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Jane E. Freedman MD

InstitutionUMass Chan Medical School
AddressUMass Chan Medical School
55 Lake Avenue North
Worcester MA 01655
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    Other Positions
    InstitutionT.H. Chan School of Medicine
    DivisionCardiovascular Medicine

    InstitutionT.H. Chan School of Medicine
    DepartmentRNA Therapeutics Institute

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentInterdisciplinary Graduate Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentMD/PhD Program

    InstitutionMorningside Graduate School of Biomedical Sciences
    DepartmentTranslational Science

    Collapse Biography 
    Collapse education and training
    Yale University, New Haven, CT, United StatesBALiberal Arts
    Tufts University, Medford, MA, United StatesMD

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Amancherla K, Schlendorf KH, Vlasschaert C, Lowery BD, Wells QS, See SB, Zorn E, Colombo PC, Reilly MP, Lindenfeld J, Uriel N, Freedman JE, Shah RV, Moslehi J, Bick AG, Clerkin K. Clonal hematopoiesis of indeterminate potential and outcomes after heart transplantation: A multi-center study. Am J Transplant. 2023 May 06. PMID: 37156299.
      Citations:    Fields:    
    2. Amancherla K, Qin J, Hulke ML, Pfeiffer RD, Agrawal V, Sheng Q, Xu Y, Schlendorf KH, Lindenfeld J, Shah RV, Freedman JE, Tucker NR, Moslehi J. Single-Nuclear RNA Sequencing of Endomyocardial Biopsies Identifies Persistence of Donor-Recipient Chimerism With Distinct Signatures in Severe Cardiac Allograft Vasculopathy. Circ Heart Fail. 2023 01; 16(1):e010119. PMID: 36524467.
      Citations:    Fields:    Translation:Humans
    3. Perry AS, Tanriverdi K, Risitano A, Hwang SJ, Murthy VL, Nayor M, Zhao S, Levy D, Shah RV, Freedman JE. The inflammatory proteome, obesity, and medical weight loss and regain in humans. Obesity (Silver Spring). 2023 01; 31(1):150-158. PMID: 36334095.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    4. Ekiz Kanik F, Celebi I, Sevenler D, Tanriverdi K, Lortlar ?nl? N, Freedman JE, ?nl? MS. Attomolar sensitivity microRNA detection using real-time digital microarrays. Sci Rep. 2022 09 28; 12(1):16220. PMID: 36171215.
      Citations: 1     Fields:    Translation:Humans
    5. Felker GM, Buttrick P, Rosenzweig A, Abel ED, Allen LA, Bristow M, Das S, DeVore AD, Drakos SG, Fang JC, Freedman JE, Hernandez AF, Li DY, McKinsey TA, Newton-Cheh C, Rogers JG, Shah RV, Shah SH, Stehlik J, Selzman CH. Heart Failure Strategically Focused Research Network: Summary of Results and Future Directions. J Am Heart Assoc. 2022 09 20; 11(18):e025517. PMID: 36073647.
      Citations:    Fields:    Translation:Humans
    6. Freedman JE. Moving Forward With Circulation Research. Circ Res. 2022 Jun 24; 131(1):4-5. PMID: 35737756.
      Citations:    Fields:    
    7. Murthy VL, Nayor M, Carnethon M, Reis JP, Lloyd-Jones D, Allen NB, Kitchen R, Piaggi P, Steffen LM, Vasan RS, Freedman JE, Clish CB, Shah RV. Circulating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study. Diabetologia. 2022 04; 65(4):657-674. PMID: 35041022.
      Citations: 1     Fields:    Translation:Humans
    8. Koupenova M, Corkrey HA, Vitseva O, Tanriverdi K, Somasundaran M, Liu P, Soofi S, Bhandari R, Godwin M, Parsi KM, Cousineau A, Maehr R, Wang JP, Cameron SJ, Rade J, Finberg RW, Freedman JE. SARS-CoV-2 Initiates Programmed Cell Death in Platelets. Circ Res. 2021 09 03; 129(6):631-646. PMID: 34293929.
      Citations: 63     Fields:    Translation:HumansCells
    9. Krishnaswamy S, Ageno W, Arabi Y, Barbui T, Cannegieter S, Carrier M, Cleuren AC, Collins P, Panicot-Dubois L, Freedman JE, Freson K, Hogg P, James AH, Kretz CA, Lavin M, Leebeek FWG, Li W, Maas C, Machlus K, Makris M, Martinelli I, Medved L, Neerman-Arbez M, O'Donnell JS, O'Sullivan J, Rajpurkar M, Schroeder V, Spiegel PC, Stanworth SJ, Green L, Undas A. Illustrated State-of-the-Art Capsules of the ISTH 2020 Congress. Res Pract Thromb Haemost. 2021 Jul; 5(5):e12532. PMID: 34296056.
    10. Figtree GA, Broadfoot K, Casadei B, Califf R, Crea F, Drummond GR, Freedman JE, Guzik TJ, Harrison D, Hausenloy DJ, Hill JA, Januzzi JL, Kingwell BA, Lam CSP, MacRae CA, Misselwitz F, Miura T, Ritchie RH, Tomaszewski M, Wu JC, Xiao J, Zannad F. A Call to Action for New Global Approaches to Cardiovascular Disease Drug Solutions. Circulation. 2021 07 13; 144(2):159-169. PMID: 33876947.
      Citations: 8     Fields:    Translation:Humans
    11. Figtree GA, Broadfoot K, Casadei B, Califf R, Crea F, Drummond GR, Freedman JE, Guzik TJ, Harrison D, Hausenloy DJ, Hill JA, Januzzi JL, Kingwell BA, Lam CSP, MacRae CA, Misselwitz F, Miura T, Ritchie RH, Tomaszewski M, Wu JC, Xiao J, Zannad F. A call to action for new global approaches to cardiovascular disease drug solutions. Eur Heart J. 2021 04 14; 42(15):1464-1475. PMID: 33847746.
      Citations: 12     Fields:    Translation:Humans
    12. Singh NS, Lokot M, Undie CC, Onyango MA, Morgan R, Harmer A, Freedman J, Heidari S. Research in forced displacement: guidance for a feminist and decolonial approach. Lancet. 2021 02 13; 397(10274):560-562. PMID: 33581808.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    13. Sahai A, Bhandari R, Koupenova M, Freedman J, Godwin M, McIntyre T, Chung M, Iskandar JP, Kamran H, Aggarwal A, Kalra A, Bartholomew J, McCrae K, Elbadawi A, Svensson L, Kapadia S, Hariri E, Cameron S. SARS-CoV-2 Receptors are Expressed on Human Platelets and the Effect of Aspirin on Clinical Outcomes in COVID-19 Patients. Res Sq. 2020 Dec 23. PMID: 33398263.
    14. Ezzaty Mirhashemi M, Shah RV, Kitchen RR, Rong J, Spahillari A, Pico AR, Vitseva O, Levy D, Demarco D, Shah S, Iafrati MD, Larson MG, Tanriverdi K, Freedman JE. The Dynamic Platelet Transcriptome in Obesity and Weight Loss. Arterioscler Thromb Vasc Biol. 2021 02; 41(2):854-864. PMID: 33297754.
      Citations: 10     Fields:    Translation:HumansCells
    15. Koupenova M, Freedman JE. Platelets and COVID-19: Inflammation, Hyperactivation and Additional Questions. Circ Res. 2020 11 06; 127(11):1419-1421. PMID: 33151798.
      Citations: 19     Fields:    Translation:HumansCellsPHPublic Health
    16. Murthy VL, Reis JP, Pico AR, Kitchen R, Lima JAC, Lloyd-Jones D, Allen NB, Carnethon M, Lewis GD, Nayor M, Vasan RS, Freedman JE, Clish CB, Shah RV. Comprehensive Metabolic Phenotyping Refines Cardiovascular Risk in Young Adults. Circulation. 2020 12; 142(22):2110-2127. PMID: 33073606.
      Citations: 10     Fields:    Translation:Humans
    17. Murthy VL, Yu B, Wang W, Zhang X, Alkis T, Pico AR, Yeri A, Bhupathiraju SN, Bressler J, Ballantyne CM, Freedman JE, Ordovas J, Boerwinkle E, Tucker KL, Shah R. Molecular Signature of Multisystem Cardiometabolic Stress and Its Association With Prognosis. JAMA Cardiol. 2020 10 01; 5(10):1144-1153. PMID: 32717046.
      Citations: 4     Fields:    Translation:Humans
    18. Palace SG, Vitseva O, Proulx MK, Freedman JE, Goguen JD, Koupenova M. Yersinia pestis escapes entrapment in thrombi by targeting platelet function. J Thromb Haemost. 2020 12; 18(12):3236-3248. PMID: 33470041.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Fazzalari A, Basadonna G, Kucukural A, Tanriverdi K, Koupenova M, Pozzi N, Kakuturu J, Friedrich AU, Korstanje R, Fowler N, Belant JL, Beyer DE, Brooks MB, Dickson EW, Blackwood M, Mueller C, Palesty JA, Freedman JE, Cahan MA. A Translational Model for Venous Thromboembolism: MicroRNA Expression in Hibernating Black Bears. J Surg Res. 2021 01; 257:203-212. PMID: 32858321.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    20. Vaze A, Tran KV, Tanriverdi K, Sardana M, Lessard D, Donahue JK, Barton B, Aurigemma G, Lubitz SA, Lin H, Nasr GH, Mandapati A, Benjamin EJ, Vasan RS, Freedman JE, McManus DD. Relations between plasma microRNAs, echocardiographic markers of atrial remodeling, and atrial fibrillation: Data from the Framingham Offspring study. PLoS One. 2020; 15(8):e0236960. PMID: 32813736.
      Citations: 5     Fields:    Translation:Humans
    21. Das S, Shah R, Dimmeler S, Freedman JE, Holley C, Lee JM, Moore K, Musunuru K, Wang DZ, Xiao J, Yin KJ. Noncoding RNAs in Cardiovascular Disease: Current Knowledge, Tools and Technologies for Investigation, and Future Directions: A Scientific Statement From the American Heart Association. Circ Genom Precis Med. 2020 08; 13(4):e000062. PMID: 32812806.
      Citations: 27     Fields:    Translation:Humans
    22. Koupenova M, Freedman JE. Platelets and Immunity: Going Viral. Arterioscler Thromb Vasc Biol. 2020 07; 40(7):1605-1607. PMID: 32579477.
      Citations: 8     Fields:    Translation:Cells
    23. Koupenova M, Mick E, Corkrey HA, Singh A, Tanriverdi SE, Vitseva O, Levy D, Keeler AM, Ezzaty Mirhashemi M, ElMallah MK, Gerstein M, Rozowsky J, Tanriverdi K, Freedman JE. Pollen-derived RNAs Are Found in the Human Circulation. iScience. 2019 Sep 27; 19:916-926. PMID: 31518900.
    24. Tran KV, Majka J, Sanghai S, Sardana M, Lessard D, Milstone Z, Tanriverdi K, Freedman JE, Fitzgibbons TP, McManus D. Micro-RNAs Are Related to Epicardial Adipose Tissue in Participants With Atrial Fibrillation: Data From the MiRhythm Study. Front Cardiovasc Med. 2019; 6:115. PMID: 31475159.
    25. Salinas J, Lin H, Aparico HJ, Huan T, Liu C, Rong J, Beiser A, Himali JJ, Freedman JE, Larson MG, Rosand J, Soreq H, Levy D, Seshadri S. Whole blood microRNA expression associated with stroke: Results from the Framingham Heart Study. PLoS One. 2019; 14(8):e0219261. PMID: 31393881.
      Citations: 11     Fields:    Translation:HumansCells
    26. Huan T, Mendelson M, Joehanes R, Yao C, Liu C, Song C, Bhattacharya A, Rong J, Tanriverdi K, Keefe J, Murabito JM, Courchesne P, Larson MG, Freedman JE, Levy D. Epigenome-wide association study of DNA methylation and microRNA expression highlights novel pathways for human complex traits. Epigenetics. 2020 Jan - Feb; 15(1-2):183-198. PMID: 31282290.
      Citations: 7     Fields:    Translation:HumansCells
    27. Freedman JE. Circulation Research. Circ Res. 2019 06 21; 125(1):5-6. PMID: 31219737.
      Citations:    Fields:    
    28. Tran KV, Tanriverdi K, Aurigemma GP, Lessard D, Sardana M, Parker M, Shaikh A, Gottbrecht M, Milstone Z, Tanriverdi S, Vitseva O, Keaney JF, Kiefe CI, McManus DD, Freedman JE. Circulating extracellular RNAs, myocardial remodeling, and heart failure in patients with acute coronary syndrome. J Clin Transl Res. 2019 Sep 08; 5(1):33-43. PMID: 31579840.
    29. Freedman JE, Trivedi CM. The Adverse Vascular Effects of E-Cigarettes: Smoke Without the Fire. J Am Coll Cardiol. 2019 06 04; 73(21):2738-2739. PMID: 31146819.
      Citations:    Fields:    Translation:HumansCells
    30. McAnena P, Tanriverdi K, Curran C, Gilligan K, Freedman JE, Brown JAL, Kerin MJ. Circulating microRNAs miR-331 and miR-195 differentiate local luminal a from metastatic breast cancer. BMC Cancer. 2019 May 10; 19(1):436. PMID: 31077182.
      Citations: 34     Fields:    Translation:HumansCells
    31. Koupenova M, Corkrey HA, Vitseva O, Manni G, Pang CJ, Clancy L, Yao C, Rade J, Levy D, Wang JP, Finberg RW, Kurt-Jones EA, Freedman JE. The role of platelets in mediating a response to human influenza infection. Nat Commun. 2019 04 16; 10(1):1780. PMID: 30992428.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    32. Shah R, Murthy V, Freedman JE. Nuts, Cardiovascular Health, and Diabetes. Circ Res. 2019 03 15; 124(6):825-826. PMID: 30870120.
      Citations:    Fields:    Translation:Humans
    33. Shah RV, Hwang SJ, Yeri A, Tanriverdi K, Pico AR, Yao C, Murthy V, Ho J, Vitseva O, Demarco D, Shah S, Iafrati MD, Levy D, Freedman JE. Proteins Altered by Surgical Weight Loss Highlight Biomarkers of Insulin Resistance in the Community. Arterioscler Thromb Vasc Biol. 2019 01; 39(1):107-115. PMID: 30580566.
      Citations: 13     Fields:    Translation:Humans
    34. Narla V, Bhakta N, Freedman JE, Tanriverdi K, Maka K, Deeks SG, Ganz P, Hsue P. Unique Circulating MicroRNA Profiles in HIV Infection. J Acquir Immune Defic Syndr. 2018 12 15; 79(5):644-650. PMID: 30204717.
      Citations: 13     Fields:    Translation:Humans
    35. Shah R, Patel T, Freedman JE. Circulating Extracellular Vesicles in Human Disease. N Engl J Med. 2018 11 29; 379(22):2180-2181. PMID: 30485772.
      Citations: 34     Fields:    Translation:HumansCells
    36. Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Hoen ENMN, Jiang H, Wang K, Ghiran I, Wang YE, Keuren-Jensen KV, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. Erratum: Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 09 06; 36(9):899. PMID: 30188530.
      Citations: 3     Fields:    
    37. Shah R, Patel T, Freedman JE. Circulating Extracellular Vesicles in Human Disease. N Engl J Med. 2018 Sep 06; 379(10):958-966. PMID: 30184457.
      Citations: 244     Fields:    Translation:HumansCells
    38. Shah RV, Rong J, Larson MG, Yeri A, Ziegler O, Tanriverdi K, Murthy V, Liu X, Xiao C, Pico AR, Huan T, Levy D, Lewis GD, Rosenzweig A, Vasan RS, Das S, Freedman JE. Associations of Circulating Extracellular RNAs With Myocardial Remodeling and Heart Failure. JAMA Cardiol. 2018 09 01; 3(9):871-876. PMID: 30090932.
      Citations: 17     Fields:    Translation:Humans
    39. Giraldez MD, Spengler RM, Etheridge A, Godoy PM, Barczak AJ, Srinivasan S, De Hoff PL, Tanriverdi K, Courtright A, Lu S, Khoory J, Rubio R, Baxter D, Driedonks TAP, Buermans HPJ, Nolte-'t Hoen ENM, Jiang H, Wang K, Ghiran I, Wang YE, Van Keuren-Jensen K, Freedman JE, Woodruff PG, Laurent LC, Erle DJ, Galas DJ, Tewari M. Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling. Nat Biotechnol. 2018 09; 36(8):746-757. PMID: 30010675.
      Citations: 73     Fields:    Translation:HumansCells
    40. Danielson KM, Shah R, Yeri A, Liu X, Camacho Garcia F, Silverman M, Tanriverdi K, Das A, Xiao C, Jerosch-Herold M, Heydari B, Abbasi S, Van Keuren-Jensen K, Freedman JE, Wang YE, Rosenzweig A, Kwong RY, Das S. Plasma Circulating Extracellular RNAs in Left Ventricular Remodeling Post-Myocardial Infarction. EBioMedicine. 2018 Jun; 32:172-181. PMID: 29779700.
      Citations: 32     Fields:    Translation:HumansCellsCTClinical Trials
    41. Koupenova M, Mick E, Corkrey HA, Huan T, Clancy L, Shah R, Benjamin EJ, Levy D, Kurt-Jones EA, Tanriverdi K, Freedman JE. Micro RNAs from DNA Viruses are Found Widely in Plasma in a Large Observational Human Population. Sci Rep. 2018 04 23; 8(1):6397. PMID: 29686252.
      Citations: 3     Fields:    Translation:HumansCells
    42. Koupenova M, Clancy L, Corkrey HA, Freedman JE. Circulating Platelets as Mediators of Immunity, Inflammation, and Thrombosis. Circ Res. 2018 01 19; 122(2):337-351. PMID: 29348254.
      Citations: 277     Fields:    Translation:HumansAnimalsCells
    43. Shah RV, Yeri AS, Murthy VL, Massaro JM, D'Agostino R, Freedman JE, Long MT, Fox CS, Das S, Benjamin EJ, Vasan RS, O'Donnell CJ, Hoffmann U. Association of Multiorgan Computed Tomographic Phenomap With Adverse Cardiovascular Health Outcomes: The Framingham Heart Study. JAMA Cardiol. 2017 11 01; 2(11):1236-1246. PMID: 28975197.
      Citations: 7     Fields:    Translation:Humans
    44. Huan T, Chen G, Liu C, Bhattacharya A, Rong J, Chen BH, Seshadri S, Tanriverdi K, Freedman JE, Larson MG, Murabito JM, Levy D. Age-associated microRNA expression in human peripheral blood is associated with all-cause mortality and age-related traits. Aging Cell. 2018 02; 17(1). PMID: 29044988.
      Citations: 53     Fields:    Translation:HumansCells
    45. Willinger CM, Rong J, Tanriverdi K, Courchesne PL, Huan T, Wasserman GA, Lin H, Dupuis J, Joehanes R, Jones MR, Chen G, Benjamin EJ, O'Connor GT, Mizgerd JP, Freedman JE, Larson MG, Levy D. MicroRNA Signature of Cigarette Smoking and Evidence for a Putative Causal Role of MicroRNAs in Smoking-Related Inflammation and Target Organ Damage. Circ Cardiovasc Genet. 2017 Oct; 10(5). PMID: 29030400.
      Citations: 24     Fields:    Translation:HumansCells
    46. Shah R, Yeri A, Das A, Courtright-Lim A, Ziegler O, Gervino E, Ocel J, Quintero-Pinzon P, Wooster L, Bailey CS, Tanriverdi K, Beaulieu LM, Freedman JE, Ghiran I, Lewis GD, Van Keuren-Jensen K, Das S. Small RNA-seq during acute maximal exercise reveal RNAs involved in vascular inflammation and cardiometabolic health: brief report. Am J Physiol Heart Circ Physiol. 2017 Dec 01; 313(6):H1162-H1167. PMID: 28916639.
      Citations: 20     Fields:    Translation:HumansAnimals
    47. Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK. Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets. Cardiovasc Res. 2017 Sep 01; 113(11):1307-1317. PMID: 28430966.
      Citations: 11     Fields:    Translation:AnimalsCells
    48. Liaw L, Freedman JE, Becker LB, Mehta NN, Liscum L. Peer Review Practices for Evaluating Biomedical Research Grants: A Scientific Statement From the American Heart Association. Circ Res. 2017 Aug 04; 121(4):e9-e19. PMID: 28684631.
      Citations: 2     Fields:    Translation:Humans
    49. Murabito JM, Rong J, Lunetta KL, Huan T, Lin H, Zhao Q, Freedman JE, Tanriverdi K, Levy D, Larson MG. Cross-sectional relations of whole-blood miRNA expression levels and hand grip strength in a community sample. Aging Cell. 2017 08; 16(4):888-894. PMID: 28597569.
      Citations: 8     Fields:    Translation:Humans
    50. Shah RV, Spahillari A, Mwasongwe S, Carr JJ, Terry JG, Mentz RJ, Addison D, Hoffmann U, Reis J, Freedman JE, Lima JAC, Correa A, Murthy VL. Subclinical Atherosclerosis, Statin Eligibility, and Outcomes in African American Individuals: The Jackson Heart Study. JAMA Cardiol. 2017 06 01; 2(6):644-652. PMID: 28315622.
      Citations: 12     Fields:    Translation:Humans
    51. Yao C, Joehanes R, Johnson AD, Huan T, Liu C, Freedman JE, Munson PJ, Hill DE, Vidal M, Levy D. Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet. 2017 06 01; 100(6):985-986. PMID: 28575653.
      Citations: 9     Fields:    
    52. Koupenova M, Kehrel BE, Corkrey HA, Freedman JE. Thrombosis and platelets: an update. Eur Heart J. 2017 Mar 14; 38(11):785-791. PMID: 28039338.
      Citations: 134     Fields:    Translation:HumansCells
    53. Mick E, Shah R, Tanriverdi K, Murthy V, Gerstein M, Rozowsky J, Kitchen R, Larson MG, Levy D, Freedman JE. Stroke and Circulating Extracellular RNAs. Stroke. 2017 04; 48(4):828-834. PMID: 28289238.
      Citations: 19     Fields:    Translation:Humans
    54. Clancy L, Beaulieu LM, Tanriverdi K, Freedman JE. The role of RNA uptake in platelet heterogeneity. Thromb Haemost. 2017 05 03; 117(5):948-961. PMID: 28276570.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    55. Yao C, Joehanes R, Johnson AD, Huan T, Liu C, Freedman JE, Munson PJ, Hill DE, Vidal M, Levy D. Dynamic Role of trans Regulation of Gene Expression in Relation to Complex Traits. Am J Hum Genet. 2017 Apr 06; 100(4):571-580. PMID: 28285768.
      Citations: 39     Fields:    Translation:Humans
    56. Shah R, Murthy V, Pacold M, Danielson K, Tanriverdi K, Larson MG, Hanspers K, Pico A, Mick E, Reis J, de Ferranti S, Freinkman E, Levy D, Hoffmann U, Osganian S, Das S, Freedman JE. Extracellular RNAs Are Associated With Insulin Resistance and Metabolic Phenotypes. Diabetes Care. 2017 Apr; 40(4):546-553. PMID: 28183786.
      Citations: 33     Fields:    Translation:Humans
    57. McManus DD, Rong J, Huan T, Lacey S, Tanriverdi K, Munson PJ, Larson MG, Joehanes R, Murthy V, Shah R, Freedman JE, Levy D. Messenger RNA and MicroRNA transcriptomic signatures of cardiometabolic risk factors. BMC Genomics. 2017 02 08; 18(1):139. PMID: 28178938.
      Citations: 23     Fields:    Translation:HumansCells
    58. Spahillari A, Talegawkar S, Correa A, Carr JJ, Terry JG, Lima J, Freedman JE, Das S, Kociol R, de Ferranti S, Mohebali D, Mwasongwe S, Tucker KL, Murthy VL, Shah RV. Ideal Cardiovascular Health, Cardiovascular Remodeling, and Heart Failure in Blacks: The Jackson Heart Study. Circ Heart Fail. 2017 Feb; 10(2). PMID: 28209767.
      Citations: 29     Fields:    Translation:Humans
    59. Joehanes R, Zhang X, Huan T, Yao C, Ying SX, Nguyen QT, Demirkale CY, Feolo ML, Sharopova NR, Sturcke A, Sch?ffer AA, Heard-Costa N, Chen H, Liu PC, Wang R, Woodhouse KA, Tanriverdi K, Freedman JE, Raghavachari N, Dupuis J, Johnson AD, O'Donnell CJ, Levy D, Munson PJ. Integrated genome-wide analysis of expression quantitative trait loci aids interpretation of genomic association studies. Genome Biol. 2017 01 25; 18(1):16. PMID: 28122634.
      Citations: 97     Fields:    Translation:HumansCells
    60. Freedman JE, Miano JM. Challenges and Opportunities in Linking Long Noncoding RNAs to Cardiovascular, Lung, and Blood Diseases. Arterioscler Thromb Vasc Biol. 2017 01; 37(1):21-25. PMID: 27856459.
      Citations: 27     Fields:    Translation:HumansAnimals
    61. Shah R, Pico AR, Freedman JE. Translational Epidemiology: Entering a Brave New World of Team Science. Circ Res. 2016 10 28; 119(10):1060-1062. PMID: 27789584.
      Citations: 1     Fields:    Translation:Humans
    62. Murthy VL, Abbasi SA, Siddique J, Colangelo LA, Reis J, Venkatesh BA, Carr JJ, Terry JG, Camhi SM, Jerosch-Herold M, de Ferranti S, Das S, Freedman J, Carnethon MR, Lewis CE, Lima JA, Shah RV. Transitions in Metabolic Risk and Long-Term Cardiovascular Health: Coronary Artery Risk Development in Young Adults (CARDIA) Study. J Am Heart Assoc. 2016 10 13; 5(10). PMID: 27737876.
      Citations: 19     Fields:    Translation:Humans
    63. Barik A, Shah RV, Spahillari A, Murthy VL, Ambale-Venkatesh B, Rai RK, Das K, Santra A, Hembram JR, Bhattacharya D, Freedman JE, Lima J, Das R, Bhattacharyya P, Das S, Chowdhury A. Hepatic steatosis is associated with cardiometabolic risk in a rural Indian population: A prospective cohort study. Int J Cardiol. 2016 Dec 15; 225:161-166. PMID: 27723535.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    64. Das A, Ambale-Venkatesh B, Lima JA, Freedman JE, Spahillari A, Das R, Das S, Shah RV, Murthy VL. Cardiometabolic disease in South Asians: A global health concern in an expanding population. Nutr Metab Cardiovasc Dis. 2017 01; 27(1):32-40. PMID: 27612985.
      Citations: 7     Fields:    Translation:Humans
    65. Freedman JE, Gerstein M, Mick E, Rozowsky J, Levy D, Kitchen R, Das S, Shah R, Danielson K, Beaulieu L, Navarro FC, Wang Y, Galeev TR, Holman A, Kwong RY, Murthy V, Tanriverdi SE, Koupenova M, Mikhalev E, Tanriverdi K. Corrigendum: Diverse human extracellular RNAs are widely detected in human plasma. Nat Commun. 2016 06 03; 7:11902. PMID: 27255613.
      Citations: 3     Fields:    
    66. Shah R, Tanriverdi K, Levy D, Larson M, Gerstein M, Mick E, Rozowsky J, Kitchen R, Murthy V, Mikalev E, Freedman JE. Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources. PLoS One. 2016; 11(4):e0153691. PMID: 27123852.
      Citations: 16     Fields:    Translation:Humans
    67. Freedman JE, Gerstein M, Mick E, Rozowsky J, Levy D, Kitchen R, Das S, Shah R, Danielson K, Beaulieu L, Navarro FC, Wang Y, Galeev TR, Holman A, Kwong RY, Murthy V, Tanriverdi SE, Koupenova-Zamor M, Mikhalev E, Tanriverdi K. Diverse human extracellular RNAs are widely detected in human plasma. Nat Commun. 2016 Apr 26; 7:11106. PMID: 27112789.
      Citations: 104     Fields:    Translation:Humans
    68. Tanriverdi K, Kucukural A, Mikhalev E, Tanriverdi SE, Lee R, Ambros VR, Freedman JE. Comparison of RNA isolation and associated methods for extracellular RNA detection by high-throughput quantitative polymerase chain reaction. Anal Biochem. 2016 May 15; 501:66-74. PMID: 26969789.
      Citations: 13     Fields:    Translation:Humans
    69. Beaulieu LM, Vitseva O, Tanriverdi K, Kucukural A, Mick E, Hamburg N, Vita J, Freedman JE. Platelet functional and transcriptional changes induced by intralipid infusion. Thromb Haemost. 2016 06 02; 115(6):1147-56. PMID: 26940969.
      Citations: 3     Fields:    Translation:HumansCells
    70. Clancy L, Freedman JE. Blood-Derived Extracellular RNA and Platelet Pathobiology: Adding Pieces to a Complex Circulating Puzzle. Circ Res. 2016 Feb 05; 118(3):374-6. PMID: 26846635.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    71. Eicher JD, Wakabayashi Y, Vitseva O, Esa N, Yang Y, Zhu J, Freedman JE, McManus DD, Johnson AD. Characterization of the platelet transcriptome by RNA sequencing in patients with acute myocardial infarction. Platelets. 2016; 27(3):230-9. PMID: 26367242.
      Citations: 62     Fields:    Translation:HumansCells
    72. Quinn JF, Patel T, Wong D, Das S, Freedman JE, Laurent LC, Carter BS, Hochberg F, Van Keuren-Jensen K, Huentelman M, Spetzler R, Kalani MY, Arango J, Adelson PD, Weiner HL, Gandhi R, Goilav B, Putterman C, Saugstad JA. Extracellular RNAs: development as biomarkers of human disease. J Extracell Vesicles. 2015; 4:27495. PMID: 26320940.
      Citations: 46     Fields:    
    73. Laurent LC, Abdel-Mageed AB, Adelson PD, Arango J, Balaj L, Breakefield X, Carlson E, Carter BS, Majem B, Chen CC, Cocucci E, Danielson K, Courtright A, Das S, Abd Elmageed ZY, Enderle D, Ezrin A, Ferrer M, Freedman J, Galas D, Gandhi R, Huentelman MJ, Van Keuren-Jensen K, Kalani Y, Kim Y, Krichevsky AM, Lai C, Lal-Nag M, Laurent CD, Leonardo T, Li F, Malenica I, Mondal D, Nejad P, Patel T, Raffai RL, Rubio R, Skog J, Spetzler R, Sun J, Tanriverdi K, Vickers K, Wang L, Wang Y, Wei Z, Weiner HL, Wong D, Yan IK, Yeri A, Gould S. Meeting report: discussions and preliminary findings on extracellular RNA measurement methods from laboratories in the NIH Extracellular RNA Communication Consortium. J Extracell Vesicles. 2015; 4:26533. PMID: 26320937.
      Citations: 34     Fields:    
    74. McManus DD, Freedman JE. MicroRNAs in platelet function and cardiovascular disease. Nat Rev Cardiol. 2015 Dec; 12(12):711-7. PMID: 26149483.
      Citations: 47     Fields:    Translation:HumansCells
    75. Beaulieu LM, Clancy L, Tanriverdi K, Benjamin EJ, Kramer CD, Weinberg EO, He X, Mekasha S, Mick E, Ingalls RR, Genco CA, Freedman JE. Specific Inflammatory Stimuli Lead to Distinct Platelet Responses in Mice and Humans. PLoS One. 2015; 10(7):e0131688. PMID: 26148065.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    76. Clancy L, Freedman JE. The role of circulating platelet transcripts. J Thromb Haemost. 2015 Jun; 13 Suppl 1:S33-9. PMID: 26149043.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    77. Huan T, Rong J, Liu C, Zhang X, Tanriverdi K, Joehanes R, Chen BH, Murabito JM, Yao C, Courchesne P, Munson PJ, O'Donnell CJ, Cox N, Johnson AD, Larson MG, Levy D, Freedman JE. Genome-wide identification of microRNA expression quantitative trait loci. Nat Commun. 2015 Mar 20; 6:6601. PMID: 25791433.
      Citations: 76     Fields:    Translation:HumansCells
    78. Huan T, Rong J, Tanriverdi K, Meng Q, Bhattacharya A, McManus DD, Joehanes R, Assimes TL, McPherson R, Samani NJ, Erdmann J, Schunkert H, Courchesne P, Munson PJ, Johnson AD, O'Donnell CJ, Zhang B, Larson MG, Freedman JE, Levy D, Yang X. Dissecting the roles of microRNAs in coronary heart disease via integrative genomic analyses. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):1011-21. PMID: 25657313.
      Citations: 29     Fields:    Translation:Humans
    79. Koupenova M, Mick E, Mikhalev E, Benjamin EJ, Tanriverdi K, Freedman JE. Sex differences in platelet toll-like receptors and their association with cardiovascular risk factors. Arterioscler Thromb Vasc Biol. 2015 Apr; 35(4):1030-7. PMID: 25657311.
      Citations: 55     Fields:    Translation:HumansCells
    80. Koupenova M, Freedman JE. Platelets: the unsung hero of the immune response. J Thromb Haemost. 2015 Feb; 13(2):268-70. PMID: 25471925.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    81. Kramer CD, Weinberg EO, Gower AC, He X, Mekasha S, Slocum C, Beaulieu LM, Wetzler L, Alekseyev Y, Gibson FC, Freedman JE, Ingalls RR, Genco CA. Distinct gene signatures in aortic tissue from ApoE-/- mice exposed to pathogens or Western diet. BMC Genomics. 2014 Dec 24; 15:1176. PMID: 25540039.
      Citations: 6     Fields:    Translation:AnimalsCells
    82. Yao C, Chen BH, Joehanes R, Otlu B, Zhang X, Liu C, Huan T, Tastan O, Cupples LA, Meigs JB, Fox CS, Freedman JE, Courchesne P, O'Donnell CJ, Munson PJ, Keles S, Levy D. Integromic analysis of genetic variation and gene expression identifies networks for cardiovascular disease phenotypes. Circulation. 2015 Feb 10; 131(6):536-49. PMID: 25533967.
      Citations: 35     Fields:    Translation:Humans
    83. McManus DD, Tanriverdi K, Lin H, Esa N, Kinno M, Mandapati D, Tam S, Okike ON, Ellinor PT, Keaney JF, Donahue JK, Benjamin EJ, Freedman JE. Plasma microRNAs are associated with atrial fibrillation and change after catheter ablation (the miRhythm study). Heart Rhythm. 2015 Jan; 12(1):3-10. PMID: 25257092.
      Citations: 53     Fields:    Translation:Humans
    84. Freedman JE, Gersh BJ. Atrial fibrillation and stroke prevention in aging patients: what's good can be even better. Circulation. 2014 Jul 08; 130(2):129-31. PMID: 24895453.
      Citations: 9     Fields:    Translation:Humans
    85. Freedman JE. Inherited dysfunctional nitric oxide signaling and the pathobiology of atherothrombotic disease. Circ Res. 2014 Apr 25; 114(9):1372-3. PMID: 24763461.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    86. Koupenova M, Vitseva O, MacKay CR, Beaulieu LM, Benjamin EJ, Mick E, Kurt-Jones EA, Ravid K, Freedman JE. Platelet-TLR7 mediates host survival and platelet count during viral infection in the absence of platelet-dependent thrombosis. Blood. 2014 Jul 31; 124(5):791-802. PMID: 24755410.
      Citations: 119     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    87. Beaulieu LM, Lin E, Mick E, Koupenova M, Weinberg EO, Kramer CD, Genco CA, Tanriverdi K, Larson MG, Benjamin EJ, Freedman JE. Interleukin 1 receptor 1 and interleukin 1? regulate megakaryocyte maturation, platelet activation, and transcript profile during inflammation in mice and humans. Arterioscler Thromb Vasc Biol. 2014 Mar; 34(3):552-64. PMID: 24458711.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    88. McManus DD, Lin H, Tanriverdi K, Quercio M, Yin X, Larson MG, Ellinor PT, Levy D, Freedman JE, Benjamin EJ. Relations between circulating microRNAs and atrial fibrillation: data from the Framingham Offspring Study. Heart Rhythm. 2014 Apr; 11(4):663-9. PMID: 24444445.
      Citations: 47     Fields:    Translation:Humans
    89. Clancy L, Freedman JE. New paradigms in thrombosis: novel mediators and biomarkers platelet RNA transfer. J Thromb Thrombolysis. 2014 Jan; 37(1):12-6. PMID: 24163053.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    90. Yao C, Joehanes R, Johnson AD, Huan T, Esko T, Ying S, Freedman JE, Murabito J, Lunetta KL, Metspalu A, Munson PJ, Levy D. Sex- and age-interacting eQTLs in human complex diseases. Hum Mol Genet. 2014 Apr 01; 23(7):1947-56. PMID: 24242183.
      Citations: 35     Fields:    Translation:Humans
    91. Ward JA, Esa N, Pidikiti R, Freedman JE, Keaney JF, Tanriverdi K, Vitseva O, Ambros V, Lee R, McManus DD. Circulating Cell and Plasma microRNA Profiles Differ between Non-ST-Segment and ST-Segment-Elevation Myocardial Infarction. Fam Med Med Sci Res. 2013 Oct 01; 2(2):108. PMID: 24432306.
    92. Zhang X, Johnson AD, Hendricks AE, Hwang SJ, Tanriverdi K, Ganesh SK, Smith NL, Peyser PA, Freedman JE, O'Donnell CJ. Genetic associations with expression for genes implicated in GWAS studies for atherosclerotic cardiovascular disease and blood phenotypes. Hum Mol Genet. 2014 Feb 01; 23(3):782-95. PMID: 24057673.
      Citations: 29     Fields:    Translation:HumansCells
    93. McManus DD, Beaulieu LM, Mick E, Tanriverdi K, Larson MG, Keaney JF, Benjamin EJ, Freedman JE. Relationship among circulating inflammatory proteins, platelet gene expression, and cardiovascular risk. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2666-73. PMID: 23968978.
      Citations: 29     Fields:    Translation:HumansCells
    94. Arora P, Wu C, Khan AM, Bloch DB, Davis-Dusenbery BN, Ghorbani A, Spagnolli E, Martinez A, Ryan A, Tainsh LT, Kim S, Rong J, Huan T, Freedman JE, Levy D, Miller KK, Hata A, Del Monte F, Vandenwijngaert S, Swinnen M, Janssens S, Holmes TM, Buys ES, Bloch KD, Newton-Cheh C, Wang TJ. Atrial natriuretic peptide is negatively regulated by microRNA-425. J Clin Invest. 2013 Aug; 123(8):3378-82. PMID: 23867623.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    95. Freedman JE, Tanriverdi K. Defining miRNA targets: balancing simplicity with complexity. Circulation. 2013 May 28; 127(21):2075-7. PMID: 23625958.
      Citations: 6     Fields:    Translation:AnimalsCells
    96. Joehanes R, Ying S, Huan T, Johnson AD, Raghavachari N, Wang R, Liu P, Woodhouse KA, Sen SK, Tanriverdi K, Courchesne P, Freedman JE, O'Donnell CJ, Levy D, Munson PJ. Gene expression signatures of coronary heart disease. Arterioscler Thromb Vasc Biol. 2013 Jun; 33(6):1418-26. PMID: 23539218.
      Citations: 68     Fields:    Translation:HumansCells
    97. Johnson AD, Hwang SJ, Voorman A, Morrison A, Peloso GM, Hsu YH, Thanassoulis G, Newton-Cheh C, Rogers IS, Hoffmann U, Freedman JE, Fox CS, Psaty BM, Boerwinkle E, Cupples LA, O'Donnell CJ. Resequencing and clinical associations of the 9p21.3 region: a comprehensive investigation in the Framingham heart study. Circulation. 2013 Feb 19; 127(7):799-810. PMID: 23315372.
      Citations: 30     Fields:    Translation:HumansCells
    98. Freedman JE, Ercan B, Morin KM, Liu CT, Tamer L, Ayaz L, Kanadasi M, Cicek D, Seyhan AI, Akilli RE, Camci C, Cengiz B, Oztuzcu S, Tanriverdi K. The distribution of circulating microRNA and their relation to coronary disease. F1000Res. 2012; 1:50. PMID: 24358814.
      Citations: 22     Fields:    
    99. Risitano A, Beaulieu LM, Vitseva O, Freedman JE. Platelets and platelet-like particles mediate intercellular RNA transfer. Blood. 2012 Jun 28; 119(26):6288-95. PMID: 22596260.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    100. Freedman JE. Appreciating and mitigating bleeding risk. Circulation. 2012 Apr 10; 125(14):e548-50. PMID: 22492953.
      Citations:    Fields:    Translation:Humans
    101. Rowley JW, Finn AV, French PA, Jennings LK, Bluestein D, Gross PL, Freedman JE, Steinhubl SR, Zimmerman GA, Becker RC, Dauerman HL, Smyth SS. Cardiovascular devices and platelet interactions: understanding the role of injury, flow, and cellular responses. Circ Cardiovasc Interv. 2012 Apr; 5(2):296-304. PMID: 22511738.
      Citations: 3     Fields:    Translation:HumansAnimals
    102. Freedman JE. A platelet transcriptome revolution. Blood. 2011 Oct 06; 118(14):3760-1. PMID: 21980048.
      Citations: 6     Fields:    
    103. Beaulieu LM, Freedman JE. Inflammation & the platelet histone trap. Blood. 2011 Aug 18; 118(7):1714-5. PMID: 21852442.
      Citations: 6     Fields:    
    104. Farb MG, Bigornia S, Mott M, Tanriverdi K, Morin KM, Freedman JE, Joseph L, Hess DT, Apovian CM, Vita JA, Gokce N. Reduced adipose tissue inflammation represents an intermediate cardiometabolic phenotype in obesity. J Am Coll Cardiol. 2011 Jul 12; 58(3):232-7. PMID: 21737012.
      Citations: 51     Fields:    Translation:HumansCells
    105. Beaulieu LM, Lin E, Morin KM, Tanriverdi K, Freedman JE. Regulatory effects of TLR2 on megakaryocytic cell function. Blood. 2011 Jun 02; 117(22):5963-74. PMID: 21454454.
      Citations: 46     Fields:    Translation:AnimalsCells
    106. Tomasson G, Lavalley M, Tanriverdi K, Finkielman JD, Davis JC, Hoffman GS, McCune WJ, St Clair EW, Specks U, Spiera R, Stone JH, Freedman JE, Merkel PA. Relationship between markers of platelet activation and inflammation with disease activity in Wegener's granulomatosis. J Rheumatol. 2011 Jun; 38(6):1048-54. PMID: 21411717.
      Citations: 23     Fields:    Translation:Humans
    107. Gersh BJ, Freedman JE, Granger CB. [Antiplatelet and anticoagulant therapy for stroke prevention in patients with non-valvular atrial fibrillation: evidence based strategies and new developments]. Rev Esp Cardiol. 2011 Apr; 64(4):260-8. PMID: 21411211.
      Citations:    Fields:    Translation:Humans
    108. Freedman JE, Iafrati HF. Use of genetics and transcriptomics in the diagnosis and treatment of coronary artery disease. Rev Esp Cardiol. 2010 Oct; 63(10):1123-6. PMID: 20875351.
      Citations: 1     Fields:    Translation:Humans
    109. Freedman JE, Vitseva O, Tanriverdi K. The role of the blood transcriptome in innate inflammation and stroke. Ann N Y Acad Sci. 2010 Oct; 1207:41-5. PMID: 20955424.
      Citations: 6     Fields:    Translation:HumansAnimals
    110. Cohen LB, Sanyal SM, Von Althann C, Bodian C, Whitson M, Bamji N, Miller KM, Mavronicolas W, Burd S, Freedman J, Aisenberg J. Clinical trial: 2-L polyethylene glycol-based lavage solutions for colonoscopy preparation - a randomized, single-blind study of two formulations. Aliment Pharmacol Ther. 2010 Sep; 32(5):637-44. PMID: 20626383.
      Citations: 15     Fields:    Translation:Humans
    111. Freedman JE, Larson MG, Tanriverdi K, O'Donnell CJ, Morin K, Hakanson AS, Vasan RS, Johnson AD, Iafrati MD, Benjamin EJ. Relation of platelet and leukocyte inflammatory transcripts to body mass index in the Framingham heart study. Circulation. 2010 Jul 13; 122(2):119-29. PMID: 20606121.
      Citations: 61     Fields:    Translation:Cells
    112. Chakrabarti S, Freedman JE. Review: Nutriceuticals as antithrombotic agents. Cardiovasc Ther. 2010 Aug; 28(4):227-35. PMID: 20553290.
      Citations: 5     Fields:    Translation:Humans
    113. Marsk R, N?slund E, Freedman J, Tynelius P, Rasmussen F. Bariatric surgery reduces mortality in Swedish men. Br J Surg. 2010 Jun; 97(6):877-83. PMID: 20309894.
      Citations: 11     Fields:    Translation:Humans
    114. Chakrabarti S, Rizvi M, Morin K, Garg R, Freedman JE. The role of CD40L and VEGF in the modulation of angiogenesis and inflammation. Vascul Pharmacol. 2010 Sep-Oct; 53(3-4):130-7. PMID: 20546942.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    115. Beaulieu LM, Freedman JE. p38: signaling improved platelet storage? Blood. 2010 Mar 04; 115(9):1665-6. PMID: 20203272.
      Citations:    Fields:    
    116. Yang D, Chen H, Koupenova M, Carroll SH, Eliades A, Freedman JE, Toselli P, Ravid K. A new role for the A2b adenosine receptor in regulating platelet function. J Thromb Haemost. 2010 Apr; 8(4):817-27. PMID: 20102488.
      Citations: 34     Fields:    Translation:AnimalsCells
    117. Beaulieu LM, Freedman JE. The role of inflammation in regulating platelet production and function: Toll-like receptors in platelets and megakaryocytes. Thromb Res. 2010 Mar; 125(3):205-9. PMID: 19945154.
      Citations: 32     Fields:    Translation:AnimalsCells
    118. Chakrabarti S, Beaulieu LM, Reyelt LA, Iafrati MD, Freedman JE. M118, a novel low-molecular weight heparin with decreased polydispersity leads to enhanced anticoagulant activity and thrombotic occlusion in ApoE knockout mice. J Thromb Thrombolysis. 2009 Nov; 28(4):394-400. PMID: 19399370.
      Citations:    Fields:    Translation:Animals
    119. Freedman JE, Gersh BJ. New therapies for stroke prevention in atrial fibrillation: the long road to enhanced efficacy. Circulation. 2009 Sep 22; 120(12):1024-6. PMID: 19738132.
      Citations:    Fields:    Translation:Humans
    120. Rex S, Beaulieu LM, Perlman DH, Vitseva O, Blair PS, McComb ME, Costello CE, Freedman JE. Immune versus thrombotic stimulation of platelets differentially regulates signalling pathways, intracellular protein-protein interactions, and alpha-granule release. Thromb Haemost. 2009 Jul; 102(1):97-110. PMID: 19572074.
      Citations: 37     Fields:    Translation:HumansCells
    121. Beaulieu LM, Freedman JE. NFkappaB regulation of platelet function: no nucleus, no genes, no problem? J Thromb Haemost. 2009 Aug; 7(8):1329-32. PMID: 19500240.
      Citations: 6     Fields:    Translation:HumansCells
    122. Faxon DP, Freedman JE. Facts and controversies of aspirin and clopidogrel therapy. Am Heart J. 2009 Mar; 157(3):412-22. PMID: 19249409.
      Citations: 4     Fields:    Translation:HumansCells
    123. Chakrabarti S, Rizvi M, Pathak D, Kirber MT, Freedman JE. Hypoxia influences CD40-CD40L mediated inflammation in endothelial and monocytic cells. Immunol Lett. 2009 Feb 21; 122(2):170-84. PMID: 19187784.
      Citations: 12     Fields:    Translation:HumansCells
    124. Freedman JE, Hylek EM. Clopidogrel, genetics, and drug responsiveness. N Engl J Med. 2009 Jan 22; 360(4):411-3. PMID: 19164193.
      Citations: 13     Fields:    Translation:Humans
    125. Lin E, Freedman JE, Beaulieu LM. Innate immunity and toll-like receptor antagonists: a potential role in the treatment of cardiovascular diseases. Cardiovasc Ther. 2009; 27(2):117-23. PMID: 19426249.
      Citations: 18     Fields:    Translation:HumansAnimals
    126. Blair P, Rex S, Vitseva O, Beaulieu L, Tanriverdi K, Chakrabarti S, Hayashi C, Genco CA, Iafrati M, Freedman JE. Stimulation of Toll-like receptor 2 in human platelets induces a thromboinflammatory response through activation of phosphoinositide 3-kinase. Circ Res. 2009 Feb 13; 104(3):346-54. PMID: 19106411.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    127. Rizvi M, Pathak D, Freedman JE, Chakrabarti S. CD40-CD40 ligand interactions in oxidative stress, inflammation and vascular disease. Trends Mol Med. 2008 Dec; 14(12):530-8. PMID: 18977174.
      Citations: 56     Fields:    Translation:Humans
    128. Keaney JF, Lipinska I, Larson MG, Dupuis J, Freedman JE, Hamburg NM, Massaro JM, Rong J, Sutherland P, Vita JA, Vasan RS, Benjamin EJ. Clinical correlates, heritability, and genetic linkage of circulating CD40 ligand in the Framingham Offspring Study. Am Heart J. 2008 Nov; 156(5):1003-1009.e1. PMID: 19061720.
      Citations: 4     Fields:    Translation:Humans
    129. Tanriverdi K, Freedman JE. Blood and cardiovascular disease: the promise and limitations of gene expression analysis. Circ Cardiovasc Genet. 2008 Oct; 1(1):7-9. PMID: 20031537.
      Citations: 1     Fields:    Translation:Humans
    130. Kleiman NS, Freedman JE, Tracy PB, Furie BC, Bray PF, Rao SV, Phillips DR, Storey RF, Rusconi CP, French PA, Steinhubl SR, Becker RC. Platelets: developmental biology, physiology, and translatable platforms for preclinical investigation and drug development. Platelets. 2008 Jun; 19(4):239-51. PMID: 18569859.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    131. Ector H, Lancellotti P, Roberts WC, Wenger NK, Moss AJ, Smith ER, Borer JS, Eagle KA, Freedman J, Krum H, Lang C, Remme WJ, Piper HM, White CJ, Loscalzo J, Marb?n E, Sobel BE, Roberts R, Rahimtoola SH, Camm AJ, Van de Werf F, Swedberg K, Timmis AD, Stone KS, Zipes DP, Iosselani DG, Taylor AJ, Rosen MR, Grines CL, DeMaria AN, Narula J, King SB, Wagner GS, Saksena S, Pearlman AS, Bodnar E, Emery RW, Cohn LH, van der Wall EE, Abdulla RI, Lesch M, Alfonso F, Ekroth R. A statement on ethics from the HEART Group. JACC Cardiovasc Imaging. 2008 May; 1(3):410-2. PMID: 19356460.
      Citations: 1     Fields:    Translation:Humans
    132. Blair P, Freedman JE. Aspirin resistance in atherosclerosis. Curr Atheroscler Rep. 2008 Apr; 10(2):149-57. PMID: 18417070.
      Citations: 1     Fields:    Translation:HumansCells
    133. Vanichakarn P, Blair P, Wu C, Freedman JE, Chakrabarti S. Neutrophil CD40 enhances platelet-mediated inflammation. Thromb Res. 2008; 122(3):346-58. PMID: 18289643.
      Citations: 27     Fields:    Translation:HumansCells
    134. Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, Freedman J, Gokce N. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring). 2008 May; 16(5):932-7. PMID: 18292749.
      Citations: 91     Fields:    Translation:HumansCells
    135. Chakrabarti S, Freedman JE. Dipyridamole, cerebrovascular disease, and the vasculature. Vascul Pharmacol. 2008 Apr-Jun; 48(4-6):143-9. PMID: 18342579.
      Citations: 18     Fields:    Translation:HumansAnimals
    136. Freedman JE. Oxidative stress and platelets. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):s11-6. PMID: 18174453.
      Citations: 78     Fields:    Translation:Humans
    137. Freedman JE. Promoting ethical conduct in the publication of research. Cardiovasc Ther. 2008; 26(2):89-90. PMID: 18485131.
      Citations: 2     Fields:    Translation:HumansAnimals
    138. Freedman JE. Transcriptomics: new targets for diagnosing and treating cardiovascular disease. Cardiovasc Ther. 2008; 26(3):179-81. PMID: 18786087.
      Citations: 1     Fields:    Translation:Humans
    139. Mutlu A, Allen DJ, Freedman J, Leytin V. The level of matrix metalloproteinase-2 in donor plasma strongly correlates with post-transfusion recovery of stored platelet concentrates. Vox Sang. 2008 Feb; 94(2):143-5. PMID: 18028261.
      Citations:    Fields:    Translation:HumansAnimals
    140. Chakrabarti S, Blair P, Wu C, Freedman JE. Redox state of dipyridamole is a critical determinant for its beneficial antioxidant and antiinflammatory effects. J Cardiovasc Pharmacol. 2007 Oct; 50(4):449-57. PMID: 18049314.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    141. Freedman JE. Heritability, platelet function, and aspirin: a link established but cause unknown. Circulation. 2007 May 15; 115(19):2468-70. PMID: 17502587.
      Citations: 2     Fields:    Translation:HumansCells
    142. Chakrabarti S, Blair P, Freedman JE. CD40-40L signaling in vascular inflammation. J Biol Chem. 2007 Jun 22; 282(25):18307-18317. PMID: 17459878.
      Citations: 30     Fields:    Translation:HumansCells
    143. Leytin V, Allen DJ, Lyubimov E, Freedman J. Higher thrombin concentrations are required to induce platelet apoptosis than to induce platelet activation. Br J Haematol. 2007 Mar; 136(5):762-4. PMID: 17313379.
      Citations: 13     Fields:    Translation:HumansCells
    144. Leung R, Gwozdz AM, Wang H, Bang KW, Packham MA, Freedman J, Rand ML. Persistence of procoagulant surface expression on activated human platelets: involvement of apoptosis and aminophospholipid translocase activity. J Thromb Haemost. 2007 Mar; 5(3):560-70. PMID: 17155950.
      Citations: 8     Fields:    Translation:HumansCells
    145. Schmugge M, Bang KW, Blanchette VS, Albisetti M, Connolly BL, Freedman J, Rand ML. Platelet activation and von Willebrand factor binding to platelets in newborn infants with central venous lines. Acta Haematol. 2007; 117(3):145-8. PMID: 17159336.
      Citations: 1     Fields:    Translation:HumansCells
    146. Tziros C, Freedman JE. The many antithrombotic actions of nitric oxide. Curr Drug Targets. 2006 Oct; 7(10):1243-51. PMID: 17073585.
      Citations: 14     Fields:    Translation:HumansAnimals
    147. Leytin V, Allen DJ, Mykhaylov S, Lyubimov E, Freedman J. Thrombin-triggered platelet apoptosis. J Thromb Haemost. 2006 Dec; 4(12):2656-63. PMID: 16961585.
      Citations: 49     Fields:    Translation:HumansCells
    148. Yang H, Reheman A, Chen P, Zhu G, Hynes RO, Freedman J, Wagner DD, Ni H. Fibrinogen and von Willebrand factor-independent platelet aggregation in vitro and in vivo. J Thromb Haemost. 2006 Oct; 4(10):2230-7. PMID: 16824188.
      Citations: 40     Fields:    Translation:AnimalsCells
    149. Rand ML, Wang H, Bang KW, Packham MA, Freedman J. Rapid clearance of procoagulant platelet-derived microparticles from the circulation of rabbits. J Thromb Haemost. 2006 Jul; 4(7):1621-3. PMID: 16839364.
      Citations: 35     Fields:    Translation:AnimalsCells
    150. Freedman JE. The aspirin resistance controversy: clinical entity or platelet heterogeneity? Circulation. 2006 Jun 27; 113(25):2865-7. PMID: 16801473.
      Citations: 5     Fields:    Translation:HumansCells
    151. Freedman JE. Resistance training: does it alter lytic potential? J Cardiopulm Rehabil. 2006 Mar-Apr; 26(2):84-5. PMID: 16569975.
      Citations:    Fields:    Translation:Humans
    152. Freedman JE. Molecular regulation of platelet-dependent thrombosis. Circulation. 2005 Oct 25; 112(17):2725-34. PMID: 16246969.
      Citations: 25     Fields:    Translation:HumansCells
    153. Vitseva O, Varghese S, Chakrabarti S, Folts JD, Freedman JE. Grape seed and skin extracts inhibit platelet function and release of reactive oxygen intermediates. J Cardiovasc Pharmacol. 2005 Oct; 46(4):445-51. PMID: 16160595.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    154. Mason PJ, Jacobs AK, Freedman JE. Aspirin resistance and atherothrombotic disease. J Am Coll Cardiol. 2005 Sep 20; 46(6):986-93. PMID: 16168280.
      Citations: 37     Fields:    Translation:Humans
    155. Mason PJ, Chakrabarti S, Albers AA, Rex S, Vitseva O, Varghese S, Freedman JE. Plasma, serum, and platelet expression of CD40 ligand in adults with cardiovascular disease. Am J Cardiol. 2005 Nov 15; 96(10):1365-9. PMID: 16275179.
      Citations: 9     Fields:    Translation:HumansCells
    156. Chakrabarti S, Varghese S, Vitseva O, Tanriverdi K, Freedman JE. CD40 ligand influences platelet release of reactive oxygen intermediates. Arterioscler Thromb Vasc Biol. 2005 Nov; 25(11):2428-34. PMID: 16141403.
      Citations: 42     Fields:    Translation:AnimalsCells
    157. Pallikadavath S, Garda L, Apte H, Freedman J, Stones RW. HIV/AIDS in rural India: context and health care needs. J Biosoc Sci. 2005 Sep; 37(5):641-55. PMID: 16174351.
      Citations: 25     Fields:    Translation:Humans
    158. Chakrabarti S, Vitseva O, Iyu D, Varghese S, Freedman JE. The effect of dipyridamole on vascular cell-derived reactive oxygen species. J Pharmacol Exp Ther. 2005 Nov; 315(2):494-500. PMID: 16046616.
      Citations: 15     Fields:    Translation:HumansCells
    159. Reheman A, Gross P, Yang H, Chen P, Allen D, Leytin V, Freedman J, Ni H. Vitronectin stabilizes thrombi and vessel occlusion but plays a dual role in platelet aggregation. J Thromb Haemost. 2005 May; 3(5):875-83. PMID: 15733060.
      Citations: 42     Fields:    Translation:AnimalsCells
    160. Iafrati MD, Vitseva O, Tanriverdi K, Blair P, Rex S, Chakrabarti S, Varghese S, Freedman JE. Compensatory mechanisms influence hemostasis in setting of eNOS deficiency. Am J Physiol Heart Circ Physiol. 2005 Apr; 288(4):H1627-32. PMID: 15563534.
      Citations: 18     Fields:    Translation:AnimalsCells
    161. Albers AR, Varghese S, Vitseva O, Vita JA, Freedman JE. The antiinflammatory effects of purple grape juice consumption in subjects with stable coronary artery disease. Arterioscler Thromb Vasc Biol. 2004 Nov; 24(11):e179-80. PMID: 15528483.
      Citations: 13     Fields:    Translation:HumansAnimalsCTClinical Trials
    162. Vitseva O, Flockhart DA, Jin Y, Varghese S, Freedman JE. The effects of tamoxifen and its metabolites on platelet function and release of reactive oxygen intermediates. J Pharmacol Exp Ther. 2005 Mar; 312(3):1144-50. PMID: 15509721.
      Citations: 10     Fields:    Translation:HumansCells
    163. Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting: Appendix 1: fundamentals of study design. Circulation. 2004 Jun 01; 109(21):e302-4. PMID: 15173052.
      Citations: 2     Fields:    Translation:Humans
    164. Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting. Circulation. 2004 Jun 01; 109(21):2672-9. PMID: 15173050.
      Citations: 12     Fields:    Translation:Humans
    165. Lader EW, Cannon CP, Ohman EM, Newby LK, Sulmasy DP, Barst RJ, Fair JM, Flather M, Freedman JE, Frye RL, Hand MM, Jesse RL, Van de Werf F, Costa F. The clinician as investigator: participating in clinical trials in the practice setting: Appendix 2: statistical concepts in study design and analysis. Circulation. 2004 Jun 01; 109(21):e305-7. PMID: 15173053.
      Citations:    Fields:    Translation:Humans
    166. Nurden AT, Breillat C, Jacquelin B, Combri? R, Freedman J, Blanchette VS, Schmugge M, Rand ML. Triple heterozygosity in the integrin alphaIIb subunit in a patient with Glanzmann's thrombasthenia. J Thromb Haemost. 2004 May; 2(5):813-9. PMID: 15099289.
      Citations: 4     Fields:    Translation:Humans
    167. Rand ML, Wang H, Bang KW, Poon KS, Packham MA, Freedman J. Procoagulant surface exposure and apoptosis in rabbit platelets: association with shortened survival and steady-state senescence. J Thromb Haemost. 2004 Apr; 2(4):651-9. PMID: 15102022.
      Citations: 11     Fields:    Translation:AnimalsCells
    168. Schmugge M, Dunn MS, Amankwah KS, Blanchette VS, Freedman J, Rand ML. The activity of the von Willebrand factor cleaving protease ADAMTS-13 in newborn infants. J Thromb Haemost. 2004 Feb; 2(2):228-33. PMID: 14995983.
      Citations: 5     Fields:    Translation:HumansCells
    169. Urquidi-Macdonald M, Mager DE, Mascelli MA, Frederick B, Freedman J, Fitzgerald DJ, Kleiman NS, Abernethy DR. Abciximab pharmacodynamic model with neural networks used to integrate sources of patient variability. Clin Pharmacol Ther. 2004 Jan; 75(1):60-9. PMID: 14749692.
      Citations: 1     Fields:    Translation:Humans
    170. Chakrabarti S, Clutton P, Varghese S, Cox D, Mascelli MA, Freedman JE. Glycoprotein IIb/IIIa inhibition enhances platelet nitric oxide release. Thromb Res. 2004; 113(3-4):225-33. PMID: 15140587.
      Citations: 3     Fields:    Translation:HumansCells
    171. Mason PJ, Freedman JE, Jacobs AK. Aspirin resistance: current concepts. Rev Cardiovasc Med. 2004; 5(3):156-63. PMID: 15346099.
      Citations: 5     Fields:    Translation:Humans
    172. Clutton P, Miermont A, Freedman JE. Regulation of endogenous reactive oxygen species in platelets can reverse aggregation. Arterioscler Thromb Vasc Biol. 2004 Jan; 24(1):187-92. PMID: 14604832.
      Citations: 14     Fields:    Translation:AnimalsCells
    173. Freedman JE, Loscalzo J. Nitric oxide and its relationship to thrombotic disorders. J Thromb Haemost. 2003 Jun; 1(6):1183-8. PMID: 12871317.
      Citations: 24     Fields:    Translation:HumansCells
    174. Freedman JE. High-fat diets and cardiovascular disease: are nutritional supplements useful? J Am Coll Cardiol. 2003 May 21; 41(10):1750-2. PMID: 12767659.
      Citations: 6     Fields:    Translation:Humans
    175. Freedman JE. CD40-CD40L and platelet function: beyond hemostasis. Circ Res. 2003 May 16; 92(9):944-6. PMID: 12750303.
      Citations: 28     Fields:    Translation:AnimalsCells
    176. Freedman JE. CD40 ligand--assessing risk instead of damage? N Engl J Med. 2003 Mar 20; 348(12):1163-5. PMID: 12646674.
      Citations: 5     Fields:    Translation:Humans
    177. Freedman JE. Nitrated lipids: defining their bioactivity. Circ Res. 2002 Sep 06; 91(5):371-2. PMID: 12215483.
      Citations:    Fields:    Translation:HumansCells
    178. Tanus-Santos JE, Desai M, Deak LR, Pezzullo JC, Abernethy DR, Flockhart DA, Freedman JE. Effects of endothelial nitric oxide synthase gene polymorphisms on platelet function, nitric oxide release, and interactions with estradiol. Pharmacogenetics. 2002 Jul; 12(5):407-13. PMID: 12142730.
      Citations: 17     Fields:    Translation:HumansCells
    179. Freedman JE, Loscalzo J. Platelet-monocyte aggregates: bridging thrombosis and inflammation. Circulation. 2002 May 07; 105(18):2130-2. PMID: 11994242.
      Citations: 63     Fields:    Translation:HumansCells
    180. Abernethy DR, Pezzullo J, Mascelli MA, Frederick B, Kleiman NS, Freedman J. Pharmacodynamics of abciximab during angioplasty: comparison to healthy subjects. Clin Pharmacol Ther. 2002 Mar; 71(3):186-95. PMID: 11907493.
      Citations: 7     Fields:    Translation:Humans
    181. Rand ML, Wang H, Mody M, Chu I, Treutiger I, Nguyen A, Packham MA, Freedman J. Concurrent measurement of the survival of two populations of rabbit platelets labeled with either two PKH lipophilic dyes or two concentrations of biotin. Cytometry. 2002 Feb 01; 47(2):111-7. PMID: 11813201.
      Citations: 4     Fields:    Translation:AnimalsCells
    182. Freedman J, Mascelli MA, Pezzullo JC, Barnathan ES, Frederick B, Jordan RE, Abernethy DR. Pharmacodynamic profile of short-term readministration of abciximab in healthy subjects. Am Heart J. 2002 Jan; 143(1):87-94. PMID: 11773917.
      Citations: 1     Fields:    Translation:Humans
    183. Freedman JE. Antioxidant versus lipid-altering therapy--some answers, more questions. N Engl J Med. 2001 Nov 29; 345(22):1636-7. PMID: 11757512.
      Citations: 1     Fields:    Translation:Humans
    184. Freedman JE. Thrombin, thrombomodulin, and extracellular signal-regulated kinases regulating cellular proliferation. Circ Res. 2001 Apr 13; 88(7):651-3. PMID: 11304485.
      Citations: 1     Fields:    Translation:HumansCells
    185. Laupacis A, Brown J, Costello B, Delage G, Freedman J, Hume H, King S, Kleinman S, Mazzulli T, Wells G. Prevention of posttransfusion CMV in the era of universal WBC reduction: a consensus statement. Transfusion. 2001 Apr; 41(4):560-9. PMID: 11316911.
      Citations: 17     Fields:    Translation:HumansCells
    186. Freedman JE, Keaney JF. Vitamin E inhibition of platelet aggregation is independent of antioxidant activity. J Nutr. 2001 Feb; 131(2):374S-7S. PMID: 11160564.
      Citations: 17     Fields:    Translation:HumansCells
    187. Freedman JE, Li L, Sauter R, Keaney JF JR. alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release. FASEB J. 2000 Dec; 14(15):2377-9. PMID: 11024007.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    188. Leytin V, Mody M, Semple JW, Garvey B, Freedman J. Quantification of platelet activation status by analyzing P-selectin expression. Biochem Biophys Res Commun. 2000 Jul 05; 273(2):565-70. PMID: 10873646.
      Citations: 6     Fields:    Translation:Humans
    189. Song S, Freedman J, Mody M, Lazarus AH. Porcine von Willebrand factor and thrombin induce the activation of c-Jun amino-terminal kinase (JNK/SAPK) whereas only thrombin induces activation of extracellular signal-related kinase 2 (ERK2) in human platelets. Br J Haematol. 2000 Jun; 109(4):851-6. PMID: 10929041.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    190. Leytin V, Mody M, Semple JW, Garvey B, Freedman J. Flow cytometric parameters for characterizing platelet activation by measuring P-selectin (CD62) expression: theoretical consideration and evaluation in thrombin-treated platelet populations. Biochem Biophys Res Commun. 2000 Mar 05; 269(1):85-90. PMID: 10694482.
      Citations: 5     Fields:    Translation:HumansCells
    191. Bang KW, Speck ER, Blanchette VS, Freedman J, Semple JW. Unique processing pathways within recipient antigen-presenting cells determine IgG immunity against donor platelet MHC antigens. Blood. 2000 Mar 01; 95(5):1735-42. PMID: 10688832.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    192. Loscalzo J, Freedman J, Inbal A, Keaney JF, Michelson AD, Vita JA. Nitric oxide insufficiency and arterial thrombosis. Trans Am Clin Climatol Assoc. 2000; 111:158-63. PMID: 10881340.
      Citations: 2     Fields:    Translation:HumansCells
    193. Kenet G, Freedman J, Shenkman B, Regina E, Brok-Simoni F, Holzman F, Vavva F, Brand N, Michelson A, Trolliet M, Loscalzo J, Inbal A. Plasma glutathione peroxidase deficiency and platelet insensitivity to nitric oxide in children with familial stroke. Arterioscler Thromb Vasc Biol. 1999 Aug; 19(8):2017-23. PMID: 10446087.
      Citations: 28     Fields:    Translation:HumansCells
    194. N?slund E, Freedman J, Lagergren J, Stockeld D, Granstr?m L. Three-year results of laparoscopic vertical banded gastroplasty. Obes Surg. 1999 Aug; 9(4):369-73. PMID: 10484295.
      Citations: 8     Fields:    Translation:Humans
    195. Freedman JE, Sauter R, Battinelli EM, Ault K, Knowles C, Huang PL, Loscalzo J. Deficient platelet-derived nitric oxide and enhanced hemostasis in mice lacking the NOSIII gene. Circ Res. 1999 Jun 25; 84(12):1416-21. PMID: 10381894.
      Citations: 63     Fields:    Translation:AnimalsCells
    196. Keaney JF, Simon DI, Freedman JE. Vitamin E and vascular homeostasis: implications for atherosclerosis. FASEB J. 1999 Jun; 13(9):965-75. PMID: 10336880.
      Citations: 16     Fields:    Translation:HumansCells
    197. Mody M, Lazarus AH, Semple JW, Freedman J. Preanalytical requirements for flow cytometric evaluation of platelet activation: choice of anticoagulant. Transfus Med. 1999 Jun; 9(2):147-54. PMID: 10354385.
      Citations: 10     Fields:    Translation:HumansCells
    198. Lieberthal W, Fuhro R, Freedman JE, Toolan G, Loscalzo J, Valeri CR. O-raffinose cross-linking markedly reduces systemic and renal vasoconstrictor effects of unmodified human hemoglobin. J Pharmacol Exp Ther. 1999 Mar; 288(3):1278-87. PMID: 10027869.
      Citations: 5     Fields:    Translation:HumansAnimals
    199. Semple JW, Speck ER, Cosgrave D, Lazarus AH, Blanchette VS, Freedman J. Extreme leukoreduction of major histocompatibility complex class II positive B cells enhances allogeneic platelet immunity. Blood. 1999 Jan 15; 93(2):713-20. PMID: 9885234.
      Citations: 7     Fields:    Translation:AnimalsCells
    200. Freedman JE, Keaney JF. Nitric oxide and superoxide detection in human platelets. Methods Enzymol. 1999; 301:61-70. PMID: 9919554.
      Citations: 3     Fields:    Translation:HumansCells
    201. Ofosu FA, Freedman J, Dewar L, Song Y, Fenton JW. A trypsin-like platelet protease propagates protease-activated receptor-1 cleavage and platelet activation. Biochem J. 1998 Dec 01; 336 ( Pt 2):283-5. PMID: 9820801.
      Citations: 3     Fields:    Translation:Humans
    202. Freedman JE, Ting B, Hankin B, Loscalzo J, Keaney JF, Vita JA. Impaired platelet production of nitric oxide predicts presence of acute coronary syndromes. Circulation. 1998 Oct 13; 98(15):1481-6. PMID: 9769300.
      Citations: 33     Fields:    Translation:HumansCells
    203. Vita JA, Keaney JF, Raby KE, Morrow JD, Freedman JE, Lynch S, Koulouris SN, Hankin BR, Frei B. Low plasma ascorbic acid independently predicts the presence of an unstable coronary syndrome. J Am Coll Cardiol. 1998 Apr; 31(5):980-6. PMID: 9561997.
      Citations: 8     Fields:    Translation:HumansCells
    204. Chang H, Mody M, Lazarus AH, Ofosu F, Garvey MB, Blanchette V, Teitel J, Freedman J. Platelet activation induced by porcine factor VIII (Hyate:C). Am J Hematol. 1998 Mar; 57(3):200-5. PMID: 9495369.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    205. Liu Z, Rudd MA, Freedman JE, Loscalzo J. S-Transnitrosation reactions are involved in the metabolic fate and biological actions of nitric oxide. J Pharmacol Exp Ther. 1998 Feb; 284(2):526-34. PMID: 9454793.
      Citations: 29     Fields:    Translation:AnimalsCells
    206. Lehmann HP, Nguyen B, Freedman J. Delivering labeled teaching images over the Web. Proc AMIA Symp. 1998; 418-22. PMID: 9929253.
      Citations: 5     Fields:    Translation:Humans
    207. Freedman JE, Loscalzo J, Barnard MR, Alpert C, Keaney JF, Michelson AD. Nitric oxide released from activated platelets inhibits platelet recruitment. J Clin Invest. 1997 Jul 15; 100(2):350-6. PMID: 9218511.
      Citations: 56     Fields:    Translation:HumansCells
    208. Upchurch GR, Welch GN, Fabian AJ, Freedman JE, Johnson JL, Keaney JF, Loscalzo J. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione peroxidase. J Biol Chem. 1997 Jul 04; 272(27):17012-7. PMID: 9202015.
      Citations: 117     Fields:    Translation:AnimalsCells
    209. Semple JW, Siminovitch KA, Mody M, Milev Y, Lazarus AH, Wright JF, Freedman J. Flow cytometric analysis of platelets from children with the Wiskott-Aldrich syndrome reveals defects in platelet development, activation and structure. Br J Haematol. 1997 Jun; 97(4):747-54. PMID: 9217172.
      Citations: 17     Fields:    Translation:HumansCells
    210. Upchurch GR, Welch GN, Freedman JE, Fabian AJ, Pigazzi A, Scribner AM, Alpert CS, Keaney JF, Loscalzo J. High-dose heparin decreases nitric oxide production by cultured bovine endothelial cells. Circulation. 1997 Apr 15; 95(8):2115-21. PMID: 9133522.
      Citations: 4     Fields:    Translation:AnimalsCells
    211. Freedman JE, Loscalzo J. Endothelial dysfunction and atherothrombotic occlusive disease. Drugs. 1997; 54 Suppl 3:41-9; discussion 49-50. PMID: 9360851.
      Citations: 1     Fields:    Translation:HumansAnimals
    212. K?hne T, Freedman J, Semple JW, Doyle J, Butchart S, Blanchette VS. Platelet and immune responses to oral cyclic dexamethasone therapy in childhood chronic immune thrombocytopenic purpura. J Pediatr. 1997 Jan; 130(1):17-24. PMID: 9003846.
      Citations: 7     Fields:    Translation:HumansCellsCTClinical Trials
    213. K?hne T, Ryan G, Blanchette V, Semple JW, Hornstein A, Mody M, Chang W, McWhirter L, Freedman J. Platelet-surface glycoproteins in healthy and preeclamptic mothers and their newborn infants. Pediatr Res. 1996 Dec; 40(6):876-80. PMID: 8947966.
      Citations: 4     Fields:    Translation:HumansCells
    214. Freedman JE, Farhat JH, Loscalzo J, Keaney JF. alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation. 1996 Nov 15; 94(10):2434-40. PMID: 8921785.
      Citations: 49     Fields:    Translation:HumansCells
    215. Semple JW, Milev Y, Cosgrave D, Mody M, Hornstein A, Blanchette V, Freedman J. Differences in serum cytokine levels in acute and chronic autoimmune thrombocytopenic purpura: relationship to platelet phenotype and antiplatelet T-cell reactivity. Blood. 1996 May 15; 87(10):4245-54. PMID: 8639783.
      Citations: 71     Fields:    Translation:HumansCells
    216. Freedman JE, Loscalzo J, Benoit SE, Valeri CR, Barnard MR, Michelson AD. Decreased platelet inhibition by nitric oxide in two brothers with a history of arterial thrombosis. J Clin Invest. 1996 Feb 15; 97(4):979-87. PMID: 8613552.
      Citations: 36     Fields:    Translation:Humans
    217. Liu L, Freedman J, Hornstein A, Dewar L, Blajchman MA, Ofosu FA. Plasmin accelerates platelet-dependent prothrombinase formation without activating the platelets. Br J Haematol. 1996 Feb; 92(2):458-65. PMID: 8603017.
      Citations:    Fields:    Translation:HumansCells
    218. Semple JW, Freedman J. Abnormal cellular immune mechanisms associated with autoimmune thrombocytopenia. Transfus Med Rev. 1995 Oct; 9(4):327-38. PMID: 8541715.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    219. Loscalzo J, Pasche B, Ouimet H, Freedman JE. Platelets and plasminogen activation. Thromb Haemost. 1995 Jul; 74(1):291-3. PMID: 8578474.
      Citations: 6     Fields:    Translation:HumansCells
    220. Freedman JE, Frei B, Welch GN, Loscalzo J. Glutathione peroxidase potentiates the inhibition of platelet function by S-nitrosothiols. J Clin Invest. 1995 Jul; 96(1):394-400. PMID: 7615810.
      Citations: 32     Fields:    Translation:HumansCells
    221. Freedman JE, Fabian A, Loscalzo J. Impaired EDRF production by endothelial cells exposed to fibrin monomer and FDP. Am J Physiol. 1995 Feb; 268(2 Pt 1):C520-6. PMID: 7532361.
      Citations: 1     Fields:    Translation:AnimalsCells
    222. Liu L, Freedman J, Hornstein A, Fenton JW, Ofosu FA. Thrombin binding to platelets and their activation in plasma. Br J Haematol. 1994 Nov; 88(3):592-600. PMID: 7529534.
      Citations: 1     Fields:    Translation:HumansCells
    223. Ouimet H, Freedman JE, Loscalzo J. Kinetics and mechanism of platelet-surface plasminogen activation by tissue-type plasminogen activator. Biochemistry. 1994 Mar 15; 33(10):2970-6. PMID: 8130211.
      Citations: 3     Fields:    Translation:HumansCells
    224. Semple JW, Freedman J. Natural killer cell numbers and activity in patients with chronic autoimmune thrombocytopenic purpura. Blood. 1994 Feb 01; 83(3):870-1. PMID: 8298145.
      Citations: 1     Fields:    Translation:HumansCells
    225. Atlas E, Freedman J, Blanchette V, Kazatchkine MD, Semple JW. Downregulation of the anti-HLA alloimmune response by variable region-reactive (anti-idiotypic) antibodies in leukemic patients transfused with platelet concentrates. Blood. 1993 Jan 15; 81(2):538-42. PMID: 8422470.
      Citations: 4     Fields:    Translation:HumansCells
    226. Rubin B, Chan CC, Burnier M, Munion L, Freedman J. Histopathologic study of the Molteno glaucoma implant in three patients. Am J Ophthalmol. 1990 Oct 15; 110(4):371-9. PMID: 2220971.
      Citations: 7     Fields:    Translation:Humans
    227. H?kfelt T, Tsuruo Y, Ulfhake B, Cullheim S, Arvidsson U, Foster GA, Schultzberg M, Schalling M, Arborelius L, Freedman J, et al. Distribution of TRH-like immunoreactivity with special reference to coexistence with other neuroactive compounds. Ann N Y Acad Sci. 1989; 553:76-105. PMID: 2497689.
      Citations: 9     Fields:    Translation:AnimalsCells
    228. Rolbin SH, Abbott D, Musclow E, Papsin F, Lie LM, Freedman J. Epidural anesthesia in pregnant patients with low platelet counts. Obstet Gynecol. 1988 Jun; 71(6 Pt 1):918-20. PMID: 3368173.
      Citations: 13     Fields:    Translation:Humans
    229. Freedman J, Garvey MB, Salomon de Friedberg Z, Hornstein A, Blanchette V. Random donor platelet crossmatching: comparison of four platelet antibody detection methods. Am J Hematol. 1988 May; 28(1):1-7. PMID: 3285667.
      Citations: 3     Fields:    Translation:HumansCells
    230. Flood PM, Friedman A, Freedman J, Horvat B, Reuter P, Ptak W. The role of contrasuppression in tumor regression. Immunol Res. 1988; 7(1):12-22. PMID: 2897407.
      Citations: 3     Fields:    Translation:AnimalsCells
    231. Freedman JE, Aghajanian GK. Role of phosphoinositide metabolites in the prolongation of afterhyperpolarizations by alpha 1-adrenoceptors in rat dorsal raphe neurons. J Neurosci. 1987 Dec; 7(12):3897-906. PMID: 2826720.
      Citations: 5     Fields:    Translation:AnimalsCells
    232. Loscalzo J, Freedman J, Rudd MA, Barsky-Vasserman I, Vaughan DE. Unsaturated fatty acids enhance low density lipoprotein uptake and degradation by peripheral blood mononuclear cells. Arteriosclerosis. 1987 Sep-Oct; 7(5):450-5. PMID: 3675304.
      Citations: 2     Fields:    Translation:HumansCells
    233. Loscalzo J, Freedman J. Purification and characterization of human platelet glutathione-S-transferase. Blood. 1986 Jun; 67(6):1595-9. PMID: 3085745.
      Citations: 5     Fields:    Translation:HumansCells
    234. Garvey MB, Freedman J. Indirect platelet radioactive antiglobulin test in patients with lymphoproliferative disease. J Lab Clin Med. 1986 Feb; 107(2):123-8. PMID: 3944493.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    235. Freedman J, Cheong T, Garvey MB. Use of the indirect platelet radioactive antiglobulin test with anti-IgG and anti-C3 in immune and nonimmune thrombocytopenias. Am J Hematol. 1985 Mar; 18(3):297-305. PMID: 3883754.
      Citations:    Fields:    Translation:HumansCells
    236. Freedman J. A clinical approach to the aetiology of uveitis in Bantu adults. Br J Ophthalmol. 1976 Jan; 60(1):64-9. PMID: 1268163.
      Citations: 1     Fields:    Translation:Humans
    237. Adler R, Freedman J, Kukar N, Gombos GM. Various parameters of diabetic retinopathy among clinic populations. Ann Ophthalmol. 1975 Nov; 7(11):1447-54. PMID: 1200555.
      Citations: 3     Fields:    Translation:Humans
    238. Freedman J. Incidence of uveitis in Bantu-speaking negroes of South Africa. Br J Ophthalmol. 1974 Jun; 58(6):595-9. PMID: 4425640.
      Citations: 5     Fields:    Translation:Humans
    239. Freedman J. Survey of ocular disease among the Nama people of South West Africa. Br J Ophthalmol. 1973 Sep; 57(9):681-7. PMID: 4543270.
      Citations: 3     Fields:    Translation:Humans
    240. Freedman J. Nama keratopathy. Br J Ophthalmol. 1973 Sep; 57(9):688-91. PMID: 4543271.
      Citations: 7     Fields:    Translation:Humans
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