden BD, Matsui H, Mathias J, O'Hagan RC, Owen DR, Pande V, Rauh D, Rosenberg SH, Roth BL, Schneider NS, Scholten C, Singh Saikatendu K, Simeonov A, Takizawa M, Tse C, Thompson PR, Treiber DK, Viana AY, Wells CI, Willson TM, Zuercher WJ, Knapp S, Mueller-Fahrnow A. Donated chemical probes for open science. Elife. 2018 04 20; 7. PMID: 29676732.
      Citations: 35     Fields:    
    53. Ledet MM, Anderson R, Harman R, Muth A, Thompson PR, Coonrod SA, Van de Walle GR. BB-Cl-Amidine as a novel therapeutic for canine and feline mammary cancer via activation of the endoplasmic reticulum stress pathway. BMC Cancer. 2018 04 12; 18(1):412. PMID: 29649984.
      Citations: 10     Fields:    Translation:AnimalsCells
    54. Tilvawala R, Nguyen SH, Maurais AJ, Nemmara VV, Nagar M, Salinger AJ, Nagpal S, Weerapana E, Thompson PR. The Rheumatoid Arthritis-Associated Citrullinome. Cell Chem Biol. 2018 06 21; 25(6):691-704.e6. PMID: 29628436.
      Citations: 82     Fields:    Translation:Humans
    55. Carmona-Rivera C, Bicker KL, Thompson PR, Buckner JH, Robinson WH, Fox DA, Kaplan MJ. Response to comment on "Synovial fibroblast-neutrophil interactions promote pathogenic adaptive immunity in rheumatoid arthritis". Sci Immunol. 2018 03 30; 3(21). PMID: 29602804.
      Citations: 2     Fields:    
    56. Mondal S, Parelkar SS, Nagar M, Thompson PR. Photochemical Control of Protein Arginine Deiminase (PAD) Activity. ACS Chem Biol. 2018 04 20; 13(4):1057-1065. PMID: 29517899.
      Citations: 10     Fields:    Translation:HumansCells
    57. Wong A, Bryzek D, Dobosz E, Scavenius C, Svoboda P, Rapala-Kozik M, Lesner A, Frydrych I, Enghild J, Mydel P, Pohl J, Thompson PR, Potempa J, Koziel J. A Novel Biological Role for Peptidyl-Arginine Deiminases: Citrullination of Cathelicidin LL-37 Controls the Immunostimulatory Potential of Cell-Free DNA. J Immunol. 2018 04 01; 200(7):2327-2340. PMID: 29475987.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    58. Nemmara VV, Subramanian V, Muth A, Mondal S, Salinger AJ, Maurais AJ, Tilvawala R, Weerapana E, Thompson PR. The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs). ACS Chem Biol. 2018 03 16; 13(3):712-722. PMID: 29341591.
      Citations: 13     Fields:    
    59. Qin H, Liu X, Li F, Miao L, Li T, Xu B, An X, Muth A, Thompson PR, Coonrod SA, Zhang X. PAD1 promotes epithelial-mesenchymal transition and metastasis in triple-negative breast cancer cells by regulating MEK1-ERK1/2-MMP2 signaling. Cancer Lett. 2017 11 28; 409:30-41. PMID: 28844713.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    60. Sun B, Dwivedi N, Bechtel TJ, Paulsen JL, Muth A, Bawadekar M, Li G, Thompson PR, Shelef MA, Schiffer CA, Weerapana E, Ho IC. Citrullination of NF-?B p65 promotes its nuclear localization and TLR-induced expression of IL-1? and TNFa. Sci Immunol. 2017 Jun 09; 2(12). PMID: 28783661.
      Citations: 43     Fields:    
    61. Kenny EF, Herzig A, Kr?ger R, Muth A, Mondal S, Thompson PR, Brinkmann V, Bernuth HV, Zychlinsky A. Diverse stimuli engage different neutrophil extracellular trap pathways. Elife. 2017 06 02; 6. PMID: 28574339.
      Citations: 297     Fields:    Translation:HumansAnimalsCells
    62. Horibata S, Rogers KE, Sadegh D, Anguish LJ, McElwee JL, Shah P, Thompson PR, Coonrod SA. Role of peptidylarginine deiminase 2 (PAD2) in mammary carcinoma cell migration. BMC Cancer. 2017 05 26; 17(1):378. PMID: 28549415.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    63. Clancy KW, Russell AM, Subramanian V, Nguyen H, Qian Y, Campbell RM, Thompson PR. Citrullination/Methylation Crosstalk on Histone H3 Regulates ER-Target Gene Transcription. ACS Chem Biol. 2017 06 16; 12(6):1691-1702. PMID: 28485572.
      Citations: 27     Fields:    Translation:HumansCells
    64. Muth A, Subramanian V, Beaumont E, Nagar M, Kerry P, McEwan P, Srinath H, Clancy K, Parelkar S, Thompson PR. Development of a Selective Inhibitor of Protein Arginine Deiminase 2. J Med Chem. 2017 04 13; 60(7):3198-3211. PMID: 28328217.
      Citations: 39     Fields:    Translation:HumansCells
    65. Cau L, Pendaries V, Lhuillier E, Thompson PR, Serre G, Takahara H, M?chin MC, Simon M. Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown. J Dermatol Sci. 2017 May; 86(2):106-113. PMID: 28242341.
      Citations: 20     Fields:    Translation:HumansCells
    66. Zhang X, Liu X, Zhang M, Li T, Muth A, Thompson PR, Coonrod SA, Zhang X. Peptidylarginine deiminase 1-catalyzed histone citrullination is essential for early embryo development. Sci Rep. 2016 12 08; 6:38727. PMID: 27929094.
      Citations: 25     Fields:    Translation:HumansCells
    67. Chang HH, Liu GY, Dwivedi N, Sun B, Okamoto Y, Kinslow JD, Deane KD, Demoruelle MK, Norris JM, Thompson PR, Sparks JA, Rao DA, Karlson EW, Hung HC, Holers VM, Ho IC. A molecular signature of preclinical rheumatoid arthritis triggered by dysregulated PTPN22. JCI Insight. 2016 Oct 20; 1(17):e90045. PMID: 27777982.
      Citations: 26     Fields:    Translation:HumansCells
    68. Young CH, Rothfuss HM, Gard PF, Muth A, Thompson PR, Ashley RL, Cherrington BD. Citrullination regulates the expression of insulin-like growth factor-binding protein 1 (IGFBP1) in ovine uterine luminal epithelial cells. Reproduction. 2017 01; 153(1):1-10. PMID: 29565015.
      Citations: 7     Fields:    Translation:AnimalsCells
    69. Papadaki G, Kambas K, Choulaki C, Vlachou K, Drakos E, Bertsias G, Ritis K, Boumpas DT, Thompson PR, Verginis P, Sidiropoulos P. Neutrophil extracellular traps exacerbate Th1-mediated autoimmune responses in rheumatoid arthritis by promoting DC maturation. Eur J Immunol. 2016 11; 46(11):2542-2554. PMID: 27585946.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    70. Khan SA, Edwards BS, Muth A, Thompson PR, Cherrington BD, Navratil AM. GnRH Stimulates Peptidylarginine Deiminase Catalyzed Histone Citrullination in Gonadotrope Cells. Mol Endocrinol. 2016 Oct; 30(10):1081-1091. PMID: 27603413.
      Citations: 12     Fields:    Translation:AnimalsCells
    71. Fuhrmann J, Subramanian V, Kojetin DJ, Thompson PR. Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation. Cell Chem Biol. 2016 08 18; 23(8):967-977. PMID: 27524296.
      Citations: 17     Fields:    Translation:Cells
    72. Bawadekar M, Gendron-Fitzpatrick A, Rebernick R, Shim D, Warner TF, Nicholas AP, Lundblad LK, Thompson PR, Shelef MA. Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation. Arthritis Res Ther. 2016 07 22; 18(1):173. PMID: 27450561.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    73. Hosseinzadeh A, Thompson PR, Segal BH, Urban CF. Nicotine induces neutrophil extracellular traps. J Leukoc Biol. 2016 11; 100(5):1105-1112. PMID: 27312847.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    74. Kawalkowska J, Quirke AM, Ghari F, Davis S, Subramanian V, Thompson PR, Williams RO, Fischer R, La Thangue NB, Venables PJ. Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses. Sci Rep. 2016 05 23; 6:26430. PMID: 27210478.
      Citations: 46     Fields:    Translation:AnimalsCells
    75. Ghari F, Quirke AM, Munro S, Kawalkowska J, Picaud S, McGouran J, Subramanian V, Muth A, Williams R, Kessler B, Thompson PR, Fillipakopoulos P, Knapp S, Venables PJ, La Thangue NB. Citrullination-acetylation interplay guides E2F-1 activity during the inflammatory response. Sci Adv. 2016 Feb; 2(2):e1501257. PMID: 26989780.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    76. Li G, Hayward IN, Jenkins BR, Rothfuss HM, Young CH, Nevalainen MT, Muth A, Thompson PR, Navratil AM, Cherrington BD. Peptidylarginine Deiminase 3 (PAD3) Is Upregulated by Prolactin Stimulation of CID-9 Cells and Expressed in the Lactating Mouse Mammary Gland. PLoS One. 2016; 11(1):e0147503. PMID: 26799659.
      Citations: 6     Fields:    Translation:AnimalsCells
    77. Fuhrmann J, Thompson PR. Protein Arginine Methylation and Citrullination in Epigenetic Regulation. ACS Chem Biol. 2016 Mar 18; 11(3):654-68. PMID: 26686581.
      Citations: 45     Fields:    Translation:HumansCells
    78. Witalison EE, Cui X, Causey CP, Thompson PR, Hofseth LJ. Molecular targeting of protein arginine deiminases to suppress colitis and prevent colon cancer. Oncotarget. 2015 Nov 03; 6(34):36053-62. PMID: 26440311.
      Citations: 24     Fields:    Translation:Animals
    79. Clancy KW, Weerapana E, Thompson PR. Detection and identification of protein citrullination in complex biological systems. Curr Opin Chem Biol. 2016 Feb; 30:1-6. PMID: 26517730.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    80. Fuhrmann J, Subramanian V, Thompson PR. Synthesis and Use of a Phosphonate Amidine to Generate an Anti-Phosphoarginine-Specific Antibody. Angew Chem Int Ed Engl. 2015 Dec 01; 54(49):14715-8. PMID: 26458230.
      Citations: 10     Fields:    Translation:Cells
    81. Lewallen DM, Bicker KL, Subramanian V, Clancy KW, Slade DJ, Martell J, Dreyton CJ, Sokolove J, Weerapana E, Thompson PR. Chemical Proteomic Platform To Identify Citrullinated Proteins. ACS Chem Biol. 2015 Nov 20; 10(11):2520-8. PMID: 26360112.
      Citations: 34     Fields:    Translation:HumansCells
    82. Kholia S, Jorfi S, Thompson PR, Causey CP, Nicholas AP, Inal JM, Lange S. A novel role for peptidylarginine deiminases in microvesicle release reveals therapeutic potential of PAD inhibition in sensitizing prostate cancer cells to chemotherapy. J Extracell Vesicles. 2015; 4:26192. PMID: 26095379.
      Citations: 57     Fields:    
    83. Horibata S, Vo TV, Subramanian V, Thompson PR, Coonrod SA. Utilization of the Soft Agar Colony Formation Assay to Identify Inhibitors of Tumorigenicity in Breast Cancer Cells. J Vis Exp. 2015 May 20; (99):e52727. PMID: 26067809.
      Citations: 72     Fields:    Translation:HumansCells
    84. Fuhrmann J, Clancy KW, Thompson PR. Chemical biology of protein arginine modifications in epigenetic regulation. Chem Rev. 2015 Jun 10; 115(11):5413-61. PMID: 25970731.
      Citations: 105     Fields:    Translation:Cells
    85. Witalison EE, Cui X, Hofseth AB, Subramanian V, Causey CP, Thompson PR, Hofseth LJ. Inhibiting protein arginine deiminases has antioxidant consequences. J Pharmacol Exp Ther. 2015 Apr; 353(1):64-70. PMID: 25635139.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    86. Slade DJ, Fang P, Dreyton CJ, Zhang Y, Fuhrmann J, Rempel D, Bax BD, Coonrod SA, Lewis HD, Guo M, Gross ML, Thompson PR. Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design. ACS Chem Biol. 2015 Apr 17; 10(4):1043-53. PMID: 25621824.
      Citations: 49     Fields:    Translation:HumansCells
    87. Lewis HD, Liddle J, Coote JE, Atkinson SJ, Barker MD, Bax BD, Bicker KL, Bingham RP, Campbell M, Chen YH, Chung CW, Craggs PD, Davis RP, Eberhard D, Joberty G, Lind KE, Locke K, Maller C, Martinod K, Patten C, Polyakova O, Rise CE, R?diger M, Sheppard RJ, Slade DJ, Thomas P, Thorpe J, Yao G, Drewes G, Wagner DD, Thompson PR, Prinjha RK, Wilson DM. Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation. Nat Chem Biol. 2015 Mar; 11(3):189-91. PMID: 25622091.
      Citations: 272     Fields:    Translation:HumansAnimalsCells
    88. Subramanian V, Knight JS, Parelkar S, Anguish L, Coonrod SA, Kaplan MJ, Thompson PR. Design, synthesis, and biological evaluation of tetrazole analogs of Cl-amidine as protein arginine deiminase inhibitors. J Med Chem. 2015 Feb 12; 58(3):1337-44. PMID: 25559347.
      Citations: 22     Fields:    Translation:HumansCells
    89. Witalison EE, Thompson PR, Hofseth LJ. Protein Arginine Deiminases and Associated Citrullination: Physiological Functions and Diseases Associated with Dysregulation. Curr Drug Targets. 2015; 16(7):700-10. PMID: 25642720.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    90. Wang M, Fuhrmann J, Thompson PR. Protein arginine methyltransferase 5 catalyzes substrate dimethylation in a distributive fashion. Biochemistry. 2014 Dec 23; 53(50):7884-92. PMID: 25485739.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    91. Smith CK, Vivekanandan-Giri A, Tang C, Knight JS, Mathew A, Padilla RL, Gillespie BW, Carmona-Rivera C, Liu X, Subramanian V, Hasni S, Thompson PR, Heinecke JW, Saran R, Pennathur S, Kaplan MJ. Neutrophil extracellular trap-derived enzymes oxidize high-density lipoprotein: an additional proatherogenic mechanism in systemic lupus erythematosus. Arthritis Rheumatol. 2014 Sep; 66(9):2532-2544. PMID: 24838349.
      Citations: 102     Fields:    Translation:HumansAnimalsCells
    92. Knight JS, Subramanian V, O'Dell AA, Yalavarthi S, Zhao W, Smith CK, Hodgin JB, Thompson PR, Kaplan MJ. Peptidylarginine deiminase inhibition disrupts NET formation and protects against kidney, skin and vascular disease in lupus-prone MRL/lpr mice. Ann Rheum Dis. 2015 Dec; 74(12):2199-206. PMID: 25104775.
      Citations: 209     Fields:    Translation:AnimalsCells
    93. Dreyton CJ, Knuckley B, Jones JE, Lewallen DM, Thompson PR. Mechanistic studies of protein arginine deiminase 2: evidence for a substrate-assisted mechanism. Biochemistry. 2014 Jul 15; 53(27):4426-33. PMID: 24989433.
      Citations: 20     Fields:    Translation:HumansCells
    94. Slade DJ, Horibata S, Coonrod SA, Thompson PR. A novel role for protein arginine deiminase 4 in pluripotency: the emerging role of citrullinated histone H1 in cellular programming. Bioessays. 2014 Aug; 36(8):736-40. PMID: 24889365.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    95. Lange S, Rocha-Ferreira E, Thei L, Mawjee P, Bennett K, Thompson PR, Subramanian V, Nicholas AP, Peebles D, Hristova M, Raivich G. Peptidylarginine deiminases: novel drug targets for prevention of neuronal damage following hypoxic ischemic insult (HI) in neonates. J Neurochem. 2014 Aug; 130(4):555-62. PMID: 24762056.
      Citations: 49     Fields:    Translation:AnimalsCells
    96. Slade DJ, Subramanian V, Thompson PR. Pluripotency: citrullination unravels stem cells. Nat Chem Biol. 2014 May; 10(5):327-8. PMID: 24743255.
      Citations: 16     Fields:    Translation:AnimalsCells
    97. U KP, Subramanian V, Nicholas AP, Thompson PR, Ferretti P. Modulation of calcium-induced cell death in human neural stem cells by the novel peptidylarginine deiminase-AIF pathway. Biochim Biophys Acta. 2014 Jun; 1843(6):1162-71. PMID: 24607566.
      Citations: 35     Fields:    Translation:HumansCells
    98. Slade DJ, Subramanian V, Fuhrmann J, Thompson PR. Chemical and biological methods to detect post-translational modifications of arginine. Biopolymers. 2014 Feb; 101(2):133-43. PMID: 23576281.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    99. Lewallen DM, Bicker KL, Madoux F, Chase P, Anguish L, Coonrod S, Hodder P, Thompson PR. A FluoPol-ABPP PAD2 high-throughput screen identifies the first calcium site inhibitor targeting the PADs. ACS Chem Biol. 2014 Apr 18; 9(4):913-21. PMID: 24467619.
      Citations: 15     Fields:    Translation:Cells
    100. Knight JS, Luo W, O'Dell AA, Yalavarthi S, Zhao W, Subramanian V, Guo C, Grenn RC, Thompson PR, Eitzman DT, Kaplan MJ. Peptidylarginine deiminase inhibition reduces vascular damage and modulates innate immune responses in murine models of atherosclerosis. Circ Res. 2014 Mar 14; 114(6):947-56. PMID: 24425713.
      Citations: 190     Fields:    Translation:AnimalsCells
    101. Dreyton CJ, Anderson ED, Subramanian V, Boger DL, Thompson PR. Insights into the mechanism of streptonigrin-induced protein arginine deiminase inactivation. Bioorg Med Chem. 2014 Feb 15; 22(4):1362-9. PMID: 24440480.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    102. Rust HL, Subramanian V, West GM, Young DD, Schultz PG, Thompson PR. Using unnatural amino acid mutagenesis to probe the regulation of PRMT1. ACS Chem Biol. 2014 Mar 21; 9(3):649-55. PMID: 24358983.
      Citations: 15     Fields:    Translation:HumansCells
    103. Lewallen DM, Sreelatha A, Dharmarajan V, Madoux F, Chase P, Griffin PR, Orth K, Hodder P, Thompson PR. Inhibiting AMPylation: a novel screen to identify the first small molecule inhibitors of protein AMPylation. ACS Chem Biol. 2014 Feb 21; 9(2):433-42. PMID: 24274060.
      Citations: 13     Fields:    Translation:HumansCells
    104. Dillon MB, Rust HL, Thompson PR, Mowen KA. Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity. J Biol Chem. 2013 Sep 27; 288(39):27872-80. PMID: 23946480.
      Citations: 21     Fields:    Translation:HumansCells
    105. Wang M, Xu RM, Thompson PR. Substrate specificity, processivity, and kinetic mechanism of protein arginine methyltransferase 5. Biochemistry. 2013 Aug 13; 52(32):5430-40. PMID: 23866019.
      Citations: 29     Fields:    Translation:AnimalsCells
    106. Fuhrmann J, Subramanian V, Thompson PR. Targeting the arginine phosphatase YwlE with a catalytic redox-based inhibitor. ACS Chem Biol. 2013 Sep 20; 8(9):2024-32. PMID: 23838530.
      Citations: 11     Fields:    Translation:Cells
    107. Knight JS, Zhao W, Luo W, Subramanian V, O'Dell AA, Yalavarthi S, Hodgin JB, Eitzman DT, Thompson PR, Kaplan MJ. Peptidylarginine deiminase inhibition is immunomodulatory and vasculoprotective in murine lupus. J Clin Invest. 2013 Jul; 123(7):2981-93. PMID: 23722903.
      Citations: 189     Fields:    Translation:HumansAnimalsCells
    108. Foyn H, Jones JE, Lewallen D, Narawane R, Varhaug JE, Thompson PR, Arnesen T. Design, synthesis, and kinetic characterization of protein N-terminal acetyltransferase inhibitors. ACS Chem Biol. 2013; 8(6):1121-7. PMID: 23557624.
      Citations: 29     Fields:    Translation:HumansCells
    109. Bicker KL, Thompson PR. The protein arginine deiminases: Structure, function, inhibition, and disease. Biopolymers. 2013 Feb; 99(2):155-63. PMID: 23175390.
      Citations: 108     Fields:    Translation:HumansCells
    110. Cui X, Witalison EE, Chumanevich AP, Chumanevich AA, Poudyal D, Subramanian V, Schetter AJ, Harris CC, Thompson PR, Hofseth LJ. The induction of microRNA-16 in colon cancer cells by protein arginine deiminase inhibition causes a p53-dependent cell cycle arrest. PLoS One. 2013; 8(1):e53791. PMID: 23308284.
      Citations: 24     Fields:    Translation:HumansCells
    111. Rohrbach AS, Slade DJ, Thompson PR, Mowen KA. Activation of PAD4 in NET formation. Front Immunol. 2012; 3:360. PMID: 23264775.
      Citations: 167     Fields:    
    112. McElwee JL, Mohanan S, Griffith OL, Breuer HC, Anguish LJ, Cherrington BD, Palmer AM, Howe LR, Subramanian V, Causey CP, Thompson PR, Gray JW, Coonrod SA. Identification of PADI2 as a potential breast cancer biomarker and therapeutic target. BMC Cancer. 2012 Oct 30; 12:500. PMID: 23110523.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    113. Bicker KL, Anguish L, Chumanevich AA, Cameron MD, Cui X, Witalison E, Subramanian V, Zhang X, Chumanevich AP, Hofseth LJ, Coonrod SA, Thompson PR. D-amino acid based protein arginine deiminase inhibitors: Synthesis, pharmacokinetics, and in cellulo efficacy. ACS Med Chem Lett. 2012 Oct 26; 3(12):1081-1085. PMID: 23420624.
    114. Bicker KL, Subramanian V, Chumanevich AA, Hofseth LJ, Thompson PR. Seeing citrulline: development of a phenylglyoxal-based probe to visualize protein citrullination. J Am Chem Soc. 2012 Oct 17; 134(41):17015-8. PMID: 23030787.
      Citations: 46     Fields:    Translation:AnimalsCells
    115. Mohanan S, Cherrington BD, Horibata S, McElwee JL, Thompson PR, Coonrod SA. Potential role of peptidylarginine deiminase enzymes and protein citrullination in cancer pathogenesis. Biochem Res Int. 2012; 2012:895343. PMID: 23019525.
    116. Zhang X, Bolt M, Guertin MJ, Chen W, Zhang S, Cherrington BD, Slade DJ, Dreyton CJ, Subramanian V, Bicker KL, Thompson PR, Mancini MA, Lis JT, Coonrod SA. Peptidylarginine deiminase 2-catalyzed histone H3 arginine 26 citrullination facilitates estrogen receptor a target gene activation. Proc Natl Acad Sci U S A. 2012 Aug 14; 109(33):13331-6. PMID: 22853951.
      Citations: 107     Fields:    Translation:HumansAnimalsCells
    117. Kan R, Jin M, Subramanian V, Causey CP, Thompson PR, Coonrod SA. Potential role for PADI-mediated histone citrullination in preimplantation development. BMC Dev Biol. 2012 Jun 19; 12:19. PMID: 22712504.
      Citations: 30     Fields:    Translation:AnimalsCells
    118. Mohamed BM, Verma NK, Davies AM, McGowan A, Crosbie-Staunton K, Prina-Mello A, Kelleher D, Botting CH, Causey CP, Thompson PR, Pruijn GJ, Kisin ER, Tkach AV, Shvedova AA, Volkov Y. Citrullination of proteins: a common post-translational modification pathway induced by different nanoparticles in vitro and in vivo. Nanomedicine (Lond). 2012 Aug; 7(8):1181-95. PMID: 22625207.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    119. Lewallen DM, Steckler CJ, Knuckley B, Chalmers MJ, Thompson PR. Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates. Mol Biosyst. 2012 Jun; 8(6):1701-6. PMID: 22456874.
      Citations: 15     Fields:    Translation:HumansCells
    120. Bicker KL, Sun J, Harrell M, Zhang Y, Pena MM, Thompson PR, Lavigne JJ. Synthetic lectin arrays for the detection and discrimination of cancer associated glycans and cell lines. Chem Sci. 2012 Apr 01; 3(4):1147-1156. PMID: 29051806.
    121. Obianyo O, Thompson PR. Kinetic mechanism of protein arginine methyltransferase 6 (PRMT6). J Biol Chem. 2012 Feb 17; 287(8):6062-71. PMID: 22219200.
      Citations: 12     Fields:    Translation:HumansCells
    122. Jones JE, Slack JL, Fang P, Zhang X, Subramanian V, Causey CP, Coonrod SA, Guo M, Thompson PR. Synthesis and screening of a haloacetamidine containing library to identify PAD4 selective inhibitors. ACS Chem Biol. 2012 Jan 20; 7(1):160-5. PMID: 22004374.
      Citations: 51     Fields:    Translation:HumansCells
    123. Causey CP, Jones JE, Slack JL, Kamei D, Jones LE, Subramanian V, Knuckley B, Ebrahimi P, Chumanevich AA, Luo Y, Hashimoto H, Sato M, Hofseth LJ, Thompson PR. The development of N-a-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-a-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors. J Med Chem. 2011 Oct 13; 54(19):6919-35. PMID: 21882827.
      Citations: 41     Fields:    Translation:HumansCells
    124. Obianyo O, Causey CP, Jones JE, Thompson PR. Activity-based protein profiling of protein arginine methyltransferase 1. ACS Chem Biol. 2011 Oct 21; 6(10):1127-35. PMID: 21838253.
      Citations: 17     Fields:    Translation:HumansCells
    125. Rust HL, Thompson PR. Kinase consensus sequences: a breeding ground for crosstalk. ACS Chem Biol. 2011 Sep 16; 6(9):881-92. PMID: 21721511.
      Citations: 47     Fields:    Translation:HumansCells
    126. Zhang X, Gamble MJ, Stadler S, Cherrington BD, Causey CP, Thompson PR, Roberson MS, Kraus WL, Coonrod SA. Genome-wide analysis reveals PADI4 cooperates with Elk-1 to activate c-Fos expression in breast cancer cells. PLoS Genet. 2011 Jun; 7(6):e1002112. PMID: 21655091.
      Citations: 61     Fields:    Translation:HumansCells
    127. Lange S, G?gel S, Leung KY, Vernay B, Nicholas AP, Causey CP, Thompson PR, Greene ND, Ferretti P. Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability. Dev Biol. 2011 Jul 15; 355(2):205-14. PMID: 21539830.
      Citations: 57     Fields:    Translation:HumansAnimals
    128. Slack JL, Jones LE, Bhatia MM, Thompson PR. Autodeimination of protein arginine deiminase 4 alters protein-protein interactions but not activity. Biochemistry. 2011 May 17; 50(19):3997-4010. PMID: 21466234.
      Citations: 31     Fields:    Translation:HumansCells
    129. Rust HL, Zurita-Lopez CI, Clarke S, Thompson PR. Mechanistic studies on transcriptional coactivator protein arginine methyltransferase 1. Biochemistry. 2011 Apr 26; 50(16):3332-45. PMID: 21417440.
      Citations: 17     Fields:    Translation:Cells
    130. Bicker KL, Sun J, Lavigne JJ, Thompson PR. Boronic acid functionalized peptidyl synthetic lectins: combinatorial library design, peptide sequencing, and selective glycoprotein recognition. ACS Comb Sci. 2011 May 09; 13(3):232-43. PMID: 21405093.
      Citations: 8     Fields:    
    131. Chumanevich AA, Causey CP, Knuckley BA, Jones JE, Poudyal D, Chumanevich AP, Davis T, Matesic LE, Thompson PR, Hofseth LJ. Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor. Am J Physiol Gastrointest Liver Physiol. 2011 Jun; 300(6):G929-38. PMID: 21415415.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    132. Willis VC, Gizinski AM, Banda NK, Causey CP, Knuckley B, Cordova KN, Luo Y, Levitt B, Glogowska M, Chandra P, Kulik L, Robinson WH, Arend WP, Thompson PR, Holers VM. N-a-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis. J Immunol. 2011 Apr 01; 186(7):4396-404. PMID: 21346230.
      Citations: 147     Fields:    Translation:Animals
    133. Slack JL, Causey CP, Luo Y, Thompson PR. Development and use of clickable activity based protein profiling agents for protein arginine deiminase 4. ACS Chem Biol. 2011 May 20; 6(5):466-76. PMID: 21265574.
      Citations: 13     Fields:    Translation:HumansCells
    134. Jones JE, Dreyton CJ, Flick H, Causey CP, Thompson PR. Mechanistic studies of agmatine deiminase from multiple bacterial species. Biochemistry. 2010 Nov 02; 49(43):9413-23. PMID: 20939536.
      Citations: 7     Fields:    Translation:Cells
    135. Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR. A fluopol-ABPP HTS assay to identify PAD inhibitors. Chem Commun (Camb). 2010 Oct 14; 46(38):7175-7. PMID: 20740228.
      Citations: 34     Fields:    Translation:HumansCells
    136. Slack JL, Causey CP, Thompson PR. Protein arginine deiminase 4: a target for an epigenetic cancer therapy. Cell Mol Life Sci. 2011 Feb; 68(4):709-20. PMID: 20706768.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    137. Bicker KL, Obianyo O, Rust HL, Thompson PR. A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1. Mol Biosyst. 2011 Jan; 7(1):48-51. PMID: 20607165.
      Citations: 9     Fields:    Translation:HumansCells
    138. Knuckley B, Causey CP, Jones JE, Bhatia M, Dreyton CJ, Osborne TC, Takahara H, Thompson PR. Substrate specificity and kinetic studies of PADs 1, 3, and 4 identify potent and selective inhibitors of protein arginine deiminase 3. Biochemistry. 2010 Jun 15; 49(23):4852-63. PMID: 20469888.
      Citations: 99     Fields:    Translation:HumansCells
    139. Obianyo O, Causey CP, Osborne TC, Jones JE, Lee YH, Stallcup MR, Thompson PR. A chloroacetamidine-based inactivator of protein arginine methyltransferase 1: design, synthesis, and in vitro and in vivo evaluation. Chembiochem. 2010 Jun 14; 11(9):1219-23. PMID: 20480486.
      Citations: 19     Fields:    Translation:HumansCells
    140. Knuckley B, Causey CP, Pellechia PJ, Cook PF, Thompson PR. Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation. Chembiochem. 2010 Jan 25; 11(2):161-5. PMID: 20014086.
      Citations: 30     Fields:    Translation:HumansCells
    141. Jones JE, Causey CP, Lovelace L, Knuckley B, Flick H, Lebioda L, Thompson PR. Characterization and inactivation of an agmatine deiminase from Helicobacter pylori. Bioorg Chem. 2010 Apr; 38(2):62-73. PMID: 20036411.
      Citations: 13     Fields:    Translation:HumansCells
    142. Jones JE, Causey CP, Knuckley B, Slack-Noyes JL, Thompson PR. Protein arginine deiminase 4 (PAD4): Current understanding and future therapeutic potential. Curr Opin Drug Discov Devel. 2009 Sep; 12(5):616-27. PMID: 19736621.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    143. Obianyo O, Osborne TC, Thompson PR. Kinetic mechanism of protein arginine methyltransferase 1. Biochemistry. 2008 Sep 30; 47(39):10420-7. PMID: 18771293.
      Citations: 33     Fields:    Translation:HumansCells
    144. Causey CP, Thompson PR. An improved synthesis of haloaceteamidine-based inactivators of protein arginine deiminase 4 (PAD4). Tetrahedron Lett. 2008 Jul 07; 49(28):4383-4385. PMID: 19587776.
      Citations: 20     Fields:    
    145. Li P, Yao H, Zhang Z, Li M, Luo Y, Thompson PR, Gilmour DS, Wang Y. Regulation of p53 target gene expression by peptidylarginine deiminase 4. Mol Cell Biol. 2008 Aug; 28(15):4745-58. PMID: 18505818.
      Citations: 120     Fields:    Translation:HumansCells
    146. Yao H, Li P, Venters BJ, Zheng S, Thompson PR, Pugh BF, Wang Y. Histone Arg modifications and p53 regulate the expression of OKL38, a mediator of apoptosis. J Biol Chem. 2008 Jul 18; 283(29):20060-8. PMID: 18499678.
      Citations: 78     Fields:    Translation:HumansCells
    147. Osborne T, Roska RL, Rajski SR, Thompson PR. In situ generation of a bisubstrate analogue for protein arginine methyltransferase 1. J Am Chem Soc. 2008 Apr 09; 130(14):4574-5. PMID: 18338885.
      Citations: 45     Fields:    
    148. Zou Y, Broughton DL, Bicker KL, Thompson PR, Lavigne JJ. Peptide borono lectins (PBLs): a new tool for glycomics and cancer diagnostics. Chembiochem. 2007 Nov 23; 8(17):2048-51. PMID: 17924602.
      Citations: 15     Fields:    Translation:AnimalsCells
    149. Osborne TC, Obianyo O, Zhang X, Cheng X, Thompson PR. Protein arginine methyltransferase 1: positively charged residues in substrate peptides distal to the site of methylation are important for substrate binding and catalysis. Biochemistry. 2007 Nov 20; 46(46):13370-81. PMID: 17960915.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    150. Knuckley B, Luo Y, Thompson PR. Profiling Protein Arginine Deiminase 4 (PAD4): a novel screen to identify PAD4 inhibitors. Bioorg Med Chem. 2008 Jan 15; 16(2):739-45. PMID: 17964793.
      Citations: 33     Fields:    Translation:Cells
    151. Knuckley B, Bhatia M, Thompson PR. Protein arginine deiminase 4: evidence for a reverse protonation mechanism. Biochemistry. 2007 Jun 05; 46(22):6578-87. PMID: 17497940.
      Citations: 47     Fields:    Translation:HumansCells
    152. Luo Y, Knuckley B, Bhatia M, Pellechia PJ, Thompson PR. Activity-based protein profiling reagents for protein arginine deiminase 4 (PAD4): synthesis and in vitro evaluation of a fluorescently labeled probe. J Am Chem Soc. 2006 Nov 15; 128(45):14468-9. PMID: 17090024.
      Citations: 32     Fields:    
    153. Luo Y, Arita K, Bhatia M, Knuckley B, Lee YH, Stallcup MR, Sato M, Thompson PR. Inhibitors and inactivators of protein arginine deiminase 4: functional and structural characterization. Biochemistry. 2006 Oct 03; 45(39):11727-36. PMID: 17002273.
      Citations: 143     Fields:    Translation:HumansCells
    154. Thompson PR, Fast W. Histone citrullination by protein arginine deiminase: is arginine methylation a green light or a roadblock? ACS Chem Biol. 2006 Aug 22; 1(7):433-41. PMID: 17168521.
      Citations: 65     Fields:    Translation:Cells
    155. Luo Y, Knuckley B, Lee YH, Stallcup MR, Thompson PR. A fluoroacetamidine-based inactivator of protein arginine deiminase 4: design, synthesis, and in vitro and in vivo evaluation. J Am Chem Soc. 2006 Feb 01; 128(4):1092-3. PMID: 16433522.
      Citations: 70     Fields:    Translation:AnimalsCells
    156. Kearney PL, Bhatia M, Jones NG, Yuan L, Glascock MC, Catchings KL, Yamada M, Thompson PR. Kinetic characterization of protein arginine deiminase 4: a transcriptional corepressor implicated in the onset and progression of rheumatoid arthritis. Biochemistry. 2005 Aug 09; 44(31):10570-82. PMID: 16060666.
      Citations: 96     Fields:    Translation:HumansCells
    157. Sagar V, Zheng W, Thompson PR, Cole PA. Bisubstrate analogue structure-activity relationships for p300 histone acetyltransferase inhibitors. Bioorg Med Chem. 2004 Jun 15; 12(12):3383-90. PMID: 15158807.
      Citations: 10     Fields:    Translation:Cells
    158. Cebrat M, Kim CM, Thompson PR, Daugherty M, Cole PA. Synthesis and analysis of potential prodrugs of coenzyme A analogues for the inhibition of the histone acetyltransferase p300. Bioorg Med Chem. 2003 Jul 31; 11(15):3307-13. PMID: 12837541.
      Citations: 15     Fields:    Translation:Humans
    159. Thompson PR, Boehr DD, Berghuis AM, Wright GD. Mechanism of aminoglycoside antibiotic kinase APH(3')-IIIa: role of the nucleotide positioning loop. Biochemistry. 2002 Jun 04; 41(22):7001-7. PMID: 12033933.
      Citations: 13     Fields:    Translation:Cells
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