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Read Pukkila-Worley MD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
364 Plantation Street
Worcester MA 01605
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionInfectious Diseases

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentImmunology and Microbiology Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    Indiana University Bloomington, Bloomington, IN, United StatesBSBiology
    University of North Carolina Chapel Hill, Chapel Hill, NC, United StatesMD

    Collapse Overview 
    Collapse overview

    For information about our work, please visit the Pukkila-Worley lab website (http://www.umassmed.edu/pukkila-worleylab).

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tse-Kang S, Wani KA, Peterson ND, Page A, Pukkila-Worley R. Activation of intestinal immunity by pathogen effector-triggered aggregation of lysosomal TIR-1/SARM1. bioRxiv. 2024 Feb 17. PMID: 38106043.
    2. Nasrallah MA, Peterson ND, Szumel ES, Liu P, Page AL, Tse SY, Wani KA, Tocheny CE, Pukkila-Worley R. Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans. PLoS Pathog. 2023 Oct; 19(10):e1011730. PMID: 37906605.
      Citations:    Fields:    Translation:HumansAnimals
    3. Cedillo L, Ahsan FM, Li S, Stuhr NL, Zhou Y, Zhang Y, Adedoja A, Murphy LM, Yerevanian A, Emans S, Dao K, Li Z, Peterson ND, Watrous J, Jain M, Das S, Pukkila-Worley R, Curran SP, Soukas AA. Ether lipid biosynthesis promotes lifespan extension and enables diverse pro-longevity paradigms in Caenorhabditis elegans. Elife. 2023 08 22; 12. PMID: 37606250.
      Citations: 2     Fields:    Translation:HumansAnimals
    4. Tse SY, Pukkila-Worley R. Protocol to assess receptor-ligand binding in C.?elegans using adapted thermal shift assays. STAR Protoc. 2023 Sep 15; 4(3):102477. PMID: 37527042.
      Citations:    Fields:    
    5. Peterson ND, Tse SY, Huang QJ, Wani KA, Schiffer CA, Pukkila-Worley R. Non-canonical pattern recognition of a pathogen-derived metabolite by a nuclear hormone receptor identifies virulent bacteria in C.?elegans. Immunity. 2023 04 11; 56(4):768-782.e9. PMID: 36804958.
      Citations: 6     Fields:    Translation:AnimalsCells
    6. Peterson ND, Icso JD, Salisbury JE, Rodr?guez T, Thompson PR, Pukkila-Worley R. Pathogen infection and cholesterol deficiency activate the C. elegans p38 immune pathway through a TIR-1/SARM1 phase transition. Elife. 2022 01 31; 11. PMID: 35098926.
      Citations: 17     Fields:    Translation:Animals
    7. Njie AB, Mitchell M, Pukkila-Worley R. Peripherally Inserted Central Catheter-Associated Nocardia nova Endocarditis in a Patient Receiving Intravenous Antibiotics for Chronic Lyme Disease. Open Forum Infect Dis. 2021 Mar; 8(3):ofab041. PMID: 33728358.
    8. Anderson SM, Pukkila-Worley R. Immunometabolism in Caenorhabditis elegans. PLoS Pathog. 2020 10; 16(10):e1008897. PMID: 33031414.
      Citations: 8     Fields:    Translation:AnimalsCells
    9. Foster KJ, Cheesman HK, Liu P, Peterson ND, Anderson SM, Pukkila-Worley R. Innate Immunity in the C.?elegans Intestine Is Programmed by a Neuronal Regulator of AWC Olfactory Neuron Development. Cell Rep. 2020 04 07; 31(1):107478. PMID: 32268082.
      Citations: 24     Fields:    Translation:AnimalsCells
    10. Foster KJ, McEwan DL, Pukkila-Worley R. Measurements of Innate Immune Function in C. elegans. Methods Mol Biol. 2020; 2144:145-160. PMID: 32410032.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    11. Nhan JD, Turner CD, Anderson SM, Yen CA, Dalton HM, Cheesman HK, Ruter DL, Uma Naresh N, Haynes CM, Soukas AA, Pukkila-Worley R, Curran SP. Redirection of SKN-1 abates the negative metabolic outcomes of a perceived pathogen infection. Proc Natl Acad Sci U S A. 2019 10 29; 116(44):22322-22330. PMID: 31611372.
      Citations: 38     Fields:    Translation:AnimalsCells
    12. Anderson SM, Cheesman HK, Peterson ND, Salisbury JE, Soukas AA, Pukkila-Worley R. The fatty acid oleate is required for innate immune activation and pathogen defense in Caenorhabditis elegans. PLoS Pathog. 2019 06; 15(6):e1007893. PMID: 31206555.
      Citations: 24     Fields:    Translation:Animals
    13. Deng P, Uma Naresh N, Du Y, Lamech LT, Yu J, Zhu LJ, Pukkila-Worley R, Haynes CM. Mitochondrial UPR repression during Pseudomonas aeruginosa infection requires the bZIP protein ZIP-3. Proc Natl Acad Sci U S A. 2019 03 26; 116(13):6146-6151. PMID: 30850535.
      Citations: 28     Fields:    Translation:AnimalsCells
    14. Peterson ND, Cheesman HK, Liu P, Anderson SM, Foster KJ, Chhaya R, Perrat P, Thekkiniath J, Yang Q, Haynes CM, Pukkila-Worley R. The nuclear hormone receptor NHR-86 controls anti-pathogen responses in C. elegans. PLoS Genet. 2019 01; 15(1):e1007935. PMID: 30668573.
      Citations: 22     Fields:    Translation:AnimalsCells
    15. Ding W, Higgins DP, Yadav DK, Godbole AA, Pukkila-Worley R, Walker AK. Stress-responsive and metabolic gene regulation are altered in low S-adenosylmethionine. PLoS Genet. 2018 11; 14(11):e1007812. PMID: 30485261.
      Citations: 13     Fields:    Translation:AnimalsCells
    16. Peterson ND, Pukkila-Worley R. Caenorhabditis elegans in high-throughput screens for anti-infective compounds. Curr Opin Immunol. 2018 10; 54:59-65. PMID: 29935375.
      Citations: 19     Fields:    Translation:HumansAnimals
    17. Pukkila-Worley R. Surveillance Immunity: An Emerging Paradigm of Innate Defense Activation in Caenorhabditis elegans. PLoS Pathog. 2016 09; 12(9):e1005795. PMID: 27631629.
      Citations: 27     Fields:    Translation:Animals
    18. Cheesman HK, Feinbaum RL, Thekkiniath J, Dowen RH, Conery AL, Pukkila-Worley R. Aberrant Activation of p38 MAP Kinase-Dependent Innate Immune Responses Is Toxic to Caenorhabditis elegans. G3 (Bethesda). 2016 Jan 27; 6(3):541-9. PMID: 26818074.
      Citations: 37     Fields:    Translation:AnimalsCells
    19. Pukkila-Worley R. Case 28-2014: A man with a rash, headache, fever, nausea, and photophobia. N Engl J Med. 2014 12 04; 371(23):2239. PMID: 25470710.
      Citations:    Fields:    Translation:HumansAnimalsCells
    20. Pukkila-Worley R, Nardi V, Branda JA. Case records of the Massachusetts General Hospital. Case 28-2014. A 39-year-old man with a rash, headache, fever, nausea, and photophobia. N Engl J Med. 2014 Sep 11; 371(11):1051-60. PMID: 25207769.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    21. Pukkila-Worley R, Feinbaum RL, McEwan DL, Conery AL, Ausubel FM. The evolutionarily conserved mediator subunit MDT-15/MED15 links protective innate immune responses and xenobiotic detoxification. PLoS Pathog. 2014 May; 10(5):e1004143. PMID: 24875643.
      Citations: 30     Fields:    Translation:AnimalsCells
    22. Tan X, Fuchs BB, Wang Y, Chen W, Yuen GJ, Chen RB, Jayamani E, Anastassopoulou C, Pukkila-Worley R, Coleman JJ, Mylonakis E. The role of Candida albicans SPT20 in filamentation, biofilm formation and pathogenesis. PLoS One. 2014; 9(4):e94468. PMID: 24732310.
      Citations: 20     Fields:    Translation:AnimalsCells
    23. Chan BT, Hohmann E, Barshak MB, Pukkila-Worley R. Treatment of listeriosis in first trimester of pregnancy. Emerg Infect Dis. 2013 May; 19(5):839-41. PMID: 23697599.
      Citations: 4     Fields:    Translation:HumansCells
    24. Uppuluri P, Chaturvedi AK, Jani N, Pukkila-Worley R, Monteagudo C, Mylonakis E, K?hler JR, Lopez Ribot JL. Physiologic expression of the Candida albicans pescadillo homolog is required for virulence in a murine model of hematogenously disseminated candidiasis. Eukaryot Cell. 2012 Dec; 11(12):1552-6. PMID: 23104566.
      Citations: 4     Fields:    Translation:Animals
    25. Pukkila-Worley R, Feinbaum R, Kirienko NV, Larkins-Ford J, Conery AL, Ausubel FM. Stimulation of host immune defenses by a small molecule protects C. elegans from bacterial infection. PLoS Genet. 2012; 8(6):e1002733. PMID: 22719261.
      Citations: 47     Fields:    Translation:AnimalsCells
    26. Pukkila-Worley R, Ausubel FM. Immune defense mechanisms in the Caenorhabditis elegans intestinal epithelium. Curr Opin Immunol. 2012 Feb; 24(1):3-9. PMID: 22236697.
      Citations: 104     Fields:    Translation:AnimalsCells
    27. Pukkila-Worley R, Ausubel FM, Mylonakis E. Candida albicans infection of Caenorhabditis elegans induces antifungal immune defenses. PLoS Pathog. 2011 Jun; 7(6):e1002074. PMID: 21731485.
      Citations: 81     Fields:    Translation:AnimalsCells
    28. Pukkila-Worley R, Mylonakis E. From the outside in and the inside out: Antifungal immune responses in Caenorhabditis elegans. Virulence. 2010 May-Jun; 1(3):111-2. PMID: 21178428.
      Citations: 13     Fields:    Translation:HumansAnimals
    29. Pukkila-Worley R, Peleg AY, Tampakakis E, Mylonakis E. Candida albicans hyphal formation and virulence assessed using a Caenorhabditis elegans infection model. Eukaryot Cell. 2009 Nov; 8(11):1750-8. PMID: 19666778.
      Citations: 99     Fields:    Translation:HumansAnimals
    30. Means TK, Mylonakis E, Tampakakis E, Colvin RA, Seung E, Puckett L, Tai MF, Stewart CR, Pukkila-Worley R, Hickman SE, Moore KJ, Calderwood SB, Hacohen N, Luster AD, El Khoury J. Evolutionarily conserved recognition and innate immunity to fungal pathogens by the scavenger receptors SCARF1 and CD36. J Exp Med. 2009 Mar 16; 206(3):637-53. PMID: 19237602.
      Citations: 123     Fields:    Translation:AnimalsCells
    31. Pukkila-Worley R, Holson E, Wagner F, Mylonakis E. Antifungal drug discovery through the study of invertebrate model hosts. Curr Med Chem. 2009; 16(13):1588-95. PMID: 19442135.
    32. Pukkila-Worley R, Mylonakis E. Epidemiology and management of cryptococcal meningitis: developments and challenges. Expert Opin Pharmacother. 2008 Mar; 9(4):551-60. PMID: 18312157.
      Citations: 32     Fields:    Translation:HumansAnimals
    33. Fraser JA, Huang JC, Pukkila-Worley R, Alspaugh JA, Mitchell TG, Heitman J. Chromosomal translocation and segmental duplication in Cryptococcus neoformans. Eukaryot Cell. 2005 Feb; 4(2):401-6. PMID: 15701802.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    34. Pukkila-Worley R, Gerrald QD, Kraus PR, Boily MJ, Davis MJ, Giles SS, Cox GM, Heitman J, Alspaugh JA. Transcriptional network of multiple capsule and melanin genes governed by the Cryptococcus neoformans cyclic AMP cascade. Eukaryot Cell. 2005 Jan; 4(1):190-201. PMID: 15643074.
      Citations: 101     Fields:    Translation:AnimalsCells
    35. Pukkila-Worley R, Alspaugh JA. Cyclic AMP signaling in Cryptococcus neoformans. FEMS Yeast Res. 2004 Jan; 4(4-5):361-7. PMID: 14734016.
      Citations: 22     Fields:    Translation:AnimalsCells
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