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George Wright PhD

TitleProfessor
InstitutionUniversity of Massachusetts Medical School
DepartmentBiochemistry and Molecular Pharmacology
AddressGL Synthesis
One Innovation Drive, Biotech Three
Worcester MA 01605
Phone508-754-6700
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    Other Positions
    InstitutionUMMS - School of Medicine
    DepartmentBiochemistry and Molecular Pharmacology

    InstitutionUMMS - Programs, Centers and Institutes
    DepartmentFaculty Affairs


    Collapse Biography 
    Collapse education and training
    University of Illinois, Chicago, Chicago, IL, United StatesBSPharmacy
    University of Illinois, Chicago, Chicago, IL, United StatesPH DPharmaceutical Chemistry

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Nakagawa M, Shaffer AL, Ceribelli M, Zhang M, Wright G, Huang DW, Xiao W, Powell J, Petrus MN, Yang Y, Phelan JD, Kohlhammer H, Dubois SP, Yoo HM, Bachy E, Webster DE, Yang Y, Xu W, Yu X, Zhao H, Bryant BR, Shimono J, Ishio T, Maeda M, Green PL, Waldmann TA, Staudt LM. Targeting the HTLV-I-Regulated BATF3/IRF4 Transcriptional Network in Adult T Cell Leukemia/Lymphoma. Cancer Cell. 2018 Aug 13; 34(2):286-297.e10. PMID: 30057145.
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    2. Phelan JD, Young RM, Webster DE, Roulland S, Wright GW, Kasbekar M, Shaffer AL, Ceribelli M, Wang JQ, Schmitz R, Nakagawa M, Bachy E, Huang DW, Ji Y, Chen L, Yang Y, Zhao H, Yu X, Xu W, Palisoc MM, Valadez RR, Davies-Hill T, Wilson WH, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Rodriguez FJ, Estephan F, Holdhoff M, Kruhlak MJ, Hewitt SM, Thomas CJ, Pittaluga S, Oellerich T, Staudt LM. A multiprotein supercomplex controlling oncogenic signalling in lymphoma. Nature. 2018 Jun 20. PMID: 29925955.
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    3. Schmitz R, Wright GW, Huang DW, Johnson CA, Phelan JD, Wang JQ, Roulland S, Kasbekar M, Young RM, Shaffer AL, Hodson DJ, Xiao W, Yu X, Yang Y, Zhao H, Xu W, Liu X, Zhou B, Du W, Chan WC, Jaffe ES, Gascoyne RD, Connors JM, Campo E, Lopez-Guillermo A, Rosenwald A, Ott G, Delabie J, Rimsza LM, Tay Kuang Wei K, Zelenetz AD, Leonard JP, Bartlett NL, Tran B, Shetty J, Zhao Y, Soppet DR, Pittaluga S, Wilson WH, Staudt LM. Genetics and Pathogenesis of Diffuse Large B-Cell Lymphoma. N Engl J Med. 2018 04 12; 378(15):1396-1407. PMID: 29641966.
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    4. Yanachkov I, Zavizion B, Metelev V, Stevens LJ, Tabatadze Y, Yanachkova M, Wright G, Krichevsky AM, Tabatadze DR. Self-neutralizing oligonucleotides with enhanced cellular uptake. Org Biomol Chem. 2017 Jan 11. PMID: 28074950.
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    5. Rui L, Drennan AC, Ceribelli M, Zhu F, Wright GW, Huang DW, Xiao W, Li Y, Grindle KM, Lu L, Hodson DJ, Shaffer AL, Zhao H, Xu W, Yang Y, Staudt LM. Epigenetic gene regulation by Janus kinase 1 in diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2016 Nov 15; 113(46):E7260-E7267. PMID: 27799566.
      View in: PubMed
    6. Yang Y, Kelly P, Shaffer AL, Schmitz R, Yoo HM, Liu X, Huang da W, Webster D, Young RM, Nakagawa M, Ceribelli M, Wright GW, Yang Y, Zhao H, Yu X, Xu W, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza L, Staudt LM. Targeting Non-proteolytic Protein Ubiquitination for the Treatment of Diffuse Large B Cell Lymphoma. Cancer Cell. 2016 Apr 11; 29(4):494-507. PMID: 27070702.
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    7. Melchior DL, Brill S, Wright GE, Schuldiner S. A liposomal method for evaluation of inhibitors of H(+)-coupled multidrug transporters. J Pharmacol Toxicol Methods. 2016 Jan-Feb; 77:53-7. PMID: 26463179.
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    8. Brush LA, Black DH, Mccormack KA, Maxwell LK, Wright G, Ritchey JW, Payton ME, Eberle R. Papiine herpesvirus 2 as a predictive model for drug sensitivity of Macacine herpesvirus 1 (monkey B virus). Comp Med. 2014 Oct; 64(5):386-93. PMID: 25402179.
      View in: PubMed
    9. Chang H, Yanachkov IB, Dix EJ, Yanachkova M, Li Y, Barnard MR, Wright GE, Michelson AD, Frelinger AL. Antiplatelet activity, P2Y1 and P2Y12 inhibition, and metabolism in plasma of stereoisomers of diadenosine 5',5'?-P¹ ,P4-dithio-P²,P³-chloromethylenetetraphosphate. PLoS One. 2014; 9(4):e94780. PMID: 24722456.
      View in: PubMed
    10. Yang Y, Schmitz R, Mitala J, Whiting A, Xiao W, Ceribelli M, Wright GW, Zhao H, Yang Y, Xu W, Rosenwald A, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Wiestner A, Kruhlak MJ, Iwai K, Bernal F, Staudt LM. Essential role of the linear ubiquitin chain assembly complex in lymphoma revealed by rare germline polymorphisms. Cancer Discov. 2014 Apr; 4(4):480-93. PMID: 24491438.
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    11. Barlow JH, Faryabi RB, Callén E, Wong N, Malhowski A, Chen HT, Gutierrez-Cruz G, Sun HW, McKinnon P, Wright G, Casellas R, Robbiani DF, Staudt L, Fernandez-Capetillo O, Nussenzweig A. Identification of early replicating fragile sites that contribute to genome instability. Cell. 2013 Jan 31; 152(3):620-32. PMID: 23352430.
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    12. Chang H, Yanachkov IB, Dix EJ, Li YF, Barnard MR, Wright GE, Michelson AD, Frelinger AL. Modified diadenosine tetraphosphates with dual specificity for P2Y1 and P2Y12 are potent antagonists of ADP-induced platelet activation. J Thromb Haemost. 2012 Dec; 10(12):2573-80. PMID: 23083103.
      View in: PubMed
    13. Barnes MH, Butler MM, Wright GE, Brown NC. Antimicrobials targeted to the replication-specific DNA polymerases of gram-positive bacteria: target potential of dnaE. Infect Disord Drug Targets. 2012 Oct; 12(5):327-31. PMID: 23017159.
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    14. Schmitz R, Young RM, Ceribelli M, Jhavar S, Xiao W, Zhang M, Wright G, Shaffer AL, Hodson DJ, Buras E, Liu X, Powell J, Yang Y, Xu W, Zhao H, Kohlhammer H, Rosenwald A, Kluin P, Müller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Ogwang MD, Reynolds SJ, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pittaluga S, Wilson W, Waldmann TA, Rowe M, Mbulaiteye SM, Rickinson AB, Staudt LM. Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics. Nature. 2012 Oct 4; 490(7418):116-20. PMID: 22885699.
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    15. Yang Y, Shaffer AL, Emre NC, Ceribelli M, Zhang M, Wright G, Xiao W, Powell J, Platig J, Kohlhammer H, Young RM, Zhao H, Yang Y, Xu W, Buggy JJ, Balasubramanian S, Mathews LA, Shinn P, Guha R, Ferrer M, Thomas C, Waldmann TA, Staudt LM. Exploiting synthetic lethality for the therapy of ABC diffuse large B cell lymphoma. Cancer Cell. 2012 Jun 12; 21(6):723-37. PMID: 22698399.
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    16. Melchior DL, Sharom FJ, Evers R, Wright GE, Chu JW, Wright SE, Chu X, Yabut J. Determining P-glycoprotein-drug interactions: evaluation of reconstituted P-glycoprotein in a liposomal system and LLC-MDR1 polarized cell monolayers. J Pharmacol Toxicol Methods. 2012 Mar; 65(2):64-74. PMID: 22394995.
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    17. Xu WC, Wright GE, Brown NC, Long ZY, Zhi CX, Dvoskin S, Gambino JJ, Barnes MH, Butler MM. 7-Alkyl-N(2)-substituted-3-deazaguanines. Synthesis, DNA polymerase III inhibition and antibacterial activity. Bioorg Med Chem Lett. 2011 Jul 15; 21(14):4197-202. PMID: 21684746.
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    18. Ngo VN, Young RM, Schmitz R, Jhavar S, Xiao W, Lim KH, Kohlhammer H, Xu W, Yang Y, Zhao H, Shaffer AL, Romesser P, Wright G, Powell J, Rosenwald A, Muller-Hermelink HK, Ott G, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Staudt LM. Oncogenically active MYD88 mutations in human lymphoma. Nature. 2011 Feb 3; 470(7332):115-9. PMID: 21179087.
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    19. Rui L, Emre NC, Kruhlak MJ, Chung HJ, Steidl C, Slack G, Wright GW, Lenz G, Ngo VN, Shaffer AL, Xu W, Zhao H, Yang Y, Lamy L, Davis RE, Xiao W, Powell J, Maloney D, Thomas CJ, Möller P, Rosenwald A, Ott G, Muller-Hermelink HK, Savage K, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Weisenburger DD, Chan WC, Gascoyne RD, Levens D, Staudt LM. Cooperative epigenetic modulation by cancer amplicon genes. Cancer Cell. 2010 Dec 14; 18(6):590-605. PMID: 21156283.
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    20. Yanachkov IB, Dix EJ, Yanachkova MI, Wright GE. P1,P2-diimidazolyl derivatives of pyrophosphate and bis-phosphonates--synthesis, properties, and use in preparation of dinucleoside tetraphosphates and analogs. Org Biomol Chem. 2011 Feb 7; 9(3):730-8. PMID: 21082127.
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    21. Davis RE, Ngo VN, Lenz G, Tolar P, Young RM, Romesser PB, Kohlhammer H, Lamy L, Zhao H, Yang Y, Xu W, Shaffer AL, Wright G, Xiao W, Powell J, Jiang JK, Thomas CJ, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Johnson NA, Rimsza LM, Campo E, Jaffe ES, Wilson WH, Delabie J, Smeland EB, Fisher RI, Braziel RM, Tubbs RR, Cook JR, Weisenburger DD, Chan WC, Pierce SK, Staudt LM. Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma. Nature. 2010 Jan 7; 463(7277):88-92. PMID: 20054396.
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    22. Chang H, Yanachkov IB, Michelson AD, Li Y, Barnard MR, Wright GE, Frelinger AL. Agonist and antagonist effects of diadenosine tetraphosphate, a platelet dense granule constituent, on platelet P2Y1, P2Y12 and P2X1 receptors. Thromb Res. 2010 Feb; 125(2):159-65. PMID: 19945153.
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    23. Lam LT, Davis RE, Ngo VN, Lenz G, Wright G, Xu W, Zhao H, Yu X, Dang L, Staudt LM. Compensatory IKKalpha activation of classical NF-kappaB signaling during IKKbeta inhibition identified by an RNA interference sensitization screen. Proc Natl Acad Sci U S A. 2008 Dec 30; 105(52):20798-803. PMID: 19104039.
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    24. Lenz G, Davis RE, Ngo VN, Lam L, George TC, Wright GW, Dave SS, Zhao H, Xu W, Rosenwald A, Ott G, Muller-Hermelink HK, Gascoyne RD, Connors JM, Rimsza LM, Campo E, Jaffe ES, Delabie J, Smeland EB, Fisher RI, Chan WC, Staudt LM. Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. Science. 2008 Mar 21; 319(5870):1676-9. PMID: 18323416.
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    25. Tabatadze D, Zamecnik P, Yanachkov I, Wright G, Pierson K, Zhang S, Bogdanov A, Metelev V. A novel thymidine phosphoramidite synthon for incorporation of internucleoside phosphate linkers during automated oligodeoxynucleotide synthesis. Nucleosides Nucleotides Nucleic Acids. 2008 Feb; 27(2):157-72. PMID: 18205070.
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    26. Focher F, Lossani A, Verri A, Spadari S, Maioli A, Gambino JJ, Wright GE, Eberle R, Black DH, Medveczky P, Medveczky M, Shugar D. Sensitivity of monkey B virus (Cercopithecine herpesvirus 1) to antiviral drugs: role of thymidine kinase in antiviral activities of substrate analogs and acyclonucleosides. Antimicrob Agents Chemother. 2007 Jun; 51(6):2028-34. PMID: 17438061.
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    27. Butler MM, Lamarr WA, Foster KA, Barnes MH, Skow DJ, Lyden PT, Kustigian LM, Zhi C, Brown NC, Wright GE, Bowlin TL. Antibacterial activity and mechanism of action of a novel anilinouracil-fluoroquinolone hybrid compound. Antimicrob Agents Chemother. 2007 Jan; 51(1):119-27. PMID: 17074800.
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    28. Zhi C, Long ZY, Manikowski A, Comstock J, Xu WC, Brown NC, Tarantino PM, Holm KA, Dix EJ, Wright GE, Barnes MH, Butler MM, Foster KA, LaMarr WA, Bachand B, Bethell R, Cadilhac C, Charron S, Lamothe S, Motorina I, Storer R. Hybrid antibacterials. DNA polymerase-topoisomerase inhibitors. J Med Chem. 2006 Feb 23; 49(4):1455-65. PMID: 16480282.
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    29. Zhi C, Long ZY, Manikowski A, Brown NC, Tarantino PM, Holm K, Dix EJ, Wright GE, Foster KA, Butler MM, LaMarr WA, Skow DJ, Motorina I, Lamothe S, Storer R. Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. J Med Chem. 2005 Nov 3; 48(22):7063-74. PMID: 16250666.
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    30. Manikowski A, Verri A, Lossani A, Gebhardt BM, Gambino J, Focher F, Spadari S, Wright GE. Inhibition of herpes simplex virus thymidine kinases by 2-phenylamino-6-oxopurines and related compounds: structure-activity relationships and antiherpetic activity in vivo. J Med Chem. 2005 Jun 2; 48(11):3919-29. PMID: 15916444.
      View in: PubMed
    31. Wright GE, Brown NC, Xu WC, Long ZY, Zhi C, Gambino JJ, Barnes MH, Butler MM. Active site directed inhibitors of replication-specific bacterial DNA polymerases. Bioorg Med Chem Lett. 2005 Feb 1; 15(3):729-32. PMID: 15664846.
      View in: PubMed
    32. Zhi C, Long ZY, Gambino J, Xu WC, Brown NC, Barnes M, Butler M, LaMarr W, Wright GE. Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth. J Med Chem. 2003 Jun 19; 46(13):2731-9. PMID: 12801236.
      View in: PubMed
    33. Daly JS, Giehl TJ, Brown NC, Zhi C, Wright GE, Ellison RT. In vitro antimicrobial activities of novel anilinouracils which selectively inhibit DNA polymerase III of gram-positive bacteria. Antimicrob Agents Chemother. 2000 Aug; 44(8):2217-21. PMID: 10898708.
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    34. Stattel JM, Wright GE. Sensitivity of bacteriophage RB69 DNA polymerase to N2-(p-n-butylphenyl)-2'-deoxyguanosine nucleotides. Nucleosides Nucleotides. 1999 Oct; 18(10):2193-9. PMID: 10616725.
      View in: PubMed
    35. Tarantino PM, Zhi C, Wright GE, Brown NC. Inhibitors of DNA polymerase III as novel antimicrobial agents against gram-positive eubacteria. Antimicrob Agents Chemother. 1999 Aug; 43(8):1982-7. PMID: 10428923.
      View in: PubMed
    36. Sun H, Zhi C, Wright GE, Ubiali D, Pregnolato M, Verri A, Focher F, Spadari S. Molecular modeling and synthesis of inhibitors of herpes simplex virus type 1 uracil-DNA glycosylase. J Med Chem. 1999 Jul 1; 42(13):2344-50. PMID: 10395474.
      View in: PubMed
    37. Tarantino PM, Zhi C, Gambino JJ, Wright GE, Brown NC. 6-Anilinouracil-based inhibitors of Bacillus subtilis DNA polymerase III: antipolymerase and antimicrobial structure-activity relationships based on substitution at uracil N3. J Med Chem. 1999 Jun 3; 42(11):2035-40. PMID: 10354411.
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    38. Stattel JM, Yanachkov I, Wright GE. Synthesis and biochemical study of N2-(p-n-butylphenyl)-2'-deoxyguanosine 5'-(alpha,beta-imido)triphosphate (BuPdGMPNHPP): a non-substrate inhibitor of B family DNA polymerases. Nucleosides Nucleotides. 1998 Aug; 17(8):1505-13. PMID: 9672707.
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    39. Young JK, Hicks RP, Wright GE, Morrison TG. The role of leucine residues in the structure and function of a leucine zipper peptide inhibitor of paramyxovirus (NDV) fusion. Virology. 1998 Mar 30; 243(1):21-31. PMID: 9527912.
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    40. Young JK, Hicks RP, Wright GE, Morrison TG. Analysis of a peptide inhibitor of paramyxovirus (NDV) fusion using biological assays, NMR, and molecular modeling. Virology. 1997 Nov 24; 238(2):291-304. PMID: 9400602.
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    41. Young JK, Marí F, Xu M, Humphreys RE, Clemente NM, Stattel JM, Nelson DJ, Gambino J, Wright GE. Structural studies by 1H NMR of a prototypic alpha-helical peptide (LYQELQKLTQTLK) and homologs in trifluoroethanol/water and on sodium dodecyl sulfate micelles. J Pept Res. 1997 Aug; 50(2):122-31. PMID: 9273896.
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    42. Yanachkov I, Pan JY, Wessling-Resnick M, Wright GE. Synthesis and effect of nonhydrolyzable xanthosine triphosphate derivatives on prenylation of Rab5D136N. Mol Pharmacol. 1997 Jan; 51(1):47-51. PMID: 9016345.
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    43. Veronikis IE, Alex S, Fang SL, Wright G, Wu SY, Chanoine JP, Emerson CH, Braverman LE. Serum iodothyronine concentrations in intestinally decontaminated rats treated with a 5'-deiodinase type I inhibitor 6-anilino-2-thiouracil. Eur J Endocrinol. 1996 Apr; 134(4):519-23. PMID: 8640307.
      View in: PubMed
    44. Hoffenberg S, Shannon TM, Noonan TP, Liu S, Daniel DS, Fishman JB, Rubins JB, Misra HK, Wright GE, Dickey BF. Specific and effective interaction of a guanine nucleotide analogue with small G proteins. Mol Pharmacol. 1996 Jan; 49(1):156-64. PMID: 8569702.
      View in: PubMed
    45. Wright GE. Nucleotide probes of DNA polymerases. Acta Biochim Pol. 1996; 43(1):115-24. PMID: 8790717.
      View in: PubMed
    46. Burstein SH, Young JK, Wright GE. Relationships between eicosanoids and cannabinoids. Are eicosanoids cannabimimetic agents?. Biochem Pharmacol. 1995 Nov 27; 50(11):1735-42. PMID: 8615850.
      View in: PubMed
    47. Xu H, Maga G, Focher F, Smith ER, Spadari S, Gambino J, Wright GE. Synthesis, properties, and pharmacokinetic studies of N2-phenylguanine derivatives as inhibitors of herpes simplex virus thymidine kinases. J Med Chem. 1995 Jan 6; 38(1):49-57. PMID: 7837239.
      View in: PubMed
    48. Brown NC, Wright GE. Mechanisms of inhibition of DNA polymerases by 2'-deoxyribonucleoside 5'-triphosphate analogs. Methods Enzymol. 1995; 262:202-17. PMID: 8594348.
      View in: PubMed
    49. Stattel JM, Wright GE. Butylphenyl-dGTP as a structural probe of B family DNA polymerases. Postepy Biochem. 1995; 41(5 Suppl):332-7. PMID: 8797233.
      View in: PubMed
    50. Wright GE, Hübscher U, Khan NN, Focher F, Verri A. Inhibitor analysis of calf thymus DNA polymerases alpha, delta and epsilon. FEBS Lett. 1994 Mar 14; 341(1):128-30. PMID: 8137912.
      View in: PubMed
    51. Khan NN, Reha-Krantz LJ, Wright GE. Analysis of inhibitors of bacteriophage T4 DNA polymerase. Nucleic Acids Res. 1994 Jan 25; 22(2):232-7. PMID: 8121808.
      View in: PubMed
    52. Misra HK, Khan NN, Agrawal S, Wright GE. Chemical and enzymatic incorporation of N2-(p-n-butylphenyl)-2'-deoxyguanosine into an oligodeoxyribonucleotide. Nucleic Acids Res. 1992 Sep 11; 20(17):4547-51. PMID: 1408755.
      View in: PubMed
    53. Gambino J, Focher F, Hildebrand C, Maga G, Noonan T, Spadari S, Wright G. Quantitative structure-activity relationships of N2-phenylguanines as inhibitors of herpes simplex virus thymidine kinases. J Med Chem. 1992 Aug 7; 35(16):2979-83. PMID: 1323680.
      View in: PubMed
    54. Khan NN, Wright GE, Brown NC. The molecular mechanism of inhibition of alpha-type DNA polymerases by N2-(butylphenyl)dGTP and 2-(butylanilino)dATP: variation in susceptibility to polymerization. Nucleic Acids Res. 1991 Apr 11; 19(7):1627-32. PMID: 2027770.
      View in: PubMed
    55. Noonan T, Brown N, Dudycz L, Wright G. Interaction of GTP derivatives with cellular and oncogenic ras-p21 proteins. J Med Chem. 1991 Apr; 34(4):1302-7. PMID: 2016705.
      View in: PubMed
    56. Butler MM, Dudycz LW, Khan NN, Wright GE, Brown NC. Development of novel inhibitor probes of DNA polymerase III based on dGTP analogs of the HPUra type: base, nucleoside and nucleotide derivatives of N2-(3,4-dichlorobenzyl)guanine. Nucleic Acids Res. 1990 Dec 25; 18(24):7381-7. PMID: 2259629.
      View in: PubMed
    57. Arabshahi L, Khan NN, Butler M, Noonan T, Brown NC, Wright GE. (Difluoromethylene)phosphates of guanine nucleosides as probes of DNA polymerases and G proteins. Biochemistry. 1990 Jul 24; 29(29):6820-6. PMID: 2118802.
      View in: PubMed
    58. Wright GE, Brown NC. Deoxyribonucleotide analogs as inhibitors and substrates of DNA polymerases. Pharmacol Ther. 1990; 47(3):447-97. PMID: 2290857.
      View in: PubMed
    59. Talanian RV, Wright GE. The roles of DNA polymerases alpha and delta in DNA replication. Pharmacol Ther. 1990; 47(1):105-15. PMID: 2195552.
      View in: PubMed
    60. Hildebrand C, Sandoli D, Focher F, Gambino J, Ciarrocchi G, Spadari S, Wright G. Structure-activity relationships of N2-substituted guanines as inhibitors of HSV1 and HSV2 thymidine kinases. J Med Chem. 1990 Jan; 33(1):203-6. PMID: 2153203.
      View in: PubMed
    61. Talanian RV, Brown NC, McKenna CE, Ye TG, Levy JN, Wright GE. Carbonyldiphosphonate, a selective inhibitor of mammalian DNA polymerase delta. Biochemistry. 1989 Oct 17; 28(21):8270-4. PMID: 2557899.
      View in: PubMed
    62. Arabshahi L, Brown N, Khan N, Wright G. Inhibition of DNA polymerase alpha by aphidicolin derivatives. Nucleic Acids Res. 1988 Jun 10; 16(11):5107-13. PMID: 3133639.
      View in: PubMed
    63. Wright G, Dudycz L. Sugar ring conformations of guanine nucleosides by proton nuclear magnetic resonance. Acta Biochim Pol. 1987; 34(2):123-34. PMID: 3673436.
      View in: PubMed
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